Wednesday, November 30, 2016

Aerobic activity offers greater preservation of brain volume, improves cognitive performance

Using a new MRI technique, researchers found that adults with mild cognitive impairment (MCI) who exercised four times a week over a six-month period experienced an increase in brain volume in specific, or local, areas of the brain, but adults who participated in aerobic exercise experienced greater gains than those who just stretched.

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http://ift.tt/2gKjS7a

Gram-negative bacteria may influence Alzheimer's disease pathology

For the first time, researchers have found higher levels of Gram-negative bacteria antigens in brain samples from late-onset Alzheimer’s disease patients. Compared to controls, patients with Alzheimer’s had much higher levels of lipopolysaccharide (LPS) and E coli K99 pili protein. In addition, The UC Davis team also found LPS molecules congregated with amyloid plaques, which have been linked to Alzheimer’s pathology and progression. The research was published today in the print edition of the journal Neurology.

from Dementia Big http://ift.tt/2gjMrLs via alcoholic dementia


http://ift.tt/2gKbvZj

Johns Hopkins researchers find evidence of brain injury in young NFL players

In a small study of young or recently retired NFL players, researchers at Johns Hopkins report finding evidence of brain injury and repair that is visible on imaging from the players compared to a control group of men without a history of concussion.

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http://ift.tt/2fDLsqF

Use of prescription analgesics differs significantly between persons with and without Alzheimer's

Approximately one third of persons with Alzheimer’s disease use prescription medicines for pain after their diagnosis, reports a recent study conducted at the University of Eastern Finland. The use of analgesics was as common among persons with Alzheimer’s disease as it was among those of the same age without the disease, but there were significant differences in the types of medicines used. The results were published in European Journal of Pain.

from Dementia Big http://ift.tt/2fI4Fm6 via alcoholic dementia


http://ift.tt/2gKanoi

Moderate coffee consumption may offer protection against age-related cognitive decline

A new report from the Institute for Scientific Information on Coffee (ISIC), a not-for-profit organisation devoted to the study and disclosure of science related to coffee and health, highlights the potential role of coffee consumption in reducing the risk of cognitive decline.

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http://ift.tt/2fDKuKY

Research aims to incorporate cardiorespiratory fitness measurements into clinical practice

A new Scientific Statement from the American Heart Association led by Queen’s University professor Robert Ross provides unequivocal evidence to confirm that cardiorespiratory fitness (CRF), a reflection of overall cardiovascular health, should be measured in clinical practice to provide additional information for patient management.

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http://ift.tt/2fDIsKR

Aerobic activity offers greater preservation of brain volume, improves cognitive performance

Aerobic activity offers greater preservation of brain volume, improves cognitive performance:

Dementia Big
Using a new MRI technique, researchers found that adults with mild cognitive impairment (MCI) who exercised four times a week over a six-month period experienced an increase in brain volume in specific, or local, areas of the brain, but adults who participated in aerobic exercise experienced greater gains than those who just stretched.


http://ift.tt/2gKiDVv

Use of prescription analgesics differs significantly between persons with and without Alzheimer's

Use of prescription analgesics differs significantly between persons with and without Alzheimer's:

Dementia Big
Approximately one third of persons with Alzheimer’s disease use prescription medicines for pain after their diagnosis, reports a recent study conducted at the University of Eastern Finland. The use of analgesics was as common among persons with Alzheimer’s disease as it was among those of the same age without the disease, but there were significant differences in the types of medicines used. The results were published in European Journal of Pain.


http://ift.tt/2gKjRA8

Johns Hopkins researchers find evidence of brain injury in young NFL players

Johns Hopkins researchers find evidence of brain injury in young NFL players:

Dementia Big
In a small study of young or recently retired NFL players, researchers at Johns Hopkins report finding evidence of brain injury and repair that is visible on imaging from the players compared to a control group of men without a history of concussion.


http://ift.tt/2fDLcHV

Gram-negative bacteria may influence Alzheimer's disease pathology

Gram-negative bacteria may influence Alzheimer's disease pathology:

Dementia Big
For the first time, researchers have found higher levels of Gram-negative bacteria antigens in brain samples from late-onset Alzheimer’s disease patients. Compared to controls, patients with Alzheimer’s had much higher levels of lipopolysaccharide (LPS) and E coli K99 pili protein. In addition, The UC Davis team also found LPS molecules congregated with amyloid plaques, which have been linked to Alzheimer’s pathology and progression. The research was published today in the print edition of the journal Neurology.


http://ift.tt/2fDLajj

Moderate coffee consumption may offer protection against age-related cognitive decline

Moderate coffee consumption may offer protection against age-related cognitive decline:

Dementia Big
A new report from the Institute for Scientific Information on Coffee (ISIC), a not-for-profit organisation devoted to the study and disclosure of science related to coffee and health, highlights the potential role of coffee consumption in reducing the risk of cognitive decline.


http://ift.tt/2gKneH6

Research aims to incorporate cardiorespiratory fitness measurements into clinical practice

Research aims to incorporate cardiorespiratory fitness measurements into clinical practice:

Dementia Big
A new Scientific Statement from the American Heart Association led by Queen’s University professor Robert Ross provides unequivocal evidence to confirm that cardiorespiratory fitness (CRF), a reflection of overall cardiovascular health, should be measured in clinical practice to provide additional information for patient management.


http://ift.tt/2fDLbDT

Monday, November 28, 2016

Alzheimer's protein plaques may also harm the heart

Alzheimer's protein plaques may also harm the heart:

Dementia Big
(HealthDay)—Protein fragments that form plaques in the brains of Alzheimer’s patients might also stiffen their heart muscle and increase their risk of heart failure, a new study reports.


http://ift.tt/2gE5b6S

ADT use not linked to dementia in prostate cancer

ADT use not linked to dementia in prostate cancer:

Dementia Big
(HealthDay)—For men with prostate cancer, use of androgen deprivation therapy (ADT) seems not to be associated with dementia, according to a study published online Nov. 21 in the Journal of Clinical Oncology.


http://ift.tt/2gQTQDl

Comparing gait parameters can predict decline in memory and thinking

Comparing gait parameters can predict decline in memory and thinking:

Dementia Big
Walking is a milestone in development for toddlers, but it’s actually only one part of the complex cognitive task known as gait that includes everything from a person’s stride length to the accompanying swing of each arm. A Mayo Clinic study recently published in the Journal of Alzheimer’s Disease found that problems associated with gait can predict a significant decline in memory and thinking.


http://ift.tt/2gE7pmr

Study using Cubresa SPECT scanner finds potential non-invasive diagnosis for Alzheimer’s

Study using Cubresa SPECT scanner finds potential non-invasive diagnosis for Alzheimer’s:

Dementia Big
Cubresa’s SPECT scanner was used to determine if a novel molecular label, TRV6001, in development for in vivo imaging of the BChE enzyme present in the brains of Alzheimer’s Disease patients follows the known distribution of the enzyme in animal models of the disease.


http://ift.tt/2gQTwoc

New study shows marijuana users have low blood flow to the brain

New study shows marijuana users have low blood flow to the brain:

Dementia Big
As the U.S. races to legalize marijuana for medicinal and recreational use, a new, large scale brain imaging study gives reason for caution. Published in the Journal of Alzheimer’s Disease, researchers using single photon emission computed tomography (SPECT), a sophisticated imaging study that evaluates blood flow and activity patterns, demonstrated abnormally low blood flow in virtually every area of the brain studies in nearly 1,000 marijuana compared to healthy controls, including areas known to be affected by Alzheimer’s pathology such as the hippocampus.


http://ift.tt/2gE9pLG

Alzheimer's protein plaques may also harm the heart

(HealthDay)—Protein fragments that form plaques in the brains of Alzheimer’s patients might also stiffen their heart muscle and increase their risk of heart failure, a new study reports.

