Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint

Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint:

Dementia Big
Amyloid-beta (Aβ) peptide oligomerization plays a central role in the pathogenesis of Alzheimer’s disease (AD), and Aβ oligomers are collectively considered an appealing therapeutic target for the treatment of AD. However, the molecular mechanisms leading to the pathologic accumulation of oligomers are unclear, and the exact structural composition of oligomers is being debated. Using targeted and quantitative mass spectrometry, we reveal site-specific Aβ autocleavage during the early phase of aggregation, producing a typical Aβ fragment signature and that truncated Aβ peptides can form stable oligomeric complexes with full-length Aβ peptide.

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