Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation

Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation:

Dementia Big
TREM2 is a lipid-sensing activating receptor on microglia known to be important for Alzheimer’s disease (AD), but whether it plays a beneficial or detrimental role in disease pathogenesis is controversial.

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