Wednesday, January 31, 2018

In-person license renewal tied to fewer crash hospitalizations of drivers with dementia

In-person license renewal tied to fewer crash hospitalizations of drivers with dementia:

Dementia Big
Requiring physicians to report patients with dementia to state driver’s licensing authorities is not associated with fewer hospitalizations from motor vehicle crashes. However, in-person license renewal laws and vision testing dramatically cut crashes involving drivers with dementia, according to a new study led by the University of Pittsburgh Graduate School of Public Health.


http://ift.tt/2DMiXPl

Inadequate oxygen levels during sleep increase risk of developing Alzheimer's disease

Inadequate oxygen levels during sleep increase risk of developing Alzheimer's disease:

Dementia Big
Inadequate oxygen levels during sleep can damage the brain and increase the risk of developing Alzheimer’s disease, University of Queensland researchers have found.


http://ift.tt/2EslQGh

Test lets volunteers check Alzheimer's risk, join clinical trials

Test lets volunteers check Alzheimer's risk, join clinical trials:

Dementia Big
People interested in helping test Alzheimer’s drugs can volunteer and get their cognitive abilities monitored on a new website run by Alzheimer’s researchers.


http://ift.tt/2DT7JsE

In-person license renewal tied to fewer crash hospitalizations of drivers with dementia

Requiring physicians to report patients with dementia to state driver’s licensing authorities is not associated with fewer hospitalizations from motor vehicle crashes. However, in-person license renewal laws and vision testing dramatically cut crashes involving drivers with dementia, according to a new study led by the University of Pittsburgh Graduate School of Public Health.

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http://ift.tt/2Euw09w

Inadequate oxygen levels during sleep increase risk of developing Alzheimer's disease

Inadequate oxygen levels during sleep can damage the brain and increase the risk of developing Alzheimer’s disease, University of Queensland researchers have found.

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http://ift.tt/2DO2UAF

Test lets volunteers check Alzheimer's risk, join clinical trials

People interested in helping test Alzheimer’s drugs can volunteer and get their cognitive abilities monitored on a new website run by Alzheimer’s researchers.

from Dementia Big http://ift.tt/2rWFxTW via alcoholic dementia


http://ift.tt/2Etxoco

Tuesday, January 30, 2018

The effects of Huntington’s disease can be seen as early as conception, finds new study

The effects of Huntington’s disease can be seen as early as conception, finds new study:

Dementia Big
In a breakthrough study, scientists at the Rockefeller University have observed the effects of Huntington’s disease in neurons as early as conception.


http://ift.tt/2nrEGoN

Neuroscientist wins NIH grant to find whether pear- or apple-shape physique is best for our brains

Neuroscientist wins NIH grant to find whether pear- or apple-shape physique is best for our brains:

Dementia Big
With the new year still ringing, many of us have fat on our minds, but Dr. Alexis M. Stranahan is more interested in what fat does to our minds.


http://ift.tt/2DNfHY1

The effects of Huntington’s disease can be seen as early as conception, finds new study

In a breakthrough study, scientists at the Rockefeller University have observed the effects of Huntington’s disease in neurons as early as conception.

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http://ift.tt/2BDXhTN

Neuroscientist wins NIH grant to find whether pear- or apple-shape physique is best for our brains

With the new year still ringing, many of us have fat on our minds, but Dr. Alexis M. Stranahan is more interested in what fat does to our minds.

from Dementia Big http://ift.tt/2DNx4Ij via alcoholic dementia


http://ift.tt/2nnUwl6

Monday, January 29, 2018

Rockefeller scientists develop system to model Huntington’s in human embryonic stem cells

Rockefeller scientists develop system to model Huntington’s in human embryonic stem cells:

Dementia Big
With new findings, scientists may be poised to break a long impasse in research on Huntington’s disease, a fatal hereditary disorder for which there is currently no treatment.


http://ift.tt/2rV74p5

Body clock disruptions occur years before memory loss in Alzheimer's

Body clock disruptions occur years before memory loss in Alzheimer's:

Dementia Big
People with Alzheimer’s disease are known to have disturbances in their internal body clocks that affect the sleep/wake cycle and may increase risk of developing the disorder. Now, new research at Washington University School of Medicine in St. Louis indicates that such circadian rhythm disruptions also occur much earlier in people whose memories are intact but whose brain scans show early, preclinical evidence of Alzheimer’s.


http://ift.tt/2GssSLD

Enhanced lifestyle counselling could protect against Alzheimer’s disease, finds new study

Enhanced lifestyle counselling could protect against Alzheimer’s disease, finds new study:

Dementia Big
Enhanced lifestyle counselling could prevent cognitive decline in people who are genetically predisposed to develop Alzheimer’s disease, finds new study.


http://ift.tt/2rOfFcT

Rockefeller scientists develop system to model Huntington’s in human embryonic stem cells

With new findings, scientists may be poised to break a long impasse in research on Huntington’s disease, a fatal hereditary disorder for which there is currently no treatment.

from Dementia Big http://ift.tt/2rP9sNZ via alcoholic dementia


http://ift.tt/2DXWKkG

Body clock disruptions occur years before memory loss in Alzheimer's

People with Alzheimer’s disease are known to have disturbances in their internal body clocks that affect the sleep/wake cycle and may increase risk of developing the disorder. Now, new research at Washington University School of Medicine in St. Louis indicates that such circadian rhythm disruptions also occur much earlier in people whose memories are intact but whose brain scans show early, preclinical evidence of Alzheimer’s.

from Dementia Big http://ift.tt/2njnSRQ via alcoholic dementia


http://ift.tt/2FtuEe7

Enhanced lifestyle counselling could protect against Alzheimer’s disease, finds new study

Enhanced lifestyle counselling could prevent cognitive decline in people who are genetically predisposed to develop Alzheimer’s disease, finds new study.

