We read with interest the research article from Casanova et al. for an upcoming edition of Alzheimer’s & Dementia (2016, article in press). We appreciate the efforts that these investigators have expended in attempting to replicate our plasma lipidomic findings in preclinical Alzheimer’s disease [1]. We enthusiastically endorse independent validation of new findings in science but assert that valid replication requires identical methods including those related to clinical characterization and biospecimen collection, processing, and analysis.
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