Wednesday, August 31, 2016

SAGA funding initiative aims to advance understanding of potential sex differences in Alzheimer's

SAGA funding initiative aims to advance understanding of potential sex differences in Alzheimer's:

Dementia Big
The first-ever Alzheimer’s Association Sex and Gender in Alzheimer’s research grant awards will provide $2.2 million to nine projects to advance understanding of the disproportionate effect of Alzheimer’s disease on women.


http://ift.tt/2bFgPdY

Study shows how caffeine counteracts age-related cognitive deficits in animals

Study shows how caffeine counteracts age-related cognitive deficits in animals:

Dementia Big
A study published in the journal Scientific Reports from Nature publishing group, describes the mechanism by which caffeine counteracts age-related cognitive deficits in animals.


http://ift.tt/2bB6Glm

Multi-purpose protein may offer clues for successful treatment of Alzheimer's disease

Multi-purpose protein may offer clues for successful treatment of Alzheimer's disease:

Dementia Big
The tidal wave approaches. In the coming decades, Alzheimer’s disease is projected to exact a devastating economic and emotional toll on society, with patient numbers in the US alone expected to reach 13.5 million by mid-century at a projected cost of over a trillion dollars.


http://ift.tt/2bFhIDb

Antipsychotic use linked to higher pneumonia risk in patients with Alzheimer's disease

Antipsychotic use linked to higher pneumonia risk in patients with Alzheimer's disease:

Dementia Big
Antipsychotic medications are associated with an increased risk of pneumonia in persons with Alzheimer’s disease (AD), according to new research from the University of Eastern Finland.


http://ift.tt/2bB6wdO

Critical protein shows promise for the treatment of Alzheimer's

Critical protein shows promise for the treatment of Alzheimer's:

Dementia Big
The tidal wave approaches. In the coming decades, Alzheimer’s disease is projected to exact a devastating economic and emotional toll on society, with patient numbers in the US alone expected to reach 13.5 million by mid-century at a projected cost of over a trillion dollars.


http://ift.tt/2bFgpUG

Progression from normal cognition to mild cognitive impairment in a diverse clinic-based and community-based elderly cohort

Progression from normal cognition to mild cognitive impairment in a diverse clinic-based and community-based elderly cohort:

Dementia Big
Investigation of the conversion rates from normal cognition (NC) to mild cognitive impairment (MCI) is important, as effective early intervention could potentially prevent or substantially delay the onset of dementia. However, reported conversion rates differ across studies and recruitment source.


http://ift.tt/2bB717l

Study examines link between PTSD and cognitive impairment in WTC responders without head injury

Study examines link between PTSD and cognitive impairment in WTC responders without head injury:

Dementia Big
New research published by the journal Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring confirms the connection between posttraumatic stress disorder (PTSD) and cognitive impairment - in this case, among those who helped with search, rescue and cleanup efforts following the 2001 World Trade Center (WTC) attacks.


http://ift.tt/2bFhvzP

The worldwide costs of dementia 2015 and comparisons with 2010

The worldwide costs of dementia 2015 and comparisons with 2010:

Dementia Big
In 2010, Alzheimer’s Disease International presented estimates of the global cost of illness (COI) of dementia. Since then, new studies have been conducted, and the number of people with dementia has increased. Here, we present an update of the global cost estimates.


http://ift.tt/2bB6FOk

The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model

The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model:

Dementia Big
The Dominantly Inherited Alzheimer Network Trial Unit (DIAN-TU) is an adaptive platform trial testing multiple drugs to slow or prevent the progression of Alzheimer’s disease in autosomal dominant Alzheimer’s disease (ADAD) families. With completion of enrollment of the first two drug arms, the DIAN-TU now plans to add new drugs to the platform, designated as the Next Generation (NexGen) prevention trial.


http://ift.tt/2bFgMPk

Study shows how caffeine counteracts age-related cognitive deficits in animals

A study published in the journal Scientific Reports from Nature publishing group, describes the mechanism by which caffeine counteracts age-related cognitive deficits in animals.

from Dementia Big http://ift.tt/2bDnc17 via alcoholic dementia


http://ift.tt/2bB78jk

SAGA funding initiative aims to advance understanding of potential sex differences in Alzheimer's

The first-ever Alzheimer’s Association Sex and Gender in Alzheimer’s research grant awards will provide $2.2 million to nine projects to advance understanding of the disproportionate effect of Alzheimer’s disease on women.

from Dementia Big http://ift.tt/2bAZbHT via alcoholic dementia


http://ift.tt/2bFhGex

Antipsychotic use linked to higher pneumonia risk in patients with Alzheimer's disease

Antipsychotic medications are associated with an increased risk of pneumonia in persons with Alzheimer’s disease (AD), according to new research from the University of Eastern Finland.

from Dementia Big http://ift.tt/2co12Wp via alcoholic dementia


http://ift.tt/2bFhWuc

Critical protein shows promise for the treatment of Alzheimer's

The tidal wave approaches. In the coming decades, Alzheimer’s disease is projected to exact a devastating economic and emotional toll on society, with patient numbers in the US alone expected to reach 13.5 million by mid-century at a projected cost of over a trillion dollars.

from Dementia Big http://ift.tt/2cbEEOU via alcoholic dementia


http://ift.tt/2bB6WAz

Multi-purpose protein may offer clues for successful treatment of Alzheimer's disease

The tidal wave approaches. In the coming decades, Alzheimer’s disease is projected to exact a devastating economic and emotional toll on society, with patient numbers in the US alone expected to reach 13.5 million by mid-century at a projected cost of over a trillion dollars.

from Dementia Big http://ift.tt/2bXnNP6 via alcoholic dementia


http://ift.tt/2bB652U

The worldwide costs of dementia 2015 and comparisons with 2010

In 2010, Alzheimer’s Disease International presented estimates of the global cost of illness (COI) of dementia. Since then, new studies have been conducted, and the number of people with dementia has increased. Here, we present an update of the global cost estimates.

from Dementia Big http://ift.tt/2bxDWvt via alcoholic dementia


http://ift.tt/2bFhsUF

Progression from normal cognition to mild cognitive impairment in a diverse clinic-based and community-based elderly cohort

Investigation of the conversion rates from normal cognition (NC) to mild cognitive impairment (MCI) is important, as effective early intervention could potentially prevent or substantially delay the onset of dementia. However, reported conversion rates differ across studies and recruitment source.

from Dementia Big http://ift.tt/2bPARmi via alcoholic dementia


http://ift.tt/2bFgZlD

Study examines link between PTSD and cognitive impairment in WTC responders without head injury

New research published by the journal Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring confirms the connection between posttraumatic stress disorder (PTSD) and cognitive impairment - in this case, among those who helped with search, rescue and cleanup efforts following the 2001 World Trade Center (WTC) attacks.

from Dementia Big http://ift.tt/2bScXZE via alcoholic dementia


http://ift.tt/2bB6xOO

The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model

The Dominantly Inherited Alzheimer Network Trial Unit (DIAN-TU) is an adaptive platform trial testing multiple drugs to slow or prevent the progression of Alzheimer’s disease in autosomal dominant Alzheimer’s disease (ADAD) families. With completion of enrollment of the first two drug arms, the DIAN-TU now plans to add new drugs to the platform, designated as the Next Generation (NexGen) prevention trial.

from Dementia Big http://ift.tt/2bxEBgt via alcoholic dementia


http://ift.tt/2bB6fas

Monday, August 29, 2016

New research finds decrease in brain blood flow after stopping exercise in healthy older adults

New research finds decrease in brain blood flow after stopping exercise in healthy older adults:

Dementia Big
We all know that we can quickly lose cardiovascular endurance if we stop exercising for a few weeks, but what impact does the cessation of exercise have on our brains? New research led by University of Maryland School of Public Health researchers examined cerebral blood flow in healthy, physically fit older adults (ages 50-80 years) before and after a 10-day period during which they stopped all exercise.


