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The pathological hallmarks of Alzheimer’s disease (AD), viz defective Aβ and tau proteins, have been the center of AD-directed therapeutic studies. Although this approach still remains valid, it has not yet produced clinically meaningful results.
The pathological hallmarks of Alzheimer’s disease (AD), viz defective Aβ and tau proteins, have been the center of AD-directed therapeutic studies. Although this approach still remains valid, it has not yet produced clinically meaningful results.
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A European study led by Umea University Professor Lars Nyberg, has shown that the dopamine D2 receptor is linked to the long-term episodic memory, which function often reduces with age and due to dementia.
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Previous studies have shown that neurological diseases such as Alzheimer’s and Parkinson’s can be induced in healthy laboratory animals, causing concern that dementia diseases can be transmitted between individuals, possibly via blood transfusions.
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(HealthDay)—Legendary coach Pat Summitt stared down myriad challenges as she thrust women’s college basketball onto the world stage. But her greatest foe wasn’t on the court—it was Alzheimer’s disease.
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In March 2015, after several years of planning by the Alzheimer's Association, its main scientific journal Alzheimer’s & Dementia, and the journal’s publisher, the association launched its first online open access journal, Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring [1] (http://ift.tt/292dqp3). Going by the acronym “DADM,” this journal was conceived of as an important new vehicle to advance the discovery, development, and validation of much-needed biomarkers to refine the ability to diagnose the disease in its earliest stages, or to sensitively track disease progression [2].
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Salk Institute scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer’s disease.
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A European study led by Umea University Professor Lars Nyberg, has shown that the dopamine D2 receptor is linked to the long-term episodic memory, which function often reduces with age and due to dementia.
Dementia Big
Previous studies have shown that neurological diseases such as Alzheimer’s and Parkinson’s can be induced in healthy laboratory animals, causing concern that dementia diseases can be transmitted between individuals, possibly via blood transfusions.
Dementia Big
(HealthDay)—Legendary coach Pat Summitt stared down myriad challenges as she thrust women’s college basketball onto the world stage. But her greatest foe wasn’t on the court—it was Alzheimer’s disease.
Dementia Big
Salk Institute scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer’s disease.
Dementia Big
In March 2015, after several years of planning by the Alzheimer's Association, its main scientific journal Alzheimer’s & Dementia, and the journal’s publisher, the association launched its first online open access journal, Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring [1] (http://ift.tt/292dqp3). Going by the acronym “DADM,” this journal was conceived of as an important new vehicle to advance the discovery, development, and validation of much-needed biomarkers to refine the ability to diagnose the disease in its earliest stages, or to sensitively track disease progression [2].
Dementia Big
Atrial fibrillation (AF), the most common cardiac arrhythmia, turns out to be a potential mechanism into the genesis of AF-related cognitive impairment/dementia.
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For a promising pathway to treating Alzheimer’s patients, “aim here.” That’s what National Institute of Standards of Technology (NIST) researchers advised collaborators hunting for molecules that, by linking to a normally occurring enzyme, rev up the brain’s capacity for clearing cholesterol—a boost associated with improvements in memory and other benefits in animal studies.
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Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer’s disease and mild cognitive impairment. Although the definition of apathy is inconsistent in the literature, apathy is primarily defined as a loss of motivation and decreased interest in daily activities.
For a promising pathway to treating Alzheimer’s patients, “aim here.” That’s what National Institute of Standards of Technology (NIST) researchers advised collaborators hunting for molecules that, by linking to a normally occurring enzyme, rev up the brain’s capacity for clearing cholesterol—a boost associated with improvements in memory and other benefits in animal studies.
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Atrial fibrillation (AF), the most common cardiac arrhythmia, turns out to be a potential mechanism into the genesis of AF-related cognitive impairment/dementia.
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Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer’s disease and mild cognitive impairment. Although the definition of apathy is inconsistent in the literature, apathy is primarily defined as a loss of motivation and decreased interest in daily activities.
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A University of Adelaide analysis of genetic mutations which cause early-onset Alzheimer’s disease suggests a new focus for research into the causes of the disease.
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Historically, efforts to improve end-of-life care have focused primarily on patients with cancer. But few studies have looked at the quality of end-of-life care for patients with other serious illnesses, such as lung, kidney or heart failure or dementia.
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A University of Adelaide analysis of genetic mutations which cause early-onset Alzheimer’s disease suggests a new focus for research into the causes of the disease.
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Historically, efforts to improve end-of-life care have focused primarily on patients with cancer. But few studies have looked at the quality of end-of-life care for patients with other serious illnesses, such as lung, kidney or heart failure or dementia.
A new grant to the Indiana University Center for Aging Research from the National Institute on Aging funds the first study to assess the potential benefits and harms to family members of early dementia screening of older adults.
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Alzheimer’s disease is the leading cause of dementia in the elderly and occurs in all ethnic and racial groups. It affects more than 5 million people age 65 and older in the United States alone and there is currently no effective treatment or cure.
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A new grant to the Indiana University Center for Aging Research from the National Institute on Aging funds the first study to assess the potential benefits and harms to family members of early dementia screening of older adults.
Dementia Big
Alzheimer’s disease is the leading cause of dementia in the elderly and occurs in all ethnic and racial groups. It affects more than 5 million people age 65 and older in the United States alone and there is currently no effective treatment or cure.
Dementia Big
A new grant to the Indiana University Center for Aging Research from the National Institute on Aging funds the first study to assess the potential benefits and harms to family members of early dementia screening of older adults.
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Dementia currently affects some 5 million people in the U.S., and that number is expected to triple by 2050. Having dementia affects the way you think, act, and make decisions.
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A new study from Western University is helping to explain why the long-term use of common anticholinergic drugs used to treat conditions like allergies and overactive bladder lead to an increased risk of developing dementia later in life.
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New research suggests that higher late life cognitive reserve—an ability to offset the losses associated with age- and disease-related changes in the brain—may help prevent delirium.
A new grant to the Indiana University Center for Aging Research from the National Institute on Aging funds the first study to assess the potential benefits and harms to family members of early dementia screening of older adults.
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Dementia currently affects some 5 million people in the U.S., and that number is expected to triple by 2050. Having dementia affects the way you think, act, and make decisions.