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http://ift.tt/2DVzovZ

Saturday, January 27, 2018

Aerobic exercise may improve cognitive symptoms in older adults at risk for AD

Aerobic exercise may improve cognitive symptoms in older adults at risk for AD:

Dementia Big
Alzheimer’s disease (AD) is a brain disorder that destroys memory and thinking skills over time. It is the most common form of dementia in older adults.


http://ift.tt/2BxvynP

Aerobic exercise may improve cognitive symptoms in older adults at risk for AD

Alzheimer’s disease (AD) is a brain disorder that destroys memory and thinking skills over time. It is the most common form of dementia in older adults.

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http://ift.tt/2BwI1YT

Friday, January 26, 2018

Aerobic exercise may mildly delay, slightly improve Alzheimer's symptoms

Aerobic exercise may mildly delay, slightly improve Alzheimer's symptoms:

Dementia Big
Alzheimer’s disease (AD) is a brain disorder that destroys memory and thinking skills over time. It is the most common form of dementia in older adults. There is presently no cure for the condition, though treatment options are available. Today, some 5.3 million Americans live with AD, and it is now the sixth leading cause of death in the United States. The number of older adults who will develop AD is expected to more than triple by 2050.


http://ift.tt/2DSE3z6

Diabetes protein linked to memory loss

Diabetes protein linked to memory loss:

Dementia Big
Researchers in China and the UK have found that the level of a protein, HbA1c, commonly used to assess if someone has diabetes is linked to worsening memory and thinking performance in healthy ageing adults. The findings are published today in the scientific journal Diabetologia.


http://ift.tt/2FiNTXK

Diabetes protein linked to memory loss

Researchers in China and the UK have found that the level of a protein, HbA1c, commonly used to assess if someone has diabetes is linked to worsening memory and thinking performance in healthy ageing adults. The findings are published today in the scientific journal Diabetologia.

from Dementia Big http://ift.tt/2naSFPM via alcoholic dementia


http://ift.tt/2DOqaSi

Aerobic exercise may mildly delay, slightly improve Alzheimer's symptoms

Alzheimer’s disease (AD) is a brain disorder that destroys memory and thinking skills over time. It is the most common form of dementia in older adults. There is presently no cure for the condition, though treatment options are available. Today, some 5.3 million Americans live with AD, and it is now the sixth leading cause of death in the United States. The number of older adults who will develop AD is expected to more than triple by 2050.

from Dementia Big http://ift.tt/2GjljHh via alcoholic dementia


http://ift.tt/2Fknnxv

Thursday, January 25, 2018

Lifestyle changes prevent cognitive decline even in genetically susceptible individuals

Lifestyle changes prevent cognitive decline even in genetically susceptible individuals:

Dementia Big
Enhanced lifestyle counselling prevents cognitive decline even in people who are carriers of the APOE4 gene, a common risk factor of Alzheimer’s disease, according to a new study published in JAMA Neurology.


http://ift.tt/2Bu5Znv

Enhanced lifestyle counseling prevents cognitive decline even in genetically susceptible people

Enhanced lifestyle counseling prevents cognitive decline even in genetically susceptible people:

Dementia Big
Enhanced lifestyle counseling prevents cognitive decline even in people who are carriers of the APOE4 gene, a common risk factor of Alzheimer’s disease, according to a new study published in JAMA Neurology.


http://ift.tt/2GeRMhR

Alzheimer's drug targeting soluble amyloid falls short in a large clinical trial

Alzheimer's drug targeting soluble amyloid falls short in a large clinical trial:

Dementia Big
A paper published today in the New England Journal of Medicine reports that solanezumab, a monoclonal antibody-based treatment for Alzheimer’s disease developed by Eli Lilly that targets amyloid plaques, did not significantly slow cognitive decline.


http://ift.tt/2rCCKzn

Drug may help those with dementia with Lewy bodies

Drug may help those with dementia with Lewy bodies:

Dementia Big
New help may be on the way for people with dementia with Lewy bodies, which is the second most common neurodegenerative type of dementia after Alzheimer’s disease. The disease can cause movement problems and issues such as hallucinations in addition to thinking and memory problems. But the drug used to treat the movement problems can also exacerbate the hallucinations, delusions and other psychiatric problems.


http://ift.tt/2GeRHe3

Enhanced lifestyle counseling prevents cognitive decline even in genetically susceptible people

Enhanced lifestyle counseling prevents cognitive decline even in people who are carriers of the APOE4 gene, a common risk factor of Alzheimer’s disease, according to a new study published in JAMA Neurology.

from Dementia Big http://ift.tt/2BsPOqo via alcoholic dementia


http://ift.tt/2Fftfrt

Drug may help those with dementia with Lewy bodies

New help may be on the way for people with dementia with Lewy bodies, which is the second most common neurodegenerative type of dementia after Alzheimer’s disease. The disease can cause movement problems and issues such as hallucinations in addition to thinking and memory problems. But the drug used to treat the movement problems can also exacerbate the hallucinations, delusions and other psychiatric problems.

from Dementia Big http://ift.tt/2E5bThR via alcoholic dementia


http://ift.tt/2DLUwoC

Alzheimer's drug targeting soluble amyloid falls short in a large clinical trial

A paper published today in the New England Journal of Medicine reports that solanezumab, a monoclonal antibody-based treatment for Alzheimer’s disease developed by Eli Lilly that targets amyloid plaques, did not significantly slow cognitive decline.

from Dementia Big http://ift.tt/2DF8hWL via alcoholic dementia


http://ift.tt/2FdEm4o

Wednesday, January 24, 2018

Number of older people with multi-morbidity likely to expand over next 20 years, study finds

Number of older people with multi-morbidity likely to expand over next 20 years, study finds:

Dementia Big
A study published today in Age and Ageing, the scientific journal of the British Geriatrics Society, reports that the number of older people diagnosed with four or more diseases will double between 2015 and 2035. A third of these people will be diagnosed with dementia, depression or a cognitive impairment.


http://ift.tt/2E4Z8DO

Number of older people with multi-morbidity likely to expand over next 20 years, study finds

A study published today in Age and Ageing, the scientific journal of the British Geriatrics Society, reports that the number of older people diagnosed with four or more diseases will double between 2015 and 2035. A third of these people will be diagnosed with dementia, depression or a cognitive impairment.

