Dementia Big
Researchers using contrast-enhanced MRI have identified leakages in the blood-brain barrier (BBB) of people with early Alzheimer’s disease (AD), according to a new study published online in the journal Radiology. The results suggest that increased BBB permeability may represent a key mechanism in the early stages of the disease.
Researchers using contrast-enhanced MRI have identified leakages in the blood-brain barrier (BBB) of people with early Alzheimer’s disease (AD), according to a new study published online in the journal Radiology. The results suggest that increased BBB permeability may represent a key mechanism in the early stages of the disease.
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Dementia Big
Some 47 million people worldwide suffer from some form of dementia. Scientists are working feverishly to find a cure for the most common form, Alzheimer’s. At the Congress of the European Academy of Neurology in Copenhagen, Prof Gunhild Waldemar issued an appeal for researchers to work together and draw up standardised guidelines for early identification and treatment of the disease.
Some 47 million people worldwide suffer from some form of dementia. Scientists are working feverishly to find a cure for the most common form, Alzheimer’s. At the Congress of the European Academy of Neurology in Copenhagen, Prof Gunhild Waldemar issued an appeal for researchers to work together and draw up standardised guidelines for early identification and treatment of the disease.
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Dementia Big
We estimated the prevalence of microinfarcts and their association with dementia in a cohort of oldest-old participants.
We estimated the prevalence of microinfarcts and their association with dementia in a cohort of oldest-old participants.
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Dementia Big
University of California, Berkeley scientists have developed a quicker and more efficient method to alter the genes of mice with CRISPR-Cas9, simplifying a procedure growing in popularity because of the ease of using the new gene-editing tool.
Dementia Big
Multiple Sclerosis (MS) is a neurological disease, characterised by demyelination and the onset of chronic, neurodegenerative damage of the central nervous system. Right now, its causes are unknown although various self-immune mechanisms are known to be involved.
Dementia Big
A team of scientists from across the globe have shown that the brains of patients with schizophrenia have the capacity to reorganize and fight the illness. This is the first time that imaging data has been used to show that our brains may have the ability to reverse the effects of schizophrenia.
Dementia Big
As the difficulty of making a decision based on sensory evidence increases, activity in the brain’s insular cortex also increases, according to researchers at Georgia State University.
Dementia Big
Massive investment and technological advances in the collection of extensive and longitudinal information on thousands of Alzheimer patients results in large amounts of data. These “big-data” databases can potentially advance CNS research and drug development. However, although necessary, they are not sufficient, and we posit that they must be matched with analytical methods that go beyond retrospective data-driven associations with various clinical phenotypes. Although these empirically derived associations can generate novel and useful hypotheses, they need to be organically integrated in a quantitative understanding of the pathology that can be actionable for drug discovery and development.
Multiple Sclerosis (MS) is a neurological disease, characterised by demyelination and the onset of chronic, neurodegenerative damage of the central nervous system. Right now, its causes are unknown although various self-immune mechanisms are known to be involved.
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As the difficulty of making a decision based on sensory evidence increases, activity in the brain’s insular cortex also increases, according to researchers at Georgia State University.
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A team of scientists from across the globe have shown that the brains of patients with schizophrenia have the capacity to reorganize and fight the illness. This is the first time that imaging data has been used to show that our brains may have the ability to reverse the effects of schizophrenia.
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University of California, Berkeley scientists have developed a quicker and more efficient method to alter the genes of mice with CRISPR-Cas9, simplifying a procedure growing in popularity because of the ease of using the new gene-editing tool.
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Massive investment and technological advances in the collection of extensive and longitudinal information on thousands of Alzheimer patients results in large amounts of data. These “big-data” databases can potentially advance CNS research and drug development. However, although necessary, they are not sufficient, and we posit that they must be matched with analytical methods that go beyond retrospective data-driven associations with various clinical phenotypes. Although these empirically derived associations can generate novel and useful hypotheses, they need to be organically integrated in a quantitative understanding of the pathology that can be actionable for drug discovery and development.
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Dementia Big
A tool developed by researchers from UPM allows us to assess usability during the design and testing process of accessible ICT-based applications.
A tool developed by researchers from UPM allows us to assess usability during the design and testing process of accessible ICT-based applications.
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The heart of healthcare is stressed. With longer shifts, staffing shortages and healthcare changes taxing our nurses, it’s no surprise that up to 80 percent report suffering compassion fatigue at some point in their careers, according to recent studies.
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Progranulin is a central protein in both neuronal survival and neurodegenerative diseases. It is thus not surprising that altered progranulin levels represent a universal theme shared across several common neurodegenerative diseases.
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Progranulin is a central protein in both neuronal survival and neurodegenerative diseases. It is thus not surprising that altered progranulin levels represent a universal theme shared across several common neurodegenerative diseases. In Alzheimer’s Disease, for instance, reduced brain levels of progranulin contribute to the specific amyloid disease pathology, while increased levels appear to protect against this pathology. In genetic forms of another type of dementia, namely frontotemporal dementia (FTD), progranulin levels can be reduced. As progranulin can be measured relatively easily in blood, it seemed that a promising new biomarker for types of dementia has now been found. In fact, treatments were proposed to increase progranulin levels, aiming to yield a therapeutic effect for many neurodegenerative diseases. It was suggested to take progranulin in blood as a measure of response for these future treatments.
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Dementia Big
Progranulin is a central protein in both neuronal survival and neurodegenerative diseases. It is thus not surprising that altered progranulin levels represent a universal theme shared across several common neurodegenerative diseases.
Dementia Big
The heart of healthcare is stressed. With longer shifts, staffing shortages and healthcare changes taxing our nurses, it’s no surprise that up to 80 percent report suffering compassion fatigue at some point in their careers, according to recent studies.
Dementia Big
Progranulin is a central protein in both neuronal survival and neurodegenerative diseases. It is thus not surprising that altered progranulin levels represent a universal theme shared across several common neurodegenerative diseases. In Alzheimer’s Disease, for instance, reduced brain levels of progranulin contribute to the specific amyloid disease pathology, while increased levels appear to protect against this pathology. In genetic forms of another type of dementia, namely frontotemporal dementia (FTD), progranulin levels can be reduced. As progranulin can be measured relatively easily in blood, it seemed that a promising new biomarker for types of dementia has now been found. In fact, treatments were proposed to increase progranulin levels, aiming to yield a therapeutic effect for many neurodegenerative diseases. It was suggested to take progranulin in blood as a measure of response for these future treatments.