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A new study from Western University is helping to explain why the long-term use of common anticholinergic drugs used to treat conditions like allergies and overactive bladder lead to an increased risk of developing dementia later in life.
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New research suggests that higher late life cognitive reserve—an ability to offset the losses associated with age- and disease-related changes in the brain—may help prevent delirium.
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A new study from Western University is helping to explain why the long-term use of common anticholinergic drugs used to treat conditions like allergies and overactive bladder lead to an increased risk of developing dementia later in life. The findings show that long-term suppression of the neurotransmitter acetylcholine - a target for anticholinergic drugs - results in dementia-like changes in the brain.
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Researchers in Aberdeen have highlighted a possible new link between Alzheimer’s disease and diabetes according to a new study published today in the journal Diabetologia.
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Frontotemporal dementia is associated with a wide variety of abnormal eating behaviors such as hyperphagia, fixations on one kind of food, even ingestion of inanimate objects, making an already-difficult situation even worse. A review by SISSA researchers gathers together the state of the art of what is known in this field, paying particular attention to the brain mechanisms involved. The information may be used for understanding eating disorders in healthy people. The review was published in the magazine Neurocase.
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A new study has shown that changes in blood flow to different brain areas may be one of the earliest changes in the brain linked to Alzheimer’s disease. The research is published today in the journal Nature Communications.
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Drugs used to treat diabetes could also be used to treat Alzheimer’s disease, and vice versa, according to new research from the University of Aberdeen.
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Delirium, or the medical term for experiencing sudden confusion, is upsetting for both older adults and their families. In fact, it is one of the most common complications older adults face after surgery (a time often referred to as the “post-operative” period).
A new study from Western University is helping to explain why the long-term use of common anticholinergic drugs used to treat conditions like allergies and overactive bladder lead to an increased risk of developing dementia later in life. The findings show that long-term suppression of the neurotransmitter acetylcholine - a target for anticholinergic drugs - results in dementia-like changes in the brain.
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Researchers in Aberdeen have highlighted a possible new link between Alzheimer’s disease and diabetes according to a new study published today in the journal Diabetologia.
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A new study has shown that changes in blood flow to different brain areas may be one of the earliest changes in the brain linked to Alzheimer’s disease. The research is published today in the journal Nature Communications.
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Frontotemporal dementia is associated with a wide variety of abnormal eating behaviors such as hyperphagia, fixations on one kind of food, even ingestion of inanimate objects, making an already-difficult situation even worse. A review by SISSA researchers gathers together the state of the art of what is known in this field, paying particular attention to the brain mechanisms involved. The information may be used for understanding eating disorders in healthy people. The review was published in the magazine Neurocase.
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Drugs used to treat diabetes could also be used to treat Alzheimer’s disease, and vice versa, according to new research from the University of Aberdeen.
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Delirium, or the medical term for experiencing sudden confusion, is upsetting for both older adults and their families. In fact, it is one of the most common complications older adults face after surgery (a time often referred to as the “post-operative” period).
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Dementia Big
Drugs used to treat diabetes could also be used to treat Alzheimer’s disease, and vice versa, according to new research from the University of Aberdeen.
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It is unknown if risk loci, identified by genome-wide association studies of late-onset Alzheimer’s disease (LOAD), are linked to common molecular mechanisms through epistatic effects.
Drugs used to treat diabetes could also be used to treat Alzheimer’s disease, and vice versa, according to new research from the University of Aberdeen.
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It is unknown if risk loci, identified by genome-wide association studies of late-onset Alzheimer’s disease (LOAD), are linked to common molecular mechanisms through epistatic effects.
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Memory loss and increased anxiety are clinical hallmarks of Alzheimer’s disease (AD). Kallikrein-8 is a protease implicated in memory acquisition and anxiety, and its mRNA is known to be up-regulated in AD-affected human hippocampus. Therefore, an involvement of Kallikrein-8 in Alzheimer’s pathogenesis is conceivable but remains to be proved.
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Patients surviving stroke without immediate dementia are at high risk of delayed-onset dementia. Mechanisms underlying delayed-onset dementia are complex and may involve vascular and/or neurodegenerative diseases.
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Many disease-modifying clinical development programs in Alzheimer’s disease (AD) have failed to date, and development of new and advanced preclinical models that generate actionable knowledge is desperately needed. This review reports on computer-based modeling and simulation approach as a powerful tool in AD research. Statistical data-analysis techniques can identify associations between certain data and phenotypes, such as diagnosis or disease progression. Other approaches integrate domain expertise in a formalized mathematical way to understand how specific components of pathology integrate into complex brain networks.
Memory loss and increased anxiety are clinical hallmarks of Alzheimer’s disease (AD). Kallikrein-8 is a protease implicated in memory acquisition and anxiety, and its mRNA is known to be up-regulated in AD-affected human hippocampus. Therefore, an involvement of Kallikrein-8 in Alzheimer’s pathogenesis is conceivable but remains to be proved.
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Patients surviving stroke without immediate dementia are at high risk of delayed-onset dementia. Mechanisms underlying delayed-onset dementia are complex and may involve vascular and/or neurodegenerative diseases.
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Many disease-modifying clinical development programs in Alzheimer’s disease (AD) have failed to date, and development of new and advanced preclinical models that generate actionable knowledge is desperately needed. This review reports on computer-based modeling and simulation approach as a powerful tool in AD research. Statistical data-analysis techniques can identify associations between certain data and phenotypes, such as diagnosis or disease progression. Other approaches integrate domain expertise in a formalized mathematical way to understand how specific components of pathology integrate into complex brain networks.
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Nicotinic acetylcholine receptors (nAChRs) have been pursued for decades as potential molecular targets to treat cognitive dysfunction in Alzheimer’s disease (AD) due to their demonstrated role in processes underlying cognition such as synaptic facilitation, and theta and gamma wave activity. Historically, activity at these receptors is facilitated in AD by use of drugs that increase the levels of their endogenous agonist acetylcholine, and more recently nAChR selective ligands have undergone clinical trials.
Nicotinic acetylcholine receptors (nAChRs) have been pursued for decades as potential molecular targets to treat cognitive dysfunction in Alzheimer’s disease (AD) due to their demonstrated role in processes underlying cognition such as synaptic facilitation, and theta and gamma wave activity. Historically, activity at these receptors is facilitated in AD by use of drugs that increase the levels of their endogenous agonist acetylcholine, and more recently nAChR selective ligands have undergone clinical trials.