http://ift.tt/2caadZo

Vesicles that trap amyloid appear to also contribute to Alzheimer's

Vesicles that trap amyloid appear to also contribute to Alzheimer's:

Dementia Big
Vesicles, fluid-filled sacs that brain cells make to trap amyloid, a hallmark of Alzheimer’s, appear to also contribute to the disease, scientists report.


http://ift.tt/2c0SzF4

Alzheimer's: Nicotinic receptors as a new therapeutic target

Alzheimer's: Nicotinic receptors as a new therapeutic target:

Dementia Big
Several scientific studies have indicated that nicotine may be beneficial for memory function. Scientists from the Institut Pasteur and the CNRS set out to shed further light on the properties attributed to nicotine - which is known to have an adverse effect on health - by determining the precise structure of the nicotinic receptors in the hippocampus region of the brain. Using mouse models for Alzheimer’s disease, they identified the β2 subunit of the nicotinic receptor as a target that, if blocked, prevents the memory loss associated with Alzheimer’s. These results were published in Neurobiology of Aging on August 12, 2016.


http://ift.tt/2ca9YgK

New test may help detect Parkinson's disease in early stages of illness

New test may help detect Parkinson's disease in early stages of illness:

Dementia Big
A test that can detect Parkinson’s disease in the early stages of the illness has moved a step closer.


http://ift.tt/2c0SBNv

New research finds decrease in brain blood flow after stopping exercise in healthy older adults

We all know that we can quickly lose cardiovascular endurance if we stop exercising for a few weeks, but what impact does the cessation of exercise have on our brains? New research led by University of Maryland School of Public Health researchers examined cerebral blood flow in healthy, physically fit older adults (ages 50-80 years) before and after a 10-day period during which they stopped all exercise.

from Dementia Big http://ift.tt/2bML6Ld via alcoholic dementia


http://ift.tt/2bxG5lE

Vesicles that trap amyloid appear to also contribute to Alzheimer's

Vesicles, fluid-filled sacs that brain cells make to trap amyloid, a hallmark of Alzheimer’s, appear to also contribute to the disease, scientists report.

from Dementia Big http://ift.tt/2bvxm76 via alcoholic dementia


http://ift.tt/2bxxSmJ

Alzheimer's: Nicotinic receptors as a new therapeutic target

Several scientific studies have indicated that nicotine may be beneficial for memory function. Scientists from the Institut Pasteur and the CNRS set out to shed further light on the properties attributed to nicotine - which is known to have an adverse effect on health - by determining the precise structure of the nicotinic receptors in the hippocampus region of the brain. Using mouse models for Alzheimer’s disease, they identified the β2 subunit of the nicotinic receptor as a target that, if blocked, prevents the memory loss associated with Alzheimer’s. These results were published in Neurobiology of Aging on August 12, 2016.

from Dementia Big http://ift.tt/2bykslO via alcoholic dementia


http://ift.tt/2bxHgBB

New test may help detect Parkinson's disease in early stages of illness

A test that can detect Parkinson’s disease in the early stages of the illness has moved a step closer.

from Dementia Big http://ift.tt/2bPYHAs via alcoholic dementia


http://ift.tt/2bxxepd

Saturday, August 27, 2016

Western diet increases Alzheimer's risk

Globally, about 42 million people now have dementia, with Alzheimer’s disease as the most common type of dementia. Rates of Alzheimer’s disease are rising worldwide. The most important risk factors seem to be linked to diet, especially the consumption of meat, sweets, and high-fat dairy products that characterize a Western Diet. For example, when Japan made the nutrition transition from the traditional Japanese diet to the Western diet, Alzheimer’s disease rates rose from 1% in 1985 to 7% in 2008, with rates lagging the nutrition transition by 20-25 years. The evidence of these risk factors, which come from ecological and observational studies, also shows that fruits, vegetables, grains, low-fat dairy products, legumes, and fish are associated with reduced risk. “Using Multicountry Ecological and Observational Studies to Determine Dietary Risk Factors for Alzheimer’s Disease,” a review article from the Journal of the American College of Nutrition presents the data.

from Dementia Big http://ift.tt/2bu5E9u via alcoholic dementia


http://ift.tt/2bWwN5o

Stiff arteries can negatively impact memory and vital brain processes

As we age, our arteries gradually become less flexible, making it harder for the heart to pump blood throughout the body.

from Dementia Big http://ift.tt/2bUwHKh via alcoholic dementia


http://ift.tt/2ci9JSf

Stiff arteries can negatively impact memory and vital brain processes

Stiff arteries can negatively impact memory and vital brain processes:

Dementia Big
As we age, our arteries gradually become less flexible, making it harder for the heart to pump blood throughout the body.


http://ift.tt/2bWwiIx

Western diet increases Alzheimer's risk

Western diet increases Alzheimer's risk:

Dementia Big
Globally, about 42 million people now have dementia, with Alzheimer’s disease as the most common type of dementia. Rates of Alzheimer’s disease are rising worldwide. The most important risk factors seem to be linked to diet, especially the consumption of meat, sweets, and high-fat dairy products that characterize a Western Diet. For example, when Japan made the nutrition transition from the traditional Japanese diet to the Western diet, Alzheimer’s disease rates rose from 1% in 1985 to 7% in 2008, with rates lagging the nutrition transition by 20-25 years. The evidence of these risk factors, which come from ecological and observational studies, also shows that fruits, vegetables, grains, low-fat dairy products, legumes, and fish are associated with reduced risk. “Using Multicountry Ecological and Observational Studies to Determine Dietary Risk Factors for Alzheimer’s Disease,” a review article from the Journal of the American College of Nutrition presents the data.


http://ift.tt/2ci9x5e

Friday, August 26, 2016

Western dietary pattern linked to risk of developing Alzheimer's disease

Globally, about 42 million people now have dementia, with Alzheimer’s disease as the most common type of dementia. Rates of Alzheimer’s disease are rising worldwide.

from Dementia Big http://ift.tt/2bj4Xy1 via alcoholic dementia


http://ift.tt/2bnk2Dn

Advances in brain research since patient HM: an interview with Dr Jacopo Annese

Jacopo Annese, President and CEO of the Institute for Brain and Society, a non-profit organization dedicated to democratizing neuroscience and making neuroscience tools and knowledge about the brain more available to the public, discusses his work on the Human Brain Library.

from Dementia Big http://ift.tt/2bigByL via alcoholic dementia


http://ift.tt/2bMaobB

Medical students developing smart helmet to help diagnose concussions

A smart helmet that can help diagnose concussions in football players is being developed by medical students at Texas Tech University Health Sciences Center El Paso.

from Dementia Big http://ift.tt/2bkNZim via alcoholic dementia


http://ift.tt/2bnjOff

Elevating brain protein allays symptoms of Alzheimer's and improves memory

Boosting levels of a specific protein in the brain alleviates hallmark features of Alzheimer’s disease in a mouse model of the disorder, according to new research published online August 25, 2016 in Scientific Reports.

from Dementia Big http://ift.tt/2bijsCe via alcoholic dementia


http://ift.tt/2bMagZt

Research supports potential role for cognitive activity in prevention of Alzheimer's disease

Are there any ways of preventing or delaying the development of Alzheimer’s disease or other forms of age-associated dementia? While several previously published studies have suggested a protective effect for cognitive activities such as reading, playing games or attending cultural events, questions have been raised about whether these studies reveal a real cause-and-effect relationship or if the associations could result from unmeasured factors.

from Dementia Big http://ift.tt/2bBEzzQ via alcoholic dementia


http://ift.tt/2bnkmlk

Medical students developing smart helmet to help diagnose concussions

Medical students developing smart helmet to help diagnose concussions:

Dementia Big
A smart helmet that can help diagnose concussions in football players is being developed by medical students at Texas Tech University Health Sciences Center El Paso.


http://ift.tt/2bMa8JA

Western dietary pattern linked to risk of developing Alzheimer's disease

Western dietary pattern linked to risk of developing Alzheimer's disease:

Dementia Big
Globally, about 42 million people now have dementia, with Alzheimer’s disease as the most common type of dementia. Rates of Alzheimer’s disease are rising worldwide.


http://ift.tt/2bnjAVv

Advances in brain research since patient HM: an interview with Dr Jacopo Annese

Advances in brain research since patient HM: an interview with Dr Jacopo Annese:

Dementia Big
Jacopo Annese, President and CEO of the Institute for Brain and Society, a non-profit organization dedicated to democratizing neuroscience and making neuroscience tools and knowledge about the brain more available to the public, discusses his work on the Human Brain Library.


http://ift.tt/2bMc6t8

Research supports potential role for cognitive activity in prevention of Alzheimer's disease

Research supports potential role for cognitive activity in prevention of Alzheimer's disease:

Dementia Big
Are there any ways of preventing or delaying the development of Alzheimer’s disease or other forms of age-associated dementia? While several previously published studies have suggested a protective effect for cognitive activities such as reading, playing games or attending cultural events, questions have been raised about whether these studies reveal a real cause-and-effect relationship or if the associations could result from unmeasured factors.


http://ift.tt/2bnjBZz

Elevating brain protein allays symptoms of Alzheimer's and improves memory

Elevating brain protein allays symptoms of Alzheimer's and improves memory:

Dementia Big
Boosting levels of a specific protein in the brain alleviates hallmark features of Alzheimer’s disease in a mouse model of the disorder, according to new research published online August 25, 2016 in Scientific Reports.


http://ift.tt/2bMa3FO

Wednesday, August 24, 2016

Study strengthens evidence that cognitive activity can reduce dementia risk

Are there any ways of preventing or delaying the development of Alzheimer’s disease or other forms of age-associated dementia? While several previously published studies have suggested a protective effect for cognitive activities such as reading, playing games or attending cultural events, questions have been raised about whether these studies reveal a real cause-and-effect relationship or if the associations could result from unmeasured factors. To address this question, a Boston-based research team conducted a formal bias analysis and concluded that, while potentially confounding factors might have affected previous studies’ results, it is doubtful that such factors totally account for observed associations between cognitive activities and a reduced risk of dementia.

from Dementia Big http://ift.tt/2bnXIq6 via alcoholic dementia


http://ift.tt/2bhyLhr

Study strengthens evidence that cognitive activity can reduce dementia risk

Study strengthens evidence that cognitive activity can reduce dementia risk:

Dementia Big
Are there any ways of preventing or delaying the development of Alzheimer’s disease or other forms of age-associated dementia? While several previously published studies have suggested a protective effect for cognitive activities such as reading, playing games or attending cultural events, questions have been raised about whether these studies reveal a real cause-and-effect relationship or if the associations could result from unmeasured factors. To address this question, a Boston-based research team conducted a formal bias analysis and concluded that, while potentially confounding factors might have affected previous studies’ results, it is doubtful that such factors totally account for observed associations between cognitive activities and a reduced risk of dementia.


http://ift.tt/2boJIfT

Tuesday, August 23, 2016

Multivariate analysis improves on cognitive testing in Alzheimer's disease

Multivariate analysis of cognitive tests in Alzheimer’s disease identifies five distinct groups of Alzheimer’s disease patients, and suggests that multivitamins might slow progression only in certain groups.

from Dementia Big http://ift.tt/2bciihh via alcoholic dementia


http://ift.tt/2btih6p

Multivariate analysis improves on cognitive testing in Alzheimer's disease

Multivariate analysis improves on cognitive testing in Alzheimer's disease:

Dementia Big
Multivariate analysis of cognitive tests in Alzheimer’s disease identifies five distinct groups of Alzheimer’s disease patients, and suggests that multivitamins might slow progression only in certain groups.


http://ift.tt/2bjHZsg

Friday, August 19, 2016

Researchers unravel mechanism by which hippocampal stem cells regulate their own fate

Researchers unravel mechanism by which hippocampal stem cells regulate their own fate:

Dementia Big
To date, it has been assumed that the differentiation of stem cells depends on the environment they are embedded in.


http://ift.tt/2bsuCsS

From pollution to caffeine intake - Imperial researcher reveals dementia risks

From pollution to caffeine intake - Imperial researcher reveals dementia risks:

Dementia Big
Dementia strikes one in 14 people in the UK over 65, and 47 million people worldwide. Yet scientists are still urgently trying to find why the disease affects some but not others.


http://ift.tt/2bp8Z8F

Neuropsychologist pinpoints risk factors for dementia

Neuropsychologist pinpoints risk factors for dementia:

Dementia Big
Dementia strikes one in 14 people in the UK over 65, and 47 million people worldwide.Yet scientists are still urgently trying to find why the disease affects some but not others.


http://ift.tt/2bsvyOa

Associations of neighborhood environment with brain imaging outcomes in the AIBL cohort

Associations of neighborhood environment with brain imaging outcomes in the AIBL cohort:

Dementia Big
“Walkable” neighborhoods offer older adults opportunities for activities that may benefit cognition-related biological mechanisms. These have not previously been examined in this context.


http://ift.tt/2bp96kq

Neuropsychologist pinpoints risk factors for dementia

Dementia strikes one in 14 people in the UK over 65, and 47 million people worldwide.Yet scientists are still urgently trying to find why the disease affects some but not others.

from Dementia Big http://ift.tt/2bn1G3h via alcoholic dementia


http://ift.tt/2bsvy0s

Researchers unravel mechanism by which hippocampal stem cells regulate their own fate

To date, it has been assumed that the differentiation of stem cells depends on the environment they are embedded in.

from Dementia Big http://ift.tt/2b4eP1s via alcoholic dementia


http://ift.tt/2bp9bEz

From pollution to caffeine intake - Imperial researcher reveals dementia risks

Dementia strikes one in 14 people in the UK over 65, and 47 million people worldwide. Yet scientists are still urgently trying to find why the disease affects some but not others.

from Dementia Big http://ift.tt/2b4NWaf via alcoholic dementia


http://ift.tt/2bsv6zv

Associations of neighborhood environment with brain imaging outcomes in the AIBL cohort

“Walkable” neighborhoods offer older adults opportunities for activities that may benefit cognition-related biological mechanisms. These have not previously been examined in this context.

from Dementia Big http://ift.tt/2b1Kfqy via alcoholic dementia


http://ift.tt/2bp98sl

Thursday, August 18, 2016

Researchers discover gene linked to age-related hearing loss

Researchers discover gene linked to age-related hearing loss:

Dementia Big
A large screening programme has identified several genes associated with age-related conditions including hearing loss, retinal degeneration and osteoarthritis.


http://ift.tt/2bAHASB

Scientists reveal why people with the ApoE4 gene are more susceptible to Alzheimer's disease

Scientists reveal why people with the ApoE4 gene are more susceptible to Alzheimer's disease:

Dementia Big
For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer’s disease at age 65 than the rest of the population. Now, researchers at the Salk Institute have identified a connection between ApoE4 and protein build-up associated with Alzheimer’s that provides a possible biochemical explanation for how extra ApoE4 causes the disease.


http://ift.tt/2bAHg6h

Research shines more light on role of proteins in maintaining synaptic transmission

Research shines more light on role of proteins in maintaining synaptic transmission:

Dementia Big
Synapses are the power junctions that allow living creatures to function. Popularly associated with learning and memory, they play a more fundamental role in our existence by regulating everything from breathing, sleeping and waking and other bodily functions.


http://ift.tt/2bqwily

Salk researchers identify new mechanism for Alzheimer's risk gene

Salk researchers identify new mechanism for Alzheimer's risk gene:

