The onset of Alzheimer's disease: The importance of family history

You’re about to turn 60, and you’re fretting. Your mother has had Alzheimer’s disease since the age of 65. At what age will the disease strike you? A Canadian study published in JAMA Neurology shows that the closer a person gets to the age at which their parent exhibited the first signs of Alzheimer’s, the more likely they are to have amyloid plaques, the cause of the cognitive decline associated with the disease, in their brain.

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The onset of Alzheimer's disease: The importance of family history

The onset of Alzheimer's disease: The importance of family history:

Dementia Big
You’re about to turn 60, and you’re fretting. Your mother has had Alzheimer’s disease since the age of 65. At what age will the disease strike you? A Canadian study published in JAMA Neurology shows that the closer a person gets to the age at which their parent exhibited the first signs of Alzheimer’s, the more likely they are to have amyloid plaques, the cause of the cognitive decline associated with the disease, in their brain.

http://ift.tt/2ox3ygj

Trump’s perfect score on brain test spawns DIY cognitive exam

Trump’s perfect score on brain test spawns DIY cognitive exam:

Dementia Big
When Donald Trump aced a cognitive test in January, scores of people tried to take it, too, based mostly on media reports that invited them to match wits with the president.

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Trump’s perfect score on brain test spawns DIY cognitive exam

When Donald Trump aced a cognitive test in January, scores of people tried to take it, too, based mostly on media reports that invited them to match wits with the president.

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Older adults with dementia more likely to be readmitted to hospital after discharge

Older adults with dementia more likely to be readmitted to hospital after discharge:

Dementia Big
About 25 percent of older adults admitted to hospitals have dementia and are at increased risk for serious problems like in-hospital falls and delirium (the medical term for an abrupt, rapid change in mental function). As a result, older adults with dementia are more likely to do poorly during hospital stays compared to older adults without dementia.

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Older adults with dementia more likely to be readmitted to hospital after discharge

About 25 percent of older adults admitted to hospitals have dementia and are at increased risk for serious problems like in-hospital falls and delirium (the medical term for an abrupt, rapid change in mental function). As a result, older adults with dementia are more likely to do poorly during hospital stays compared to older adults without dementia.

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Dementia increases the risk of 30-day readmission to the hospital after discharge

About 25 percent of older adults admitted to hospitals have dementia and are at increased risk for serious problems like in-hospital falls and delirium (the medical term for an abrupt, rapid change in mental function). As a result, older adults with dementia are more likely to do poorly during hospital stays compared to older adults without dementia.

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Dementia increases the risk of 30-day readmission to the hospital after discharge

Dementia increases the risk of 30-day readmission to the hospital after discharge:

Dementia Big
About 25 percent of older adults admitted to hospitals have dementia and are at increased risk for serious problems like in-hospital falls and delirium (the medical term for an abrupt, rapid change in mental function). As a result, older adults with dementia are more likely to do poorly during hospital stays compared to older adults without dementia.

http://ift.tt/2EZ9Q1E

Cardiorespiratory fitness, white matter integrity tied to cognition

(HealthDay)—Cardiorespiratory fitness (CRF) is associated with better white matter (WM) fiber integrity in patients with mild cognitive impairment (MCI), according to a study published recently in the Journal of Alzheimer’s Disease.

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New intervention improves communication behaviors in couples affected by dementia

They do it with the best of intentions. “Do you remember our wedding day?” “Who is that person next to you in the picture?” For couples with decades of shared memories, a partner’s decline in the ability to communicate is one of the most frightening and frustrating consequences of Alzheimer’s disease and related dementias.

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Cardiorespiratory fitness, white matter integrity tied to cognition

Cardiorespiratory fitness, white matter integrity tied to cognition:

Dementia Big
(HealthDay)—Cardiorespiratory fitness (CRF) is associated with better white matter (WM) fiber integrity in patients with mild cognitive impairment (MCI), according to a study published recently in the Journal of Alzheimer’s Disease.

http://ift.tt/2sQsgwE

New intervention improves communication behaviors in couples affected by dementia

New intervention improves communication behaviors in couples affected by dementia:

Dementia Big
They do it with the best of intentions. “Do you remember our wedding day?” “Who is that person next to you in the picture?” For couples with decades of shared memories, a partner’s decline in the ability to communicate is one of the most frightening and frustrating consequences of Alzheimer’s disease and related dementias.

http://ift.tt/2F1j2mg

Physical and mental multitasking may boost memory, study suggests

Performing memory training exercises at the same time as pedaling a stationary bike led to better gains in memory than doing the training exercises after working up a sweat, according to a 55-person study led by UCLA researchers. The findings suggest that exercise may temporarily make it easier for the brain to create new memories.

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Researchers explore how people with Alzheimer's disease use end-of-life medical services

Because people are now living longer and often healthier lives, the rate of some illnesses that are more likely to develop with age has risen. These illnesses include dementia. In fact, the number of us living with dementia was already 47 million worldwide in 2015. It could reach 131 million by 2050.