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Leaky blood vessels in the brain called cerebral microbleeds are associated with an increased risk of physical and cognitive disability in patients with multiple sclerosis (MS), according to a new study by researchers in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo.
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USC researchers announced Tuesday they will test a promising drug aimed at preventing or delaying the symptoms of Alzheimer’s disease.
USC researchers announced Tuesday they will test a promising drug aimed at preventing or delaying the symptoms of Alzheimer’s disease.
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Leaky blood vessels in the brain called cerebral microbleeds are associated with an increased risk of physical and cognitive disability in patients with multiple sclerosis (MS), according to a new study by researchers in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo.
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Cerebral vessel disease may be an under-recognised risk factor for Alzheimer’s disease dementia, say researchers.
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Positron emission tomography (PET) with three different radiotracers can now measure amyloid plaques, tau tangles and metabolic activity in the brains of living Alzheimer’s patients. This multimodal study shows significant correlation between increased tau and decreased metabolic activity in the brain—a clear sign of neurodegeneration—reveal researchers at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).
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Results from quantitative MRI and neuropsychological testing show unprecedented improvements in ten patients with early Alzheimer’s disease (AD) or its precursors following treatment with a programmatic and personalized therapy. Results from an approach dubbed metabolic enhancement for neurodegeneration are now available online in the journal Aging.
Cerebral vessel disease may be an under-recognised risk factor for Alzheimer’s disease dementia, say researchers.
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Results from quantitative MRI and neuropsychological testing show unprecedented improvements in ten patients with early Alzheimer’s disease (AD) or its precursors following treatment with a programmatic and personalized therapy. Results from an approach dubbed metabolic enhancement for neurodegeneration are now available online in the journal Aging.
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Positron emission tomography (PET) with three different radiotracers can now measure amyloid plaques, tau tangles and metabolic activity in the brains of living Alzheimer’s patients. This multimodal study shows significant correlation between increased tau and decreased metabolic activity in the brain—a clear sign of neurodegeneration—reveal researchers at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).
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This longitudinal, exploratory study was designed to better understand the lived experience of spousal caregivers age 60 and older providing care to partners with Alzheimer’s disease and related dementias resident in a care facility. Twenty eight spousal caregivers were interviewed up to three times over a period of 2 years, and long-term care facility staff from four locations across British Columbia (BC), Canada participated in four focus groups. Thematic analysis of interview and focus group transcripts revealed a central, unifying theme ‘together but apart’. The results identify key targets for policy makers and service providers to support positive health and well-being outcomes for spousal caregivers providing care to their partners diagnosed with Alzheimer’s disease and related dementia and living in care facilities.
While there is considerable evidence on the impact of specific design features on problems associated with dementia, the link between the quality of the built environment and quality of life of people with dementia is largely unexplored. This study explored the environmental and personal characteristics that are associated with quality of life in people with dementia living in residential aged care. Data were obtained from 275 residents of 35 aged care homes and analysed using linear regression. The quality of the built environment was significantly associated with the quality of life of the resident measured by global self-report. Environmental ratings were not associated with proxy or detailed self-report ratings. Higher quality of life is associated with buildings that facilitate engagement with a variety of activities both inside and outside, are familiar, provide a variety of private and community spaces and the amenities and opportunities to take part in domestic activities.
The dynamic nature of psychosocial interventions implies that trying to measure their effects using standardised clinical trial measures may not capture their full effects. Rich and valuable data during the sessions may be missed by using standard quality of life questionnaires. This paper compares observational measures in the context of recording the well-being of a person with dementia during and outside of a visual arts intervention. A literature search was conducted using systematic principles of searching, screening and retrieval to identify peer-reviewed English language evaluations of research projects using observational measures with people with dementia. Psychometric properties, strengths and weaknesses of 11 observational tools are reviewed in order to identify the most appropriate one for evaluating a visual art intervention for people with dementia. This review supports the Greater Cincinnati Chapter Well-Being Observation Tool as an appropriate measure to evaluate a visual art programme for people with dementia. The results of this review will help researchers plan projects to show the full range of effects for people with dementia for taking part in art sessions.
Research shows that people with late-onset dementia and their relatives can benefit from using assistive technology (AT). Few researchers have investigated the use and utility of AT in everyday life for younger people with dementia (YPD) and their family carers. The aim of this study is to explore what characterised the implementation process when the AT was experienced as beneficial to the YPD and the family carer in their daily life. The qualitative longitudinal study followed 12 younger people (i.e. those under 65 years of age), who had recently been diagnosed with dementia and 14 of their family carers. In-depth interviews and observations during the process were conducted at the beginning, and were repeated every 3rd month for up to 12 months. The data were analysed, and the participants’ experiences further discussed on the basis of embodied, social- and everyday life-situated approaches, in order to provide a deeper understanding of the interactive processes involved in the trajectory. Five elements in the process were identified as important for the experience of usefulness and successful incorporation of AT. The AT had to: (1) be valuable by addressing practical, emotional, and relational challenges; (2) fit well into, or be a better solution for, habitual practice and established strategies; (3) generate positive emotions, and become a reliable and trustworthy tool; (4) be user-friendly, adaptable, and manageable; and (5) interest and engage the family carer. The study demonstrated the importance of understanding the use and utility of AT on the basis of embodied and social participation in daily life. The family carers played a significant role in whether or not, and in which ways, AT was absorbed into the everyday life practice of YPD.
Photography is a tool that has been used in research for many years. It allows people to create a record of an event, capture a complex phenomenon or to tell a story with pictures. Because it does not rely on language, it can be used with vulnerable populations who might not normally be included in research. This paper discusses the use of photography as one component of the evaluation strategy for a project that provided an opportunity for people with younger onset dementia to return to the workplace one day per week. Participants in the workplace project used photography to create a record of their experience of returning to the workplace. Based on the nature of the participant’s comments, photographs were grouped into four broad areas: impact of dementia, impact on family, the work experience and new friends. Issues related to the use of photography with people who have dementia are explored based on the experiences gained during this project.