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http://ift.tt/2DyYUUn

Tuesday, January 23, 2018

Personality changes occur early on during development of Alzheimer's disease, research finds

Personality changes occur early on during development of Alzheimer's disease, research finds:

Dementia Big
A key feature of Alzheimer’s disease is memory loss and losing one’s ability to think and make decisions (also called “cognitive ability”). Those changes can begin slowly, during a phase called “mild cognitive impairment” (or MCI). A variety of diseases can cause MCI, but the most common is Alzheimer’s disease.


http://ift.tt/2rwyhhB

Personality changes during transition to developing mild cognitive impairment

Personality changes during transition to developing mild cognitive impairment:

Dementia Big
A key feature of Alzheimer’s disease is memory loss and losing one’s ability to think and make decisions (also called “cognitive ability”). Those changes can begin slowly, during a phase called “mild cognitive impairment” (or MCI). A variety of diseases can cause MCI, but the most common is Alzheimer’s disease.


http://ift.tt/2GdUOTG

Curcumin could provide meaningful cognitive benefits, study suggests

Curcumin could provide meaningful cognitive benefits, study suggests:

Dementia Big
Lovers of Indian food, give yourselves a second helping: Daily consumption of a certain form of curcumin – the substance that gives Indian curry its bright color – improved memory and mood in people with mild, age-related memory loss, according to the results of a study conducted by UCLA researchers.


http://ift.tt/2ru3yS6

Energy storehouses in the brain may be source of Alzheimer's, targets of new therapy

Energy storehouses in the brain may be source of Alzheimer's, targets of new therapy:

Dementia Big
Alzheimer’s disease, a severely debilitating and ultimately fatal brain disorder, affects millions worldwide. To date, clinical efforts to find a cure or adequate treatment have met with dispiriting failure.


http://ift.tt/2G9PEIb

Personality changes occur early on during development of Alzheimer's disease, research finds

A key feature of Alzheimer’s disease is memory loss and losing one’s ability to think and make decisions (also called “cognitive ability”). Those changes can begin slowly, during a phase called “mild cognitive impairment” (or MCI). A variety of diseases can cause MCI, but the most common is Alzheimer’s disease.

from Dementia Big http://ift.tt/2E42hUI via alcoholic dementia


http://ift.tt/2rC829u

Curcumin could provide meaningful cognitive benefits, study suggests

Lovers of Indian food, give yourselves a second helping: Daily consumption of a certain form of curcumin – the substance that gives Indian curry its bright color – improved memory and mood in people with mild, age-related memory loss, according to the results of a study conducted by UCLA researchers.

from Dementia Big http://ift.tt/2n5XURL via alcoholic dementia


http://ift.tt/2Gc2F40

Energy storehouses in the brain may be source of Alzheimer's, targets of new therapy

Alzheimer’s disease, a severely debilitating and ultimately fatal brain disorder, affects millions worldwide. To date, clinical efforts to find a cure or adequate treatment have met with dispiriting failure.

from Dementia Big http://ift.tt/2DwUD41 via alcoholic dementia


http://ift.tt/2rwyfpZ

Personality changes during transition to developing mild cognitive impairment

A key feature of Alzheimer’s disease is memory loss and losing one’s ability to think and make decisions (also called “cognitive ability”). Those changes can begin slowly, during a phase called “mild cognitive impairment” (or MCI). A variety of diseases can cause MCI, but the most common is Alzheimer’s disease.

from Dementia Big http://ift.tt/2DBjIit via alcoholic dementia


http://ift.tt/2GdeuXM

Sunday, January 21, 2018

Researchers describe atom-by-atom changes in ALS-linked protein

Researchers describe atom-by-atom changes in ALS-linked protein:

Dementia Big
For the first time, researchers have described atom-by-atom changes in a family of proteins linked to amyotrophic lateral sclerosis (ALS), a group of brain disorders known as frontotemporal dementia and degenerative diseases of muscle and bone.


http://ift.tt/2DyjfMN

Researchers describe atom-by-atom changes in ALS-linked protein

For the first time, researchers have described atom-by-atom changes in a family of proteins linked to amyotrophic lateral sclerosis (ALS), a group of brain disorders known as frontotemporal dementia and degenerative diseases of muscle and bone.