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Liquefied brain tissue after stroke may harm surviving brain, UA study finds

Scientists have known for years that the brain liquefies after a stroke. If cut off from blood and oxygen for a long enough period, a portion of the brain will die, slowly morphing from a hard, rubbery substance into liquid goop.

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End-of-life hospital and healthcare use among older adults with Alzheimer's disease

Because people are now living longer and often healthier lives, the rate of some illnesses that are more likely to develop with age has risen. These illnesses include dementia. In fact, the number of us living with dementia was already 47 million worldwide in 2015. It could reach 131 million by 2050.

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Physical and mental multitasking may boost memory, study suggests

Physical and mental multitasking may boost memory, study suggests:

Dementia Big
Performing memory training exercises at the same time as pedaling a stationary bike led to better gains in memory than doing the training exercises after working up a sweat, according to a 55-person study led by UCLA researchers. The findings suggest that exercise may temporarily make it easier for the brain to create new memories.

http://ift.tt/2CCWdjt

Researchers explore how people with Alzheimer's disease use end-of-life medical services

Researchers explore how people with Alzheimer's disease use end-of-life medical services:

Dementia Big
Because people are now living longer and often healthier lives, the rate of some illnesses that are more likely to develop with age has risen. These illnesses include dementia. In fact, the number of us living with dementia was already 47 million worldwide in 2015. It could reach 131 million by 2050.

http://ift.tt/2HCoI4E

Liquefied brain tissue after stroke may harm surviving brain, UA study finds

Liquefied brain tissue after stroke may harm surviving brain, UA study finds:

Dementia Big
Scientists have known for years that the brain liquefies after a stroke. If cut off from blood and oxygen for a long enough period, a portion of the brain will die, slowly morphing from a hard, rubbery substance into liquid goop.

http://ift.tt/2CCWa7h

End-of-life hospital and healthcare use among older adults with Alzheimer's disease

End-of-life hospital and healthcare use among older adults with Alzheimer's disease:

Dementia Big
Because people are now living longer and often healthier lives, the rate of some illnesses that are more likely to develop with age has risen. These illnesses include dementia. In fact, the number of us living with dementia was already 47 million worldwide in 2015. It could reach 131 million by 2050.

http://ift.tt/2HC2Mqc

Study reveals a significant link between heavy alcohol use and dementia

Study reveals a significant link between heavy alcohol use and dementia:

Dementia Big
New research has found alcohol use disorders to be one of the most vital avoidable risk factors for the onset of all types of dementia, early-onset dementia in particular.

http://ift.tt/2ogea32

Creative couples' intervention significantly helps people with Alzheimer's communicate

Creative couples' intervention significantly helps people with Alzheimer's communicate:

Dementia Big
They do it with the best of intentions. “Do you remember our wedding day?” “Who is that person next to you in the picture?” For couples with decades of shared memories, a partner’s decline in the ability to communicate is one of the most frightening and frustrating consequences of Alzheimer’s disease and related dementias. For these couples, the communication strategies they have used before simply do not work anymore. Impaired communication leads to misunderstandings, conflict, isolation, and loss of intimacy.

http://ift.tt/2EJjUZf

Largest study of its kind finds alcohol use biggest risk factor for dementia

Largest study of its kind finds alcohol use biggest risk factor for dementia:

Dementia Big
Alcohol use disorders are the most important preventable risk factors for the onset of all types of dementia, especially early-onset dementia. This according to a nationwide observational study, published in The Lancet Public Health journal, of over one million adults diagnosed with dementia in France.

http://ift.tt/2ojUw6f

Study reveals a significant link between heavy alcohol use and dementia

New research has found alcohol use disorders to be one of the most vital avoidable risk factors for the onset of all types of dementia, early-onset dementia in particular.

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Creative couples' intervention significantly helps people with Alzheimer's communicate

They do it with the best of intentions. “Do you remember our wedding day?” “Who is that person next to you in the picture?” For couples with decades of shared memories, a partner’s decline in the ability to communicate is one of the most frightening and frustrating consequences of Alzheimer’s disease and related dementias. For these couples, the communication strategies they have used before simply do not work anymore. Impaired communication leads to misunderstandings, conflict, isolation, and loss of intimacy.

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Largest study of its kind finds alcohol use biggest risk factor for dementia

Alcohol use disorders are the most important preventable risk factors for the onset of all types of dementia, especially early-onset dementia. This according to a nationwide observational study, published in The Lancet Public Health journal, of over one million adults diagnosed with dementia in France.

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Study links heavy drinking with increased risk of dementia - Alzheimer's Society comment

Study links heavy drinking with increased risk of dementia - Alzheimer's Society comment :

Dementia Big
A study published on 20 February in the Lancet Public Health has suggested that alcohol abuse addiction disorders are a major risk factor for dementia, specifically early onset dementia. 