This report will elucidate the psychometric properties of the Cultural Justifications for Caregiving Scale (CJCS) and evaluate the differences in cultural values and demographic variables among a group of African American and White caregivers. The CJCS measures the cultural reasons for and expectations about providing care to an older relative.
MethodsCJCS data were collected from 202 adults caring for an older relative with memory loss. The factor structure of the CJCS was analyzed for reliability and its correlation with other measures pertaining to the caregiving experience.
ResultsExploratory factor analyses suggested two underlying factors relating to Duty and Reciprocity with high levels of reliability. The two factors showed different correlational patterns with other measures associated with the caregiving experience (CG demographics and well-being).
DiscussionFindings provide further evidence that the CJCS is a reliable measure for use with African American and White caregivers. Moreover, cultural motivations to provide care may differ for ethnically diverse CGs based on religious backgrounds and beliefs about family expectations surrounding the care of loved ones. The application of the CJCS is also discussed.
The topic of well-being is becoming increasingly significant as a key outcome measure in dementia care. Previous work on personhood of individuals with dementia suggests that their subjective well-being can be described in terms of comfort, inclusion, identity, occupation and attachment. The study aimed to examine Tom Kitwood’s model of psychological needs and well-being in dementia based on the self-report of individuals with moderate or severe dementia and to differentiate and elaborate this model in the light of the empirical qualitative data. Nineteen inhabitants of a special long-term care unit were interviewed using a semi-structured interview. Data were analysed using content analysis. Thirty components within Kitwood’s model have been identified. A conceptual framework of subjective well-being in dementia was developed based on a theoretical background. The study was able to find indications that Kitwood’s model has empirical relevance. Nevertheless, it requires to be extended by the domain agency. Furthermore, the study suggests that individuals with dementia are important informants of their subjective well-being.
Younger onset dementia (YOD) not only affects the person with the diagnosis but the whole family, which often includes young people. A limited body of research on this group of young people indicates that they experience varying degrees of emotional trauma. We explored the lived experiences of young people having a parent with YOD from the perspective of the social model of disability. Data were available from semi-structured interviews with 12 young people who had a parent with YOD looking at their lived experiences between 8 and 24 years. Thematic analysis identified four main themes: the emotional toll of caring, keeping the family together, grief and loss and psychological distress. The social model of disability theory provides a helpful framework for these families who experience significant emotional distress, demonstrating that the disability is often socially constructed by a society, which marginalizes and excludes them. A ‘whole family’ approach is proposed, where the needs of young people and their parents are respected and responded to age appropriately.
This study explored staff perceptions of the role of physical environment in dementia care facilities in affecting resident’s behaviors and staff care practice. We conducted focus groups with staff (n = 15) in two purposely selected care facilities in Vancouver, Canada. Focus group participants included nurses, care aides, recreation staff, administrative staff, and family. Data analysis revealed two themes: (a) a supportive physical environment contributes positively to both quality of staff care interaction and residents’ quality of life and (b) an unsupportive physical environment contributes negatively to residents’ quality of life and thereby makes the work of staff more challenging. The staff participants collectively viewed that comfort, familiarity, and an organized space were important therapeutic resources for supporting the well-being of residents. Certain behaviors of residents were influenced by poor environmental factors, including stimulation overload, safety risks, wayfinding challenge, and rushed care. This study demonstrates the complex interrelationships among the dementia care setting’s physical environment, staff experiences, and residents’ quality of life.
The current exploratory investigation aims to establish the reliability and validity of a hope measure, the Herth Hope Index, among families impacted by early cognitive impairment (N = 96). Exploratory factor analysis was used to examine the dimensionality of the measure. Bivariate analyses were used to examine construct validity. The sample had moderately high hope scores. A two-factor structure emerged from the factor analysis, explaining 51.44% of the variance. Both factors exhibited strong internal consistency (Cronbach’s alphas ranged from .83 to .86). Satisfaction with social support was positively associated with hope, supporting convergent validity. Neurocognitive status, illness insight, and depression were not associated with hope, indicating discriminant validity. Families impacted by cognitive impairment may maintain hope in the face of a potentially progressive illness, regardless of cognitive status. The Herth Hope Index can be utilized as a reliable and valid measure of hope by practitioners providing support to families impacted by cognitive impairment.
A case study comprised of formal interviews, formal observations and informal discussions investigated the motivations and experiences accessing dementia care health and social care services for a Muslim, Pakistani male with dementia. Motivations derived from ‘desperation’ and an inability to access support from family or religious community. Experiences of accessing services were mostly negative. Dementia services were ill-informed about how to support persons with young onset dementia, with pre-existing mental health conditions, from an ethnic minority. Education and training to remove barriers to all dementia care services is required for persons with dementia, their families and within dementia services and religious communities.
Dignity is seen as an essential need, fundamental right, and inherent quality of each human being. There is however, a need for increased knowledge on crucial dimensions constituting dignity experience in persons living with dementia. This study explored personal dimensions of life which persons with dementia perceived crucial for experiencing dignity in their daily lives. Based on the findings of eight empirical sub-dimensions, three main dimensions crucial for constituting dignity experience, were identified through hermeneutical interpretation: A historical dignity-dimension, acknowledging one’s own life-projects and life-history; an intrapersonal dignity-dimension, recognizing one’s own human worth, and living according to internal values; and an interpersonal dignity-dimension, experiencing being part of a caring and confirming communion. Knowledge of dignity preservation should be a crucial foundation for future dementia care.
This study explored how the relatives of people with Alzheimer’s disease expressed Self 2 and Self 3 according to Harré’s social constructionist theory of selfhood. Having a relative with Alzheimer’s disease affects one’s life. In this study, we concentrated on how close relatives of people with Alzheimer’s disease experienced their sense of self. This study was descriptive and qualitative. Interviews were conducted with 20 relatives of 10 people with Alzheimer’s disease from 2009 to 2011. The data were analysed according to Harré’s social constructionist theory of selfhood including Selves 2 and 3. Participants reported that Alzheimer’s disease challenged their personal attributes, relations and positioning. Understanding how Alzheimer’s disease affects the sense of self among close relatives is important, as this knowledge is pivotal for supporting these relatives who are often informal caregivers in ways that enable a fulfilling and meaningful life.