from Dementia Big http://ift.tt/2gce89h via alcoholic dementia


http://ift.tt/2fwceRE

ADT use not linked to dementia in prostate cancer

(HealthDay)—For men with prostate cancer, use of androgen deprivation therapy (ADT) seems not to be associated with dementia, according to a study published online Nov. 21 in the Journal of Clinical Oncology.

from Dementia Big http://ift.tt/2futQNO via alcoholic dementia


http://ift.tt/2gCUVdH

Comparing gait parameters can predict decline in memory and thinking

Walking is a milestone in development for toddlers, but it’s actually only one part of the complex cognitive task known as gait that includes everything from a person’s stride length to the accompanying swing of each arm. A Mayo Clinic study recently published in the Journal of Alzheimer’s Disease found that problems associated with gait can predict a significant decline in memory and thinking.

from Dementia Big http://ift.tt/2goOBXV via alcoholic dementia


http://ift.tt/2fwffkY

Study using Cubresa SPECT scanner finds potential non-invasive diagnosis for Alzheimer’s

Cubresa’s SPECT scanner was used to determine if a novel molecular label, TRV6001, in development for in vivo imaging of the BChE enzyme present in the brains of Alzheimer’s Disease patients follows the known distribution of the enzyme in animal models of the disease.

from Dementia Big http://ift.tt/2fWO12V via alcoholic dementia


http://ift.tt/2gCPStB

New study shows marijuana users have low blood flow to the brain

As the U.S. races to legalize marijuana for medicinal and recreational use, a new, large scale brain imaging study gives reason for caution. Published in the Journal of Alzheimer’s Disease, researchers using single photon emission computed tomography (SPECT), a sophisticated imaging study that evaluates blood flow and activity patterns, demonstrated abnormally low blood flow in virtually every area of the brain studies in nearly 1,000 marijuana compared to healthy controls, including areas known to be affected by Alzheimer’s pathology such as the hippocampus.

from Dementia Big http://ift.tt/2gan3Im via alcoholic dementia


http://ift.tt/2fwc9gP

Friday, November 25, 2016

People living with dementia boosted by new guide to care

People with dementia and their carers can ask for the care they deserve with confidence after the launch of a new guide to their care rights.

from Dementia Big http://ift.tt/2fVc7xP via alcoholic dementia


http://ift.tt/2fuW2eo

People living with dementia boosted by new guide to care

People living with dementia boosted by new guide to care:

Dementia Big
People with dementia and their carers can ask for the care they deserve with confidence after the launch of a new guide to their care rights.


http://ift.tt/2gnPHpL

Wednesday, November 23, 2016

An Alzheimer's drug fails, but many others still in testing

Another major Alzheimer’s drug study has failed, leaving patients and families wondering if there ever will be a treatment to slow or reverse the most common form of dementia, which afflicts more than 5 million in the United States alone.

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http://ift.tt/2gjpsRo

Home-based telemental health provides improved quality of life for depressed elderly veterans

Home-based telemental health for depression is well received by patients and delivers as good a quality of life as in-person visits, according to the results of a clinical trial in 241 depressed elderly veterans reported in the Journal of Clinical Psychiatry by investigators at the Medical University of South Carolina and the Ralph H. Johnson VA Medical Center.

from Dementia Big http://ift.tt/2fRLv0U via alcoholic dementia


http://ift.tt/2fqNiWL

Another failure in search for treatment to slow Alzheimer's

An experimental treatment for Alzheimer’s failed again in a widely anticipated study, disappointing many who had hoped drugmaker Eli Lilly had finally found a way to slow the progression of the mind-robbing disease.

from Dementia Big http://ift.tt/2forKtO via alcoholic dementia


http://ift.tt/2gjn9Ob

An Alzheimer's drug fails, but many others still in testing

An Alzheimer's drug fails, but many others still in testing:

Dementia Big
Another major Alzheimer’s drug study has failed, leaving patients and families wondering if there ever will be a treatment to slow or reverse the most common form of dementia, which afflicts more than 5 million in the United States alone.


http://ift.tt/2fqRXbf

Home-based telemental health provides improved quality of life for depressed elderly veterans

Home-based telemental health provides improved quality of life for depressed elderly veterans:

Dementia Big
Home-based telemental health for depression is well received by patients and delivers as good a quality of life as in-person visits, according to the results of a clinical trial in 241 depressed elderly veterans reported in the Journal of Clinical Psychiatry by investigators at the Medical University of South Carolina and the Ralph H. Johnson VA Medical Center.


http://ift.tt/2gjo1lX

Another failure in search for treatment to slow Alzheimer's

Another failure in search for treatment to slow Alzheimer's:

Dementia Big
An experimental treatment for Alzheimer’s failed again in a widely anticipated study, disappointing many who had hoped drugmaker Eli Lilly had finally found a way to slow the progression of the mind-robbing disease.


http://ift.tt/2fqYkLz

Tuesday, November 22, 2016

Unique structure of brain blood vessel amyloid latest clue to Alzheimer's development?

Accumulating amounts of amyloid, which is a fragment of a larger protein, in the brain have been associated with the development of dementia, including Alzheimer’s disease. Now a team of neuroscience and biochemistry researchers at Stony Brook University have made a novel discovery that illustrates for the first time the difference between amyloid buildup in brain blood vessels and amyloid buildup around brain neurons. Their findings, which may provide a new path to research on Alzheimer’s disease and its cause, will be published November 21 in Nature Communications.

from Dementia Big http://ift.tt/2gG9W3q via alcoholic dementia


http://ift.tt/2gdBAQd

New study finds downward trend in dementia prevalence among American seniors

In a hopeful sign for the health of the nation’s brains, the percentage of American seniors with dementia is dropping, a new study finds.

from Dementia Big http://ift.tt/2gbxdFl via alcoholic dementia


http://ift.tt/2gzbueJ

Study finds occupational therapy unable to delay Alzheimer's patients' functional decline

In the first study to investigate whether two years of in-home occupational therapy might help those with Alzheimer’s disease delay the loss of their physical function, researchers from the Indiana Center for Aging Research and the Regenstrief Institute have found that occupational therapy tailored to the individual patient’s needs did not delay the loss of everyday functions such as walking, eating, bathing and toileting.

from Dementia Big http://ift.tt/2fz48nf via alcoholic dementia


http://ift.tt/2gdFXuD

Dementia on the downslide, especially among people with more education

In a hopeful sign for the health of the nation’s brains, the percentage of American seniors with dementia is dropping, a new study finds.

from Dementia Big http://ift.tt/2gCaZkK via alcoholic dementia


http://ift.tt/2gzcE9W

Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1

Circadian alterations are prevalent in Alzheimer’s disease (AD) and may contribute to cognitive impairment, behavioral symptoms, and neurodegeneration. Epigenetic mechanisms regulate the circadian clock, and changes in DNA methylation have been reported in AD brains, but the pathways that mediate circadian deregulation in AD are incompletely understood. We hypothesized that aberrant DNA methylation may affect circadian rhythms in AD.

from Dementia Big http://ift.tt/2fWINVl via alcoholic dementia


http://ift.tt/2gdFJmW

Researchers call sun avoidance as emerging health problem in the U.S.

A landmark study published Friday in the Journal Dermato-Endocrinology has world-renowned researchers calling insufficient sun exposure an emerging health problem in the United States.

from Dementia Big http://ift.tt/2gBY56w via alcoholic dementia


http://ift.tt/2gzbNpL

Unique structure of brain blood vessel amyloid latest clue to Alzheimer's development?