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Study links heavy drinking with increased risk of dementia - Alzheimer's Society comment

A study published on 20 February in the Lancet Public Health has suggested that alcohol abuse addiction disorders are a major risk factor for dementia, specifically early onset dementia. 

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The new Dementia Action Plan for Wales – Alzheimer’s Society comment

The new Dementia Action Plan for Wales – Alzheimer’s Society comment:

Dementia Big
On 14 February 2018, Welsh Government launched its brand new Dementia Action Plan for Wales.

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The new Dementia Action Plan for Wales – Alzheimer’s Society comment

On 14 February 2018, Welsh Government launched its brand new Dementia Action Plan for Wales.

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Data detectives shift suspicions in Alzheimer's to inside villain

Data detectives shift suspicions in Alzheimer's to inside villain:

Dementia Big
The mass pursuit of a conspicuous suspect in Alzheimer’s disease may have encumbered research success for decades. Now, a new data analysis that has untangled evidence amassed in years of Alzheimer’s studies encourages researchers to refocus their investigations.

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New e-Health solution developed to prevent cardiovascular disease, dementia in senior citizens

New e-Health solution developed to prevent cardiovascular disease, dementia in senior citizens:

Dementia Big
An innovative e-Health solution, based on an interactive Internet platform, has been developed to support senior citizens in improving their lifestyle to prevent cardiovascular disease, cognitive decline and dementia.

http://ift.tt/2C8cSzG

Data detectives shift suspicions in Alzheimer's to inside villain

The mass pursuit of a conspicuous suspect in Alzheimer’s disease may have encumbered research success for decades. Now, a new data analysis that has untangled evidence amassed in years of Alzheimer’s studies encourages researchers to refocus their investigations.

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New e-Health solution developed to prevent cardiovascular disease, dementia in senior citizens

An innovative e-Health solution, based on an interactive Internet platform, has been developed to support senior citizens in improving their lifestyle to prevent cardiovascular disease, cognitive decline and dementia.

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Emergency nurses experience regular verbal and physical abuse

The first ever review of the experience of hospital A&E staff reveals that they have resigned themselves to patient violence and aggression.

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Emergency nurses experience regular verbal and physical abuse

Emergency nurses experience regular verbal and physical abuse:

Dementia Big
The first ever review of the experience of hospital A&E staff reveals that they have resigned themselves to patient violence and aggression.

http://ift.tt/2FgwznN

Molecular markers may ID Alzheimer's before clinical onset

(HealthDay)—For young adults with autosomal dominant Alzheimer’s disease (AD), molecular markers can identify changes associated with the disease before clinical onset, according to a study published online Feb. 12 in JAMA Neurology.

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Not being aware of memory problems predicts onset of Alzheimer's disease

Not being aware of memory problems predicts onset of Alzheimer's disease:

Dementia Big
Doctors who work with individuals at risk of developing dementia have long suspected that patients who do not realize they experience memory problems are at greater risk of seeing their condition worsen in a short time frame, a suspicion that now has been confirmed by a team of McGill University clinician scientists.

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Genetic technique reverses Alzheimer's processes in mice

Genetic technique reverses Alzheimer's processes in mice:

Dementia Big
Researchers in the US have used genetic techniques to slow the progression of Alzheimer’s in mice that show features of the disease. The study, which centered around a protein called BACE1, was reported today in the Journal of Experimental Medicine.

http://ift.tt/2EreZfr

Poor fitness levels increase the risk dementia, concludes study

Poor fitness levels increase the risk dementia, concludes study:

Dementia Big
A new study has added to the growing body of evidence that regular exercise improves brain health and reduces the risk of Alzheimer’s disease.

http://ift.tt/2F7zmze

Amyloid protein may be transmitted through neurosurgical instruments, study suggests

Amyloid protein may be transmitted through neurosurgical instruments, study suggests:

Dementia Big
Amyloid beta pathology - protein deposits in the brain - might have been transmitted by contaminated neurosurgical instruments, suggests a new UCL-led study.

http://ift.tt/2Eut3Fb

Not being aware of memory problems predicts onset of Alzheimer's disease

Doctors who work with individuals at risk of developing dementia have long suspected that patients who do not realize they experience memory problems are at greater risk of seeing their condition worsen in a short time frame, a suspicion that now has been confirmed by a team of McGill University clinician scientists.

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Genetic technique reverses Alzheimer's processes in mice

Researchers in the US have used genetic techniques to slow the progression of Alzheimer’s in mice that show features of the disease. The study, which centered around a protein called BACE1, was reported today in the Journal of Experimental Medicine.

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Poor fitness levels increase the risk dementia, concludes study

A new study has added to the growing body of evidence that regular exercise improves brain health and reduces the risk of Alzheimer’s disease.

