Several attempts have been made to treat Alzheimer’s disease (AD) using anti-amyloid strategies with disappointing results. It is clear that the “amyloid cascade hypothesis” alone cannot fully explain the neuronal damage in AD, as evidenced both by autopsy and imaging studies. Neuroinflammation plays a significant role in neurodegenerative diseases, whereas the debate is ongoing about its precise role, whether it is protective or harmful. In this review, we focus on the potential mechanism of glial activation and how local and systemic factors influence disease progression.
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