Friday, February 9, 2018

Alzheimer's research—intracellular calcium store malfunction leads to brain hyperactivity

Alzheimer´s disease is the key cause of dementia in elderly patients. Those affected develop deficiencies in their abilities to learn, think logically, communicate, and to master the challenges of everyday life. To find out more about how the disease comes about, researchers at the University of Tübingen used mice, developing the same amyloid protein deposits in their brains as human patients, and which also suffer memory loss. Several years ago, a team led by Professor Olga Garaschuk showed that in these mice, the disease coincided with a noticeable increase in nerve cell activity in the brain. There were similar findings in human Alzheimer’s patients.

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