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Amyloid protein may be transmitted through neurosurgical instruments, study suggests

Amyloid beta pathology - protein deposits in the brain - might have been transmitted by contaminated neurosurgical instruments, suggests a new UCL-led study.

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Poor fitness linked to weaker brain fiber, higher dementia risk

Poor fitness linked to weaker brain fiber, higher dementia risk:

Dementia Big
Scientists have more evidence that exercise improves brain health and could be a lifesaving ingredient that prevents Alzheimer’s disease.

http://ift.tt/2Bvm0gD

Higher levels of lifestyle physical activity linked to more gray matter in older adults’ brains

Higher levels of lifestyle physical activity linked to more gray matter in older adults’ brains:

Dementia Big
Higher levels of lifestyle physical activity – such as house cleaning, walking a dog and gardening, as well as exercise – are associated with more gray matter in the brains of older adults, according to a study by researchers at Rush University Medical Center.

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Researchers successfully reverse Alzheimer's disease in mouse model

Researchers successfully reverse Alzheimer's disease in mouse model:

Dementia Big
A team of researchers from the Cleveland Clinic Lerner Research Institute have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer’s disease, thereby improving the animals’ cognitive function. The study, which will be published February 14 in the Journal of Experimental Medicine, raises hopes that drugs targeting this enzyme will be able to successfully treat Alzheimer’s disease in humans.

http://ift.tt/2BsNXWe

Poor fitness linked to weaker brain fiber, higher dementia risk

Scientists have more evidence that exercise improves brain health and could be a lifesaving ingredient that prevents Alzheimer’s disease.

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http://ift.tt/2EJESuq

Higher levels of lifestyle physical activity linked to more gray matter in older adults’ brains

Higher levels of lifestyle physical activity – such as house cleaning, walking a dog and gardening, as well as exercise – are associated with more gray matter in the brains of older adults, according to a study by researchers at Rush University Medical Center.

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Researchers successfully reverse Alzheimer's disease in mouse model

A team of researchers from the Cleveland Clinic Lerner Research Institute have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer’s disease, thereby improving the animals’ cognitive function. The study, which will be published February 14 in the Journal of Experimental Medicine, raises hopes that drugs targeting this enzyme will be able to successfully treat Alzheimer’s disease in humans.

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Can treatments for arthritis be repurposed for dementia? – Alzheimer’s Society comments

Can treatments for arthritis be repurposed for dementia? – Alzheimer’s Society comments:

Dementia Big
New research suggests that drugs used to treat rheumatoid arthritis could reduce the risk of patients developing dementia.

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Can treatments for arthritis be repurposed for dementia? – Alzheimer’s Society comments

New research suggests that drugs used to treat rheumatoid arthritis could reduce the risk of patients developing dementia.

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Arthritis drugs linked to lower Alzheimer's risk

Arthritis drugs linked to lower Alzheimer's risk:

Dementia Big
Scientists from the University of Southampton have teamed up with researchers from the University of Oxford to look at whether existing drugs for arthritis have any effect on a person’s risk of developing dementia. By looking at two groups of people – one receiving the drug treatment and one not – they found that fewer people developed dementia after five years of taking the drugs, compared to those who did not receive the treatment for arthritis.

http://ift.tt/2EDzhFT

How to support someone with dementia—and feel better yourself

How to support someone with dementia—and feel better yourself:

Dementia Big
Visiting a loved one with dementia can feel frustrating, even hopeless, but there are ways to turn that precious time into a better experience, says a University of Alberta researcher.

http://ift.tt/2ssJjou

Arthritis drugs linked to lower Alzheimer's risk

Scientists from the University of Southampton have teamed up with researchers from the University of Oxford to look at whether existing drugs for arthritis have any effect on a person’s risk of developing dementia. By looking at two groups of people – one receiving the drug treatment and one not – they found that fewer people developed dementia after five years of taking the drugs, compared to those who did not receive the treatment for arthritis.

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How to support someone with dementia—and feel better yourself

Visiting a loved one with dementia can feel frustrating, even hopeless, but there are ways to turn that precious time into a better experience, says a University of Alberta researcher.

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Scientists develop new array to identify biomarkers for wide range of diseases

Scientists develop new array to identify biomarkers for wide range of diseases:

Dementia Big
Scientists have developed a way to identify biomarkers for a wide range of diseases by assessing the antibodies we are making to the complex sugars coating our cells.

http://ift.tt/2Cg2iSO

People who survive childhood heart defects may be at elevated risk of developing dementia

People who survive childhood heart defects may be at elevated risk of developing dementia:

Dementia Big
People born with heart defects who survive into adulthood may be at higher risk of developing dementia, particularly dementia that starts before 65 years of age, according to new research in the American Heart Association’s journal Circulation.

http://ift.tt/2En8lLe

Survivors of childhood heart defects may have higher risk of premature dementia

Survivors of childhood heart defects may have higher risk of premature dementia:

Dementia Big
People born with heart defects who survive into adulthood may be at higher risk of developing dementia, particularly dementia that starts before 65 years of age, according to new research in the American Heart Association’s journal Circulation.

http://ift.tt/2CgSfga

Scientists develop new array to identify biomarkers for wide range of diseases

Scientists have developed a way to identify biomarkers for a wide range of diseases by assessing the antibodies we are making to the complex sugars coating our cells.