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http://ift.tt/2EZTimt

Friday, January 19, 2018

New initiative seeks to transform the way people live with dementia

New initiative seeks to transform the way people live with dementia:

Dementia Big
Challenge Dementia, supported by Nesta, launches today as the first national search for next generation products, technologies and services that could transform the way people live with dementia helping them to live enjoyable and fulfilling lives for as long as possible.


http://ift.tt/2DsbLfl

Rocky start for Alzheimer's drug research in 2018

Rocky start for Alzheimer's drug research in 2018:

Dementia Big
The year 2018, barely underway, has already dealt a series of disheartening blows to the quest for an Alzheimer’s cure.


http://ift.tt/2mRMksr

New initiative seeks to transform the way people live with dementia

Challenge Dementia, supported by Nesta, launches today as the first national search for next generation products, technologies and services that could transform the way people live with dementia helping them to live enjoyable and fulfilling lives for as long as possible.

from Dementia Big http://ift.tt/2FUlaK2 via alcoholic dementia


http://ift.tt/2DrFp4h

Rocky start for Alzheimer's drug research in 2018

The year 2018, barely underway, has already dealt a series of disheartening blows to the quest for an Alzheimer’s cure.

from Dementia Big http://ift.tt/2DsEvEI via alcoholic dementia


http://ift.tt/2mRMhwL

Thursday, January 18, 2018

Signaling molecules likely involved in concussions, rodent studies show

Signaling molecules likely involved in concussions, rodent studies show:

Dementia Big
Traumatic brain injuries, whether suffered from a blow on the football field or the battle field, can be devastating, leading to disability and shortened lives.


http://ift.tt/2mT2HWk

Neuronal loss very limited in Alzheimer's disease, new study shows

Neuronal loss very limited in Alzheimer's disease, new study shows:

Dementia Big
Frequently encountered in the elderly, Alzheimer’s is considered a neurodegenerative disease, which means that it is accompanied by a significant, progressive loss of neurons and their nerve endings, or synapses. A joint French and Canadian study published in Scientific Reports now challenges this view.


http://ift.tt/2Bc1WvK

Neuronal loss very limited in Alzheimer's disease, new study shows

Frequently encountered in the elderly, Alzheimer’s is considered a neurodegenerative disease, which means that it is accompanied by a significant, progressive loss of neurons and their nerve endings, or synapses. A joint French and Canadian study published in Scientific Reports now challenges this view.

from Dementia Big http://ift.tt/2Dq47kB via alcoholic dementia


http://ift.tt/2mREwYn

Signaling molecules likely involved in concussions, rodent studies show

Traumatic brain injuries, whether suffered from a blow on the football field or the battle field, can be devastating, leading to disability and shortened lives.

from Dementia Big http://ift.tt/2EUiUB4 via alcoholic dementia


http://ift.tt/2Bcbebt

Wednesday, January 17, 2018

Neuronal loss is very limited in Alzheimer’s disease, shows new study

Neuronal loss is very limited in Alzheimer’s disease, shows new study:

Dementia Big
Frequently encountered in the elderly, Alzheimer’s is considered a neurodegenerative disease, which means that it is accompanied by a significant, progressive loss of neurons and their nerve endings, or synapses.


http://ift.tt/2DldIKo

Alzheimer's disease: Neuronal loss very limited

Alzheimer's disease: Neuronal loss very limited:

Dementia Big
Frequently encountered in the elderly, Alzheimer’s is considered a neurodegenerative disease, which means that it is accompanied by a significant, progressive loss of neurons and their nerve endings, or synapses. A joint French and Canadian study published in Scientific Reports now challenges this view.


http://ift.tt/2B9Tf5d

Neuronal loss is very limited in Alzheimer’s disease, shows new study

Frequently encountered in the elderly, Alzheimer’s is considered a neurodegenerative disease, which means that it is accompanied by a significant, progressive loss of neurons and their nerve endings, or synapses.

from Dementia Big http://ift.tt/2DdBMea via alcoholic dementia


http://ift.tt/2DjhXWO

Alzheimer's disease: Neuronal loss very limited

Frequently encountered in the elderly, Alzheimer’s is considered a neurodegenerative disease, which means that it is accompanied by a significant, progressive loss of neurons and their nerve endings, or synapses. A joint French and Canadian study published in Scientific Reports now challenges this view.

from Dementia Big http://ift.tt/2B8doIW via alcoholic dementia


http://ift.tt/2Bai0OQ

Monday, January 15, 2018

Mitochondrial impairment may actually protect the brain in Parkinson's disease, study shows

A Norwegian study shows that impairment in mitochondria may actually protect the brain in Parkinson’s disease.

from Dementia Big http://ift.tt/2DBLeZF via alcoholic dementia


http://ift.tt/2Dl9iCm

Whole of Britain to be put on a diet plan come March

New Year resolutions have not been broken yet and Public Health England is coming up with a set of new guidelines for healthier eating. The entire country needs to watch calories and PHE is coming up with the “calorie caps” on all meals come March this year.

from Dementia Big http://ift.tt/2FHDnum via alcoholic dementia


http://ift.tt/2mzrWvW

Mitochondrial impairment may actually protect the brain in Parkinson's disease, study shows

Mitochondrial impairment may actually protect the brain in Parkinson's disease, study shows:

Dementia Big
A Norwegian study shows that impairment in mitochondria may actually protect the brain in Parkinson’s disease.


http://ift.tt/2mCcnnd

Whole of Britain to be put on a diet plan come March

Whole of Britain to be put on a diet plan come March:

Dementia Big
New Year resolutions have not been broken yet and Public Health England is coming up with a set of new guidelines for healthier eating. The entire country needs to watch calories and PHE is coming up with the “calorie caps” on all meals come March this year.


http://ift.tt/2DjtbcV

Friday, January 12, 2018

Worsening of anxiety symptoms may be early indicator of Alzheimer's disease

A new study suggests an association between elevated amyloid beta levels and the worsening of anxiety symptoms. The findings support the hypothesis that neuropsychiatric symptoms could represent the early manifestation of Alzheimer’s disease in older adults.

from Dementia Big http://ift.tt/2D8MINq via alcoholic dementia


http://ift.tt/2DajH4s

Seeing Alzheimer's disease

What if we could diagnose early-stage Alzheimer’s disease (AD) by looking into a person’s eyes?

