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Researchers from the Institute of Neurosciences at the Universitat Autònoma de Barcelona and the Vall d'Hebron Research Institute are the first to demonstrate that regulation of the brain’s Klotho gene using gene therapy protects against age-related learning and memory problems in mice.
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Much of Professor Emeritus Richard Wurtman’s career in MIT’s Department of Brain and Cognitive Sciences revolved around developing new treatments for diseases and conditions by modifying chemicals produced in the brain.
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Alzheimer’s disease, the leading cause of dementia, has long been assumed to originate in the brain. But research from the University of British Columbia and Chinese scientists indicates that it could be triggered by breakdowns elsewhere in the body.
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The pioneering clinical trial is part of a large European Union funded project and involved 311 patients across 11 sites in four countries (Finland, Germany, the Netherlands and Sweden). The trial involved patients with prodromal Alzheimer’s (often referred to as Mild Cognitive Impairment or MCI). Patients were randomised to receive either the nutritional intervention or an iso-caloric control drink for 24 months.
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Researchers at The University of Texas Health Science Center at Houston (UTHealth) School of Dentistry and McGovern Medical School have discovered a previously unknown characteristic of brain-cell aging that could help detect late-onset Alzheimer’s disease decades before symptoms begin.
Researchers from the Institute of Neurosciences at the Universitat Autònoma de Barcelona and the Vall d'Hebron Research Institute are the first to demonstrate that regulation of the brain’s Klotho gene using gene therapy protects against age-related learning and memory problems in mice.
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Much of Professor Emeritus Richard Wurtman’s career in MIT’s Department of Brain and Cognitive Sciences revolved around developing new treatments for diseases and conditions by modifying chemicals produced in the brain.
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Alzheimer’s disease, the leading cause of dementia, has long been assumed to originate in the brain. But research from the University of British Columbia and Chinese scientists indicates that it could be triggered by breakdowns elsewhere in the body.
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The pioneering clinical trial is part of a large European Union funded project and involved 311 patients across 11 sites in four countries (Finland, Germany, the Netherlands and Sweden). The trial involved patients with prodromal Alzheimer’s (often referred to as Mild Cognitive Impairment or MCI). Patients were randomised to receive either the nutritional intervention or an iso-caloric control drink for 24 months.
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Researchers at The University of Texas Health Science Center at Houston (UTHealth) School of Dentistry and McGovern Medical School have discovered a previously unknown characteristic of brain-cell aging that could help detect late-onset Alzheimer’s disease decades before symptoms begin.
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Dementia Big
The full results from the European LipiDiDiet clinical trial has been published online in The Lancet Neurology today.
The full results from the European LipiDiDiet clinical trial has been published online in The Lancet Neurology today.
Dementia Big
Alzheimer’s disease, the leading cause of dementia, has long been assumed to originate in the brain. But research from the University of British Columbia and Chinese scientists indicates that it could be triggered by breakdowns elsewhere in the body.
Alzheimer’s disease, the leading cause of dementia, has long been assumed to originate in the brain. But research from the University of British Columbia and Chinese scientists indicates that it could be triggered by breakdowns elsewhere in the body.
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Researchers at The University of Texas Health Science Center at Houston School of Dentistry and McGovern Medical School have discovered a previously unknown characteristic of brain-cell aging that could help detect late-onset Alzheimer’s disease decades before symptoms begin.
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Researchers at The University of Texas Health Science Center at Houston School of Dentistry and McGovern Medical School have discovered a previously unknown characteristic of brain-cell aging that could help detect late-onset Alzheimer’s disease decades before symptoms begin.
Biogen and Ionis have been awarded the prestigious 2017 Prix Galien USA Award for Best Biotechnology Product for SPINRAZA (nusinersen). The Prix Galien USA Award recognizes extraordinary achievement in scientific innovation that improves the state of human health. The award was presented at a ceremony in New York City on October 26, 2017.
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Biogen and Ionis have been awarded the prestigious 2017 Prix Galien USA Award for Best Biotechnology Product for SPINRAZA (nusinersen). The Prix Galien USA Award recognizes extraordinary achievement in scientific innovation that improves the state of human health. The award was presented at a ceremony in New York City on October 26, 2017.