Dementia Big
For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer’s disease at age 65 than the rest of the population.


http://ift.tt/2bqwhhu

Society needs to challenge ageism more, says leading gericare expert

Society needs to challenge ageism more, says leading gericare expert:

Dementia Big
An interactive “dementia atlas” published online by the Department of Health needs to lead to society challenging ageism more, according to a leading expert on the care of older people at City University London.


http://ift.tt/2bqxC8a

Researchers discover gene linked to age-related hearing loss

A large screening programme has identified several genes associated with age-related conditions including hearing loss, retinal degeneration and osteoarthritis.

from Dementia Big http://ift.tt/2bhqWb2 via alcoholic dementia


http://ift.tt/2b24q93

Salk researchers identify new mechanism for Alzheimer's risk gene

For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer’s disease at age 65 than the rest of the population.

from Dementia Big http://ift.tt/2bgFGaa via alcoholic dementia


http://ift.tt/2biEGlZ

Scientists reveal why people with the ApoE4 gene are more susceptible to Alzheimer's disease

For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer’s disease at age 65 than the rest of the population. Now, researchers at the Salk Institute have identified a connection between ApoE4 and protein build-up associated with Alzheimer’s that provides a possible biochemical explanation for how extra ApoE4 causes the disease.

from Dementia Big http://ift.tt/2b014xl via alcoholic dementia


http://ift.tt/2b23Yb8

Society needs to challenge ageism more, says leading gericare expert

An interactive “dementia atlas” published online by the Department of Health needs to lead to society challenging ageism more, according to a leading expert on the care of older people at City University London.

from Dementia Big http://ift.tt/2byb5EQ via alcoholic dementia


http://ift.tt/2biEbs5

Research shines more light on role of proteins in maintaining synaptic transmission

Synapses are the power junctions that allow living creatures to function. Popularly associated with learning and memory, they play a more fundamental role in our existence by regulating everything from breathing, sleeping and waking and other bodily functions.

from Dementia Big http://ift.tt/2bthekh via alcoholic dementia


http://ift.tt/2b24ohr

Wednesday, August 17, 2016

Physical function tied to clinical, subclinical neurological disease

(HealthDay)—Physical function is associated with clinical and subclinical brain disease, according to a study published online Aug. 8 in the Journal of Alzheimer’s Disease.

from Dementia Big http://ift.tt/2bljvSv via alcoholic dementia


http://ift.tt/2aUAwTe

Modifying huntingtin protein protects against behavioral symptoms in Huntington's model mice

There is new hope in the fight against Huntington’s disease. Scientists at the Gladstone Institutes discovered that changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.

from Dementia Big http://ift.tt/2bDMX6J via alcoholic dementia


http://ift.tt/2brcQSW

Healthy BMI, exercise and diet can lower abnormal protein build-ups linked to Alzheimer’s

A study by researchers at UCLA’s Semel Institute for Neuroscience and Human Behavior has found that a healthy diet, regular physical activity and a normal body mass index can reduce the incidence of protein build-ups that are associated with the onset of Alzheimer’s disease.

from Dementia Big http://ift.tt/2bk1wuM via alcoholic dementia


http://ift.tt/2aUAw5v

Use of feeding tubes decreases among nursing home residents with advanced dementia

In a study appearing in the August 16 issue of JAMA, Susan L. Mitchell, M.D., M.P.H., of Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, and colleagues examined feeding tube insertion rates from 2000-2014 among U.S. nursing home residents with advanced dementia.

from Dementia Big http://ift.tt/2b1q5dH via alcoholic dementia


http://ift.tt/2brdu2M

Diet and exercise can reduce protein build-ups linked to Alzheimer's

A study by researchers at UCLA’s Semel Institute for Neuroscience and Human Behavior has found that a healthy diet, regular physical activity and a normal body mass index can reduce the incidence of protein build-ups that are associated with the onset of Alzheimer’s disease.

from Dementia Big http://ift.tt/2beak1Q via alcoholic dementia


http://ift.tt/2b0BwU1

Physical function tied to clinical, subclinical neurological disease

Physical function tied to clinical, subclinical neurological disease:

Dementia Big
(HealthDay)—Physical function is associated with clinical and subclinical brain disease, according to a study published online Aug. 8 in the Journal of Alzheimer’s Disease.


http://ift.tt/2bG8jQY

Modifying huntingtin protein protects against behavioral symptoms in Huntington's model mice

Modifying huntingtin protein protects against behavioral symptoms in Huntington's model mice:

Dementia Big
There is new hope in the fight against Huntington’s disease. Scientists at the Gladstone Institutes discovered that changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.


http://ift.tt/2b3FkTe

Use of feeding tubes decreases among nursing home residents with advanced dementia

Use of feeding tubes decreases among nursing home residents with advanced dementia:

Dementia Big
In a study appearing in the August 16 issue of JAMA, Susan L. Mitchell, M.D., M.P.H., of Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, and colleagues examined feeding tube insertion rates from 2000-2014 among U.S. nursing home residents with advanced dementia.


http://ift.tt/2bG98JP

Healthy BMI, exercise and diet can lower abnormal protein build-ups linked to Alzheimer’s

Healthy BMI, exercise and diet can lower abnormal protein build-ups linked to Alzheimer’s:

Dementia Big
A study by researchers at UCLA’s Semel Institute for Neuroscience and Human Behavior has found that a healthy diet, regular physical activity and a normal body mass index can reduce the incidence of protein build-ups that are associated with the onset of Alzheimer’s disease.


http://ift.tt/2b3Ey8P

Diet and exercise can reduce protein build-ups linked to Alzheimer's

Diet and exercise can reduce protein build-ups linked to Alzheimer's:

Dementia Big
A study by researchers at UCLA’s Semel Institute for Neuroscience and Human Behavior has found that a healthy diet, regular physical activity and a normal body mass index can reduce the incidence of protein build-ups that are associated with the onset of Alzheimer’s disease.


http://ift.tt/2bG9gsG

Saturday, August 13, 2016

RACP releases new Choosing Wisely Australia recommendations on appropriate use of medicines for older adults

RACP releases new Choosing Wisely Australia recommendations on appropriate use of medicines for older adults:

Dementia Big
The latest lists developed by specialties from the Royal Australasian College of Physicians as part of the Choosing Wisely Australia initiative deliver a strong message on appropriate use of medicines for older Australians.


http://ift.tt/2bqxyWq

RACP releases new Choosing Wisely Australia recommendations on appropriate use of medicines for older adults

The latest lists developed by specialties from the Royal Australasian College of Physicians as part of the Choosing Wisely Australia initiative deliver a strong message on appropriate use of medicines for older Australians.

from Dementia Big http://ift.tt/2aRkxlK via alcoholic dementia


http://ift.tt/2be61Xu

Friday, August 12, 2016

Combining virtual reality and treadmill training could help reduce risk of falls in older adults

Combining virtual reality and treadmill training could help reduce risk of falls in older adults:

Dementia Big
Combining virtual reality and treadmill training helps prevent falls in older adults better than treadmill training alone, according to a new randomised controlled trial published in The Lancet.


http://ift.tt/2aQ2kWT

Commonly used anti-inflammatory drug shows potential to treat Alzheimer's disease

Commonly used anti-inflammatory drug shows potential to treat Alzheimer's disease:

Dementia Big
A research project has shown that an experimental model of Alzheimer’s disease can be successfully treated with a commonly used anti-inflammatory drug.


http://ift.tt/2b2asRY

Being overweight associated with reduced white matter volume

Being overweight associated with reduced white matter volume:

Dementia Big
From middle-age onwards, the brains of people who are obese or overweight exhibit differences in white matter similar to lean individuals who are 10 years their senior, according to researchers from the University of Cambridge.


http://ift.tt/2aQ2uO7

Treatment option for Alzheimer's disease possible

Treatment option for Alzheimer's disease possible:

Dementia Big
A research project has shown that an experimental model of Alzheimer’s disease can be successfully treated with a commonly used anti-inflammatory drug.


http://ift.tt/2b2anhj

Commonly used anti-inflammatory drug shows potential to treat Alzheimer's disease

A research project has shown that an experimental model of Alzheimer’s disease can be successfully treated with a commonly used anti-inflammatory drug.

from Dementia Big http://ift.tt/2aOp9sU via alcoholic dementia


http://ift.tt/2aQ2gXv

Combining virtual reality and treadmill training could help reduce risk of falls in older adults

Combining virtual reality and treadmill training helps prevent falls in older adults better than treadmill training alone, according to a new randomised controlled trial published in The Lancet.

from Dementia Big http://ift.tt/2blr0t0 via alcoholic dementia


http://ift.tt/2b2amKg

Being overweight associated with reduced white matter volume

From middle-age onwards, the brains of people who are obese or overweight exhibit differences in white matter similar to lean individuals who are 10 years their senior, according to researchers from the University of Cambridge.

from Dementia Big http://ift.tt/2aVfFOa via alcoholic dementia


http://ift.tt/2aQ2uxB

Treatment option for Alzheimer's disease possible

A research project has shown that an experimental model of Alzheimer’s disease can be successfully treated with a commonly used anti-inflammatory drug.

from Dementia Big http://ift.tt/2bkPr5Y via alcoholic dementia


http://ift.tt/2b2aMA6

Wednesday, August 10, 2016

Gene signature in healthy brains pinpoints the origins of Alzheimer's disease

Gene signature in healthy brains pinpoints the origins of Alzheimer's disease:

Dementia Big
Researchers have discovered a gene signature in healthy brains that echoes the pattern in which Alzheimer’s disease spreads through the brain much later in life. The findings, published in the journal Science Advances, could help uncover the molecular origins of this devastating disease, and may be used to develop preventative treatments for at-risk individuals to be taken well before symptoms appear.


http://ift.tt/2b9AN55

Study reveals association between physical function and neurological disease

Study reveals association between physical function and neurological disease:

Dementia Big
A new study, based on data from the Framingham Heart Study (FHS) suggests a simple test of physical functioning may be able to help physicians identify individuals who are at a higher risk for developing Alzheimer’s disease and stroke.


http://ift.tt/2bkdrGn

Easy-to-test clinical markers may help identify people at risk for age-related neurological diseases

Easy-to-test clinical markers may help identify people at risk for age-related neurological diseases:

Dementia Big
A new study, based on data from the Framingham Heart Study suggests a simple test of physical functioning may be able to help physicians identify individuals who are at a higher risk for developing Alzheimer’s disease and stroke.


http://ift.tt/2b9AxTx

Mixed brain lesions mediate the association between cardiovascular risk burden and cognitive decline in old age: A population-based study

Mixed brain lesions mediate the association between cardiovascular risk burden and cognitive decline in old age: A population-based study:

Dementia Big
The underlying pathological mechanisms linking cardiovascular burden to cognitive decline remain unclear.


http://ift.tt/2bkdvpn

Researchers use imaging technique to predict dementia status in adults with down syndrome

Researchers use imaging technique to predict dementia status in adults with down syndrome:

Dementia Big
Researchers at the University of Kentucky Sanders-Brown Center on Aging found that magnetic resonance spectroscopy (MRS), a noninvasive imaging technique, might help distinguish between people with Down syndrome who have dementia and those who do not. The researchers describe their findings in an article published in the journal, NeuroImage: Clinical.


http://ift.tt/2b9zSSh

An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease

An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease:

Dementia Big
Cerebrovascular lesions on MRI are common in Alzheimer’s disease (AD) dementia, but less is known about their frequency and impact on dementia with Lewy bodies (DLB).


http://ift.tt/2bkdVfG

Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation

Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation:

Dementia Big
TREM2 is a lipid-sensing activating receptor on microglia known to be important for Alzheimer’s disease (AD), but whether it plays a beneficial or detrimental role in disease pathogenesis is controversial.


http://ift.tt/2b9AebD

Mild cognitive impairment and risk of depression and anxiety: a population-based study

Mild cognitive impairment and risk of depression and anxiety: a population-based study:

Dementia Big
Many people with mild cognitive impairment (MCI) suffer from concomitant depression or anxiety. Whether MCI increases the risk of future depression or anxiety is unknown.


http://ift.tt/2bkdRfM

Gene signature in healthy brains pinpoints the origins of Alzheimer's disease

Researchers have discovered a gene signature in healthy brains that echoes the pattern in which Alzheimer’s disease spreads through the brain much later in life. The findings, published in the journal Science Advances, could help uncover the molecular origins of this devastating disease, and may be used to develop preventative treatments for at-risk individuals to be taken well before symptoms appear.

from Dementia Big http://ift.tt/2aM7yD9 via alcoholic dementia


http://ift.tt/2b9ANCf

Easy-to-test clinical markers may help identify people at risk for age-related neurological diseases

A new study, based on data from the Framingham Heart Study suggests a simple test of physical functioning may be able to help physicians identify individuals who are at a higher risk for developing Alzheimer’s disease and stroke.

from Dementia Big http://ift.tt/2bgpRC3 via alcoholic dementia


http://ift.tt/2bkdLVD

Study reveals association between physical function and neurological disease

A new study, based on data from the Framingham Heart Study (FHS) suggests a simple test of physical functioning may be able to help physicians identify individuals who are at a higher risk for developing Alzheimer’s disease and stroke.

from Dementia Big http://ift.tt/2aZcTqu via alcoholic dementia


http://ift.tt/2b9AnMe

Researchers use imaging technique to predict dementia status in adults with down syndrome

Researchers at the University of Kentucky Sanders-Brown Center on Aging found that magnetic resonance spectroscopy (MRS), a noninvasive imaging technique, might help distinguish between people with Down syndrome who have dementia and those who do not. The researchers describe their findings in an article published in the journal, NeuroImage: Clinical.

from Dementia Big http://ift.tt/2aYXqXA via alcoholic dementia


http://ift.tt/2bkeNRp

Mixed brain lesions mediate the association between cardiovascular risk burden and cognitive decline in old age: A population-based study

The underlying pathological mechanisms linking cardiovascular burden to cognitive decline remain unclear.

from Dementia Big http://ift.tt/2aTFL4b via alcoholic dementia


http://ift.tt/2b9AHKO

Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation

TREM2 is a lipid-sensing activating receptor on microglia known to be important for Alzheimer’s disease (AD), but whether it plays a beneficial or detrimental role in disease pathogenesis is controversial.

from Dementia Big http://ift.tt/2bdOP63 via alcoholic dementia


http://ift.tt/2bkdL80

An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease

Cerebrovascular lesions on MRI are common in Alzheimer’s disease (AD) dementia, but less is known about their frequency and impact on dementia with Lewy bodies (DLB).

from Dementia Big http://ift.tt/2aTFXjP via alcoholic dementia


http://ift.tt/2b9AdV7

Mild cognitive impairment and risk of depression and anxiety: a population-based study

Many people with mild cognitive impairment (MCI) suffer from concomitant depression or anxiety. Whether MCI increases the risk of future depression or anxiety is unknown.

from Dementia Big http://ift.tt/2aKB3Uz via alcoholic dementia


http://ift.tt/2aXJIlD

Tuesday, August 9, 2016

MedDiet improves memory and slows cognitive decline, study shows

MedDiet improves memory and slows cognitive decline, study shows:

Dementia Big
Eating a Mediterranean diet can slow down cognitive decline.The Mediterranean diet can improve your mind, as well your heart, shows a study published in the open-access journal


http://ift.tt/2bhfxXs

Older adults experience restriction on rights to sexual freedom in assisted-living facilities, study finds