from Dementia Big http://ift.tt/2EASl3M via alcoholic dementia


http://ift.tt/2AVmf0E

Curry spice holds clues to Alzheimer's drug targets

Californian researchers have shed more light on the action of an experimental Alzheimer’s drug based on a modified component of the curry spice turmeric. The researchers from the Salk Institute, found that the drug, J147, targets cell processes in the mitochondria – an area of the cell responsible for generating the energy. The results are published in the journal Aging Cell.

from Dementia Big http://ift.tt/2D4jNKX via alcoholic dementia


http://ift.tt/2D6PDXB

Worsening of anxiety symptoms may be early indicator of Alzheimer's disease

Worsening of anxiety symptoms may be early indicator of Alzheimer's disease:

Dementia Big
A new study suggests an association between elevated amyloid beta levels and the worsening of anxiety symptoms. The findings support the hypothesis that neuropsychiatric symptoms could represent the early manifestation of Alzheimer’s disease in older adults.


http://ift.tt/2mxUw1s

Seeing Alzheimer's disease

Seeing Alzheimer's disease:

Dementia Big
What if we could diagnose early-stage Alzheimer’s disease (AD) by looking into a person’s eyes?


http://ift.tt/2r0v21y

Curry spice holds clues to Alzheimer's drug targets

Curry spice holds clues to Alzheimer's drug targets:

Dementia Big
Californian researchers have shed more light on the action of an experimental Alzheimer’s drug based on a modified component of the curry spice turmeric. The researchers from the Salk Institute, found that the drug, J147, targets cell processes in the mitochondria – an area of the cell responsible for generating the energy. The results are published in the journal Aging Cell.


http://ift.tt/2mxXbsd

Anxiety: An early indicator of Alzheimer's disease?

A new study suggests an association between elevated amyloid beta levels and the worsening of anxiety symptoms. The findings support the hypothesis that neuropsychiatric symptoms could represent the early manifestation of Alzheimer’s disease in older adults.

from Dementia Big http://ift.tt/2mkmvAS via alcoholic dementia


http://ift.tt/2mn4sKx

One of the most promising drugs for Alzheimer's disease fails in clinical trials

To the roughly 400 clinical trials that have tested some experimental treatment for Alzheimer’s disease and come up short, we can now add three more.

from Dementia Big http://ift.tt/2EybBPH via alcoholic dementia


http://ift.tt/2D4MJ4N

Anxiety: An early indicator of Alzheimer's disease?

Anxiety: An early indicator of Alzheimer's disease?:

Dementia Big
A new study suggests an association between elevated amyloid beta levels and the worsening of anxiety symptoms. The findings support the hypothesis that neuropsychiatric symptoms could represent the early manifestation of Alzheimer’s disease in older adults.


http://ift.tt/2Fxe0v5

One of the most promising drugs for Alzheimer's disease fails in clinical trials

One of the most promising drugs for Alzheimer's disease fails in clinical trials:

Dementia Big
To the roughly 400 clinical trials that have tested some experimental treatment for Alzheimer’s disease and come up short, we can now add three more.


http://ift.tt/2Ey89Ve

Thursday, January 11, 2018

Why a drug treatment for dementia eludes researchers

Finding a cure for neurodegenerative diseases such as Alzheimer’s is challenging. They’re difficult to diagnose, and drugs struggle to get into the brain as the brain’s blood supply is largely separate to the rest of the body. Not surprisingly, several companies have left this territory in recent years. This week, pharmaceutical giant Pfizer announced it will stop research into developing drugs to treat Alzheimer’s disease, after costly failed attempts over the past decade.

from Dementia Big http://ift.tt/2FpzWbo via alcoholic dementia


http://ift.tt/2qWeDes

For elder health, trips to the ER are often a tipping point

Twice a day, the 86-year-old man went for long walks and visited with neighbors along the way. Then, one afternoon he fell while mowing his lawn. In the emergency room, doctors diagnosed a break in his upper arm and put him in a sling.

from Dementia Big http://ift.tt/2D27NcZ via alcoholic dementia


http://ift.tt/2mvafhN

Why a drug treatment for dementia eludes researchers

Why a drug treatment for dementia eludes researchers:

Dementia Big
Finding a cure for neurodegenerative diseases such as Alzheimer’s is challenging. They’re difficult to diagnose, and drugs struggle to get into the brain as the brain’s blood supply is largely separate to the rest of the body. Not surprisingly, several companies have left this territory in recent years. This week, pharmaceutical giant Pfizer announced it will stop research into developing drugs to treat Alzheimer’s disease, after costly failed attempts over the past decade.


http://ift.tt/2qWewzy

For elder health, trips to the ER are often a tipping point

For elder health, trips to the ER are often a tipping point:

Dementia Big
Twice a day, the 86-year-old man went for long walks and visited with neighbors along the way. Then, one afternoon he fell while mowing his lawn. In the emergency room, doctors diagnosed a break in his upper arm and put him in a sling.


http://ift.tt/2mtjcbu

Wednesday, January 10, 2018

Pfizer to stop Alzheimer’s and Parkinson’s disease research

Pfizer to stop Alzheimer’s and Parkinson’s disease research:

Dementia Big
Pharmaceutical giant Pfizer has announced its intention to stop research and development in areas including Alzheimer’s disease and Parkinson’s disease.


http://ift.tt/2mpDu5G

Pfizer to stop Alzheimer’s and Parkinson’s disease research

Pharmaceutical giant Pfizer has announced its intention to stop research and development in areas including Alzheimer’s disease and Parkinson’s disease.

