Vitamin C deficiency and mitochondrial dysfunction in Alzheimer's disease

Early clinical features of sporadic Alzheimer’s disease include alterations in mitochondrial function that appear prior to classical features. Mitochondrial dysfunction increases the production of reactive oxygen species (ROS), which then drive the production of Amyloid beta, creating a vicious cycle accelerating Alzheimer’s pathology. Vitamin C is an effective antioxidant and thus, could be protective against disease pathology.

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