Dementia Big
A new study from Örebro University, published in Science Signaling today, shows that heart medication reduces the build-up of plaque in the brain’s blood vessels in mice. The question is if this is true also in humans? If the answer is yes, it might bring scientists a step closer to developing a medicine against Alzheimer’s disease.
Dementia Big
Neuroscientist Anne Hafkemeijer is able to distinguish two different forms of dementia using advanced imaging techniques. This is the first step towards early recognition of dementia in patients on the basis of brain networks. PhD defence 26 May.
Dementia Big
The effort to find ways to detect and diagnose preclinical Alzheimer’s disease (AD) has taken a big step forward with the use of positron emission tomography (PET), a “nuclear medicine” for imaging processes in the body, when PET is used with a special ‘tracer’ that binds to the amyloid plaques in the brain that are a characteristic cause of AD.
Dementia Big
Neuroscientist Anne Hafkemeijer is able to distinguish two different forms of dementia using advanced imaging techniques. This is the first step towards early recognition of dementia in patients on the basis of brain networks.
The effort to find ways to detect and diagnose preclinical Alzheimer’s disease (AD) has taken a big step forward with the use of positron emission tomography (PET), a “nuclear medicine” for imaging processes in the body, when PET is used with a special ‘tracer’ that binds to the amyloid plaques in the brain that are a characteristic cause of AD.
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Neuroscientist Anne Hafkemeijer is able to distinguish two different forms of dementia using advanced imaging techniques. This is the first step towards early recognition of dementia in patients on the basis of brain networks.
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A new study from Örebro University, published in Science Signaling today, shows that heart medication reduces the build-up of plaque in the brain’s blood vessels in mice. The question is if this is true also in humans? If the answer is yes, it might bring scientists a step closer to developing a medicine against Alzheimer’s disease.
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Neuroscientist Anne Hafkemeijer is able to distinguish two different forms of dementia using advanced imaging techniques. This is the first step towards early recognition of dementia in patients on the basis of brain networks. PhD defence 26 May.
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Dementia Big
Mild cognitive impairment (MCI) is a slight but noticeable and measurable decline in cognitive abilities, such as remembering names or a list of items. While changes may not be severe enough to disrupt daily life, a clinical diagnosis of MCI indicates an increased risk of eventually developing Alzheimer’s disease or another type of dementia.
Dementia Big
The effort to find ways to detect and diagnose preclinical Alzheimer’s disease (AD) has taken a big step forward with the use of positron emission tomography (PET), a “nuclear medicine” for imaging processes in the body, when PET is used with a special ‘tracer’ that binds to the amyloid plaques in the brain that are a characteristic cause of AD.
Dementia Big
Mild cognitive impairment (MCI) is a slight but noticeable and measurable decline in cognitive abilities, such as remembering names or a list of items. While changes may not be severe enough to disrupt daily life, a clinical diagnosis of MCI indicates an increased risk of eventually developing Alzheimer’s disease or another type of dementia.
Dementia Big
Alzheimer disease (AD) and Parkinson disease (PD) involve tau pathology. Tau is detectable in blood, but its clearance from neuronal cells and the brain is poorly understood.
Dementia Big
Influenza vaccination is associated with a lower risk of dementia in patients with heart failure, according to a study in more than 20 000 patients presented today at Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure by Dr Ju-Chi Liu, director of the Division of Cardiovascular Medicine, Department of Medicine, Taipei Medical University - Shuang Ho Hospital, in New Taipei City, Taiwan.
Mild cognitive impairment (MCI) is a slight but noticeable and measurable decline in cognitive abilities, such as remembering names or a list of items. While changes may not be severe enough to disrupt daily life, a clinical diagnosis of MCI indicates an increased risk of eventually developing Alzheimer’s disease or another type of dementia.
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The effort to find ways to detect and diagnose preclinical Alzheimer’s disease (AD) has taken a big step forward with the use of positron emission tomography (PET), a “nuclear medicine” for imaging processes in the body, when PET is used with a special ‘tracer’ that binds to the amyloid plaques in the brain that are a characteristic cause of AD.
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Mild cognitive impairment (MCI) is a slight but noticeable and measurable decline in cognitive abilities, such as remembering names or a list of items. While changes may not be severe enough to disrupt daily life, a clinical diagnosis of MCI indicates an increased risk of eventually developing Alzheimer’s disease or another type of dementia.
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Influenza vaccination is associated with a lower risk of dementia in patients with heart failure, according to a study in more than 20 000 patients presented today at Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure by Dr Ju-Chi Liu, director of the Division of Cardiovascular Medicine, Department of Medicine, Taipei Medical University - Shuang Ho Hospital, in New Taipei City, Taiwan.
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Alzheimer disease (AD) and Parkinson disease (PD) involve tau pathology. Tau is detectable in blood, but its clearance from neuronal cells and the brain is poorly understood.
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Diagnosis, treatment and care of dementia is one of the major concerns in neurology research and associated healthcare programs. Dementia affects older age groups with a greater frequency, and as our population ages, the burden of dementia on public health is rapidly increasing.
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Our objective was to compare the levels of three synaptic proteins involved in different steps of the synaptic transmission: Rab3A, SNAP25, and neurogranin, in three common forms of dementia: Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and Parkinson’s disease dementia.
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Dementia Big
Diagnosis, treatment and care of dementia is one of the major concerns in neurology research and associated healthcare programs. Dementia affects older age groups with a greater frequency, and as our population ages, the burden of dementia on public health is rapidly increasing.
Dementia Big
Our objective was to compare the levels of three synaptic proteins involved in different steps of the synaptic transmission: Rab3A, SNAP25, and neurogranin, in three common forms of dementia: Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and Parkinson’s disease dementia.
Diagnosis, treatment and care of dementia is one of the major concerns in neurology research and associated healthcare programs. Dementia affects older age groups with a greater frequency, and as our population ages, the burden of dementia on public health is rapidly increasing.
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Our objective was to compare the levels of three synaptic proteins involved in different steps of the synaptic transmission: Rab3A, SNAP25, and neurogranin, in three common forms of dementia: Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and Parkinson’s disease dementia.