from Dementia Big http://ift.tt/2mpY5Xp via alcoholic dementia


http://ift.tt/2qNEx3Y

Alzheimer’s Research UK calls on pharma to continue supporting dementia research

Alzheimer’s Research UK is calling for a recommitment from pharmaceutical companies to continue efforts to fund research into dementia, the leading cause of death in the UK.

from Dementia Big http://ift.tt/2CZLd40 via alcoholic dementia


http://ift.tt/2EtgPvY

General anesthesia may be more complex in its workings than we know now

Associate Professor Bruno van Swinderen from Queensland Brain Institute, University of Queensland with his colleagues have studied the workings of general anesthetics on the brain and found that these agents did more than just put a person to sleep. These findings could pave the way for better and more effective anesthetics they believe. The study was published in the latest issue of the journal Cell Reports.

from Dementia Big http://ift.tt/2mkDbJq via alcoholic dementia


http://ift.tt/2FncTxV

Researchers awarded grant to repurpose FDA-approved drugs for treating Alzheimer's patients

Researchers from Case Western Reserve University School of Medicine and collaborators have received a five-year, $2.8 million grant from the National Institute on Aging to identify FDA-approved medications that could be repurposed to treat Alzheimer’s disease.

from Dementia Big http://ift.tt/2D02ytq via alcoholic dementia


http://ift.tt/2Euztn8

Alzheimer’s Research UK calls on pharma to continue supporting dementia research

Alzheimer’s Research UK calls on pharma to continue supporting dementia research:

Dementia Big
Alzheimer’s Research UK is calling for a recommitment from pharmaceutical companies to continue efforts to fund research into dementia, the leading cause of death in the UK.


http://ift.tt/2qQLjpB

General anesthesia may be more complex in its workings than we know now

General anesthesia may be more complex in its workings than we know now:

Dementia Big
Associate Professor Bruno van Swinderen from Queensland Brain Institute, University of Queensland with his colleagues have studied the workings of general anesthetics on the brain and found that these agents did more than just put a person to sleep. These findings could pave the way for better and more effective anesthetics they believe. The study was published in the latest issue of the journal Cell Reports.


http://ift.tt/2mkYISj

Researchers awarded grant to repurpose FDA-approved drugs for treating Alzheimer's patients

Researchers awarded grant to repurpose FDA-approved drugs for treating Alzheimer's patients:

Dementia Big
Researchers from Case Western Reserve University School of Medicine and collaborators have received a five-year, $2.8 million grant from the National Institute on Aging to identify FDA-approved medications that could be repurposed to treat Alzheimer’s disease.


http://ift.tt/2qQLam3

Tuesday, January 9, 2018

Key synaptic proteins could be targets for early interventions in patients with dementias

One of the most intriguing properties of the brain is its means to undergo synaptic plasticity which represents the basis for learning and memory, abilities that severely decline in the case of a dementia.

from Dementia Big http://ift.tt/2maAVUa via alcoholic dementia


http://ift.tt/2meRu1n

Researchers develop drug that supports cellular traffic jam theory in ALS/FTD

Neurodegeneration in ALS/FTD may be caused by TDP-43 aggregation in the cytoplasm, causing cellular traffic jams. The trial drug can sequester TDP-43.

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Different disease types associated with distinct amyloid-beta prion strains found in Alzheimer's patients

An international team of researchers has found different disease type associations with distinct amyloid-beta prion strains in the brains of dead Alzheimer’s patients. In their paper published in Proceedings of the National Academy of Sciences, the group describes their study of sliced brain fragments and what they learned about the nature of amyloid-beta prions.

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Researchers develop drug that supports cellular traffic jam theory in ALS/FTD

Researchers develop drug that supports cellular traffic jam theory in ALS/FTD:

Dementia Big
Neurodegeneration in ALS/FTD may be caused by TDP-43 aggregation in the cytoplasm, causing cellular traffic jams. The trial drug can sequester TDP-43.


http://ift.tt/2CWIhVH

Key synaptic proteins could be targets for early interventions in patients with dementias

Key synaptic proteins could be targets for early interventions in patients with dementias:

Dementia Big
One of the most intriguing properties of the brain is its means to undergo synaptic plasticity which represents the basis for learning and memory, abilities that severely decline in the case of a dementia.


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Different disease types associated with distinct amyloid-beta prion strains found in Alzheimer's patients

Different disease types associated with distinct amyloid-beta prion strains found in Alzheimer's patients:

Dementia Big
An international team of researchers has found different disease type associations with distinct amyloid-beta prion strains in the brains of dead Alzheimer’s patients. In their paper published in Proceedings of the National Academy of Sciences, the group describes their study of sliced brain fragments and what they learned about the nature of amyloid-beta prions.


http://ift.tt/2CWXTbP

Alzheimer's Society responds to Jeremy Hunt MP's appointment as Health and Social Care Secretary

Yesterday, Monday 8 January, Jeremy Hunt MP was appointed as Health and Social Care Secretary as part of a cabinet reshuffle by Prime Minister Theresa May.



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Alzheimer's Society responds to Jeremy Hunt MP's appointment as Health and Social Care Secretary

Alzheimer's Society responds to Jeremy Hunt MP's appointment as Health and Social Care Secretary:

Dementia Big
Yesterday, Monday 8 January, Jeremy Hunt MP was appointed as Health and Social Care Secretary as part of a cabinet reshuffle by Prime Minister Theresa May.


http://ift.tt/2CMzHFW

Her sister’s keeper: Caring for a sibling with mental illness

When sisters Jean and Ruby were growing up in Harlem, they invented a game of make-believe called “Eartha.” The little girls would put on their prettiest dresses and shiniest shoes and sit down to tea as grown-up ladies. They discussed details of their hoped-for husbands and children, and all the exciting things they would do together.