Older adults experience restriction on rights to sexual freedom in assisted-living facilities, study finds:

Dementia Big
Older adults in assisted-living facilities experience limits to their rights to sexual freedom because of a lack of policies regarding the issue and the actions of staff and administrators at these facilities, according to research conducted by the Gerontology Institute at Georgia State University.


http://ift.tt/2b6jUYX

Quest Diagnostics introduces digital cognitive assessment tool to help physicians assess patients with dementia

Quest Diagnostics introduces digital cognitive assessment tool to help physicians assess patients with dementia:

Dementia Big
Quest Diagnostics, the world’s leading provider of diagnostic information services, today announced CogniSense, a digital cognitive assessment tool that aids in a physician’s assessment, diagnosis and care management of individuals with cognitive dysfunction.


http://ift.tt/2bhfr2h

Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery

Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery:

Dementia Big
Alzheimer’s disease (AD) progression follows a specific spreading pattern, emphasizing the need to characterize those brain areas that degenerate first. The brainstem’s locus coeruleus (LC) is the first area to develop neurofibrillary changes (neurofibrillary tangles [NFTs]).


http://ift.tt/2b6jGB2

Older adults experience restriction on rights to sexual freedom in assisted-living facilities, study finds

Older adults in assisted-living facilities experience limits to their rights to sexual freedom because of a lack of policies regarding the issue and the actions of staff and administrators at these facilities, according to research conducted by the Gerontology Institute at Georgia State University.

from Dementia Big http://ift.tt/2b2orKT via alcoholic dementia


http://ift.tt/2bheCGs

MedDiet improves memory and slows cognitive decline, study shows

Eating a Mediterranean diet can slow down cognitive decline.The Mediterranean diet can improve your mind, as well your heart, shows a study published in the open-access journal

from Dementia Big http://ift.tt/2aDIHi0 via alcoholic dementia


http://ift.tt/2b6jrpE

Quest Diagnostics introduces digital cognitive assessment tool to help physicians assess patients with dementia

Quest Diagnostics, the world’s leading provider of diagnostic information services, today announced CogniSense, a digital cognitive assessment tool that aids in a physician’s assessment, diagnosis and care management of individuals with cognitive dysfunction.

from Dementia Big http://ift.tt/2b7DYrc via alcoholic dementia


http://ift.tt/2b6jH8m

Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery

Alzheimer’s disease (AD) progression follows a specific spreading pattern, emphasizing the need to characterize those brain areas that degenerate first. The brainstem’s locus coeruleus (LC) is the first area to develop neurofibrillary changes (neurofibrillary tangles [NFTs]).

from Dementia Big http://ift.tt/2b9DcNo via alcoholic dementia


http://ift.tt/2bheV42

Sunday, August 7, 2016

Medical and Scientific Advisory Council

Medical and Scientific Advisory Council:

Dementia Big
A Scilly family is cycling unsupported from John O’Groats to Land’s End to raise money for charity – despite only having five miles of island road to practice on.


http://ift.tt/2aDsniH

Subscriber Information

Subscriber Information:

Dementia Big


http://ift.tt/2b3yOQ8

Contents

Contents:

Dementia Big


http://ift.tt/2aDsnj0

Alzheimer's Association Update

Alzheimer's Association Update:

Dementia Big
The Alzheimer’s Association has announced a $4.3 million research grant to support a new phase of the Dominantly Inherited Alzheimer’s Network Trials Unit (DIAN-TU) known as DIAN-TU Next Generation (NexGen). The award will accelerate testing of potential Alzheimer’s disease (AD) therapies, as well as testing of new diagnostic approaches, in people with genetically based, younger-onset AD or dominantly inherited AD (DIAD) using an innovative trial design that is being applied to AD. DIAN-TU is a landmark, global AD prevention study led by researchers at Washington University in St.


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Editorial Board

Editorial Board:

Dementia Big


http://ift.tt/2aDsfQm

Contents

from Dementia Big http://ift.tt/2aDrI0I via alcoholic dementia


http://ift.tt/2arly6Q

Medical and Scientific Advisory Council

A Scilly family is cycling unsupported from John O’Groats to Land’s End to raise money for charity – despite only having five miles of island road to practice on.



from Dementia Big http://ift.tt/2aDr5V0 via alcoholic dementia
http://ift.tt/2bbQjcQ

Editorial Board

from Dementia Big http://ift.tt/2aDrOpi via alcoholic dementia


http://ift.tt/2armVSX

Subscriber Information

from Dementia Big http://ift.tt/2b3xjl7 via alcoholic dementia


http://ift.tt/2aDrOWk

Alzheimer's Association Update

The Alzheimer’s Association has announced a $4.3 million research grant to support a new phase of the Dominantly Inherited Alzheimer’s Network Trials Unit (DIAN-TU) known as DIAN-TU Next Generation (NexGen). The award will accelerate testing of potential Alzheimer’s disease (AD) therapies, as well as testing of new diagnostic approaches, in people with genetically based, younger-onset AD or dominantly inherited AD (DIAD) using an innovative trial design that is being applied to AD. DIAN-TU is a landmark, global AD prevention study led by researchers at Washington University in St.

from Dementia Big http://ift.tt/2b3xf4N via alcoholic dementia


http://ift.tt/2b0tDAc

Friday, August 5, 2016

Therapeutic strategies targeting Alzheimer's disease-related molecules

Therapeutic strategies targeting Alzheimer's disease-related molecules:

Dementia Big
Therapeutic strategies targeting Alzheimer’s disease (AD)-related molecule β-amyloid (Aβ), Tau protein and BACE enzyme have been recently explored. However, the therapeutic efficacy for a single target is not ideal. The clinical trials that clean Aβ from the brain in AD patients were largely unsuccessful. It is well known that the inflammatory response is one component of AD pathogenesis, leading to a series of irreversible pathological events. Epidemiological evidences show that long-term use of non-steroidal anti-inflammatory drugs has a sparing role in AD, but it failed to prevent the progression of symptoms in AD patients in randomized clinical trials. Possible reasons for the failure of anti-inflammatory drugs may be associated with: 1) the advanced state of disease or the dosing regimens of drugs; 2) most of the available anti-inflammatory drugs are not really “anti-inflammatory”; 3) these “anti-inflammatory” drugs only prevent the pro-inflammatory responses, but do not trigger the anti-inflammatory responses.


http://ift.tt/2aY19qs

Researchers describe structure of Alzheimer fibrils at atomic resolution

Researchers describe structure of Alzheimer fibrils at atomic resolution:

Dementia Big
Elongated fibres (fibrils) of the beta-amyloid protein form the typical senile plaque present in the brains of patients with Alzheimer’s disease.


http://ift.tt/2aASOpx

Therapeutic strategies targeting Alzheimer's disease-related molecules

Therapeutic strategies targeting Alzheimer’s disease (AD)-related molecule β-amyloid (Aβ), Tau protein and BACE enzyme have been recently explored. However, the therapeutic efficacy for a single target is not ideal. The clinical trials that clean Aβ from the brain in AD patients were largely unsuccessful. It is well known that the inflammatory response is one component of AD pathogenesis, leading to a series of irreversible pathological events. Epidemiological evidences show that long-term use of non-steroidal anti-inflammatory drugs has a sparing role in AD, but it failed to prevent the progression of symptoms in AD patients in randomized clinical trials. Possible reasons for the failure of anti-inflammatory drugs may be associated with: 1) the advanced state of disease or the dosing regimens of drugs; 2) most of the available anti-inflammatory drugs are not really “anti-inflammatory”; 3) these “anti-inflammatory” drugs only prevent the pro-inflammatory responses, but do not trigger the anti-inflammatory responses.