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http://ift.tt/2EDVJyD

People who survive childhood heart defects may be at elevated risk of developing dementia

People born with heart defects who survive into adulthood may be at higher risk of developing dementia, particularly dementia that starts before 65 years of age, according to new research in the American Heart Association’s journal Circulation.

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Survivors of childhood heart defects may have higher risk of premature dementia

People born with heart defects who survive into adulthood may be at higher risk of developing dementia, particularly dementia that starts before 65 years of age, according to new research in the American Heart Association’s journal Circulation.

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Alzheimer’s study on mice reveals important mechanism behind neural hyperactivity

Alzheimer´s disease is the key cause of dementia in elderly patients. Those affected develop deficiencies in their abilities to learn, think logically, communicate, and to master the challenges of everyday life.

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Scientists adapt new brain disease test for Parkinson's, dementia with Lewy bodies

Scientists adapt new brain disease test for Parkinson's, dementia with Lewy bodies:

Dementia Big
National Institutes of Health scientists developing a rapid, practical test for the early diagnosis of prion diseases have modified the assay to offer the possibility of improving early diagnosis of Parkinson’s disease and dementia with Lewy bodies. The group, led by NIH’s National Institute of Allergy and Infectious Diseases (NIAID), tested 60 cerebral spinal fluid samples, including 12 from people with Parkinson’s disease, 17 from people with dementia with Lewy bodies, and 31 controls, including 16 of whom had Alzheimer’s disease. The test correctly excluded all the 31 controls and diagnosed both Parkinson’s disease and dementia with Lewy bodies with 93 percent accuracy.

http://ift.tt/2EvwjTF

NIH scientists modify new RT-QuIC assay to detect Parkinson's, dementia with Lewy bodies

NIH scientists modify new RT-QuIC assay to detect Parkinson's, dementia with Lewy bodies:

Dementia Big
National Institutes of Health scientists developing a rapid, practical test for the early diagnosis of prion diseases have modified the assay to offer the possibility of improving early diagnosis of Parkinson’s disease and dementia with Lewy bodies.

http://ift.tt/2smnwyI

Alzheimer's research—intracellular calcium store malfunction leads to brain hyperactivity

Alzheimer's research—intracellular calcium store malfunction leads to brain hyperactivity:

Dementia Big
Alzheimer´s disease is the key cause of dementia in elderly patients. Those affected develop deficiencies in their abilities to learn, think logically, communicate, and to master the challenges of everyday life. To find out more about how the disease comes about, researchers at the University of Tübingen used mice, developing the same amyloid protein deposits in their brains as human patients, and which also suffer memory loss. Several years ago, a team led by Professor Olga Garaschuk showed that in these mice, the disease coincided with a noticeable increase in nerve cell activity in the brain. There were similar findings in human Alzheimer’s patients.

http://ift.tt/2smnvuE

NIH scientists modify new RT-QuIC assay to detect Parkinson's, dementia with Lewy bodies

National Institutes of Health scientists developing a rapid, practical test for the early diagnosis of prion diseases have modified the assay to offer the possibility of improving early diagnosis of Parkinson’s disease and dementia with Lewy bodies.

from Dementia Big http://ift.tt/2BiJm9c via alcoholic dementia

http://ift.tt/2EtTv4V

Scientists adapt new brain disease test for Parkinson's, dementia with Lewy bodies

National Institutes of Health scientists developing a rapid, practical test for the early diagnosis of prion diseases have modified the assay to offer the possibility of improving early diagnosis of Parkinson’s disease and dementia with Lewy bodies. The group, led by NIH’s National Institute of Allergy and Infectious Diseases (NIAID), tested 60 cerebral spinal fluid samples, including 12 from people with Parkinson’s disease, 17 from people with dementia with Lewy bodies, and 31 controls, including 16 of whom had Alzheimer’s disease. The test correctly excluded all the 31 controls and diagnosed both Parkinson’s disease and dementia with Lewy bodies with 93 percent accuracy.

from Dementia Big http://ift.tt/2EfJ1Tv via alcoholic dementia

http://ift.tt/2smnuqA

Alzheimer's research—intracellular calcium store malfunction leads to brain hyperactivity

Alzheimer´s disease is the key cause of dementia in elderly patients. Those affected develop deficiencies in their abilities to learn, think logically, communicate, and to master the challenges of everyday life. To find out more about how the disease comes about, researchers at the University of Tübingen used mice, developing the same amyloid protein deposits in their brains as human patients, and which also suffer memory loss. Several years ago, a team led by Professor Olga Garaschuk showed that in these mice, the disease coincided with a noticeable increase in nerve cell activity in the brain. There were similar findings in human Alzheimer’s patients.

from Dementia Big http://ift.tt/2Efxl37 via alcoholic dementia

http://ift.tt/2nSb05a

Scientists identify potential early biomarker for Alzheimer's disease

One of the first clear signs of the onset of Alzheimer’s disease is the loss of short-term memory, the ability to remember recent events. However, scientists believe that changes in the brain begin decades before clinicians notice such signs. 