Unique structure of brain blood vessel amyloid latest clue to Alzheimer's development?:

Dementia Big
Accumulating amounts of amyloid, which is a fragment of a larger protein, in the brain have been associated with the development of dementia, including Alzheimer’s disease. Now a team of neuroscience and biochemistry researchers at Stony Brook University have made a novel discovery that illustrates for the first time the difference between amyloid buildup in brain blood vessels and amyloid buildup around brain neurons. Their findings, which may provide a new path to research on Alzheimer’s disease and its cause, will be published November 21 in Nature Communications.


http://ift.tt/2gdFj0e

New study finds downward trend in dementia prevalence among American seniors

New study finds downward trend in dementia prevalence among American seniors:

Dementia Big
In a hopeful sign for the health of the nation’s brains, the percentage of American seniors with dementia is dropping, a new study finds.


http://ift.tt/2gzcFL2

Researchers call sun avoidance as emerging health problem in the U.S.

Researchers call sun avoidance as emerging health problem in the U.S.:

Dementia Big
A landmark study published Friday in the Journal Dermato-Endocrinology has world-renowned researchers calling insufficient sun exposure an emerging health problem in the United States.


http://ift.tt/2gdH6Co

Dementia on the downslide, especially among people with more education

Dementia on the downslide, especially among people with more education:

Dementia Big
In a hopeful sign for the health of the nation’s brains, the percentage of American seniors with dementia is dropping, a new study finds.


http://ift.tt/2gzaCXf

Study finds occupational therapy unable to delay Alzheimer's patients' functional decline

Study finds occupational therapy unable to delay Alzheimer's patients' functional decline:

Dementia Big
In the first study to investigate whether two years of in-home occupational therapy might help those with Alzheimer’s disease delay the loss of their physical function, researchers from the Indiana Center for Aging Research and the Regenstrief Institute have found that occupational therapy tailored to the individual patient’s needs did not delay the loss of everyday functions such as walking, eating, bathing and toileting.


http://ift.tt/2gdDcJx

Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1

Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1:

Dementia Big
Circadian alterations are prevalent in Alzheimer’s disease (AD) and may contribute to cognitive impairment, behavioral symptoms, and neurodegeneration. Epigenetic mechanisms regulate the circadian clock, and changes in DNA methylation have been reported in AD brains, but the pathways that mediate circadian deregulation in AD are incompletely understood. We hypothesized that aberrant DNA methylation may affect circadian rhythms in AD.


http://ift.tt/2gdCHPU

Monday, November 21, 2016

New model for studying Alzheimer's disease

The vast majority of Alzheimer’s disease cases are not directly inherited but linked to environmental and genetic factors. Yet most models used for studying Alzheimer’s in animals mimic the inherited form of the disease.

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http://ift.tt/2fU70M1

Study compares risk of pneumonia linked to using different antidementia drugs

A recent study from the University of Eastern Finland shows that among users of antidementia drugs, persons using memantine have the highest risk of pneumonia. The use of rivastigmine patches is associated with an increased risk as well.

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http://ift.tt/2gaxTOJ

New model for studying Alzheimer's disease

New model for studying Alzheimer's disease:

Dementia Big
The vast majority of Alzheimer’s disease cases are not directly inherited but linked to environmental and genetic factors. Yet most models used for studying Alzheimer’s in animals mimic the inherited form of the disease.


http://ift.tt/2fUd7QG

Study compares risk of pneumonia linked to using different antidementia drugs

Study compares risk of pneumonia linked to using different antidementia drugs:

Dementia Big
A recent study from the University of Eastern Finland shows that among users of antidementia drugs, persons using memantine have the highest risk of pneumonia. The use of rivastigmine patches is associated with an increased risk as well.


http://ift.tt/2gawAQ1

Sunday, November 20, 2016

Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic

The last decade has seen a substantial increase in research focused on the identification of blood-based biomarkers that have utility in Alzheimer’s disease (AD). Blood-based biomarkers have significant advantages of being time- and cost-efficient as well as reduced invasiveness and increased patient acceptance. Despite these advantages and increased research efforts, the field has been hampered by lack of reproducibility and an unclear path for moving basic discovery toward clinical utilization.

from Dementia Big http://ift.tt/2g6vnqx via alcoholic dementia


http://ift.tt/2g6CC0n

Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample

Whether co-occurring neuropathologies interact or independently affect clinical disease progression is uncertain. We estimated rates of clinical progression and tested whether associations between clinical progression and Alzheimer’s disease neuropathology (ADNP) were modified by co-occurring Lewy body disease (LBD) or vascular brain injury (VBI).

from Dementia Big http://ift.tt/2gtjG0W via alcoholic dementia


http://ift.tt/2fgd8je

Evaluation of α-synuclein as a novel cerebrospinal fluid biomarker in different forms of prion diseases

Accurate diagnosis of prion diseases and discrimination from alternative dementias gain importance in the clinical routine, but partial overlap in cerebrospinal fluid (CSF) biomarkers impedes absolute discrimination in the differential diagnostic context.

from Dementia Big http://ift.tt/2f9yxaS via alcoholic dementia


http://ift.tt/2g6A6a7

Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic

Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic:

Dementia Big
The last decade has seen a substantial increase in research focused on the identification of blood-based biomarkers that have utility in Alzheimer’s disease (AD). Blood-based biomarkers have significant advantages of being time- and cost-efficient as well as reduced invasiveness and increased patient acceptance. Despite these advantages and increased research efforts, the field has been hampered by lack of reproducibility and an unclear path for moving basic discovery toward clinical utilization.


http://ift.tt/2fghBCD

Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample

Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample:

Dementia Big
Whether co-occurring neuropathologies interact or independently affect clinical disease progression is uncertain. We estimated rates of clinical progression and tested whether associations between clinical progression and Alzheimer’s disease neuropathology (ADNP) were modified by co-occurring Lewy body disease (LBD) or vascular brain injury (VBI).


http://ift.tt/2g6BMAO

Evaluation of α-synuclein as a novel cerebrospinal fluid biomarker in different forms of prion diseases

Evaluation of α-synuclein as a novel cerebrospinal fluid biomarker in different forms of prion diseases:

Dementia Big
Accurate diagnosis of prion diseases and discrimination from alternative dementias gain importance in the clinical routine, but partial overlap in cerebrospinal fluid (CSF) biomarkers impedes absolute discrimination in the differential diagnostic context.


http://ift.tt/2fgh7N7

Friday, November 18, 2016

Study offers new insight into how Alzheimer's disease begins

Study offers new insight into how Alzheimer's disease begins:

Dementia Big
A new study from The University of Texas Medical Branch at Galveston offers important insight into how Alzheimer’s disease begins within the brain. The researchers found a relationship between inflammation, a toxic protein and the onset of the disease. The study also identified a way that doctors can detect early signs of Alzheimer’s by looking at the back of patients’ eyes.


http://ift.tt/2fpGR76

Researchers use SIG-Blocks for cognitive testing and training of adults and children

Researchers use SIG-Blocks for cognitive testing and training of adults and children:

Dementia Big
Psychologists have long used building blocks to assess cognitive skills. But researchers at Case Western Reserve University are imbedding the blocks with technology that may provide a clearer view of problems a child or adult may suffer due to developmental disabilities, brain trauma or dementia.


http://ift.tt/2ePepPV

Discovery opens door to new Alzheimer's treatments

Discovery opens door to new Alzheimer's treatments:

Dementia Big
Australian researchers have shed new light on the nerve cell processes that lead to Alzheimer’s disease (AD), overturning previously held ideas of how the disease develops and opening the door to new treatment options that could halt or slow its progression.


http://ift.tt/2fpFqG1

Study offers new insight into how Alzheimer's disease begins

A new study from The University of Texas Medical Branch at Galveston offers important insight into how Alzheimer’s disease begins within the brain. The researchers found a relationship between inflammation, a toxic protein and the onset of the disease. The study also identified a way that doctors can detect early signs of Alzheimer’s by looking at the back of patients’ eyes.