from Dementia Big http://ift.tt/2aDuC7u via alcoholic dementia


http://ift.tt/2aBEd18

Researchers describe structure of Alzheimer fibrils at atomic resolution

Elongated fibres (fibrils) of the beta-amyloid protein form the typical senile plaque present in the brains of patients with Alzheimer’s disease.

from Dementia Big http://ift.tt/2b7hmq0 via alcoholic dementia


http://ift.tt/2aPfLWT

Thursday, August 4, 2016

Alzheimer fibrils at atomic resolution

Alzheimer fibrils at atomic resolution:

Dementia Big
Elongated fibres (fibrils) of the beta-amyloid protein form the typical senile plaque present in the brains of patients with Alzheimer’s disease. A European research team, working in conjunction with a team from the United States, has now succeeded in explaining the structure of the beta-amyloid peptide 1–42, which is the most important to the illness, at atomic resolution. This simplifies the targeted search for medicinal products to treat Alzheimer’s dementia.


http://ift.tt/2axAk7l

New app helps people with dementia stay connected to memories

New app helps people with dementia stay connected to memories:

Dementia Big
People suffering from Alzheimer’s and other forms of age-related dementia sometimes have trouble recognizing friends and family or knowing what to talk about when they visit.


http://ift.tt/2ayEyi6

Research findings may have implications for ALS and other neurological disorders

Research findings may have implications for ALS and other neurological disorders:

Dementia Big
Amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) is a progressive disorder that devastates motor nerve cells. People diagnosed with ALS slowly lose the ability to control muscle movement, and are ultimately unable to speak, eat, move, or breathe.


http://ift.tt/2axAI5J

New biochip test helps identify individuals at increased risk of Alzheimer's disease

New biochip test helps identify individuals at increased risk of Alzheimer's disease:

Dementia Big
Researchers today unveiled results from a new blood test to help identify which patients are at an elevated risk of Alzheimer’s disease.


http://ift.tt/2axBMGv

Study suggests 'use it or lose it' to defend against memory loss

Study suggests 'use it or lose it' to defend against memory loss:

Dementia Big
Iowa State University researchers have identified a protein essential for building memories that appears to predict the progression of memory loss and brain atrophy in Alzheimer’s patients.


http://ift.tt/2ayEJtJ

Alzheimer fibrils at atomic resolution

Elongated fibres (fibrils) of the beta-amyloid protein form the typical senile plaque present in the brains of patients with Alzheimer’s disease. A European research team, working in conjunction with a team from the United States, has now succeeded in explaining the structure of the beta-amyloid peptide 1–42, which is the most important to the illness, at atomic resolution. This simplifies the targeted search for medicinal products to treat Alzheimer’s dementia.

from Dementia Big http://ift.tt/2b51Vyj via alcoholic dementia


http://ift.tt/2ayFcfm

Research findings may have implications for ALS and other neurological disorders

Amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) is a progressive disorder that devastates motor nerve cells. People diagnosed with ALS slowly lose the ability to control muscle movement, and are ultimately unable to speak, eat, move, or breathe.

from Dementia Big http://ift.tt/2aDUPjI via alcoholic dementia


http://ift.tt/2axBcst

New app helps people with dementia stay connected to memories

People suffering from Alzheimer’s and other forms of age-related dementia sometimes have trouble recognizing friends and family or knowing what to talk about when they visit.

from Dementia Big http://ift.tt/2aSckRv via alcoholic dementia


http://ift.tt/2ayDPgU

Study suggests 'use it or lose it' to defend against memory loss

Iowa State University researchers have identified a protein essential for building memories that appears to predict the progression of memory loss and brain atrophy in Alzheimer’s patients.

from Dementia Big http://ift.tt/2aJnmpI via alcoholic dementia


http://ift.tt/2axAM5f

New biochip test helps identify individuals at increased risk of Alzheimer's disease

Researchers today unveiled results from a new blood test to help identify which patients are at an elevated risk of Alzheimer’s disease.

from Dementia Big http://ift.tt/2b3eNFh via alcoholic dementia


http://ift.tt/2ayE8ID

Wednesday, August 3, 2016

UK Biobank celebrates 10 years of pioneering health research

UK Biobank celebrates 10 years of pioneering health research:

Dementia Big
UK Biobank, a large scale medical research programme, is an extraordinary undertaking with the ultimate aim of improving the prevention, diagnosis and treatment of host of serious conditions.


http://ift.tt/2avvLxq

Researchers estimate $40 billion in annual costs to care for elderly stroke survivors

Researchers estimate $40 billion in annual costs to care for elderly stroke survivors:

Dementia Big
It’s assumed that family and friends will help out in the event of a medical crisis, but that’s not always feasible. And when stroke survivors need more than 20 hours of care per week, as a study in the August edition of Stroke shows, it’s a large burden for their loved ones.


http://ift.tt/2ausDyx

A panel of biomarkers may predict early Alzheimer's disease

A panel of biomarkers may predict early Alzheimer's disease:

Dementia Big
University of Wisconsin-Madison Alzheimer’s researchers have identified a scientific approach that may help predict which older adults are more likely to develop cognitive symptoms of Alzheimer’s disease well before the onset of dementia.


http://ift.tt/2avwvTo

Penn's ADCC receives $8.8 million grant to continue research on treatment for AD and related dementias

Penn's ADCC receives $8.8 million grant to continue research on treatment for AD and related dementias:

Dementia Big
The University of Pennsylvania’s Alzheimer’s Disease Core Center has been awarded an estimated $8.8 million over five years from the National Institute on Aging to continue its mission of investigating mechanisms, diagnostics, treatments and strategies for Alzheimer’s Disease (AD) and related dementias including Parkinson’s disease (PD), Parkinson’s disease dementia (PDD), Lewy Body dementia (LBD) and frontotemporal lobar degeneration (FTLD).


http://ift.tt/2ausJq9

Exercise results in larger brain size and lowered dementia risk

Exercise results in larger brain size and lowered dementia risk:

Dementia Big
Using the landmark Framingham Heart Study to assess how physical activity affects the size of the brain and one’s risk for developing dementia, UCLA researchers found an association between low physical activity and a higher risk for dementia in older individuals. This suggests that regular physical activity for older adults could lead to higher brain volumes and a reduced risk for developing dementia.


http://ift.tt/2avwnmN

Regular physical exercise could lead to higher brain volumes and decreased dementia risk

Regular physical exercise could lead to higher brain volumes and decreased dementia risk:

Dementia Big
Using the landmark Framingham Heart Study to assess how physical activity affects the size of the brain and one’s risk for developing dementia, UCLA researchers found an association between low physical activity and a higher risk for dementia in older individuals.


http://ift.tt/2avwvTb

Lower weight in late life may increase risk of Alzheimer's Disease

Lower weight in late life may increase risk of Alzheimer's Disease:

Dementia Big
Researchers at Brigham and Women’s Hospital (BWH) and Massachusetts General Hospital (MGH) have found an association between lower weight and more extensive deposits of the Alzheimer’s-associated protein beta-amyloid in the brains of cognitively normal older individuals. The association—reported in the Journal of Alzheimer’s Disease—was seen in particular among individuals carrying the APOE4 gene variant, which is known to increase the risk of Alzheimer’s.


http://ift.tt/2auuAec

Tool to measure brain blood flow identifies tell-tale signs of dementia and Alzheimer's early

Tool to measure brain blood flow identifies tell-tale signs of dementia and Alzheimer's early:

Dementia Big
A network of over 200 scientists, clinicians and industry partners developed a cost-effective diagnostic tool for measuring the tell-tale signs of dementia and Alzheimer’s. The tool uses a new, non-invasive technique to measure blood flow to the brain, known as Arterial Spin Labelling (ASL). The network set a reference for the best possible way of measuring blood flow, allowing all researchers using ASL in neurodegeneration to compare the network’s results. The three main vendors of MRI machines – GE Healthcare, Siemens Healthcare, and Philips Healthcare – have already taken up the tool. A company spinning out of the network has raised £1.1 million from the UK’s National Health Service to improve the calibration of ASL devices in order to ensure consistent and reliable results.