Sunovion Pharmaceuticals Inc. today announced post-hoc analysis results of a positive Phase 3 placebo-controlled clinical study, as well as interim data from a long-term open-label extension study evaluating Latuda (lurasidone HCI) in children and adolescents (10 to 17 years of age) with major depressive episodes associated with bipolar I disorder (bipolar depression).
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Dementia Big
Sunovion Pharmaceuticals Inc. today announced post-hoc analysis results of a positive Phase 3 placebo-controlled clinical study, as well as interim data from a long-term open-label extension study evaluating Latuda (lurasidone HCI) in children and adolescents (10 to 17 years of age) with major depressive episodes associated with bipolar I disorder (bipolar depression).
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Alzheimer’s disease (AD) is the most common form of dementia, affecting some 46 million people globally, and a leading cause of mortality in the elderly.
Alzheimer’s disease (AD) is the most common form of dementia, affecting some 46 million people globally, and a leading cause of mortality in the elderly.
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New research by Which? has found that almost half of people who had arranged care for themselves or a loved one said there weren’t any places in at least one of the local care homes they considered.
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New research by Which? has found that almost half of people who had arranged care for themselves or a loved one said there weren’t any places in at least one of the local care homes they considered.
A healthy heart is important to the well-being of older adults. The American Heart Association (AHA) defines “ideal cardiovascular health” based on four health behaviors (current smoking, body mass index, physical activity, and healthy diet and three health factors (total cholesterol, blood pressure), and fasting blood glucose level).
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Dementia Big
A healthy heart is important to the well-being of older adults. The American Heart Association (AHA) defines “ideal cardiovascular health” based on four health behaviors (current smoking, body mass index, physical activity, and healthy diet and three health factors (total cholesterol, blood pressure), and fasting blood glucose level).
A tremendous amount of amyloid-β peptide (Aβ) (a peptide of ~40 amino acids) accumulates in the brains of Alzheimer’s disease patients. γ-Secretase inhibitors were designed to inhibit the enzymatic activity that produces Aβ. By reducing Aβ production, γ-secretase inhibitors were able to treat Alzheimer’s disease (Aβ hypothesis). In fact, nearly 50 clinical trials have been conducted using potential γ-secretase inhibitors for Alzheimer’s disease or several types of cancer. However, all of these trials failed, except for two studies which are currently ongoing.
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Dementia Big
A tremendous amount of amyloid-β peptide (Aβ) (a peptide of ~40 amino acids) accumulates in the brains of Alzheimer’s disease patients. γ-Secretase inhibitors were designed to inhibit the enzymatic activity that produces Aβ. By reducing Aβ production, γ-secretase inhibitors were able to treat Alzheimer’s disease (Aβ hypothesis). In fact, nearly 50 clinical trials have been conducted using potential γ-secretase inhibitors for Alzheimer’s disease or several types of cancer. However, all of these trials failed, except for two studies which are currently ongoing.
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New research published today suggests that blood-thinning drugs may be associated with reduction in dementia risk, as well as reducing the risk of stroke in patients with atrial fibrillation (AF).
New research published today suggests that blood-thinning drugs may be associated with reduction in dementia risk, as well as reducing the risk of stroke in patients with atrial fibrillation (AF).
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In an innovative study, researchers at the Centre for Addiction and Mental Health (CAMH) have discovered brain changes linked to memory loss in people with Alzheimer’s disease. The discovery provides a new focus for exploring ways to treat or prevent dementia, which currently affects more than 560,000 Canadians.
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The size, shape and number of dendritic spines in the brain may play a major role in whether someone gets Alzheimer’s disease, according to new research from the University of Alabama at Birmingham. Dendritic spines are sub-units of neurons that act as the connector to other neurons.
In an innovative study, researchers at the Centre for Addiction and Mental Health (CAMH) have discovered brain changes linked to memory loss in people with Alzheimer’s disease. The discovery provides a new focus for exploring ways to treat or prevent dementia, which currently affects more than 560,000 Canadians.
