Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome

Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome:

Dementia Big
Individuals with Down syndrome (DS) exhibit Alzheimer’s disease (AD) neuropathology and dementia early in life. Blood biomarkers of AD neuropathology would be valuable, as non-AD intellectual disabilities of DS and AD dementia overlap clinically. We hypothesized that elevations of amyloid-β (Aβ) peptides and phosphorylated-tau in neuronal exosomes may document preclinical AD.

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