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Her sister’s keeper: Caring for a sibling with mental illness

Her sister’s keeper: Caring for a sibling with mental illness:

Dementia Big
When sisters Jean and Ruby were growing up in Harlem, they invented a game of make-believe called “Eartha.” The little girls would put on their prettiest dresses and shiniest shoes and sit down to tea as grown-up ladies. They discussed details of their hoped-for husbands and children, and all the exciting things they would do together.


http://ift.tt/2DaaHsZ

Monday, January 8, 2018

Pfizer ends neuroscience discovery programme, including research into Alzheimer’s disease treatment – Alzheimer’s Society comment

Pfizer ends neuroscience discovery programme, including research into Alzheimer’s disease treatment – Alzheimer’s Society comment:

Dementia Big
Pfizer has announced that it will be ending its neuroscience discovery and early development efforts, an area which includes research into drug development for Alzheimer’s disease.


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Pfizer ends neuroscience discovery programme, including research into Alzheimer’s disease treatment – Alzheimer’s Society comment

Pfizer has announced that it will be ending its neuroscience discovery and early development efforts, an area which includes research into drug development for Alzheimer’s disease.



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Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

Sangamo Therapeutics, Inc. and Pfizer Inc. today announced a collaboration for the development of a potential gene therapy using zinc finger protein transcription factors (ZFP-TFs) to treat amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) linked to mutations of the C9ORF72 gene.

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Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS:

Dementia Big
Sangamo Therapeutics, Inc. and Pfizer Inc. today announced a collaboration for the development of a potential gene therapy using zinc finger protein transcription factors (ZFP-TFs) to treat amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) linked to mutations of the C9ORF72 gene.


http://ift.tt/2FfZkAy

Friday, January 5, 2018

How Alzheimer's disease spreads throughout the brain – new study

How Alzheimer's disease spreads throughout the brain – new study:

Dementia Big
Alzheimer’s disease is a devastating brain illness that affects an estimated 47m people worldwide. It is the most common cause of dementia in the Western world. Despite this, there are currently no treatments that are effective in curing Alzheimer’s disease or preventing its relentless progression.


http://ift.tt/2CYKk9r

Further evidence shows education reduces risk of Alzheimer's

Further evidence shows education reduces risk of Alzheimer's:

Dementia Big
New research from Cambridge University, supported by European Union funding, has added weight to the theory that education protects against Alzheimer’s disease.


http://ift.tt/2CwrK7k

Molecular mechanism behind HIV-associated dementia revealed

Molecular mechanism behind HIV-associated dementia revealed:

Dementia Big
For the first time, scientists have identified and inhibited a molecular process that can lead to neurodegeneration in patients with HIV, according to a Northwestern Medicine study published in Nature Communications.


http://ift.tt/2CVWZtx

Team develops world-first array of compounds for detection, imaging of Alzheimer's disease

Team develops world-first array of compounds for detection, imaging of Alzheimer's disease:

Dementia Big
Hong Kong Baptist University (HKBU) chemists have invented a new class of multifunctional cyanine compounds that can be used for detection, imaging and treatment of Alzheimer’s disease. The research team was jointly led by Professor Ricky Wong Man-shing and Associate Professor Dr Li Hung-wing, with members from the Department of Chemistry of HKBU. By making use of the proprietary compounds, the HKBU team has proved that cyanine compounds applied on a nano-detection platform can quantify trace amounts of Alzheimer’s disease-related protein biomarkers present in human fluids such as cerebrospinal fluid, serum, saliva, and urine. It is a rapid, low-cost and ultrasensitive detection assay. The compounds also serve as an imaging agent for in vivo detection and monitoring of disease progression and understanding the disease pathogenesis, as well as a drug candidate for treatment of the disease.


http://ift.tt/2CwrBki

Advances in brain imaging settle debate over spread of key protein in Alzheimer's

Advances in brain imaging settle debate over spread of key protein in Alzheimer's:

Dementia Big
Recent advances in brain imaging have enabled scientists to show for the first time that a key protein which causes nerve cell death spreads throughout the brain in Alzheimer’s disease - and hence that blocking its spread may prevent the disease from taking hold.


http://ift.tt/2CYw68D

How Alzheimer's disease spreads throughout the brain – new study

Alzheimer’s disease is a devastating brain illness that affects an estimated 47m people worldwide. It is the most common cause of dementia in the Western world. Despite this, there are currently no treatments that are effective in curing Alzheimer’s disease or preventing its relentless progression.

from Dementia Big http://ift.tt/2F2PC4m via alcoholic dementia


http://ift.tt/2CwrvsW

Further evidence shows education reduces risk of Alzheimer's

New research from Cambridge University, supported by European Union funding, has added weight to the theory that education protects against Alzheimer’s disease.

from Dementia Big http://ift.tt/2F2PamE via alcoholic dementia


http://ift.tt/2CVVX0T

Molecular mechanism behind HIV-associated dementia revealed

For the first time, scientists have identified and inhibited a molecular process that can lead to neurodegeneration in patients with HIV, according to a Northwestern Medicine study published in Nature Communications.

from Dementia Big http://ift.tt/2AuYgVR via alcoholic dementia


http://ift.tt/2CuFNuq

Team develops world-first array of compounds for detection, imaging of Alzheimer's disease

Hong Kong Baptist University (HKBU) chemists have invented a new class of multifunctional cyanine compounds that can be used for detection, imaging and treatment of Alzheimer’s disease. The research team was jointly led by Professor Ricky Wong Man-shing and Associate Professor Dr Li Hung-wing, with members from the Department of Chemistry of HKBU. By making use of the proprietary compounds, the HKBU team has proved that cyanine compounds applied on a nano-detection platform can quantify trace amounts of Alzheimer’s disease-related protein biomarkers present in human fluids such as cerebrospinal fluid, serum, saliva, and urine. It is a rapid, low-cost and ultrasensitive detection assay. The compounds also serve as an imaging agent for in vivo detection and monitoring of disease progression and understanding the disease pathogenesis, as well as a drug candidate for treatment of the disease.