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The size, shape and number of dendritic spines in the brain may play a major role in whether someone gets Alzheimer’s disease, according to new research from the University of Alabama at Birmingham. Dendritic spines are sub-units of neurons that act as the connector to other neurons.
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Dementia Big
Opioid use is not associated with an increased risk of Alzheimer’s disease, shows a recent study from the University of Eastern Finland. Researchers did not find any risk neither for long-term use nor for higher cumulative doses. Opioids are powerful pain relieving drugs that act on the nervous system.
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Study suggests Alzheimer’s disease and Type 2 diabetes might both be the price of a longer lifespan, with altered insulin function the common cause.
Opioid use is not associated with an increased risk of Alzheimer’s disease, shows a recent study from the University of Eastern Finland. Researchers did not find any risk neither for long-term use nor for higher cumulative doses. Opioids are powerful pain relieving drugs that act on the nervous system.
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Study suggests Alzheimer’s disease and Type 2 diabetes might both be the price of a longer lifespan, with altered insulin function the common cause.
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With $3.8 million in support from the National Institute on Aging, University of California, Irvine neurobiologists are working to identify the early indicators of dementia in older adults as disease-related brain plaques accumulate but before symptoms can be observed.
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Testing drugs to prevent or delay the onset of Alzheimer’s dementia and using them in the clinic will mean identifying and informing adults who have a higher risk of Alzheimer’s but are still cognitively normal. A new study from the Perelman School of Medicine at the University of Pennsylvania has shed light on how seniors cope with such information.
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Dementia Big
With $3.8 million in support from the National Institute on Aging, University of California, Irvine neurobiologists are working to identify the early indicators of dementia in older adults as disease-related brain plaques accumulate but before symptoms can be observed.
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Testing drugs to prevent or delay the onset of Alzheimer’s dementia and using them in the clinic will mean identifying and informing adults who have a higher risk of Alzheimer’s but are still cognitively normal. A new study from the Perelman School of Medicine at the University of Pennsylvania has shed light on how seniors cope with such information.
A delayed neurological response to processing the written word could be an indicator that a patient with mild memory problems is at an increased risk of developing Alzheimer’s disease, research led by the University of Birmingham has discovered.
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Dementia Big
A delayed neurological response to processing the written word could be an indicator that a patient with mild memory problems is at an increased risk of developing Alzheimer’s disease, research led by the University of Birmingham has discovered.
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A delayed neurological response to processing the written word could be an indicator that a patient with mild memory problems is at an increased risk of developing Alzheimer’s disease, research led by the University of Birmingham has discovered.
A delayed neurological response to processing the written word could be an indicator that a patient with mild memory problems is at an increased risk of developing Alzheimer’s disease, research led by the University of Birmingham has discovered.
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UK cinematic experiences are made more inclusive by industry influencers.
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UK cinematic experiences are made more inclusive by industry influencers.
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Scientists at the Massachusetts General Hospital (MGH), in collaboration with colleagues at the University California, San Diego (UCSD), have characterized a new class of drugs as potential therapeutics for Alzheimer’s disease and discovered a piece in the puzzle of how they would work. Their study, using disease-related animal and cellular models, shows that treatment with a representative compound of this class of gamma-secretase modulators leads to a reduction of the Alzheimer’s-associated beta-amyloid. The study has been online published in EBioMedicine, an open-access journal jointly published by Cell Press and The Lancet.
Scientists at the Massachusetts General Hospital (MGH), in collaboration with colleagues at the University California, San Diego (UCSD), have characterized a new class of drugs as potential therapeutics for Alzheimer’s disease and discovered a piece in the puzzle of how they would work. Their study, using disease-related animal and cellular models, shows that treatment with a representative compound of this class of gamma-secretase modulators leads to a reduction of the Alzheimer’s-associated beta-amyloid. The study has been online published in EBioMedicine, an open-access journal jointly published by Cell Press and The Lancet.
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An estimated 5.5 million Americans live with Alzheimer’s disease, a type of dementia that causes problems with memory, thinking and behavior. Although treatments can slow the worsening of symptoms, scientists are still working to better understand the neurodegenerative disease so that curative and preventative medicines can be developed.