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Dementia Big
The Predictors study was designed to predict the length of time to major disease outcomes in Alzheimer’s disease (AD) patients. Here, we describe the development of a new, Predictors 3, cohort.
The Predictors study was designed to predict the length of time to major disease outcomes in Alzheimer’s disease (AD) patients. Here, we describe the development of a new, Predictors 3, cohort.
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The Predictors study was designed to predict the length of time to major disease outcomes in Alzheimer’s disease (AD) patients. Here, we describe the development of a new, Predictors 3, cohort.
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Prediabetes is associated with increased risk of diabetes, cardiovascular disease, dementia and cancer. However, the disease risk considerably varies among subjects.
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Dementia Big
Prediabetes is associated with increased risk of diabetes, cardiovascular disease, dementia and cancer. However, the disease risk considerably varies among subjects.
Prediabetes is associated with increased risk of diabetes, cardiovascular disease, dementia and cancer. However, the disease risk considerably varies among subjects.
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Diagnosis, treatment and care of dementia is one of the major concerns in neurology research and associated healthcare programs. Dementia affects older age groups with a greater frequency, and as our population ages, the burden of dementia on public health is rapidly increasing. The most common cause of dementia is Alzheimer’s disease (AD), which accounts for 60 to 80 per cent of total cases. Much effort has been put into understanding its causes since, although still incurable, an early diagnosis can slow the progression of the disease, improving the quality of life of patients and their families.
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Coprophagia, eating one’s feces, is common in animals but rarely seen in humans. Mayo Clinic researchers reviewed the cases of a dozen adult patients diagnosed with coprophagia over the past 20 years and found that the behavior is associated with a wide range of neuropsychiatric disorders, particularly neurodegenerative dementias.
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Moblie and wearable technology used to support independent living for people with dementia could hold the key to cutting social isolation.
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Dementia Big
Moblie and wearable technology used to support independent living for people with dementia could hold the key to cutting social isolation.
Dementia Big
Coprophagia, eating one’s feces, is common in animals but rarely seen in humans. Mayo Clinic researchers reviewed the cases of a dozen adult patients diagnosed with coprophagia over the past 20 years and found that the behavior is associated with a wide range of neuropsychiatric disorders, particularly neurodegenerative dementias.
Dementia Big
Diagnosis, treatment and care of dementia is one of the major concerns in neurology research and associated healthcare programs. Dementia affects older age groups with a greater frequency, and as our population ages, the burden of dementia on public health is rapidly increasing. The most common cause of dementia is Alzheimer’s disease (AD), which accounts for 60 to 80 per cent of total cases. Much effort has been put into understanding its causes since, although still incurable, an early diagnosis can slow the progression of the disease, improving the quality of life of patients and their families.
Diagnosis, treatment and care of dementia is one of the major concerns in neurology research and associated healthcare programs. Dementia affects older age groups with a greater frequency, and as our population ages, the burden of dementia on public health is rapidly increasing. The most common cause of dementia is Alzheimer’s disease (AD), which accounts for 60 to 80 per cent of total cases. Much effort has been put into understanding its causes since, although still incurable, an early diagnosis can slow the progression of the disease, improving the quality of life of patients and their families.
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Moblie and wearable technology used to support independent living for people with dementia could hold the key to cutting social isolation.
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Coprophagia, eating one’s feces, is common in animals but rarely seen in humans. Mayo Clinic researchers reviewed the cases of a dozen adult patients diagnosed with coprophagia over the past 20 years and found that the behavior is associated with a wide range of neuropsychiatric disorders, particularly neurodegenerative dementias.
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A third of the global burden of disease for mental, neurological and substance use disorders occurs in India and China – more than in all high-income countries combined – yet most people with mental disorders in these countries do not receive needed treatment.
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Mobile and wearable technology used to support independent living for people with dementia could hold the key to cutting social isolation.
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High blood pressure could significantly raise the risk of developing the second most common form of dementia, according to a new study from The George Institute for Global Health.
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A consortium of European researchers is pursuing a new and unexpected lead in Alzheimer’s research. They are examining the intestinal microbiome and its effect on neurodegeneration. EPFL is coordinating the consortium, which is part of the pan-European Horizon 2020 initiative.
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The National Center for Geriatrics and Gerontology (“NCGG”) in Japan has succeeded in identifying an index finger-thumb tapping pattern unique to Alzheimer’s-type dementia through clinical research focusing on the rhythmical movement of both hands (Figure 1). This result was achieved using a waveform analysis technique for finger-tapping movement developed by Hitachi, Ltd. which allows a variety of tapping patterns to be extracted from the measurement data on motor ability using the magnetic sensors, such as the discrepancy in contact time between the fingers. This achievement opens the way to advancing tests for the early detection of Alzheimer’s-type dementia.
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Clusters of immune cells in the brain previously associated with Alzheimer’s actually protect against the disease by containing the spread of damaging amyloid plaques, a new Yale University School of Medicine study shows.
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A third of the global burden of disease for mental, neurological and substance use disorders occurs in India and China – more than in all high-income countries combined – yet most people with mental disorders in these countries do not receive needed treatment.
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via Stopping Dementia
Mobile and wearable technology used to support independent living for people with dementia could hold the key to cutting social isolation.
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via Stopping Dementia
The National Center for Geriatrics and Gerontology (“NCGG”) in Japan has succeeded in identifying an index finger-thumb tapping pattern unique to Alzheimer’s-type dementia through clinical research focusing on the rhythmical movement of both hands (Figure 1). This result was achieved using a waveform analysis technique for finger-tapping movement developed by Hitachi, Ltd. which allows a variety of tapping patterns to be extracted from the measurement data on motor ability using the magnetic sensors, such as the discrepancy in contact time between the fingers. This achievement opens the way to advancing tests for the early detection of Alzheimer’s-type dementia.
from Dementia Big http://ift.tt/1U1CtY4
via Stopping Dementia
A consortium of European researchers is pursuing a new and unexpected lead in Alzheimer’s research. They are examining the intestinal microbiome and its effect on neurodegeneration. EPFL is coordinating the consortium, which is part of the pan-European Horizon 2020 initiative.
from Dementia Big http://ift.tt/1rW5Epd
via Stopping Dementia
High blood pressure could significantly raise the risk of developing the second most common form of dementia, according to a new study from The George Institute for Global Health.