http://ift.tt/2avvP0f

Penn's ADCC receives $8.8 million grant to continue research on treatment for AD and related dementias

The University of Pennsylvania’s Alzheimer’s Disease Core Center has been awarded an estimated $8.8 million over five years from the National Institute on Aging to continue its mission of investigating mechanisms, diagnostics, treatments and strategies for Alzheimer’s Disease (AD) and related dementias including Parkinson’s disease (PD), Parkinson’s disease dementia (PDD), Lewy Body dementia (LBD) and frontotemporal lobar degeneration (FTLD).

from Dementia Big http://ift.tt/2ayO7uS via alcoholic dementia


http://ift.tt/2ausPxQ

UK Biobank celebrates 10 years of pioneering health research

UK Biobank, a large scale medical research programme, is an extraordinary undertaking with the ultimate aim of improving the prevention, diagnosis and treatment of host of serious conditions.

from Dementia Big http://ift.tt/2ahQaaK via alcoholic dementia


http://ift.tt/2avw632

A panel of biomarkers may predict early Alzheimer's disease

University of Wisconsin-Madison Alzheimer’s researchers have identified a scientific approach that may help predict which older adults are more likely to develop cognitive symptoms of Alzheimer’s disease well before the onset of dementia.

from Dementia Big http://ift.tt/2atVoij via alcoholic dementia


http://ift.tt/2ausStE

Researchers estimate $40 billion in annual costs to care for elderly stroke survivors

It’s assumed that family and friends will help out in the event of a medical crisis, but that’s not always feasible. And when stroke survivors need more than 20 hours of care per week, as a study in the August edition of Stroke shows, it’s a large burden for their loved ones.

from Dementia Big http://ift.tt/2atrhud via alcoholic dementia


http://ift.tt/2avvTx6

Lower weight in late life may increase risk of Alzheimer's Disease

Researchers at Brigham and Women’s Hospital (BWH) and Massachusetts General Hospital (MGH) have found an association between lower weight and more extensive deposits of the Alzheimer’s-associated protein beta-amyloid in the brains of cognitively normal older individuals. The association—reported in the Journal of Alzheimer’s Disease—was seen in particular among individuals carrying the APOE4 gene variant, which is known to increase the risk of Alzheimer’s.

from Dementia Big http://ift.tt/2ayFQaX via alcoholic dementia


http://ift.tt/2aNIQDR

Regular physical exercise could lead to higher brain volumes and decreased dementia risk

Using the landmark Framingham Heart Study to assess how physical activity affects the size of the brain and one’s risk for developing dementia, UCLA researchers found an association between low physical activity and a higher risk for dementia in older individuals.

from Dementia Big http://ift.tt/2ayorPJ via alcoholic dementia


http://ift.tt/2aBqD94

Exercise results in larger brain size and lowered dementia risk

Using the landmark Framingham Heart Study to assess how physical activity affects the size of the brain and one’s risk for developing dementia, UCLA researchers found an association between low physical activity and a higher risk for dementia in older individuals. This suggests that regular physical activity for older adults could lead to higher brain volumes and a reduced risk for developing dementia.

from Dementia Big http://ift.tt/2aMF4LN via alcoholic dementia


http://ift.tt/2b2uIDG

Tool to measure brain blood flow identifies tell-tale signs of dementia and Alzheimer's early

A network of over 200 scientists, clinicians and industry partners developed a cost-effective diagnostic tool for measuring the tell-tale signs of dementia and Alzheimer’s. The tool uses a new, non-invasive technique to measure blood flow to the brain, known as Arterial Spin Labelling (ASL). The network set a reference for the best possible way of measuring blood flow, allowing all researchers using ASL in neurodegeneration to compare the network’s results. The three main vendors of MRI machines – GE Healthcare, Siemens Healthcare, and Philips Healthcare – have already taken up the tool. A company spinning out of the network has raised £1.1 million from the UK’s National Health Service to improve the calibration of ASL devices in order to ensure consistent and reliable results.

from Dementia Big http://ift.tt/2asIMrq via alcoholic dementia


http://ift.tt/2ahVYkC

Tuesday, August 2, 2016

New guide offers person-centred analysis of people living with dementia

New guide offers person-centred analysis of people living with dementia:

Dementia Big
The Good Care Group offer high quality live in care services, for elderly people to live in their home for as long as possible.


http://ift.tt/2aJrlnR

Scientists uncover novel sites of expression in the brain for gene linked to ALS and FTD

Scientists uncover novel sites of expression in the brain for gene linked to ALS and FTD:

Dementia Big
For the first time novel expression sites in the brain have been identified for a gene which is associated with Motor Neuron Disease and Frontotemporal Dementia.


http://ift.tt/2axaIbK

Treating people in mental health hospitals with locked wards does not reduce risk of suicide attempts

Treating people in mental health hospitals with locked wards does not reduce risk of suicide attempts:

Dementia Big
Treating people with mental ill health in hospitals with locked wards, as opposed to hospitals without locked wards, does not reduce their risk of suicide attempts or of unauthorised absence from hospital, also known as ‘absconding’, according to a new 15-year study in Germany of around 145000 patient cases, published in The Lancet Psychiatry journal.


http://ift.tt/2aJs60k

Promising Alzheimer's research takes a step forward

Promising Alzheimer's research takes a step forward:

Dementia Big
Scientists from the University of Liverpool and Victoria University of Wellington have been awarded over £478K to advance a potential treatment for Alzheimer’s disease.


http://ift.tt/2ax9MEt

First U.S. clinical trial using adult allogeneic stem cells to treat Alzheimer's disease

First U.S. clinical trial using adult allogeneic stem cells to treat Alzheimer's disease:

Dementia Big
A new study to assess the safety, tolerability and preliminary efficacy of allogeneic stem cells in persons with mild to moderate dementia due to Alzheimer’s disease (AD) is beginning enrollment at Emory University and University of California, Irvine. It is the first clinical trial in the U.S. to use this stem cell-based treatment.


http://ift.tt/2aJsdsJ

METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research

METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research:

Dementia Big
Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer’s disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinically “silent” cerebrovascular disease, long-term outcomes (cognitive, stroke, or functional), and risk factors.


http://ift.tt/2axasJR

New guide offers person-centred analysis of people living with dementia

The Good Care Group offer high quality live in care services, for elderly people to live in their home for as long as possible.

from Dementia Big http://ift.tt/2aoQbF3 via alcoholic dementia


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Scientists uncover novel sites of expression in the brain for gene linked to ALS and FTD

For the first time novel expression sites in the brain have been identified for a gene which is associated with Motor Neuron Disease and Frontotemporal Dementia.

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Promising Alzheimer's research takes a step forward

Scientists from the University of Liverpool and Victoria University of Wellington have been awarded over £478K to advance a potential treatment for Alzheimer’s disease.

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Treating people in mental health hospitals with locked wards does not reduce risk of suicide attempts

Treating people with mental ill health in hospitals with locked wards, as opposed to hospitals without locked wards, does not reduce their risk of suicide attempts or of unauthorised absence from hospital, also known as ‘absconding’, according to a new 15-year study in Germany of around 145000 patient cases, published in The Lancet Psychiatry journal.

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First U.S. clinical trial using adult allogeneic stem cells to treat Alzheimer's disease

A new study to assess the safety, tolerability and preliminary efficacy of allogeneic stem cells in persons with mild to moderate dementia due to Alzheimer’s disease (AD) is beginning enrollment at Emory University and University of California, Irvine. It is the first clinical trial in the U.S. to use this stem cell-based treatment.

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METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research

Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer’s disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinically “silent” cerebrovascular disease, long-term outcomes (cognitive, stroke, or functional), and risk factors.

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