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How often do you get a good night’s sleep? Centers for Disease Control and Prevention guidelines recommend adults get an average of at least seven hours of sleep a night. Dr. Ronald Petersen, a Mayo Clinic neurologist, says prolonged lack of sleep could raise your risk of many health issues, including Alzheimer’s disease.
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Dementia Big
An estimated 5.5 million Americans live with Alzheimer’s disease, a type of dementia that causes problems with memory, thinking and behavior. Although treatments can slow the worsening of symptoms, scientists are still working to better understand the neurodegenerative disease so that curative and preventative medicines can be developed.
Dementia Big
How often do you get a good night’s sleep? Centers for Disease Control and Prevention guidelines recommend adults get an average of at least seven hours of sleep a night. Dr. Ronald Petersen, a Mayo Clinic neurologist, says prolonged lack of sleep could raise your risk of many health issues, including Alzheimer’s disease.
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More than 25.5 million people around the world are dying each year with serious physical and psychological suffering caused by disease, injury or illness, according to a major new report.
More than 25.5 million people around the world are dying each year with serious physical and psychological suffering caused by disease, injury or illness, according to a major new report.
Men and women feel pain differently, and the same is true for people with Alzheimer’s disease.
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Dementia Big
Men and women feel pain differently, and the same is true for people with Alzheimer’s disease.
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Investigators at Case Western Reserve University School of Medicine and University Hospitals Health System have identified a new molecular pathway that controls lifespan and healthspan in worms and mammals.
Investigators at Case Western Reserve University School of Medicine and University Hospitals Health System have identified a new molecular pathway that controls lifespan and healthspan in worms and mammals.
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Dementia Big
McGill University researchers have discovered a cellular mechanism that may contribute to the breakdown of communication between neurons in Alzheimer’s disease.
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Microglia, immune cells that act as the central nervous system’s damage sensors, have recently been implicated in Alzheimer’s disease.
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McGill University researchers have discovered a cellular mechanism that may contribute to the breakdown of communication between neurons in Alzheimer’s disease.
McGill University researchers have discovered a cellular mechanism that may contribute to the breakdown of communication between neurons in Alzheimer’s disease.
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Microglia, immune cells that act as the central nervous system’s damage sensors, have recently been implicated in Alzheimer’s disease.
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McGill University researchers have discovered a cellular mechanism that may contribute to the breakdown of communication between neurons in Alzheimer’s disease.
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Dementia Big
Figuring out how to pedal a bike and memorizing the rules of chess require two different types of learning, and now for the first time, researchers have been able to distinguish each type of learning by the brain-wave patterns it produces.
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A new clinical guide summarizes the evidence regarding the effects of calcium in reducing the risk of osteoporosis after the menopause.
Figuring out how to pedal a bike and memorizing the rules of chess require two different types of learning, and now for the first time, researchers have been able to distinguish each type of learning by the brain-wave patterns it produces.
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A new clinical guide summarizes the evidence regarding the effects of calcium in reducing the risk of osteoporosis after the menopause.
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Dementia is still the leading cause of death in England and Wales.
Leading health economist, William Laing, has today published his proposal for a long-term solution for funding social care.
Alzheimer’s Society Cymru’s Sue Phelps visited Buckingham Palace on Wednesday 11 October to receive her well-deserved MBE for services to dementia in Wales.
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Dementia is still the leading cause of death in England and Wales.
Dementia Big
Leading health economist, William Laing, has today published his proposal for a long-term solution for funding social care.
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Alzheimer’s Society Cymru’s Sue Phelps visited Buckingham Palace on Wednesday 11 October to receive her well-deserved MBE for services to dementia in Wales.
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An Oregon woman with Alzheimer’s disease, whose husband claimed she was kept alive with spoon-feeding against her written wishes, has died.
An Oregon woman with Alzheimer’s disease, whose husband claimed she was kept alive with spoon-feeding against her written wishes, has died.