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Changing the way we look at dementia

In November, six people with Alzheimer’s disease and related types of cognitive impairment stood before an audience of 100 in North Haven, Conn.

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http://ift.tt/2FWvGzG

Positivity keeps dementia at bay finds study

Persons who have developed positive attitudes towards life and aging are less likely to develop dementia finds a new study. Becca Levy from the Yale School of Public Health, USA, and colleagues have published the reports of this encouraging study in the latest issue of the journal PLOS ONE.

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Alzheimer's disease: Dual mechanism of actions of overactive and cytosolic BRCA1 in neuronal death

A new study suggests a dual mechanism of actions of overactive and cytosolic re-localized BRCA1, the major guardian of genomic stability, in neurons death by aberrant DNA damage response and presenilin 1 dysfunction in Alzheimer’s disease.

from Dementia Big http://ift.tt/2nMdr9m via alcoholic dementia

http://ift.tt/2FWoFPs

Scientists identify potential early biomarker for Alzheimer's disease

Scientists identify potential early biomarker for Alzheimer's disease:

Dementia Big
One of the first clear signs of the onset of Alzheimer’s disease is the loss of short-term memory, the ability to remember recent events. However, scientists believe that changes in the brain begin decades before clinicians notice such signs. 

http://ift.tt/2Bgo5ga

Changing the way we look at dementia

Changing the way we look at dementia:

Dementia Big
In November, six people with Alzheimer’s disease and related types of cognitive impairment stood before an audience of 100 in North Haven, Conn.

http://ift.tt/2EqKqtA

Positivity keeps dementia at bay finds study

Positivity keeps dementia at bay finds study:

Dementia Big
Persons who have developed positive attitudes towards life and aging are less likely to develop dementia finds a new study. Becca Levy from the Yale School of Public Health, USA, and colleagues have published the reports of this encouraging study in the latest issue of the journal PLOS ONE.

http://ift.tt/2BjAz73

Alzheimer's disease: Dual mechanism of actions of overactive and cytosolic BRCA1 in neuronal death

Alzheimer's disease: Dual mechanism of actions of overactive and cytosolic BRCA1 in neuronal death:

Dementia Big
A new study suggests a dual mechanism of actions of overactive and cytosolic re-localized BRCA1, the major guardian of genomic stability, in neurons death by aberrant DNA damage response and presenilin 1 dysfunction in Alzheimer’s disease.

http://ift.tt/2EsUbHC

Positive attitudes about aging reduce risk of dementia in older adults

Positive attitudes about aging reduce risk of dementia in older adults:

Dementia Big
Research has shown that older persons who have acquired positive beliefs about old age from their surrounding culture are less likely to develop dementia. This protective effect was found for all participants, as well as among those carrying a gene that puts them at higher risk of developing dementia, a new study led by the Yale School of Public Health has found.

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Redefined Alzheimer's biology has implications for drug design

Redefined Alzheimer's biology has implications for drug design:

Dementia Big
Despite the 25-year focus on the build-up in brain tissues of one protein, amyloid beta, as the purported origin of Alzheimer’s disease (AD), a new study argues that it is likely triggered instead by the failure of a system that clears wastes from the brain - and actually begins decades before memories fade.

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USC scientists uncover cellular mechanism responsible for ALS and frontotemporal dementia

USC scientists uncover cellular mechanism responsible for ALS and frontotemporal dementia:

Dementia Big
Scientists have for the first time discovered a mechanism that limits the number of “cellular janitors” in the nervous system, leading to increased risk for two neurodegenerative diseases: amyotrophic lateral sclerosis and frontotemporal dementia, according to a Keck School of Medicine of USC study published today in Nature Medicine.

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Social interaction could enhance dementia care, finds study

Social interaction could enhance dementia care, finds study:

Dementia Big
Increasing social interaction among people living with dementia in care homes could improve the quality of their life and save money, suggests new study.

