mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease

mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease:

Dementia Big
A major obstacle to presymptomatic diagnosis and disease-modifying therapy for Alzheimer’s disease (AD) is inadequate understanding of molecular mechanisms of AD pathogenesis. For example, impaired brain insulin signaling is an AD hallmark, but whether and how it might contribute to the synaptic dysfunction and neuron death that underlie memory and cognitive impairment has been mysterious. Neuron death in AD is often caused by cell cycle reentry (CCR) mediated by amyloid-β oligomers (AβOs) and tau, the precursors of plaques and tangles.

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