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Dementia Big
Effective treatments for Alzheimer’s disease are five to 10 years away, according to a Keck School of Medicine of USC researcher.
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Green tea is widely considered to be beneficial for the brain. The antioxidant and detoxifying properties of green tea extracts help fight catastrophic diseases such as Alzheimer’s. However, scientists have never fully understood how they work at the molecular level and how they could be harnessed to find better treatments.
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Late-onset sporadic Alzheimer’s disease (AD) accounts for about 99 percent of all cases, and is linked to multiple factors and pathogenetic mechanisms. One important contributor is a protein post-translational modification (PTM), known as O-linked β-N-acetylglucosamine, or O-GlcNAc.
Effective treatments for Alzheimer’s disease are five to 10 years away, according to a Keck School of Medicine of USC researcher.
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Green tea is widely considered to be beneficial for the brain. The antioxidant and detoxifying properties of green tea extracts help fight catastrophic diseases such as Alzheimer’s. However, scientists have never fully understood how they work at the molecular level and how they could be harnessed to find better treatments.
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Late-onset sporadic Alzheimer’s disease (AD) accounts for about 99 percent of all cases, and is linked to multiple factors and pathogenetic mechanisms. One important contributor is a protein post-translational modification (PTM), known as O-linked β-N-acetylglucosamine, or O-GlcNAc.
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Dementia Big
Menopause causes metabolic changes in the brain that may increase the risk of Alzheimer’s disease, a team from Weill Cornell Medicine and the University of Arizona Health Sciences has shown in new research.
Dementia Big
Behavioral and psychological symptoms are difficult for dementia patients and their caregivers, but despite research efforts, there are still gaps in knowledge about what causes or precipitates these symptoms, according to researchers.
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While memory loss is an early symptom of Alzheimer’s disease, its presence doesn’t mean a person will develop dementia. A new study at the Centre for Addiction and Mental Health has found a clinically useful way to predict who won’t develop Alzheimer’s disease, based on patients’ awareness of their memory problems.
Dementia Big
Menopause causes metabolic changes in the brain that may increase the risk of Alzheimer’s disease, a team from Weill Cornell Medicine and the University of Arizona Health Sciences has shown in new research.
Menopause causes metabolic changes in the brain that may increase the risk of Alzheimer’s disease, a team from Weill Cornell Medicine and the University of Arizona Health Sciences has shown in new research.
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Behavioral and psychological symptoms are difficult for dementia patients and their caregivers, but despite research efforts, there are still gaps in knowledge about what causes or precipitates these symptoms, according to researchers.
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While memory loss is an early symptom of Alzheimer’s disease, its presence doesn’t mean a person will develop dementia. A new study at the Centre for Addiction and Mental Health has found a clinically useful way to predict who won’t develop Alzheimer’s disease, based on patients’ awareness of their memory problems.
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Menopause causes metabolic changes in the brain that may increase the risk of Alzheimer’s disease, a team from Weill Cornell Medicine and the University of Arizona Health Sciences has shown in new research.
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While memory loss is an early symptom of Alzheimer’s disease, its presence doesn’t mean a person will develop dementia. A new study at the Centre for Addiction and Mental Health (CAMH) has found a clinically useful way to predict who won’t develop Alzheimer’s disease, based on patients’ awareness of their memory problems.
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Behavioral and psychological symptoms are difficult for dementia patients and their caregivers, but despite research efforts, there are still gaps in knowledge about what causes or precipitates these symptoms, according to researchers.
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Dementia Big
While memory loss is an early symptom of Alzheimer’s disease, its presence doesn’t mean a person will develop dementia. A new study at the Centre for Addiction and Mental Health (CAMH) has found a clinically useful way to predict who won’t develop Alzheimer’s disease, based on patients’ awareness of their memory problems.
Dementia Big
Behavioral and psychological symptoms are difficult for dementia patients and their caregivers, but despite research efforts, there are still gaps in knowledge about what causes or precipitates these symptoms, according to researchers.
Strictly Come Dancing star Ruth Langsford took a break from the dancefloor to join 3,000 people who united against dementia at an Alzheimer’s Society Memory Walk.