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One in five older adults experience brain network weakening following knee replacement surgery

One in five older adults experience brain network weakening following knee replacement surgery:

Dementia Big
A new University of Florida study finds that 23 percent of adults age 60 and older who underwent a total knee replacement experienced a decline in activity in at least one region of the brain responsible for specific cognitive functions. Fifteen percent of patients declined across all brain networks the team evaluated.

http://ift.tt/2GU2MSd

Compound prevents neurological damage, shows cognitive benefits in mouse model of Alzheimer's disease

Compound prevents neurological damage, shows cognitive benefits in mouse model of Alzheimer's disease:

Dementia Big
The supplement nicotinamide riboside (NR) – a form of vitamin B3 – prevented neurological damage and improved cognitive and physical function in a new mouse model of Alzheimer’s disease. The results of the study, conducted by researchers at the National Institute on Aging (NIA) part of the National Institutes of Health, suggest a potential new target for treating Alzheimer’s disease. The findings appear in the Feb. 5, 2018, issue of Proceedings of the National Academy of Sciences.

http://ift.tt/2FXbFZX

Loss of coenzyme Q10 increases pre-diabetes risk

Loss of coenzyme Q10 increases pre-diabetes risk:

Dementia Big
Levels of CoQ and the presence of insulin resistance were analyzed in a range of experimental laboratory settings, mouse models and samples from humans, as part of an ambitious research collaboration conducted with the University of Sydney, Victor Chang Cardiac Research Institute, Duke University School of Medicine, Garvan Institute of Medical Research, Genentech Inc. and the University of New South Wales.

http://ift.tt/2GWazih

Positive attitudes about aging reduce risk of dementia in older adults

Research has shown that older persons who have acquired positive beliefs about old age from their surrounding culture are less likely to develop dementia. This protective effect was found for all participants, as well as among those carrying a gene that puts them at higher risk of developing dementia, a new study led by the Yale School of Public Health has found.

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http://ift.tt/2E7eIhz

Redefined Alzheimer's biology has implications for drug design

Despite the 25-year focus on the build-up in brain tissues of one protein, amyloid beta, as the purported origin of Alzheimer’s disease (AD), a new study argues that it is likely triggered instead by the failure of a system that clears wastes from the brain - and actually begins decades before memories fade.

from Dementia Big http://ift.tt/2BK4lme via alcoholic dementia

http://ift.tt/2EPRfT2

USC scientists uncover cellular mechanism responsible for ALS and frontotemporal dementia

Scientists have for the first time discovered a mechanism that limits the number of “cellular janitors” in the nervous system, leading to increased risk for two neurodegenerative diseases: amyotrophic lateral sclerosis and frontotemporal dementia, according to a Keck School of Medicine of USC study published today in Nature Medicine.

from Dementia Big http://ift.tt/2sfnDvZ via alcoholic dementia

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Social interaction could enhance dementia care, finds study

Increasing social interaction among people living with dementia in care homes could improve the quality of their life and save money, suggests new study.

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http://ift.tt/2EP92dg

One in five older adults experience brain network weakening following knee replacement surgery

A new University of Florida study finds that 23 percent of adults age 60 and older who underwent a total knee replacement experienced a decline in activity in at least one region of the brain responsible for specific cognitive functions. Fifteen percent of patients declined across all brain networks the team evaluated.

from Dementia Big http://ift.tt/2ENdCJ2 via alcoholic dementia

http://ift.tt/2EaVyrj

Compound prevents neurological damage, shows cognitive benefits in mouse model of Alzheimer's disease

The supplement nicotinamide riboside (NR) – a form of vitamin B3 – prevented neurological damage and improved cognitive and physical function in a new mouse model of Alzheimer’s disease. The results of the study, conducted by researchers at the National Institute on Aging (NIA) part of the National Institutes of Health, suggest a potential new target for treating Alzheimer’s disease. The findings appear in the Feb. 5, 2018, issue of Proceedings of the National Academy of Sciences.

from Dementia Big http://ift.tt/2C1A2Dd via alcoholic dementia

http://ift.tt/2EOu7Ez

Loss of coenzyme Q10 increases pre-diabetes risk

Levels of CoQ and the presence of insulin resistance were analyzed in a range of experimental laboratory settings, mouse models and samples from humans, as part of an ambitious research collaboration conducted with the University of Sydney, Victor Chang Cardiac Research Institute, Duke University School of Medicine, Garvan Institute of Medical Research, Genentech Inc. and the University of New South Wales.

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Research highlights need for more structured educational programs for informal dementia carers

Research highlights need for more structured educational programs for informal dementia carers:

Dementia Big
Directly involving the thousands of family members and friends who serve as ‘informal carers’ for people with dementia in the evaluation of patients’ symptoms and behaviour could offer improved insights for healthcare professionals and help alleviate feelings of stress, guilt and isolation felt by many who fulfil these duties, a new study has found.

http://ift.tt/2DZMc5j

Research highlights need for more structured educational programs for informal dementia carers

Directly involving the thousands of family members and friends who serve as ‘informal carers’ for people with dementia in the evaluation of patients’ symptoms and behaviour could offer improved insights for healthcare professionals and help alleviate feelings of stress, guilt and isolation felt by many who fulfil these duties, a new study has found.