from Dementia Big http://ift.tt/2folUJQ via alcoholic dementia


http://ift.tt/2ePg3kI

Researchers use SIG-Blocks for cognitive testing and training of adults and children

Psychologists have long used building blocks to assess cognitive skills. But researchers at Case Western Reserve University are imbedding the blocks with technology that may provide a clearer view of problems a child or adult may suffer due to developmental disabilities, brain trauma or dementia.

from Dementia Big http://ift.tt/2f7fmOB via alcoholic dementia


http://ift.tt/2fpF2ak

Discovery opens door to new Alzheimer's treatments

Australian researchers have shed new light on the nerve cell processes that lead to Alzheimer’s disease (AD), overturning previously held ideas of how the disease develops and opening the door to new treatment options that could halt or slow its progression.

from Dementia Big http://ift.tt/2g07tMZ via alcoholic dementia


http://ift.tt/2ePfUh4

Thursday, November 17, 2016

Discovery of neurotransmission gene may permit early detection of Alzheimer's disease

A new Tel Aviv University study identified a gene coding for a protein that turns off neurotransmission signaling, which contributes to Alzheimer’s disease (AD).

from Dementia Big http://ift.tt/2fgKBYE via alcoholic dementia


http://ift.tt/2gkIqax

More human-like model of Alzheimer's better mirrors tangles in the brain

Tangled up brain fibrils made up of a rogue protein known as tau are the hallmark of Alzheimer’s disease (AD) that likely hold the key to treatments, making them of great interest to researchers. Mimicking the formation and spread of these tangles in animal models with greater accuracy allows scientists to better investigate new therapies to stop or slow their spread.

from Dementia Big http://ift.tt/2fx4PjB via alcoholic dementia


http://ift.tt/2f4sJzm

Accelerated MRI brain mapping technique to improve neurodegenerative diagnosis

A new brain imaging technique developed by University of Queensland researchers is paving the way for improved diagnosis and treatment of neurodegenerative diseases such as Alzheimer’s or Parkinson’s disease.

from Dementia Big http://ift.tt/2fg6Spw via alcoholic dementia


http://ift.tt/2f4tUi5

GPs must be encouraged to play active role in palliative care

Hospitals typically provide excellent end-of-life care for their patients. But when GPs assume responsibility for terminal patients, things don’t always go so well.

from Dementia Big http://ift.tt/2f3Rmzt via alcoholic dementia


http://ift.tt/2gkEarB

Atrial fibrillation patients treated with anticoagulant drug have higher risk of developing dementia

Atrial fibrillation patients who use the drug, warfarin, to prevent harmful blood clots from forming in their hearts to lower risk of stroke are at higher risk of developing dementia than patients who use warfarin for non-atrial fibrillation conditions, according to a new study from the Intermountain Medical Center Heart Institute.

from Dementia Big http://ift.tt/2fEBx05 via alcoholic dementia


http://ift.tt/2f4pDvc

Discovery of neurotransmission gene may permit early detection of Alzheimer's disease

Discovery of neurotransmission gene may permit early detection of Alzheimer's disease:

Dementia Big
A new Tel Aviv University study identified a gene coding for a protein that turns off neurotransmission signaling, which contributes to Alzheimer’s disease (AD).


http://ift.tt/2gkIAi3

More human-like model of Alzheimer's better mirrors tangles in the brain

More human-like model of Alzheimer's better mirrors tangles in the brain:

Dementia Big
Tangled up brain fibrils made up of a rogue protein known as tau are the hallmark of Alzheimer’s disease (AD) that likely hold the key to treatments, making them of great interest to researchers. Mimicking the formation and spread of these tangles in animal models with greater accuracy allows scientists to better investigate new therapies to stop or slow their spread.


http://ift.tt/2f4vAIj

Accelerated MRI brain mapping technique to improve neurodegenerative diagnosis

Accelerated MRI brain mapping technique to improve neurodegenerative diagnosis:

Dementia Big
A new brain imaging technique developed by University of Queensland researchers is paving the way for improved diagnosis and treatment of neurodegenerative diseases such as Alzheimer’s or Parkinson’s disease.


http://ift.tt/2gkGu1S

GPs must be encouraged to play active role in palliative care

GPs must be encouraged to play active role in palliative care:

Dementia Big
Hospitals typically provide excellent end-of-life care for their patients. But when GPs assume responsibility for terminal patients, things don’t always go so well.


http://ift.tt/2f4tusg

Atrial fibrillation patients treated with anticoagulant drug have higher risk of developing dementia

Atrial fibrillation patients treated with anticoagulant drug have higher risk of developing dementia:

Dementia Big
Atrial fibrillation patients who use the drug, warfarin, to prevent harmful blood clots from forming in their hearts to lower risk of stroke are at higher risk of developing dementia than patients who use warfarin for non-atrial fibrillation conditions, according to a new study from the Intermountain Medical Center Heart Institute.


http://ift.tt/2gkHQK5

Tuesday, November 15, 2016

Antibiotic restores cell communication in brain areas damaged by Alzheimer's disease

New research from the Djavad Mowafaghian Centre for Brain Health at UBC has found a way to partially restore brain cell communication around areas damaged by plaques associated with Alzheimer’s disease.

from Dementia Big http://ift.tt/2fRMfB9 via alcoholic dementia


http://ift.tt/2eZ9UgJ

Experts to examine impact of live music on health and morbidity in children with learning disabilities

Experts in the fields of music, education, neurology, psychiatry and psychology will gather at a conference at the Royal Society of Medicine in London on Monday 28 November to examine the current evidence for the value and impact of music interventions, especially live music, on health and morbidity in children with learning disabilities.

from Dementia Big http://ift.tt/2eBB81Q via alcoholic dementia


http://ift.tt/2gfC8ca

Length of telomeres may reveal if vitamin D and omega-3 supplements improve heart health, longevity

The length of your telomeres appears to be a window into your heart health and longevity, and scientists are measuring them to see if vitamin D and omega-3 supplements really improve both.

from Dementia Big http://ift.tt/2fOJqAL via alcoholic dementia


http://ift.tt/2eZ9Sp7

Antibiotic restores cell communication in brain areas damaged by Alzheimer's disease

Antibiotic restores cell communication in brain areas damaged by Alzheimer's disease:

Dementia Big
New research from the Djavad Mowafaghian Centre for Brain Health at UBC has found a way to partially restore brain cell communication around areas damaged by plaques associated with Alzheimer’s disease.


http://ift.tt/2gfICb3

Experts to examine impact of live music on health and morbidity in children with learning disabilities

Experts to examine impact of live music on health and morbidity in children with learning disabilities:

Dementia Big
Experts in the fields of music, education, neurology, psychiatry and psychology will gather at a conference at the Royal Society of Medicine in London on Monday 28 November to examine the current evidence for the value and impact of music interventions, especially live music, on health and morbidity in children with learning disabilities.


http://ift.tt/2eZaR8Y

Length of telomeres may reveal if vitamin D and omega-3 supplements improve heart health, longevity

Length of telomeres may reveal if vitamin D and omega-3 supplements improve heart health, longevity:

Dementia Big
The length of your telomeres appears to be a window into your heart health and longevity, and scientists are measuring them to see if vitamin D and omega-3 supplements really improve both.


http://ift.tt/2gfzD9N

Monday, November 14, 2016

Some elderly with Alzheimer's brain plaques stay sharp

(HealthDay)—In a discovery that challenges conventional thinking, researchers report that several people over the age of 90 had excellent memory even though their brains showed signs that they had Alzheimer’s disease.

from Dementia Big http://ift.tt/2eyP3FW via alcoholic dementia


http://ift.tt/2eyXocx

Study finds long-term use of transdermal opioid patches twice as common among Alzheimer's patients