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via Stopping Dementia
Clusters of immune cells in the brain previously associated with Alzheimer’s actually protect against the disease by containing the spread of damaging amyloid plaques, a new Yale University School of Medicine study shows.
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Dementia Big
A third of the global burden of disease for mental, neurological and substance use disorders occurs in India and China – more than in all high-income countries combined – yet most people with mental disorders in these countries do not receive needed treatment.
Dementia Big
High blood pressure could significantly raise the risk of developing the second most common form of dementia, according to a new study from The George Institute for Global Health.
Dementia Big
The National Center for Geriatrics and Gerontology (“NCGG”) in Japan has succeeded in identifying an index finger-thumb tapping pattern unique to Alzheimer’s-type dementia through clinical research focusing on the rhythmical movement of both hands (Figure 1). This result was achieved using a waveform analysis technique for finger-tapping movement developed by Hitachi, Ltd. which allows a variety of tapping patterns to be extracted from the measurement data on motor ability using the magnetic sensors, such as the discrepancy in contact time between the fingers. This achievement opens the way to advancing tests for the early detection of Alzheimer’s-type dementia.
Dementia Big
Mobile and wearable technology used to support independent living for people with dementia could hold the key to cutting social isolation.
Dementia Big
Clusters of immune cells in the brain previously associated with Alzheimer’s actually protect against the disease by containing the spread of damaging amyloid plaques, a new Yale University School of Medicine study shows.
Dementia Big
A consortium of European researchers is pursuing a new and unexpected lead in Alzheimer’s research. They are examining the intestinal microbiome and its effect on neurodegeneration. EPFL is coordinating the consortium, which is part of the pan-European Horizon 2020 initiative.
Dementia Big
High blood pressure could significantly raise the risk of developing the second most common form of dementia, according to a new study from The George Institute for Global Health.
Dementia Big
(HealthDay)—Making meals more enjoyable for people with dementia might reduce their risk of malnutrition and dehydration, researchers report.
High blood pressure could significantly raise the risk of developing the second most common form of dementia, according to a new study from The George Institute for Global Health.
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(HealthDay)—Making meals more enjoyable for people with dementia might reduce their risk of malnutrition and dehydration, researchers report.
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High blood pressure could significantly raise the risk of developing the second most common form of dementia, according to a new study from The George Institute for Global Health.
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(HealthDay)—Making meals more enjoyable for people with dementia might reduce their risk of malnutrition and dehydration, researchers report.
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Patients with primary progressive aphasia show selective vulnerabilities in effortless learning and delayed retrieval of verbal information if their syndrome is related to Alzheimer’s disease rather than frontotemporal lobar degeneration, research indicates.
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Recent research suggests that exercise might provide some measure of protection from Alzheimer’s disease and other dementias.
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Dementia Big
Patients with primary progressive aphasia show selective vulnerabilities in effortless learning and delayed retrieval of verbal information if their syndrome is related to Alzheimer’s disease rather than frontotemporal lobar degeneration, research indicates.
Dementia Big
Recent research suggests that exercise might provide some measure of protection from Alzheimer’s disease and other dementias.
Patients with primary progressive aphasia show selective vulnerabilities in effortless learning and delayed retrieval of verbal information if their syndrome is related to Alzheimer’s disease rather than frontotemporal lobar degeneration, research indicates.
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Recent research suggests that exercise might provide some measure of protection from Alzheimer’s disease and other dementias.
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Dementia Big
As the population ages and demography changes, the UK is facing an unprecedented challenge of how to care for and support its older people.
Dementia Big
As the population ages and demography changes, the U.K. is facing an unprecedented challenge of how to care for and support its older people. While the fact that people are living longer should be celebrated, the flip side is that age-related illness such as dementia are on the rise and it’s important for us, as a country to find solutions and alleviate the difficulties people may face as a result.
Dementia Big
Recent research suggests that exercise might provide some measure of protection from Alzheimer’s disease and other dementias.
As the population ages and demography changes, the UK is facing an unprecedented challenge of how to care for and support its older people.
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via Stopping Dementia
As the population ages and demography changes, the U.K. is facing an unprecedented challenge of how to care for and support its older people. While the fact that people are living longer should be celebrated, the flip side is that age-related illness such as dementia are on the rise and it’s important for us, as a country to find solutions and alleviate the difficulties people may face as a result.
from Dementia Big http://ift.tt/1TVa1qL
via Stopping Dementia
Recent research suggests that exercise might provide some measure of protection from Alzheimer’s disease and other dementias.
from Dementia Big http://ift.tt/1OwwTvn
via Stopping Dementia
As the population ages and demography changes, the UK is facing an unprecedented challenge of how to care for and support its older people.
from Dementia Big http://ift.tt/1TlpoM2 via alcoholic dementia
Recent research suggests that exercise might provide some measure of protection from Alzheimer’s disease and other dementias.
from Dementia Big http://ift.tt/1OwwTvn via alcoholic dementia
As the population ages and demography changes, the U.K. is facing an unprecedented challenge of how to care for and support its older people. While the fact that people are living longer should be celebrated, the flip side is that age-related illness such as dementia are on the rise and it’s important for us, as a country to find solutions and alleviate the difficulties people may face as a result.
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A pioneering study led by researchers from the University of Sheffield is helping to give a voice to children and young adults who are living with a parent with dementia.
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Dementia Big
A pioneering study led by researchers from the University of Sheffield is helping to give a voice to children and young adults who are living with a parent with dementia.
Dementia Big
Cedars-Sinai neuroscience researchers are studying whether extensive changes in lifestyle among patients with mild cognitive impairment can slow the progression of Alzheimer’s disease.
Cedars-Sinai neuroscience researchers are studying whether extensive changes in lifestyle among patients with mild cognitive impairment can slow the progression of Alzheimer’s disease.
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Cedars-Sinai neuroscience researchers are studying whether extensive changes in lifestyle among patients with mild cognitive impairment can slow the progression of Alzheimer’s disease.
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Dementia Big
AN out of control immune system has been identified as a possible cause of neurodegenerative diseases such as Alzheimer’s.