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Research highlights need for better support for thousands of informal dementia carers

Research highlights need for better support for thousands of informal dementia carers:

Dementia Big
Directly involving the thousands of family members and friends who serve as ‘informal carers’ for people with dementia in the evaluation of patients’ symptoms and behaviour could offer improved insights for healthcare professionals and help alleviate feelings of stress, guilt and isolation felt by many who fulfil these duties, a new study has found.

http://ift.tt/2DYyhZj

Blood-based marker for Alzheimer's disease shows diagnostic potential

Blood-based marker for Alzheimer's disease shows diagnostic potential:

Dementia Big
Researchers in Japan and Australia have used the ratio of different forms of the hallmark Alzheimer’s protein, amyloid, in blood to detect those who have high levels of the protein in their brain. Their findings are published today in the scientific publication Nature and take researchers a step closer to developing a blood test for the Alzheimer’s protein.

http://ift.tt/2EzBkbq

Blood-based marker for Alzheimer's disease shows diagnostic potential

Researchers in Japan and Australia have used the ratio of different forms of the hallmark Alzheimer’s protein, amyloid, in blood to detect those who have high levels of the protein in their brain. Their findings are published today in the scientific publication Nature and take researchers a step closer to developing a blood test for the Alzheimer’s protein.

from Dementia Big http://ift.tt/2BQiQ3o via alcoholic dementia

http://ift.tt/2DXNpX1

Research highlights need for better support for thousands of informal dementia carers

Directly involving the thousands of family members and friends who serve as ‘informal carers’ for people with dementia in the evaluation of patients’ symptoms and behaviour could offer improved insights for healthcare professionals and help alleviate feelings of stress, guilt and isolation felt by many who fulfil these duties, a new study has found.

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British Red Cross report highlights that older people at risk from emergency hospital readmissions

Alzheimer’s Society responds to In and Out of Hospital, a report published by the British Red Cross.

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British Red Cross report highlights that older people at risk from emergency hospital readmissions

British Red Cross report highlights that older people at risk from emergency hospital readmissions:

Dementia Big
Alzheimer’s Society responds to In and Out of Hospital, a report published by the British Red Cross.

http://ift.tt/2GE3X86

Low levels of alcohol helps the brain clear away toxins, study shows

Low levels of alcohol helps the brain clear away toxins, study shows:

Dementia Big
While a couple of glasses of wine can help clear the mind after a busy day, new research shows that it may actually help clean the mind as well.

http://ift.tt/2nCvE8x

Fight for Sight awards new grants for 13 vital eye research projects

Fight for Sight awards new grants for 13 vital eye research projects:

Dementia Big
Fight for Sight, the leading eye research charity, has awarded grants totaling over £180,000 for thirteen vital research projects in partnership with nine different organizations.

http://ift.tt/2DXjtOO

Low levels of alcohol helps the brain clear away toxins, study shows

While a couple of glasses of wine can help clear the mind after a busy day, new research shows that it may actually help clean the mind as well.

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http://ift.tt/2DVwB70

Fight for Sight awards new grants for 13 vital eye research projects

Fight for Sight, the leading eye research charity, has awarded grants totaling over £180,000 for thirteen vital research projects in partnership with nine different organizations.

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Deep brain stimulation may be promising Alzheimer's treatment

(HealthDay)—For patients with Alzheimer’s disease (AD), the use of deep brain stimulation (DBS) at the ventral capsule/ventral striatum (VC/VS) region is well tolerated and is associated with less decline on the Clinical Dementia Rating-Sum of Boxes (CDR-SB), according to a study published online Jan. 30 in the Journal of Alzheimer’s Disease.

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Minimally invasive blood test for Alzheimer's disease

Scientists from Japan and Australia have teamed up to develop and validate a blood test for Alzheimer’s disease, with the potential to massively ramp up the pace of Alzheimer’s disease drug trials.

from Dementia Big http://ift.tt/2GCZVwO via alcoholic dementia

http://ift.tt/2DUqbVH

Deep brain stimulation may be promising Alzheimer's treatment

Deep brain stimulation may be promising Alzheimer's treatment:

Dementia Big
(HealthDay)—For patients with Alzheimer’s disease (AD), the use of deep brain stimulation (DBS) at the ventral capsule/ventral striatum (VC/VS) region is well tolerated and is associated with less decline on the Clinical Dementia Rating-Sum of Boxes (CDR-SB), according to a study published online Jan. 30 in the Journal of Alzheimer’s Disease.

http://ift.tt/2nyNnO6

Minimally invasive blood test for Alzheimer's disease

Minimally invasive blood test for Alzheimer's disease:

Dementia Big
Scientists from Japan and Australia have teamed up to develop and validate a blood test for Alzheimer’s disease, with the potential to massively ramp up the pace of Alzheimer’s disease drug trials.

http://ift.tt/2DSR5NQ