Approximately seven per cent of persons with Alzheimer’s disease use strong pain medicines, opioids, for non-cancer pain for a period longer than six months, according to a recent study conducted at the University of Eastern Finland.

from Dementia Big http://ift.tt/2fQ1IQQ via alcoholic dementia


http://ift.tt/2fadiq2

Ability to recognize and recall odors may identify those at risk for Alzheimer's disease

A non-invasive protocol testing the ability to recognize, remember and distinguish between odors was able to identify older individuals who - according to genetic, imaging and more detailed memory tests - were at increased risk of Alzheimer’s disease. The report of a study by a team of Massachusetts General Hospital (MGH) investigators has been published online in Annals of Neurology.

from Dementia Big http://ift.tt/2fRGplv via alcoholic dementia


http://ift.tt/2eyXq4a

Long-term use of opioid patches common among persons with Alzheimer's disease

Approximately seven per cent of persons with Alzheimer’s disease use strong pain medicines, opioids, for non-cancer pain for a period longer than six months, according to a recent study conducted at the University of Eastern Finland. One third of people initiating opioid use became long-term users, and long-term use was heavily associated with transdermal opioid patches. The results were published in PAIN.

from Dementia Big http://ift.tt/2fRWNk7 via alcoholic dementia


http://ift.tt/2fa8hhg

New figures show dementia is leading cause of death in England and Wales

New figures released by the Office of National Statistics show that for the first time, Alzheimer’s disease and other dementias are the leading cause of death for England and Wales. Of the 529,655 deaths registered during 2015, dementia accounted for 61,686 (11.6 percent).

from Dementia Big http://ift.tt/2fyvY3v via alcoholic dementia


http://ift.tt/2eyVLf6

Brain training can help in fight against dementia: Meta-analysis

Researchers at the University of Sydney have found that engaging in computer-based brain training can improve memory and mood in older adults with mild cognitive impairment - but training is no longer effective once a dementia diagnosis has been made.

from Dementia Big http://ift.tt/2g9kNBV via alcoholic dementia


http://ift.tt/2fa8Yaj

Brain training could help improve memory and mood in older adults with mild cognitive impairment

Researchers at the University of Sydney have found that engaging in computer-based brain training can improve memory and mood in older adults with mild cognitive impairment - but training is no longer effective once a dementia diagnosis has been made.

from Dementia Big http://ift.tt/2fxGSXc via alcoholic dementia


http://ift.tt/2eyWqx5

Some elderly with Alzheimer's brain plaques stay sharp

Some elderly with Alzheimer's brain plaques stay sharp:

Dementia Big
(HealthDay)—In a discovery that challenges conventional thinking, researchers report that several people over the age of 90 had excellent memory even though their brains showed signs that they had Alzheimer’s disease.


http://ift.tt/2facGRl

Ability to recognize and recall odors may identify those at risk for Alzheimer's disease

Ability to recognize and recall odors may identify those at risk for Alzheimer's disease:

Dementia Big
A non-invasive protocol testing the ability to recognize, remember and distinguish between odors was able to identify older individuals who - according to genetic, imaging and more detailed memory tests - were at increased risk of Alzheimer’s disease. The report of a study by a team of Massachusetts General Hospital (MGH) investigators has been published online in Annals of Neurology.


http://ift.tt/2eyY3KX

Study finds long-term use of transdermal opioid patches twice as common among Alzheimer's patients

Study finds long-term use of transdermal opioid patches twice as common among Alzheimer's patients:

Dementia Big
Approximately seven per cent of persons with Alzheimer’s disease use strong pain medicines, opioids, for non-cancer pain for a period longer than six months, according to a recent study conducted at the University of Eastern Finland.


http://ift.tt/2faf3U7

Long-term use of opioid patches common among persons with Alzheimer's disease

Long-term use of opioid patches common among persons with Alzheimer's disease:

Dementia Big
Approximately seven per cent of persons with Alzheimer’s disease use strong pain medicines, opioids, for non-cancer pain for a period longer than six months, according to a recent study conducted at the University of Eastern Finland. One third of people initiating opioid use became long-term users, and long-term use was heavily associated with transdermal opioid patches. The results were published in PAIN.


http://ift.tt/2ez1fXh

Brain training can help in fight against dementia: Meta-analysis

Brain training can help in fight against dementia: Meta-analysis:

Dementia Big
Researchers at the University of Sydney have found that engaging in computer-based brain training can improve memory and mood in older adults with mild cognitive impairment - but training is no longer effective once a dementia diagnosis has been made.


http://ift.tt/2fa8JfC

New figures show dementia is leading cause of death in England and Wales

New figures show dementia is leading cause of death in England and Wales:

Dementia Big
New figures released by the Office of National Statistics show that for the first time, Alzheimer’s disease and other dementias are the leading cause of death for England and Wales. Of the 529,655 deaths registered during 2015, dementia accounted for 61,686 (11.6 percent).


http://ift.tt/2eyX2Tb

Brain training could help improve memory and mood in older adults with mild cognitive impairment

Brain training could help improve memory and mood in older adults with mild cognitive impairment:

Dementia Big
Researchers at the University of Sydney have found that engaging in computer-based brain training can improve memory and mood in older adults with mild cognitive impairment - but training is no longer effective once a dementia diagnosis has been made.


http://ift.tt/2fa4dxB

Thursday, November 10, 2016

Creating therapies for Alzheimer's disease by targeting neural circuits

Age-related dementia will affect 10 percent of people in the U.S. within their lifetime.

from Dementia Big http://ift.tt/2fGYVJy via alcoholic dementia


http://ift.tt/2fGTE4S

KU research on physical activity could be key to designing interventions for people with early AD

For older adults, physical activity is apt to shield against cognitive decline and forms of dementia such as Alzheimer’s disease (AD). Yet, as people age and some experience cognitive impairment, they tend to become less physically active.

from Dementia Big http://ift.tt/2eXAYxF via alcoholic dementia


http://nrgeticform.tumblr.com/post/153025805060

Study elucidates why women have higher risk of developing Alzheimer's disease than men

Women have a two-fold higher risk of developing Alzheimer’s disease than men, yet strikingly little is known about how changes in brain function promote this difference – and how early in midlife those changes can be detected.

from Dementia Big http://ift.tt/2fGVz9C via alcoholic dementia


http://ift.tt/2fGWQNI

Creating therapies for Alzheimer's disease by targeting neural circuits

Creating therapies for Alzheimer's disease by targeting neural circuits:

Dementia Big
Age-related dementia will affect 10 percent of people in the U.S. within their lifetime.


http://ift.tt/2fGXT09

KU research on physical activity could be key to designing interventions for people with early AD

KU research on physical activity could be key to designing interventions for people with early AD:

Dementia Big
For older adults, physical activity is apt to shield against cognitive decline and forms of dementia such as Alzheimer’s disease (AD). Yet, as people age and some experience cognitive impairment, they tend to become less physically active.


http://ift.tt/2fGTBGe

Study elucidates why women have higher risk of developing Alzheimer's disease than men

Study elucidates why women have higher risk of developing Alzheimer's disease than men:

Dementia Big
Women have a two-fold higher risk of developing Alzheimer’s disease than men, yet strikingly little is known about how changes in brain function promote this difference – and how early in midlife those changes can be detected.


http://ift.tt/2fH28sQ

Wednesday, November 9, 2016

New findings on physical activity could shape treatment for mild Alzheimer's disease

New findings on physical activity could shape treatment for mild Alzheimer's disease:

Dementia Big
For older adults, physical activity is apt to shield against cognitive decline and forms of dementia such as Alzheimer’s disease (AD). Yet, as people age and some experience cognitive impairment, they tend to become less physically active.