Dementia Big
A new Massive Open Online Course (MOOC) to educate anyone interested in learning more about autism, Asperger’s and Attention-Deficit/Hyperactivity Disorder (ADHD) has been launched by the University of Derby.
Dementia Big
Tau tangles may be a better indicator of cognitive changes during Alzheimer’s disease progression than beta-amyloid deposition, researchers propose.
Dementia Big
University of Adelaide researchers have developed a new theory for the causes of dementia and other neurodegenerative diseases, involving an out-of-control immune system.
AN out of control immune system has been identified as a possible cause of neurodegenerative diseases such as Alzheimer’s.
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Tau tangles may be a better indicator of cognitive changes during Alzheimer’s disease progression than beta-amyloid deposition, researchers propose.
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via Stopping Dementia
University of Adelaide researchers have developed a new theory for the causes of dementia and other neurodegenerative diseases, involving an out-of-control immune system.
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via Stopping Dementia
A new Massive Open Online Course (MOOC) to educate anyone interested in learning more about autism, Asperger’s and Attention-Deficit/Hyperactivity Disorder (ADHD) has been launched by the University of Derby.
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via Stopping Dementia
University of Adelaide researchers have developed a new theory for the causes of dementia and other neurodegenerative diseases, involving an out-of-control immune system.
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A new Massive Open Online Course (MOOC) to educate anyone interested in learning more about autism, Asperger’s and Attention-Deficit/Hyperactivity Disorder (ADHD) has been launched by the University of Derby.
from Dementia Big http://ift.tt/1Wv3pWp via alcoholic dementia
AN out of control immune system has been identified as a possible cause of neurodegenerative diseases such as Alzheimer’s.
from Dementia Big http://ift.tt/1Nt7XKk via alcoholic dementia
Tau tangles may be a better indicator of cognitive changes during Alzheimer’s disease progression than beta-amyloid deposition, researchers propose.
from Dementia Big http://ift.tt/1Wu9thL via alcoholic dementia
A new position statement by the European Menopause and Andropause Society published in the journal Maturitas provides a pathway with the latest post-reproductive health strategies, with the aim of optimizing care at an international scale.
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LaVision BioTec, developers of advanced microscopy solutions for the life sciences, report on the work of Ali Ertürk, a Group Leader at the Institute for Stroke and Dementia Research (part of the Klinikum der Universität München) at the Ludwig Maximilians University in Munich, Germany.
from Dementia Big http://ift.tt/1YnGp9I
via Stopping Dementia
A buildup of plaque and dysfunctional proteins in the brain are hallmarks of Alzheimer’s disease. While much Alzheimer’s research has focused on accumulation of the protein amyloid beta, researchers have begun to pay closer attention to another protein, tau, long associated with this disease but not studied as thoroughly, in part, because scientists only recently have developed effective ways to image tau.
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via Stopping Dementia
Dementia Big
A buildup of plaque and dysfunctional proteins in the brain are hallmarks of Alzheimer’s disease. While much Alzheimer’s research has focused on accumulation of the protein amyloid beta, researchers have begun to pay closer attention to another protein, tau, long associated with this disease but not studied as thoroughly, in part, because scientists only recently have developed effective ways to image tau.
Dementia Big
LaVision BioTec, developers of advanced microscopy solutions for the life sciences, report on the work of Ali Ertürk, a Group Leader at the Institute for Stroke and Dementia Research (part of the Klinikum der Universität München) at the Ludwig Maximilians University in Munich, Germany.
Dementia Big
A new position statement by the European Menopause and Andropause Society published in the journal Maturitas provides a pathway with the latest post-reproductive health strategies, with the aim of optimizing care at an international scale.
LaVision BioTec, developers of advanced microscopy solutions for the life sciences, report on the work of Ali Ertürk, a Group Leader at the Institute for Stroke and Dementia Research (part of the Klinikum der Universität München) at the Ludwig Maximilians University in Munich, Germany.
from Dementia Big http://ift.tt/1YnGp9I via alcoholic dementia
A new position statement by the European Menopause and Andropause Society published in the journal Maturitas provides a pathway with the latest post-reproductive health strategies, with the aim of optimizing care at an international scale.
from Dementia Big http://ift.tt/1T8AeWS via alcoholic dementia
A buildup of plaque and dysfunctional proteins in the brain are hallmarks of Alzheimer’s disease. While much Alzheimer’s research has focused on accumulation of the protein amyloid beta, researchers have begun to pay closer attention to another protein, tau, long associated with this disease but not studied as thoroughly, in part, because scientists only recently have developed effective ways to image tau.
from Dementia Big http://ift.tt/1TGYVW5 via alcoholic dementia
Dementia Big
A large study shows that nearly a third of patients who survive an intracerebral haemorrhage will go on to develop dementia within 4 years.
Dementia Big
Eating a meal of seafood or other foods containing omega-3 fatty acids at least once a week may protect against age-related memory loss and thinking problems in older people, according to a team of researchers at Rush University Medical Center and Wageningen University in the Netherlands.
Dementia Big
Oxford spinout EvOx Therapeutics will harness the body’s own precision communications system to deliver drugs to specific parts of the body, with the aim of treating conditions which are currently untreatable including those affecting the brain, as well as autoimmune diseases and cancers.
Dementia Big
A buildup of plaque and dysfunctional proteins in the brain are hallmarks of Alzheimer’s disease. While much Alzheimer’s research has focused on accumulation of the protein amyloid beta, researchers have begun to pay closer attention to another protein, tau, long associated with this disease but not studied as thoroughly, in part, because scientists only recently have developed effective ways to image tau.
Dementia Big
Scientists in Manchester, who have developed a stem cell gene therapy to reverse a fatal childhood illness, have agreed to work with a new therapeutics company to test it in a human trial.
Dementia Big
Several attempts have been made to treat Alzheimer’s disease (AD) using anti-amyloid strategies with disappointing results. It is clear that the “amyloid cascade hypothesis” alone cannot fully explain the neuronal damage in AD, as evidenced both by autopsy and imaging studies. Neuroinflammation plays a significant role in neurodegenerative diseases, whereas the debate is ongoing about its precise role, whether it is protective or harmful. In this review, we focus on the potential mechanism of glial activation and how local and systemic factors influence disease progression.