Peer support is well established in fields such as the disability movement and mental health and is increasingly recognised as one way of enabling support by and for people with a diagnosis of dementia and their immediate carers. It was central to the implementation of the National Dementia Strategy (NDS) for England, when 40 demonstration sites were established. This mixed-methods study included in-depth qualitative interviews with people living with dementia (n = 101) and staff/stakeholders (n = 82) at 8 of the 40 sites. Data analysis was a five-stage process: coding framework developed (using 25 transcripts); further development of the framework (using a further 70 transcripts); development of emerging themes; modelling of themes and verification of models based on the entire data set. Peer support had positive emotional and social impact that was rooted in identification with others, a commonality of experience and reciprocity of support. There was also a contrast between the quality of peer support and support from professionals. This emphasises the significance of lived experience and promoting a strength-based approach to interpersonal support that is enabling and challenges a deficit approach to understanding dementia.
Caregiving in a rural context is unique, but the experience of rural caregivers is understudied. This paper describes how rural caregivers cope with caring for a loved one diagnosed with mild cognitive impairment or dementia using qualitative description to generate a low-inference summary of a response to an open-ended question. This approach allowed these rural caregivers to describe their positive experiences in addition to the more commonly explored caregiver experiences related to stress. Analyses of coping revealed use of social support, engaging in relaxing and physical activity, and cognitive reframing. In addition, caregivers reported strong faith and religiosity, and to a lesser frequency behavioral changes, checking in with the person with dementia via telephone, and joint activity. Predominantly, these methods reflect approach-based strategies. The current data suggest that these caregivers manage well and adopt adaptive coping strategies to meet the demands of the caregiving role.
Arts for health initiatives and networks are being developed in a number of countries and an international literature is emerging on the evidence of their benefits to people’s health, wellbeing and quality of life. Engagement in cultural and creative arts by older people can increase their morale and self-confidence and provides opportunities for social connection. Museums and galleries are increasingly required to justify their expenditure, reach and impact and some are working in partnership with local councils, hospitals, schools and communities to improve access to their collections. There is a body of literature emerging that describes such initiatives but empirical evidence of their benefits is less developed. This article reports an evaluation of an art for health initiative – Coffee, Cake & Culture organised and delivered by Whitworth Art Gallery and Manchester Museum in 2012 for older people living in a care home and a supported living facility. The study has identified the benefits and impacts of the arts for health programme and its feasibility for older people, with or without diagnosed memory loss – dementia, living in a care home or supported living facility and their care staff. The findings demonstrate there were benefits to the older people and their care staff in terms of wellbeing, social engagement, learning, social inclusion and creativity. These benefits were immediate and continued in the short term on their return home. The majority of older people and care staff had not previously been to the art gallery or museum and the programme encouraged creative arts and cultural appreciation which promoted social inclusion, wellbeing and quality of life. The programme is feasible and important lessons were identified for future planning. Further research involving partnerships of researchers, arts for health curators, artists, care staff, older people and their families is warranted.
One in 15 Australians over 65 experience dementia, and are commonly supported by spouses. Evidence demonstrates declining wellbeing for these caregivers as their role continues. There are indications of improvement once caregivers transition out of the role (recovery) but alternate suggestions that caregiving stress may be too damaging to be appeased (wear and tear). It seems plausible that reason for transition (care recipient’s move into residential care or death) will affect caregivers’ outcomes. A synthetic cohort method compared caregivers’ stress and wellbeing prior to, and one and two years post-transition. There was evidence of wear and tear for physical wellbeing but recovery for psychological wellbeing over time; with little difference based on reason for transition. Caregiver outcomes seem to be a function of the action rather than the reason for transition, but factors such as age must be considered when designing methods to support post-transition wellbeing.
The ‘Snoezelen’ is an approach based on stimulation and sensory stimulation proposals, giving priority to the notion of caretaking. The aim of this paper is to present the creation and validation of the COMMUNI-CARE scale. This is a new tool that allows for an evaluation of the psycho-emotional well-being that the patient with dementia shows in a ‘Snoezelen’ multisensory stimulation environment.
MethodsIn total 429 evaluations in 143 multisensory stimulation interventions were made using the COMMUNI-CARE scale, in 16 patients between 53 and 85 years of age, diagnosed with moderate to severe dementia. The goal was to evaluate the psycho-emotional well-being the patients present.
ResultsThe tool’s internal consistency showed a Crombach alpha of 0.90. The concurrent validity between the COMMUNI-CARE scale and the Clinical Global Impression (CGI) was of r = –0.961. The Kappa index used to determine the reliability between evaluators was of K = 0.87.
ConclusionsThe COMMUNI-CARE scale fulfills the basic principles of classic psychometrics of construct, and criterion validity and reliability. It does so while showing a clear idea, through its five subscales (anxiety, communication, pleasure, adaptation to the surroundings and affection), of the degree of well-being that the patient with dementia shows during such interventions. This scale embodies, through psychometrics, a very subjective human experience with a tool unavailable to date.
In this review we explore the provision of assistive technology products and services currently available for people with dementia within the United Kingdom. A scoping review of assistive technology products and services currently available highlighted 171 products or product types and 331 services. In addition, we assimilated data on the amount and quality of information provided by assistive technology services alongside assistive technology costs. We identify a range of products available across three areas: assistive technology used ‘by’, ‘with’ and ‘on’ people with dementia. Assistive technology provision is dominated by ‘telecare’ provided by local authorities, with services being subject to major variations in pricing and information provision; few currently used available resources for assistive technology in dementia. We argue that greater attention should be paid to information provision about assistive technology services across an increasingly mixed economy of dementia care providers, including primary care, local authorities, private companies and local/national assistive technology resources.
This article explores how the provision of information about dementia impacts on carers and the caring relationships in which they are involved. Narrative interviews were undertaken with 25 carers who had undertaken the Alzheimer’s Society – run Carer Information and Support Programme in one of seven sites across London and the South East. Thematic analysis identified two major themes relating to the impact of information on carer and caring relationships (‘understanding and care’ and ‘emotional impact of information’), and another theme relating to the context within which the information was provided and shared (‘relational practices in information-giving and receiving’). Findings suggest that while information, particularly in the form of new knowledge about how dementia progresses, helps to improve understanding and increase confidence, competence and a sense of security and achievement in caring practices, it can also confound and complicate caring practices in ways that reflect and reinforce previously difficult relationships. Providing information in the context of carers’ support was important for most participants but others were less able to benefit from this, especially where they felt unrecognised or where the timing of information felt inappropriate to their needs. Our analysis complements and extends previous scholarship emphasising the relational nature of care by showing how information can both enhance and complicate care relationships, depending on both specific care contexts and on how carers experience the context of information provision.