http://nrgeticform.tumblr.com/post/152965159435

Elucidating sex differences in Alzheimer's disease risk

Elucidating sex differences in Alzheimer's disease risk:

Dementia Big
Women have a two-fold higher risk of developing Alzheimer’s disease than men, yet strikingly little is known about how changes in brain function promote this difference—and how early in midlife those changes can be detected. Now, in a population-based study involving more than 200 healthy women and men ages 47 to 55, a team of researchers led by the Brigham and Women’s Hospital reveals specific changes in memory function that correspond to sex and menopausal stage, rather than chronological age. The work implicates key areas of the brain that are vulnerable to age-related decline and highlights the importance of ovarian hormones in maintaining memory function.


http://nrgeticform.tumblr.com/post/152965159185

Behavior of Alzheimer's-linked protein is revealed

Behavior of Alzheimer's-linked protein is revealed:

Dementia Big
Enzymes called kinases manage a wide range of cell processes, from metabolism, cell signaling, nutrient transport, and many others. Because they can affect so many different cell activities, kinases are tightly regulated within cells to make sure that the enzymes only act when necessary. Improperly activated kinases are linked to illnesses such as cancer and Alzheimer’s disease. A group of scientists from VIB, Vrije Universiteit Brussel (VUB) and Université Libre de Bruxelles (ULB) led by Prof. Tom Lenaerts (VUB-ULB) and prof. Nico van Nuland (VIB-VUB) has uncovered a new mechanism for controlling the activation of a kinase implicated in Alzheimer’s disease, generating novel insights into how to control this protein’s activity.


http://nrgeticform.tumblr.com/post/152965158890

Middle-aged women outperform age-matched men on all memory measures, study shows

Middle-aged women outperform age-matched men on all memory measures, study shows:

Dementia Big
In the battle of the sexes, women have long claimed that they can remember things better and longer than men can.


http://nrgeticform.tumblr.com/post/152965158615

Dementia diagnosis delayed by complex referral criteria

Dementia diagnosis delayed by complex referral criteria:

Dementia Big
Complex and time-consuming memory clinic referral criteria are contributing to delays in the diagnosis of dementia, according to a paper published today by the Journal of the Royal Society of Medicine. Around 850,000 people are living with dementia in the UK but the number thought to have dementia substantially exceeds those with a formal diagnosis. Early diagnosis is a priority for the government and the NHS.


http://nrgeticform.tumblr.com/post/152965158265

New findings on physical activity could shape treatment for mild Alzheimer's disease

For older adults, physical activity is apt to shield against cognitive decline and forms of dementia such as Alzheimer’s disease (AD). Yet, as people age and some experience cognitive impairment, they tend to become less physically active.

from Dementia Big http://medicalxpress.com/news/2016-11-physical-treatment-mild-alzheimer-disease.html via alcoholic dementia


http://nrgeticform.tumblr.com/post/152964669995

Elucidating sex differences in Alzheimer's disease risk

Women have a two-fold higher risk of developing Alzheimer’s disease than men, yet strikingly little is known about how changes in brain function promote this difference—and how early in midlife those changes can be detected. Now, in a population-based study involving more than 200 healthy women and men ages 47 to 55, a team of researchers led by the Brigham and Women’s Hospital reveals specific changes in memory function that correspond to sex and menopausal stage, rather than chronological age. The work implicates key areas of the brain that are vulnerable to age-related decline and highlights the importance of ovarian hormones in maintaining memory function.

from Dementia Big http://medicalxpress.com/news/2016-11-elucidating-sex-differences-alzheimer-disease.html via alcoholic dementia


http://nrgeticform.tumblr.com/post/152964669770

Behavior of Alzheimer's-linked protein is revealed

Enzymes called kinases manage a wide range of cell processes, from metabolism, cell signaling, nutrient transport, and many others. Because they can affect so many different cell activities, kinases are tightly regulated within cells to make sure that the enzymes only act when necessary. Improperly activated kinases are linked to illnesses such as cancer and Alzheimer’s disease. A group of scientists from VIB, Vrije Universiteit Brussel (VUB) and Université Libre de Bruxelles (ULB) led by Prof. Tom Lenaerts (VUB-ULB) and prof. Nico van Nuland (VIB-VUB) has uncovered a new mechanism for controlling the activation of a kinase implicated in Alzheimer’s disease, generating novel insights into how to control this protein’s activity.

from Dementia Big http://medicalxpress.com/news/2016-11-behavior-alzheimer-linked-protein-revealed.html via alcoholic dementia


http://nrgeticform.tumblr.com/post/152964669575

Middle-aged women outperform age-matched men on all memory measures, study shows

In the battle of the sexes, women have long claimed that they can remember things better and longer than men can.

from Dementia Big http://www.news-medical.net/news/20161109/Middle-aged-women-outperform-age-matched-men-on-all-memory-measures-study-shows.aspx via alcoholic dementia


http://nrgeticform.tumblr.com/post/152964669265

Dementia diagnosis delayed by complex referral criteria

Complex and time-consuming memory clinic referral criteria are contributing to delays in the diagnosis of dementia, according to a paper published today by the Journal of the Royal Society of Medicine. Around 850,000 people are living with dementia in the UK but the number thought to have dementia substantially exceeds those with a formal diagnosis. Early diagnosis is a priority for the government and the NHS.

from Dementia Big http://medicalxpress.com/news/2016-11-dementia-diagnosis-complex-referral-criteria.html via alcoholic dementia


http://nrgeticform.tumblr.com/post/152964668780

Tuesday, November 8, 2016

Scientists investigate role of mitochondria in Alzheimer's disease pathology

Scientists investigate role of mitochondria in Alzheimer's disease pathology:

Dementia Big
On Nov. 25, 1901, a 51-year-old woman is admitted to a hospital in Frankfurt, Germany, displaying a bizarre constellation of symptoms.


http://ift.tt/2fB7hTb

Power outage in the brain may be source of Alzheimer's

Power outage in the brain may be source of Alzheimer's:

Dementia Big
On Nov. 25, 1901, a 51-year-old woman is admitted to a hospital in Frankfurt, Germany, displaying a bizarre constellation of symptoms. Her behavior is erratic. She shows signs of paranoia as well as auditory hallucinations, disorientation, and severe memory impairment. Asked to write her own name, she manages “Mrs.,” then lingers over the page, unable to remember the rest. “I have lost myself,” she tells the attending physician.


http://ift.tt/2eIOnfj

Optimised long-term care for persons with dementia

Optimised long-term care for persons with dementia:

Dementia Big
Life expectancy is rising – as is the need for professional long-term care. The care services currently being provided barely meet the existing demand. Therefore, the available resources need to be adapted intelligently. This is the only way, affordable services of sufficient quality can continue to be provided in the future. In-depth and critical analyses are needed as an evidence base for the required adaptation of the existing system, and very few of these are currently available on institutional long-term care in Europe. As part of a project that is being carried out at Danube University Krems in cooperation with the Charles University in Prague and the MAS Alzheimerhilfe, a patient/carer organization in Upper Austria, epidemiological data on the care situation in the Austria and the Czech Republic are now being collected for the first time. The Project is being funded by the Austrian Science Fund FWF and the GACR in the Czech Republic – FWF being the lead agency – and focuses on the situation of persons with dementia who require particularly intensive support.


http://ift.tt/2fB6EZH

Optimised long-term care for persons with dementia

Life expectancy is rising – as is the need for professional long-term care. The care services currently being provided barely meet the existing demand. Therefore, the available resources need to be adapted intelligently. This is the only way, affordable services of sufficient quality can continue to be provided in the future. In-depth and critical analyses are needed as an evidence base for the required adaptation of the existing system, and very few of these are currently available on institutional long-term care in Europe. As part of a project that is being carried out at Danube University Krems in cooperation with the Charles University in Prague and the MAS Alzheimerhilfe, a patient/carer organization in Upper Austria, epidemiological data on the care situation in the Austria and the Czech Republic are now being collected for the first time. The Project is being funded by the Austrian Science Fund FWF and the GACR in the Czech Republic – FWF being the lead agency – and focuses on the situation of persons with dementia who require particularly intensive support.