from Dementia Big http://ift.tt/2CIOAgd via alcoholic dementia


http://ift.tt/2CXocMA

Advances in brain imaging settle debate over spread of key protein in Alzheimer's

Recent advances in brain imaging have enabled scientists to show for the first time that a key protein which causes nerve cell death spreads throughout the brain in Alzheimer’s disease - and hence that blocking its spread may prevent the disease from taking hold.

from Dementia Big http://ift.tt/2CtJWif via alcoholic dementia


http://ift.tt/2CuFMqm

Thursday, January 4, 2018

Mice with frequent flier miles advance the Alzheimer's cause

Alzheimer’s disease wreaks emotional havoc on patients, who are robbed of their memories, their dignity, and their lives. It’s financially devastating as well: care for Alzheimer’s patients is predicted to top $1 trillion by about the time children born today are having children of their own.

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Mice with frequent flier miles advance the Alzheimer's cause

Mice with frequent flier miles advance the Alzheimer's cause:

Dementia Big
Alzheimer’s disease wreaks emotional havoc on patients, who are robbed of their memories, their dignity, and their lives. It’s financially devastating as well: care for Alzheimer’s patients is predicted to top $1 trillion by about the time children born today are having children of their own.


http://ift.tt/2qtBvBX

Wednesday, January 3, 2018

MIND diet ranked among top five for 2018

For the third consecutive year, a diet created, studied and reported on by researchers at Rush University Medical Center has been ranked among the top five diets for 2018 in multiple categories by U.S. News & World Report.

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Researchers discover novel genes responsible for Alzheimer's disease

Researchers have identified several new genes responsible for Alzheimer’s disease (AD) including those leading to functional and structural changes in the brain and elevated levels of AD proteins in cerebrospinal fluid (CSF).

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Researchers identify genetic factors that contribute to Alzheimer's disease

Researchers have identified several new genes responsible for Alzheimer’s disease (AD) including those leading to functional and structural changes in the brain and elevated levels of AD proteins in cerebrospinal fluid (CSF).

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MIND diet ranked among top five for 2018

MIND diet ranked among top five for 2018:

Dementia Big
For the third consecutive year, a diet created, studied and reported on by researchers at Rush University Medical Center has been ranked among the top five diets for 2018 in multiple categories by U.S. News & World Report.


http://ift.tt/2CP427g

Researchers discover novel genes responsible for Alzheimer's disease

Researchers discover novel genes responsible for Alzheimer's disease:

Dementia Big
Researchers have identified several new genes responsible for Alzheimer’s disease (AD) including those leading to functional and structural changes in the brain and elevated levels of AD proteins in cerebrospinal fluid (CSF).


http://ift.tt/2CmmkvE

Researchers identify genetic factors that contribute to Alzheimer's disease

Researchers identify genetic factors that contribute to Alzheimer's disease:

Dementia Big
Researchers have identified several new genes responsible for Alzheimer’s disease (AD) including those leading to functional and structural changes in the brain and elevated levels of AD proteins in cerebrospinal fluid (CSF).


http://ift.tt/2COAOpn

Tuesday, January 2, 2018

Founding member of Alzheimer's Society's Research Network awarded MBE

Alzheimer’s Society volunteer, Barbara Woodward-Carlton, has been awarded an MBE in the New Year’s Honours.



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Founding member of Alzheimer's Society's Research Network awarded MBE

Founding member of Alzheimer's Society's Research Network awarded MBE:

Dementia Big
Alzheimer’s Society volunteer, Barbara Woodward-Carlton, has been awarded an MBE in the New Year’s Honours.


http://ift.tt/2CJAiJb

Diabetes drug holds promise of being developed into new treatment for Alzheimer's

A drug developed for diabetes could be used to treat Alzheimer’s after scientists found it “significantly reversed memory loss” in mice through a triple method of action.

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Care suffers as more nursing homes feed money into corporate webs

When one of Martha Jane Pierce’s sons peeled back the white sock that had been covering his 82-year-old mother’s right foot for a month, he discovered rotting flesh.

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http://ift.tt/2CAPhVz

Diabetes drug holds promise of being developed into new treatment for Alzheimer's

Diabetes drug holds promise of being developed into new treatment for Alzheimer's:

Dementia Big
A drug developed for diabetes could be used to treat Alzheimer’s after scientists found it “significantly reversed memory loss” in mice through a triple method of action.


http://ift.tt/2DOAbLK

Care suffers as more nursing homes feed money into corporate webs

Care suffers as more nursing homes feed money into corporate webs:

Dementia Big
When one of Martha Jane Pierce’s sons peeled back the white sock that had been covering his 82-year-old mother’s right foot for a month, he discovered rotting flesh.


http://ift.tt/2CCrggP

Monday, January 1, 2018

Diabetes drug 'significantly reverses memory loss' in mice with Alzheimer's

A drug developed for diabetes could be used to treat Alzheimer’s after scientists found it “significantly reversed memory loss” in mice through a triple method of action.

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http://ift.tt/2lCMPpv

Diabetes drug 'significantly reverses memory loss' in mice with Alzheimer's

Diabetes drug 'significantly reverses memory loss' in mice with Alzheimer's:

Dementia Big
A drug developed for diabetes could be used to treat Alzheimer’s after scientists found it “significantly reversed memory loss” in mice through a triple method of action.


http://ift.tt/2CvmnZm