A large study shows that nearly a third of patients who survive an intracerebral haemorrhage will go on to develop dementia within 4 years.
from Dementia Big http://ift.tt/1T5W4Kv
via Stopping Dementia
Eating a meal of seafood or other foods containing omega-3 fatty acids at least once a week may protect against age-related memory loss and thinking problems in older people, according to a team of researchers at Rush University Medical Center and Wageningen University in the Netherlands.
from Dementia Big http://ift.tt/1rXa7b1
via Stopping Dementia
A buildup of plaque and dysfunctional proteins in the brain are hallmarks of Alzheimer’s disease. While much Alzheimer’s research has focused on accumulation of the protein amyloid beta, researchers have begun to pay closer attention to another protein, tau, long associated with this disease but not studied as thoroughly, in part, because scientists only recently have developed effective ways to image tau.
from Dementia Big http://ift.tt/21XjKD1
via Stopping Dementia
Scientists in Manchester, who have developed a stem cell gene therapy to reverse a fatal childhood illness, have agreed to work with a new therapeutics company to test it in a human trial.
from Dementia Big http://ift.tt/1rYW3xI
via Stopping Dementia
Oxford spinout EvOx Therapeutics will harness the body’s own precision communications system to deliver drugs to specific parts of the body, with the aim of treating conditions which are currently untreatable including those affecting the brain, as well as autoimmune diseases and cancers.
from Dementia Big http://ift.tt/1Nqt8MX
via Stopping Dementia
Several attempts have been made to treat Alzheimer’s disease (AD) using anti-amyloid strategies with disappointing results. It is clear that the “amyloid cascade hypothesis” alone cannot fully explain the neuronal damage in AD, as evidenced both by autopsy and imaging studies. Neuroinflammation plays a significant role in neurodegenerative diseases, whereas the debate is ongoing about its precise role, whether it is protective or harmful. In this review, we focus on the potential mechanism of glial activation and how local and systemic factors influence disease progression.
from Dementia Big http://ift.tt/1ZHjFBL
via Stopping Dementia
A large study shows that nearly a third of patients who survive an intracerebral haemorrhage will go on to develop dementia within 4 years.
from Dementia Big http://ift.tt/1T5W4Kv via alcoholic dementia
Eating a meal of seafood or other foods containing omega-3 fatty acids at least once a week may protect against age-related memory loss and thinking problems in older people, according to a team of researchers at Rush University Medical Center and Wageningen University in the Netherlands.
from Dementia Big http://ift.tt/1rXa7b1 via alcoholic dementia
Oxford spinout EvOx Therapeutics will harness the body’s own precision communications system to deliver drugs to specific parts of the body, with the aim of treating conditions which are currently untreatable including those affecting the brain, as well as autoimmune diseases and cancers.
from Dementia Big http://ift.tt/1Nqt8MX via alcoholic dementia
A buildup of plaque and dysfunctional proteins in the brain are hallmarks of Alzheimer’s disease. While much Alzheimer’s research has focused on accumulation of the protein amyloid beta, researchers have begun to pay closer attention to another protein, tau, long associated with this disease but not studied as thoroughly, in part, because scientists only recently have developed effective ways to image tau.
from Dementia Big http://ift.tt/21XjKD1 via alcoholic dementia
Scientists in Manchester, who have developed a stem cell gene therapy to reverse a fatal childhood illness, have agreed to work with a new therapeutics company to test it in a human trial.
from Dementia Big http://ift.tt/1rYW3xI via alcoholic dementia
Several attempts have been made to treat Alzheimer’s disease (AD) using anti-amyloid strategies with disappointing results. It is clear that the “amyloid cascade hypothesis” alone cannot fully explain the neuronal damage in AD, as evidenced both by autopsy and imaging studies. Neuroinflammation plays a significant role in neurodegenerative diseases, whereas the debate is ongoing about its precise role, whether it is protective or harmful. In this review, we focus on the potential mechanism of glial activation and how local and systemic factors influence disease progression.
from Dementia Big http://ift.tt/1ZHjFBL via alcoholic dementia
Chronic use of some drugs for heartburn and gastroesophageal reflux (GERD) speeds up the aging of blood vessels, according to a published paper in Circulation Research, an American Heart Association journal.
from Dementia Big http://ift.tt/1ZDR6Fk
via Stopping Dementia
Patients with late-life depression have an increased risk of dementia if their symptoms increase over time, whereas a single episode of depression, even if severe, does not carry a significant risk, study findings indicate.
from Dementia Big http://ift.tt/1ZCvzNf
via Stopping Dementia
Dementia Big
Patients with late-life depression have an increased risk of dementia if their symptoms increase over time, whereas a single episode of depression, even if severe, does not carry a significant risk, study findings indicate.
Dementia Big
Chronic use of some drugs for heartburn and gastroesophageal reflux (GERD) speeds up the aging of blood vessels, according to a published paper in Circulation Research, an American Heart Association journal.
Patients with late-life depression have an increased risk of dementia if their symptoms increase over time, whereas a single episode of depression, even if severe, does not carry a significant risk, study findings indicate.
from Dementia Big http://ift.tt/1ZCvzNf via alcoholic dementia
Chronic use of some drugs for heartburn and gastroesophageal reflux (GERD) speeds up the aging of blood vessels, according to a published paper in Circulation Research, an American Heart Association journal.
from Dementia Big http://ift.tt/1ZDR6Fk via alcoholic dementia
This article scans recent developments within citizenship studies and relates them to the field of dementia, specifically the ‘dementia friendly communities’ agenda. The dementia friendly communities agenda is selected for several reasons, most notably because, it is an area of practice in the field of dementia where citizenship is perhaps most clearly enacted. The aim of the article is to help with the advancement of social citizenship as a key concept for dementia studies, by using two of the latest ideas within citizenship studies; namely, understandings of citizenship as (a) occurring in ordinary places and (b) potentially enacted within the domestic sphere to explore dementia friendly communities. It is argued that the interplay between these two developments pave the way for deeper consideration and realisation of social citizenship in the context of people with dementia.
