Therapeutic strategies targeting Alzheimer's disease-related molecules

Therapeutic strategies targeting Alzheimer's disease-related molecules:

Dementia Big
Therapeutic strategies targeting Alzheimer’s disease (AD)-related molecule β-amyloid (Aβ), Tau protein and BACE enzyme have been recently explored. However, the therapeutic efficacy for a single target is not ideal. The clinical trials that clean Aβ from the brain in AD patients were largely unsuccessful. It is well known that the inflammatory response is one component of AD pathogenesis, leading to a series of irreversible pathological events. Epidemiological evidences show that long-term use of non-steroidal anti-inflammatory drugs has a sparing role in AD, but it failed to prevent the progression of symptoms in AD patients in randomized clinical trials. Possible reasons for the failure of anti-inflammatory drugs may be associated with: 1) the advanced state of disease or the dosing regimens of drugs; 2) most of the available anti-inflammatory drugs are not really “anti-inflammatory”; 3) these “anti-inflammatory” drugs only prevent the pro-inflammatory responses, but do not trigger the anti-inflammatory responses.

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