A research team at King’s College London has used a new approach to study a hallmark dementia protein called tau in mice, revealing that a drug called phenylbutyrate can protect against damage caused by the protein.
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New Alzheimer’s disease research details a technique that speedily measures levels in the brain of a damaging protein fragment, and insight into why mutations in a specific gene increase the risk of developing the disease.
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Although brains—even adult brains—are far more malleable than we used to think, they are eventually subject to age-related illnesses, like dementia, and loss of cognitive function.
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Acute haematoma parameters predict the onset of dementia in the first 6 months after intracerebral haemorrhage, but not that of delayed dementia, report researchers.
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Dementia Big
A research team at King’s College London has used a new approach to study a hallmark dementia protein called tau in mice, revealing that a drug called phenylbutyrate can protect against damage caused by the protein.
Dementia Big
New Alzheimer’s disease research details a technique that speedily measures levels in the brain of a damaging protein fragment, and insight into why mutations in a specific gene increase the risk of developing the disease.
Dementia Big
Although brains—even adult brains—are far more malleable than we used to think, they are eventually subject to age-related illnesses, like dementia, and loss of cognitive function.
Dementia Big
Acute haematoma parameters predict the onset of dementia in the first 6 months after intracerebral haemorrhage, but not that of delayed dementia, report researchers.
Dementia Big
Researchers at the Babraham Institute have found a way to replicate one of the earliest changes in Alzheimer’s disease in a dish. This means that it should now be possible to find out a lot more about why it happens - and how to stop it. The new findings are published in the journal Molecular Neurodegeneration and supported by the charity Alzheimer’s Research UK.
Dementia Big
New research from the Center for BrainHealth at The University of Texas at Dallas shows that strategy-based reasoning training can improve the cognitive performance for those with mild cognitive impairment (MCI), a preclinical stage of those at risk for Alzheimer’s disease.
Dementia Big
Alzheimer’s is a devastating and incurable disease marked by beta-amyloid and tau protein aggregations in the brain, yet the direct relationship between these proteins and neurodegeneration has remained a mystery. New molecular imaging research is revealing how tau, rather than amyloid-deposition, may be more directly instigating neuronal dysfunction, say presenters at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).
Dementia Big
Alzheimer’s is a devastating and incurable disease marked by beta-amyloid and tau protein aggregations in the brain, yet the direct relationship between these proteins and neurodegeneration has remained a mystery.
Dementia Big
Larger hematoma size and location were risk factors associated with dementia after an intracerebral hemorrhage when a blood vessel in the brain bursts, according to an article published online by JAMA Neurology.
Researchers at the Babraham Institute have found a way to replicate one of the earliest changes in Alzheimer’s disease in a dish. This means that it should now be possible to find out a lot more about why it happens - and how to stop it. The new findings are published in the journal Molecular Neurodegeneration and supported by the charity Alzheimer’s Research UK.
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Alzheimer’s is a devastating and incurable disease marked by beta-amyloid and tau protein aggregations in the brain, yet the direct relationship between these proteins and neurodegeneration has remained a mystery.
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New research from the Center for BrainHealth at The University of Texas at Dallas shows that strategy-based reasoning training can improve the cognitive performance for those with mild cognitive impairment (MCI), a preclinical stage of those at risk for Alzheimer’s disease.
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Larger hematoma size and location were risk factors associated with dementia after an intracerebral hemorrhage when a blood vessel in the brain bursts, according to an article published online by JAMA Neurology.
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Alzheimer’s is a devastating and incurable disease marked by beta-amyloid and tau protein aggregations in the brain, yet the direct relationship between these proteins and neurodegeneration has remained a mystery. New molecular imaging research is revealing how tau, rather than amyloid-deposition, may be more directly instigating neuronal dysfunction, say presenters at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).
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Dementia Big
We’re pretty familiar with the notion that exercise is good for our health. But new WA research suggests that something as simple as encouraging the elderly to walk down a flight of stairs could help prevent cognitive decline, a precursor to diseases such as dementia and Alzheimer’s.
We’re pretty familiar with the notion that exercise is good for our health. But new WA research suggests that something as simple as encouraging the elderly to walk down a flight of stairs could help prevent cognitive decline, a precursor to diseases such as dementia and Alzheimer’s.
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Dementia Big
Much of the research on Alzheimer’s disease has focused on the amyloid beta protein, which clumps together into sticky fibrils that form deposits in the brains of people with the disease. In recent years, attention has turned away from the fibrils themselves to an intermediate stage in the aggregation of amyloid beta. “Oligomers” consisting of a few molecules of the protein stuck together are more mobile than the large, insoluble fibrils and seem to be much more toxic. But the actual structure of these soluble oligomers remains unknown, and it’s unclear how they trigger the neurotoxic effects that lead to Alzheimer’s disease.
Dementia Big
Reliable information can be obtained on the progression of dementias by measuring specific proteins in the blood and cerebrospinal fluid. A test of this kind is especially significant to the development of new therapies, as reported in the journal Neuron by scientists from the University of Basel and University Hospital Basel, along with international colleagues.
Much of the research on Alzheimer’s disease has focused on the amyloid beta protein, which clumps together into sticky fibrils that form deposits in the brains of people with the disease. In recent years, attention has turned away from the fibrils themselves to an intermediate stage in the aggregation of amyloid beta. “Oligomers” consisting of a few molecules of the protein stuck together are more mobile than the large, insoluble fibrils and seem to be much more toxic. But the actual structure of these soluble oligomers remains unknown, and it’s unclear how they trigger the neurotoxic effects that lead to Alzheimer’s disease.
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Reliable information can be obtained on the progression of dementias by measuring specific proteins in the blood and cerebrospinal fluid. A test of this kind is especially significant to the development of new therapies, as reported in the journal Neuron by scientists from the University of Basel and University Hospital Basel, along with international colleagues.