from Dementia Big http://ift.tt/2fTu0hq via alcoholic dementia


http://ift.tt/2eIRowx

Power outage in the brain may be source of Alzheimer's

On Nov. 25, 1901, a 51-year-old woman is admitted to a hospital in Frankfurt, Germany, displaying a bizarre constellation of symptoms. Her behavior is erratic. She shows signs of paranoia as well as auditory hallucinations, disorientation, and severe memory impairment. Asked to write her own name, she manages “Mrs.,” then lingers over the page, unable to remember the rest. “I have lost myself,” she tells the attending physician.

from Dementia Big http://ift.tt/2fLyJ5L via alcoholic dementia


http://ift.tt/2fB4Ksi

Scientists investigate role of mitochondria in Alzheimer's disease pathology

On Nov. 25, 1901, a 51-year-old woman is admitted to a hospital in Frankfurt, Germany, displaying a bizarre constellation of symptoms.

from Dementia Big http://ift.tt/2eR6Tjk via alcoholic dementia


http://ift.tt/2eIKQOn

Monday, November 7, 2016

Implementation of subjective cognitive decline criteria in research studies

Implementation of subjective cognitive decline criteria in research studies:

Dementia Big
Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer’s disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed.


http://ift.tt/2fwJP9u

Sunday, November 6, 2016

Implementation of subjective cognitive decline criteria in research studies

Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer’s disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed.

from Dementia Big http://ift.tt/2eKG1BK via alcoholic dementia


http://ift.tt/2eEeBzN

Saturday, November 5, 2016

Study challenges model of Alzheimer's disease progression

Alzheimer’s disease is a neurodegenerative disorder for which, despite years of research, there are no effective treatments or cures.

from Dementia Big http://ift.tt/2fD4DB1 via alcoholic dementia


http://ift.tt/2fnFLcX

Study challenges model of Alzheimer's disease progression

Study challenges model of Alzheimer's disease progression:

Dementia Big
Alzheimer’s disease is a neurodegenerative disorder for which, despite years of research, there are no effective treatments or cures.


http://ift.tt/2ft1jUb

Friday, November 4, 2016

Diagnosis of Alzheimer's disease: Llama antibodies detect cerebral lesions

The major challenge facing physicians treating Alzheimer’s is the ability to detect markers of the disease as early as possible. These markers, located in the brain, are difficult to access, hampering diagnosis. Using two types of llama antibody capable of crossing the blood-brain barrier, scientists from the Institut Pasteur, Inserm, the CNRS, the CEA, Pierre & Marie Curie and Paris Descartes Universities and Roche have developed a non-invasive approach to reach brain cells in a mouse model of the disease. Once in the brain, these llama antibodies can specifically mark and show amyloid plaques and neurofibrillary tangles, the two types of lesions that characterize Alzheimer’s disease. These results were published in the Journal of Controlled Release on October 7, 2016.

from Dementia Big http://ift.tt/2fleHtM via alcoholic dementia


http://ift.tt/2eHrrL5

Words matter when talking about Alzheimer's

Using war metaphors in reference to Alzheimer’s disease should be replaced with messages of resilience against a complex, age-associated condition that may not be fully defeatable, according to a team of researchers.

from Dementia Big http://ift.tt/2fyoQs1 via alcoholic dementia


http://ift.tt/2e97SiR

Lack of shrinkage in the hippocampus may help predict people at risk for dementia with Lewy bodies

Dementia with Lewy bodies is a progressive disease that causes hallucinations, decline in mental abilities, rigid muscles, slow movement and tremors. With symptoms similar to Alzheimer’s disease and Parkinson’s disease, a correct diagnosis can be difficult.

from Dementia Big http://ift.tt/2fksQY6 via alcoholic dementia


http://ift.tt/2f97Q7k

Lack of shrinkage in the hippocampus may help predict people at risk for dementia with Lewy bodies

Dementia with Lewy bodies is a progressive disease that causes hallucinations, decline in mental abilities, rigid muscles, slow movement and tremors. With symptoms similar to Alzheimer’s disease and Parkinson’s disease, a correct diagnosis can be difficult.

from Dementia Big http://ift.tt/2fksQY6 via alcoholic dementia


http://ift.tt/2f97Q7k

Brain inflammation may have direct involvement in development of chronic traumatic encephalopathy

For the first time, researchers have shown that inflammation in the brain may have direct involvement in the development of chronic traumatic encephalopathy (CTE). In addition, they found that the number of years one plays contact sports may predict the occurrence of CTE and that this association is partly due to increased inflammation in the brain.

from Dementia Big http://ift.tt/2eqEtPi via alcoholic dementia


http://ift.tt/2fkkovv

Diagnosis of Alzheimer's disease: Llama antibodies detect cerebral lesions

Diagnosis of Alzheimer's disease: Llama antibodies detect cerebral lesions:

Dementia Big
The major challenge facing physicians treating Alzheimer’s is the ability to detect markers of the disease as early as possible. These markers, located in the brain, are difficult to access, hampering diagnosis. Using two types of llama antibody capable of crossing the blood-brain barrier, scientists from the Institut Pasteur, Inserm, the CNRS, the CEA, Pierre & Marie Curie and Paris Descartes Universities and Roche have developed a non-invasive approach to reach brain cells in a mouse model of the disease. Once in the brain, these llama antibodies can specifically mark and show amyloid plaques and neurofibrillary tangles, the two types of lesions that characterize Alzheimer’s disease. These results were published in the Journal of Controlled Release on October 7, 2016.


http://ift.tt/2f9bQol

Words matter when talking about Alzheimer's

Words matter when talking about Alzheimer's:

Dementia Big
Using war metaphors in reference to Alzheimer’s disease should be replaced with messages of resilience against a complex, age-associated condition that may not be fully defeatable, according to a team of researchers.


http://ift.tt/2fkncc0

Lack of shrinkage in the hippocampus may help predict people at risk for dementia with Lewy bodies

Lack of shrinkage in the hippocampus may help predict people at risk for dementia with Lewy bodies:

Dementia Big
Dementia with Lewy bodies is a progressive disease that causes hallucinations, decline in mental abilities, rigid muscles, slow movement and tremors. With symptoms similar to Alzheimer’s disease and Parkinson’s disease, a correct diagnosis can be difficult.


http://ift.tt/2f97i11

Brain inflammation may have direct involvement in development of chronic traumatic encephalopathy

Brain inflammation may have direct involvement in development of chronic traumatic encephalopathy:

Dementia Big
For the first time, researchers have shown that inflammation in the brain may have direct involvement in the development of chronic traumatic encephalopathy (CTE). In addition, they found that the number of years one plays contact sports may predict the occurrence of CTE and that this association is partly due to increased inflammation in the brain.


http://ift.tt/2fkq74D

Thursday, November 3, 2016

Researchers report promising new Alzheimer's drug

Researchers report promising new Alzheimer's drug:

Dementia Big
A new experimental treatment against Alzheimer’s has proved to be promising and free of harmful side effects, researchers in the United States reported Wednesday.


http://ift.tt/2e4RaAM

Lack of brain shrinkage may help identify people at risk for dementia with Lewy bodies

Lack of brain shrinkage may help identify people at risk for dementia with Lewy bodies:

Dementia Big
A lack of shrinkage in the area of the brain responsible for memory may be a sign that people with thinking and memory problems may go on to develop dementia with Lewy bodies rather than Alzheimer’s disease, according to a new study published in the November 2, 2016, online issue of Neurology, a medical journal of the American Academy of Neurology.


http://ift.tt/2eCIVbt

Is a marker of preclinical Alzheimer's disease associated with loneliness?