from Dementia Big http://ift.tt/1WnzcbA
via Stopping Dementia
Recently, there has been increasing attention given to finding ways to help people diagnosed with dementia ‘live well’ with their condition. Frequently however, the attention has been placed on the family care partner as the foundation for creating a context that supports the person with dementia to live well. A recent participatory action research (PAR) study highlighted the importance of beginning to challenge some of the assumptions around how best to include family, especially within a context of supporting citizenship. Three advisory groups consisting of 20 people with dementia, 13 care partners, and three service providers, were set up in three locations across Canada to help develop a self-management program for people with dementia. The hubs met monthly for up to two years. One of the topics that emerged as extremely important to consider in the structuring of the program revolved around whether or not these groups should be segregated to include only people with dementia. A thematic analysis of these ongoing discussions coalesced around four inter-related themes: creating safe spaces; maintaining voice and being heard; managing the balancing act; and the importance of solidarity. Underpinning these discussions was the fifth theme, recognition that ‘one size doesn’t fit all’. Overall an important finding was that the presence of family care-partners could have unintended consequences in relation to creating the space for active citizenship to occur in small groups of people with dementia although it could also offer some opportunities. The involvement of care partners in groups with people with dementia is clearly one that is complex without an obvious answer and dependent on a variety of factors to inform a solution, which can and should be questioned and revisited.
from Dementia Big http://ift.tt/1WnzaAK
via Stopping Dementia
Since living with dementia implies increasing difficulties in taking charge of rights due to cognitive as well as communicative impairments, many people with dementia are vulnerable and in need of support in order to realize full citizenship. In Sweden, all adults right to self-determination is strongly emphasized in law, regulations, and policies. Further, and in contrast to the situation in many other countries, people living with dementia cannot be declared as incompetent of making decisions concerning social care and their right to self-determination cannot legally be taken away. The article shows that in the Swedish welfare system, the focus is more on protecting the self-determination of citizens than on supporting people in making decisions and exercising citizenship. Subsequently, this causes legally constructed zones of inclusion and exclusion. This article examines and problematizes how different institutional contexts, legal constructions, norms, and practices in Sweden affect the management of issues concerning guardianship, supported decision-making and self-determination, and outline the implications for people living with dementia.
from Dementia Big http://ift.tt/1OmZvHd
via Stopping Dementia
Despite growing recognition of the rights of people with dementia for full citizenship, issues related to democracy, whether from theoretical or practical perspectives, remain neglected. Especially since discourses on dementia have expanded to this rights-based approach, it is imperative to begin to examine the meanings and practices of democracy within a context of dementia. Accordingly, the purpose of this article is to assess implications of dementia in the context of democracy. Rather than surveying the variety of democratic concepts, it will focus the analytical framework on representative democracy and then outline several challenges to and for representative democracy and citizens with dementia. The intention is to begin to identify paths for ensuring representation, inclusion and participation for those who have dementia.
from Dementia Big http://ift.tt/1OmZxyW
via Stopping Dementia
Sexual citizenship and sexual rights scholarship have made important contributions to broadening citizenship and more fully accommodating rights related to sexuality. However, this scholarship has concentrated primarily on the sexuality and intimacy-related needs of younger people and those who are not cognitively impaired. Consequently, it has inadvertently served to marginalize persons living with dementia who reside in long-term residential care settings. We argue that supporting sexual rights for persons with dementia requires a particular human rights ontology for citizenship—one that recognizes that corporeality is a fundamental source of self-expression, interdependence, and reciprocal engagement. This is an ontology that underpins our model of relational citizenship and that grounds our articulation of an ethic of embodied relational sexuality. In our view, this ethic offers important direction for the development of policy, legislation, and clinical guidelines to support sexual rights for persons with dementia in long-term residential care.
from Dementia Big http://ift.tt/1OmZxyS
via Stopping Dementia
The proliferation of community-based activity programs for people with dementia suggests an appetite for new approaches to support quality of life and well-being for this population. Such groups also have potential to promote social citizenship, although this remains poorly understood. This article presents findings from a subset of data from an ethnographic study of a community-based program for people with young onset dementia; it focuses on Paul’s Club and the experiences of 12–15 members who are physically healthy, with moderate to moderately severe dementia. Analysis suggests how aspects of social citizenship are constructed and revealed through the Club’s everyday practice of walking in the neighbourhood. Three major themes emerged: Keeping the focus off dementia; Creating a place of belonging; and Claiming a place in the community. How the group balances consideration of members’ vulnerability and agency is discussed, and the article concludes with implications for future practice and research initiatives.
from Dementia Big http://ift.tt/1WnzaAE
via Stopping Dementia
This paper makes a contribution to an emerging debate on dementia and citizenship through a focus on the everyday experiences of women living with dementia and in receipt of care. In particular, a link is drawn between hairdressing and citizenship in the context of dementia care. Informed by a wider debate over the importance of an emplaced, embodied and performative approach to citizenship, the authors highlight the way that intersecting forms of resistance unfold in the salon. The Hair and Care project, as the name implies, focused upon hair care and styling in the context of a wider consideration of appearance and how it is managed and what it means for people living with dementia. With a focus upon the routine, mundane and thereby often unproblematised aspects of everyday life in/with care, the discussion draws together two key ideas concerned with the interplay of power and resistance: Essed’s (1991) theory of ‘everyday discrimination’ and Scott’s (1985) notion of ‘everyday resistance’. The findings illuminate the creative and collective forms of agency exercised by older women living with dementia, in the context of their relationships with one another and with the hairdressers whose services and support inspire their loyalty and patronage. Findings from the study point to the link between (inter-)personal practices of appearance management and a wider set of social conditions that are manifest in the on-going struggle over time, space and bodies in dementia care.
from Dementia Big http://ift.tt/1Wnzak8
via Stopping Dementia
The ethics of care is an emerging field of interest in many disciplines, including care for people with dementia. The ethics of care as proposed by Joan Tronto is a political argument for care together with a set of principles, the integrity of care, to guide and critique practice. This two-pronged approach enables on one hand, a political, complex and situated examination of inequality, and on the other hand the integrity of care provides a set of principles to guide inclusive citizenship practices. This approach has the significant advantage of recognition of the fight that people with dementia face to achieve rights and citizenship as an issue of social justice. In this paper, three challenges to citizenship are discussed in relation to people with dementia using an ethics of care lens: (a) citizenship as a relationship between the individual and the state; (b) citizenship as a practice and © citizenship as identity and belonging. I propose that citizenship can be achieved by promoting inclusion in defining and creating policy, research and practice.