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Her Majesty the Queen has officially opened the Cardiff University Brain Research Imaging Centre, a unique neuroimaging research hub.
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A research team, led by Dr. Robert Nagele from Rowan University School of Osteopathic Medicine and Durin Technologies, Inc., has announced the development of a blood test that leverages the body’s immune response system to detect an early stage of Alzheimer’s disease - referred to as the mild cognitive impairment (MCI) stage - with unparalleled accuracy. In a “proof of concept” study involving 236 subjects, the test demonstrated an overall accuracy, sensitivity and specificity rate of 100 percent in identifying subjects whose MCI was actually caused by an early stage of Alzheimer’s disease.
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Dementia Big
Her Majesty the Queen has officially opened the Cardiff University Brain Research Imaging Centre, a unique neuroimaging research hub.
Dementia Big
A research team, led by Dr. Robert Nagele from Rowan University School of Osteopathic Medicine and Durin Technologies, Inc., has announced the development of a blood test that leverages the body’s immune response system to detect an early stage of Alzheimer’s disease - referred to as the mild cognitive impairment (MCI) stage - with unparalleled accuracy. In a “proof of concept” study involving 236 subjects, the test demonstrated an overall accuracy, sensitivity and specificity rate of 100 percent in identifying subjects whose MCI was actually caused by an early stage of Alzheimer’s disease.
Dementia Big
A research team, led by Dr. Robert Nagele from Rowan University School of Osteopathic Medicine and Durin Technologies, Inc., has announced the development of a blood test that leverages the body’s immune response system to detect an early stage of Alzheimer’s disease - referred to as the mild cognitive impairment (MCI) stage - with unparalleled accuracy.
Dementia Big
It has been recognised for over 60 years that regular physical activity provides health benefits. Our bodies are designed to be stimulated by physical exertion. Fitness is associated with lower all-cause mortality, along with improved sleep, quality of life, social life and reduced stress. On the other hand, physical inactivity predicts obesity, diabetes, cardiovascular disease, mental health issues, reduced quality of life and overall mortality. The evidence is clear: we need to get moving.
Dementia Big
Older adults who likely have dementia but have not been given the diagnosis are more likely to engage in potentially unsafe activities, new research suggests.
Dementia Big
A high cerebral microbleed count increases an individual’s risk of cognitive deterioration and dementia, study results indicate.
Dementia Big
The MAPT H1 haplotype has been associated with several neurodegenerative diseases. We were interested in exploring the role of MAPT haplotypic variation in risk of Dementia with Lewy bodies (DLB).
A research team, led by Dr. Robert Nagele from Rowan University School of Osteopathic Medicine and Durin Technologies, Inc., has announced the development of a blood test that leverages the body’s immune response system to detect an early stage of Alzheimer’s disease - referred to as the mild cognitive impairment (MCI) stage - with unparalleled accuracy.
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It has been recognised for over 60 years that regular physical activity provides health benefits. Our bodies are designed to be stimulated by physical exertion. Fitness is associated with lower all-cause mortality, along with improved sleep, quality of life, social life and reduced stress. On the other hand, physical inactivity predicts obesity, diabetes, cardiovascular disease, mental health issues, reduced quality of life and overall mortality. The evidence is clear: we need to get moving.
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A high cerebral microbleed count increases an individual’s risk of cognitive deterioration and dementia, study results indicate.
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Older adults who likely have dementia but have not been given the diagnosis are more likely to engage in potentially unsafe activities, new research suggests.
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The MAPT H1 haplotype has been associated with several neurodegenerative diseases. We were interested in exploring the role of MAPT haplotypic variation in risk of Dementia with Lewy bodies (DLB).
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Dementia Big
With a more-is-better mindset common in society, frequent commercials encouraging checks of glycated hemoglobin (HbA1C) levels, and ads for new diabetes medications to lower HbA1C in adults with Type 2 diabetes, Mayo Clinic researchers were not too surprised to find overtesting occurring.
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Nursing homes in the United States care for increasing numbers of people with dementia, yet many lack access to geriatric psychiatrists, behavioral neurologists and other specialists who may help manage symptoms associated with dementia, including behavioral issues.
Nursing homes in the United States care for increasing numbers of people with dementia, yet many lack access to geriatric psychiatrists, behavioral neurologists and other specialists who may help manage symptoms associated with dementia, including behavioral issues.
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With a more-is-better mindset common in society, frequent commercials encouraging checks of glycated hemoglobin (HbA1C) levels, and ads for new diabetes medications to lower HbA1C in adults with Type 2 diabetes, Mayo Clinic researchers were not too surprised to find overtesting occurring.
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Dementia Big
Alzheimer’s disease (AD) is a devastating condition with no known effective treatment. The disease is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD.
Alzheimer’s disease (AD) is a devastating condition with no known effective treatment. The disease is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD.
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Dementia Big
A study led by biomedical researchers at Indiana University has found evidence that an enzyme known as NMNAT2 may help protect against the debilitating effects of certain degenerative brain diseases, including Alzheimer’s.
Dementia Big
Simon Fraser University researchers hope that a brain vital-sign test becomes as routine during a doctor’s check-up as taking a blood pressure or heart rate measurement.
Dementia Big
Blacks between the ages of 45 and 54 die of strokes at a rate that is three times greater than their white counterparts, according to the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, which looked at stroke incidence and mortality of nearly 30,000 participants over the age of 45 from an ethnically and demographically diverse sample of the U.S. population.
Dementia Big
A Johns Hopkins study on data from more than 7,000 older Americans has found that those who show signs of probable dementia but are not yet formally diagnosed are nearly twice as likely as those with such a diagnosis to engage in potentially unsafe activities, such as driving, cooking, and managing finances and medications.
Dementia Big
The relentless desire by mice to run on cage “exercise” wheels has helped explain at a molecular level how exercise benefits a mammal’s brain.
Dementia Big
A dietary supplement containing a blend of thirty vitamins and minerals—all natural ingredients widely available in health food stores—has shown remarkable anti-aging properties that can prevent and even reverse massive brain cell loss, according to new research from McMaster University.
A study led by biomedical researchers at Indiana University has found evidence that an enzyme known as NMNAT2 may help protect against the debilitating effects of certain degenerative brain diseases, including Alzheimer’s.
