Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation

TREM2 is a lipid-sensing activating receptor on microglia known to be important for Alzheimer’s disease (AD), but whether it plays a beneficial or detrimental role in disease pathogenesis is controversial.

from Dementia Big http://ift.tt/2bdOP63 via alcoholic dementia

http://ift.tt/2bkdL80