from Dementia Big http://ift.tt/1OmZvqQ
via Stopping Dementia
Sexual citizenship and sexual rights scholarship have made important contributions to broadening citizenship and more fully accommodating rights related to sexuality. However, this scholarship has concentrated primarily on the sexuality and intimacy-related needs of younger people and those who are not cognitively impaired. Consequently, it has inadvertently served to marginalize persons living with dementia who reside in long-term residential care settings. We argue that supporting sexual rights for persons with dementia requires a particular human rights ontology for citizenship—one that recognizes that corporeality is a fundamental source of self-expression, interdependence, and reciprocal engagement. This is an ontology that underpins our model of relational citizenship and that grounds our articulation of an ethic of embodied relational sexuality. In our view, this ethic offers important direction for the development of policy, legislation, and clinical guidelines to support sexual rights for persons with dementia in long-term residential care.
from Dementia Big http://ift.tt/1WnzaAt
via Stopping Dementia
In recent years there has been an increasing interest in the concept of citizenship as a lens through which to understand dementia practice. This move from an individualist, personhood-based approach towards an understanding of people with dementia as a group facing social and structural discrimination parallels, in some ways, that previously seen in the realms of disability and mental health which have sought to politicize those experiences. In so doing, the debate has sought to reconfigure power relations, insisting that members of such discriminated groups are people with power entitled to the same from life as everyone else. Much of the discussion to date has, understandably, focused on the larger issues of social inclusion, rights and responsibilities – reflecting the traditional concern of citizenship of individuals’ relationship to the state or the society in which they live. More recently, there has been a move to conceptualising citizenship as a practice – something that is realised through action and in relationship – rather than a status bestowed. In this paper, we seek to contribute to the discussion by introducing the concepts of midi- and micro-citizenship, taken from organisation studies, as a further means by which to link the personal and the political, and as grounds to build citizenship-alliances between people with dementia living in long-term care (LTC) facilities and front-line dementia care staff. We will then seek to illustrate the usefulness of these concepts in understanding citizenship in practice in LTC facilities through analysis of data drawn from focus groups involving LTC staff, and interviews with family carers whose relatives live in LTC facilities. In conclusion, we will explore some of the possibilities that such an approach holds for dementia care practice.
from Dementia Big http://ift.tt/1OmZxyI
via Stopping Dementia
This article scans recent developments within citizenship studies and relates them to the field of dementia, specifically the ‘dementia friendly communities’ agenda. The dementia friendly communities agenda is selected for several reasons, most notably because, it is an area of practice in the field of dementia where citizenship is perhaps most clearly enacted. The aim of the article is to help with the advancement of social citizenship as a key concept for dementia studies, by using two of the latest ideas within citizenship studies; namely, understandings of citizenship as (a) occurring in ordinary places and (b) potentially enacted within the domestic sphere to explore dementia friendly communities. It is argued that the interplay between these two developments pave the way for deeper consideration and realisation of social citizenship in the context of people with dementia.
Despite growing recognition of the rights of people with dementia for full citizenship, issues related to democracy, whether from theoretical or practical perspectives, remain neglected. Especially since discourses on dementia have expanded to this rights-based approach, it is imperative to begin to examine the meanings and practices of democracy within a context of dementia. Accordingly, the purpose of this article is to assess implications of dementia in the context of democracy. Rather than surveying the variety of democratic concepts, it will focus the analytical framework on representative democracy and then outline several challenges to and for representative democracy and citizens with dementia. The intention is to begin to identify paths for ensuring representation, inclusion and participation for those who have dementia.
Recently, there has been increasing attention given to finding ways to help people diagnosed with dementia ‘live well’ with their condition. Frequently however, the attention has been placed on the family care partner as the foundation for creating a context that supports the person with dementia to live well. A recent participatory action research (PAR) study highlighted the importance of beginning to challenge some of the assumptions around how best to include family, especially within a context of supporting citizenship. Three advisory groups consisting of 20 people with dementia, 13 care partners, and three service providers, were set up in three locations across Canada to help develop a self-management program for people with dementia. The hubs met monthly for up to two years. One of the topics that emerged as extremely important to consider in the structuring of the program revolved around whether or not these groups should be segregated to include only people with dementia. A thematic analysis of these ongoing discussions coalesced around four inter-related themes: creating safe spaces; maintaining voice and being heard; managing the balancing act; and the importance of solidarity. Underpinning these discussions was the fifth theme, recognition that ‘one size doesn’t fit all’. Overall an important finding was that the presence of family care-partners could have unintended consequences in relation to creating the space for active citizenship to occur in small groups of people with dementia although it could also offer some opportunities. The involvement of care partners in groups with people with dementia is clearly one that is complex without an obvious answer and dependent on a variety of factors to inform a solution, which can and should be questioned and revisited.
Since living with dementia implies increasing difficulties in taking charge of rights due to cognitive as well as communicative impairments, many people with dementia are vulnerable and in need of support in order to realize full citizenship. In Sweden, all adults right to self-determination is strongly emphasized in law, regulations, and policies. Further, and in contrast to the situation in many other countries, people living with dementia cannot be declared as incompetent of making decisions concerning social care and their right to self-determination cannot legally be taken away. The article shows that in the Swedish welfare system, the focus is more on protecting the self-determination of citizens than on supporting people in making decisions and exercising citizenship. Subsequently, this causes legally constructed zones of inclusion and exclusion. This article examines and problematizes how different institutional contexts, legal constructions, norms, and practices in Sweden affect the management of issues concerning guardianship, supported decision-making and self-determination, and outline the implications for people living with dementia.
The ethics of care is an emerging field of interest in many disciplines, including care for people with dementia. The ethics of care as proposed by Joan Tronto is a political argument for care together with a set of principles, the integrity of care, to guide and critique practice. This two-pronged approach enables on one hand, a political, complex and situated examination of inequality, and on the other hand the integrity of care provides a set of principles to guide inclusive citizenship practices. This approach has the significant advantage of recognition of the fight that people with dementia face to achieve rights and citizenship as an issue of social justice. In this paper, three challenges to citizenship are discussed in relation to people with dementia using an ethics of care lens: (a) citizenship as a relationship between the individual and the state; (b) citizenship as a practice and © citizenship as identity and belonging. I propose that citizenship can be achieved by promoting inclusion in defining and creating policy, research and practice.