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Simon Fraser University researchers hope that a brain vital-sign test becomes as routine during a doctor’s check-up as taking a blood pressure or heart rate measurement.
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Blacks between the ages of 45 and 54 die of strokes at a rate that is three times greater than their white counterparts, according to the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, which looked at stroke incidence and mortality of nearly 30,000 participants over the age of 45 from an ethnically and demographically diverse sample of the U.S. population.
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The relentless desire by mice to run on cage “exercise” wheels has helped explain at a molecular level how exercise benefits a mammal’s brain.
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A Johns Hopkins study on data from more than 7,000 older Americans has found that those who show signs of probable dementia but are not yet formally diagnosed are nearly twice as likely as those with such a diagnosis to engage in potentially unsafe activities, such as driving, cooking, and managing finances and medications.
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A dietary supplement containing a blend of thirty vitamins and minerals—all natural ingredients widely available in health food stores—has shown remarkable anti-aging properties that can prevent and even reverse massive brain cell loss, according to new research from McMaster University.
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Dementia Big
An innovative virtual reality smartphone app – “A Walk Through Dementia” – will launch at a three-day public installation at St Pancras International Station from 2 June.
Dementia Big
A Johns Hopkins study on data from more than 7,000 older Americans has found that those who show signs of probable dementia but are not yet formally diagnosed are nearly twice as likely as those with such a diagnosis to engage in potentially unsafe activities, such as driving, cooking, and managing finances and medications.
Dementia Big
It’s an unfortunate fact that the Alzheimer’s brain gives up most of its chemical secrets only after the patient has died.
Dementia Big
While most people will agree that excessive consumption of alcohol can have a detrimental effect on the brain, there is less agreement regarding the effects of light or moderate drinking.
Dementia Big
Most people know that a diet high in fiber helps to keep us “regular.” Now Australian researchers have uncovered a surprising benefit of this often-undervalued dietary component.
An innovative virtual reality smartphone app – “A Walk Through Dementia” – will launch at a three-day public installation at St Pancras International Station from 2 June.
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It’s an unfortunate fact that the Alzheimer’s brain gives up most of its chemical secrets only after the patient has died.
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A Johns Hopkins study on data from more than 7,000 older Americans has found that those who show signs of probable dementia but are not yet formally diagnosed are nearly twice as likely as those with such a diagnosis to engage in potentially unsafe activities, such as driving, cooking, and managing finances and medications.
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While most people will agree that excessive consumption of alcohol can have a detrimental effect on the brain, there is less agreement regarding the effects of light or moderate drinking.
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Most people know that a diet high in fiber helps to keep us “regular.” Now Australian researchers have uncovered a surprising benefit of this often-undervalued dietary component.
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Dementia Big
Biomarkers could revolutionise the early detection of and therapy for Alzheimer’s disease. However, experts attending the Congress of the European Academy of Neurology (EAN) in Copenhagen criticized that the big breakthroughs are slow in coming because of a lack of priorities in research. A roadmap should help to push along advances in this area.
Dementia Big
Chronic pain often goes unnoticed and therefore untreated in patients with cognitive impairments such as dementia. This was shown in a recent Slovenian study that was presented at the Congress of the European Academy of Neurology (EAN) in Copenhagen.
Dementia Big
Scientists from the Gladstone Institutes have identified a new pathway by which salicylic acid–a key compound in the nonsteroidal anti-inflammatory drugs aspirin and diflunisal–stops inflammation and cancer.
Dementia Big
People with Alzheimer’s disease could benefit from earlier diagnosis if a long-term memory test combined with a brain scan were carried out, a study suggests.
Dementia Big
Chronic pain often goes unnoticed and therefore untreated in patients with cognitive impairments such as dementia. This was shown in a recent Slovenian study that was presented at the Congress of the European Academy of Neurology in Copenhagen.
Dementia Big
Researchers using contrast-enhanced MRI have identified leakages in the blood-brain barrier (BBB) of people with early Alzheimer’s disease (AD), according to a new study published online in the journal Radiology. The results suggest that increased BBB permeability may represent a key mechanism in the early stages of the disease.
Dementia Big
Some 47 million people worldwide suffer from some form of dementia. Scientists are working feverishly to find a cure for the most common form, Alzheimer’s. At the Congress of the European Academy of Neurology in Copenhagen, Prof Gunhild Waldemar issued an appeal for researchers to work together and draw up standardised guidelines for early identification and treatment of the disease.
Chronic pain often goes unnoticed and therefore untreated in patients with cognitive impairments such as dementia. This was shown in a recent Slovenian study that was presented at the Congress of the European Academy of Neurology (EAN) in Copenhagen.
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Chronic pain often goes unnoticed and therefore untreated in patients with cognitive impairments such as dementia. This was shown in a recent Slovenian study that was presented at the Congress of the European Academy of Neurology in Copenhagen.
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Biomarkers could revolutionise the early detection of and therapy for Alzheimer’s disease. However, experts attending the Congress of the European Academy of Neurology (EAN) in Copenhagen criticized that the big breakthroughs are slow in coming because of a lack of priorities in research. A roadmap should help to push along advances in this area.
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Researchers using contrast-enhanced MRI have identified leakages in the blood-brain barrier (BBB) of people with early Alzheimer’s disease (AD), according to a new study published online in the journal Radiology. The results suggest that increased BBB permeability may represent a key mechanism in the early stages of the disease.
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Researchers using contrast-enhanced MRI have identified leakages in the blood-brain barrier (BBB) of people with early Alzheimer’s disease (AD), according to a new study published online in the journal Radiology. The results suggest that increased BBB permeability may represent a key mechanism in the early stages of the disease.
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Some 47 million people worldwide suffer from some form of dementia. Scientists are working feverishly to find a cure for the most common form, Alzheimer’s. At the Congress of the European Academy of Neurology in Copenhagen, Prof Gunhild Waldemar issued an appeal for researchers to work together and draw up standardised guidelines for early identification and treatment of the disease.
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Scientists from the Gladstone Institutes have identified a new pathway by which salicylic acid–a key compound in the nonsteroidal anti-inflammatory drugs aspirin and diflunisal–stops inflammation and cancer.
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People with Alzheimer’s disease could benefit from earlier diagnosis if a long-term memory test combined with a brain scan were carried out, a study suggests.
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