Is a marker of preclinical Alzheimer's disease associated with loneliness?:

Dementia Big
A new article published online by JAMA Psychiatry used data from a study of 79 cognitively normal adults to examine whether cortical amyloid levels in the brain, a marker of preclinical Alzheimer disease, was associated with self-reported loneliness.


http://ift.tt/2e4M3Rj

Lack of brain shrinkage may help predict who develops dementia with Lewy bodies

Lack of brain shrinkage may help predict who develops dementia with Lewy bodies:

Dementia Big
Dementia with Lewy bodies is a progressive disease that causes hallucinations, decline in mental abilities, rigid muscles, slow movement and tremors. With symptoms similar to Alzheimer’s disease and Parkinson’s disease, a correct diagnosis can be difficult.


http://ift.tt/2eCACfZ

Earlier Alzheimer's diagnosis may be possible with new imaging compound

Earlier Alzheimer's diagnosis may be possible with new imaging compound:

Dementia Big
By the time unambiguous signs of memory loss and cognitive decline appear in people with Alzheimer’s disease, their brains already are significantly damaged, dotted with clumps of a destructive protein known as amyloid beta. For years, scientists have sought methods and clues to help identify brain changes associated with Alzheimer’s earlier in the disease process, so they can try to stop or even reverse the changes before they severely affect people’s lives.


http://ift.tt/2e4M4ol

Amyloid study pinpoints protein culprits

Amyloid study pinpoints protein culprits:

Dementia Big
A five-year trial at a Brisbane Hospital has increased the accuracy of diagnosing patients with amyloidosis, a group of rare and incurable diseases caused by abnormal protein deposits in tissues and organs.


http://ift.tt/2eCF7ai

Researchers report promising new Alzheimer's drug

A new experimental treatment against Alzheimer’s has proved to be promising and free of harmful side effects, researchers in the United States reported Wednesday.

from Dementia Big http://ift.tt/2eCeQsL via alcoholic dementia


http://ift.tt/2e4L9UR

Lack of brain shrinkage may help identify people at risk for dementia with Lewy bodies

A lack of shrinkage in the area of the brain responsible for memory may be a sign that people with thinking and memory problems may go on to develop dementia with Lewy bodies rather than Alzheimer’s disease, according to a new study published in the November 2, 2016, online issue of Neurology, a medical journal of the American Academy of Neurology.

from Dementia Big http://ift.tt/2fd0J0w via alcoholic dementia


http://ift.tt/2eCABIX

Lack of brain shrinkage may help predict who develops dementia with Lewy bodies

Dementia with Lewy bodies is a progressive disease that causes hallucinations, decline in mental abilities, rigid muscles, slow movement and tremors. With symptoms similar to Alzheimer’s disease and Parkinson’s disease, a correct diagnosis can be difficult.

from Dementia Big http://ift.tt/2eAQyPB via alcoholic dementia


http://ift.tt/2e4Ojb4

Is a marker of preclinical Alzheimer's disease associated with loneliness?

A new article published online by JAMA Psychiatry used data from a study of 79 cognitively normal adults to examine whether cortical amyloid levels in the brain, a marker of preclinical Alzheimer disease, was associated with self-reported loneliness.

from Dementia Big http://ift.tt/2fEqebx via alcoholic dementia


http://ift.tt/2eCHLwG

Amyloid study pinpoints protein culprits

A five-year trial at a Brisbane Hospital has increased the accuracy of diagnosing patients with amyloidosis, a group of rare and incurable diseases caused by abnormal protein deposits in tissues and organs.

from Dementia Big http://ift.tt/2emTIsR via alcoholic dementia


http://ift.tt/2e4Niji

Earlier Alzheimer's diagnosis may be possible with new imaging compound

By the time unambiguous signs of memory loss and cognitive decline appear in people with Alzheimer’s disease, their brains already are significantly damaged, dotted with clumps of a destructive protein known as amyloid beta. For years, scientists have sought methods and clues to help identify brain changes associated with Alzheimer’s earlier in the disease process, so they can try to stop or even reverse the changes before they severely affect people’s lives.

from Dementia Big http://ift.tt/2e1Ymhc via alcoholic dementia


http://ift.tt/2eCE769

Tuesday, November 1, 2016

New study to explore therapeutic pill for treatment of concussion

New study to explore therapeutic pill for treatment of concussion:

Dementia Big
The goal of finding a treatment for concussion may be one step closer due to a new study being launched by University of Miami researchers.


http://ift.tt/2eSGBQE

Eating plenty of fruits and vegetables combined with regular exercise linked to better cognitive functioning

Eating plenty of fruits and vegetables combined with regular exercise linked to better cognitive functioning:

Dementia Big
It’s tempting to dip into the leftover Halloween treats, but new research out of York University has found eating plenty of fruits and vegetables, combined with regular exercise, leads to better cognitive functioning for younger and older adults, and may delay the onset of dementia.


http://ift.tt/2fbV4WA

Virtual reality plus treadmill training may help reduce falls linked to aging, Parkinson's disease

Virtual reality plus treadmill training may help reduce falls linked to aging, Parkinson's disease:

Dementia Big
A combination of virtual reality and treadmill training may prove effective in preventing dangerous falls associated with aging, Parkinson’s disease, mild cognitive impairment or dementia, according to a new Tel Aviv University-Tel Aviv Sourasky Medical Center study published in The Lancet.


http://ift.tt/2eSGgxf

Researchers explore interaction between two brain regions during formation of long-term memories

Researchers explore interaction between two brain regions during formation of long-term memories:

Dementia Big
Our brain has a tough task every time we experience something new - it must be flexible to take in new information instantly, but also stable enough to store it for a long time.


http://ift.tt/2fbSOyn

Personalised care for dementia sufferers

Personalised care for dementia sufferers:

Dementia Big
The company Noen AS runs courses for its helpers to enable them to establish close relationships with their dementia patients. The aim is to increase the patients’ quality of life. Researchers have developed an IT tool to help the company demonstrate that its approach is on the right lines.


http://ift.tt/2eSJd0K

New study to explore therapeutic pill for treatment of concussion

The goal of finding a treatment for concussion may be one step closer due to a new study being launched by University of Miami researchers.

from Dementia Big http://ift.tt/2ft7pJl via alcoholic dementia


http://ift.tt/2ffuVUZ

Eating plenty of fruits and vegetables combined with regular exercise linked to better cognitive functioning

It’s tempting to dip into the leftover Halloween treats, but new research out of York University has found eating plenty of fruits and vegetables, combined with regular exercise, leads to better cognitive functioning for younger and older adults, and may delay the onset of dementia.

from Dementia Big http://ift.tt/2fa6auT via alcoholic dementia


http://ift.tt/2elp4jh

Virtual reality plus treadmill training may help reduce falls linked to aging, Parkinson's disease

A combination of virtual reality and treadmill training may prove effective in preventing dangerous falls associated with aging, Parkinson’s disease, mild cognitive impairment or dementia, according to a new Tel Aviv University-Tel Aviv Sourasky Medical Center study published in The Lancet.

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Researchers explore interaction between two brain regions during formation of long-term memories

Our brain has a tough task every time we experience something new - it must be flexible to take in new information instantly, but also stable enough to store it for a long time.

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Personalised care for dementia sufferers

The company Noen AS runs courses for its helpers to enable them to establish close relationships with their dementia patients. The aim is to increase the patients’ quality of life. Researchers have developed an IT tool to help the company demonstrate that its approach is on the right lines.

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