Noen AS runs courses to improve personalised care for dementia patients

Noen AS runs courses to improve personalised care for dementia patients:

Dementia Big
The company Noen AS runs courses for its helpers to enable them to establish close relationships with their dementia patients.

http://ift.tt/2e5Dwsm

Distinct structures of tau protein aggregates may help determine type of dementia, study shows

Distinct structures of tau protein aggregates may help determine type of dementia, study shows:

Dementia Big
The distinct structures of toxic protein aggregates that form in degenerating brains determine which type of dementia will occur, which regions of brain will be affected, and how quickly the disease will spread, according to a study from the Peter O'Donnell Jr. Brain Institute.

http://ift.tt/2fx56nR

Noen AS runs courses to improve personalised care for dementia patients

The company Noen AS runs courses for its helpers to enable them to establish close relationships with their dementia patients.

from Dementia Big http://ift.tt/2fwqBVt via alcoholic dementia

http://ift.tt/2f9WG16

Distinct structures of tau protein aggregates may help determine type of dementia, study shows

The distinct structures of toxic protein aggregates that form in degenerating brains determine which type of dementia will occur, which regions of brain will be affected, and how quickly the disease will spread, according to a study from the Peter O'Donnell Jr. Brain Institute.

from Dementia Big http://ift.tt/2eqiZzM via alcoholic dementia

http://ift.tt/2ef9kyo

Structure of toxic tau aggregates determines type of dementia, rate of progression

The distinct structures of toxic protein aggregates that form in degenerating brains determine which type of dementia will occur, which regions of brain will be affected, and how quickly the disease will spread, according to a study from the Peter O'Donnell Jr. Brain Institute.

from Dementia Big http://ift.tt/2eECmId via alcoholic dementia

http://ift.tt/2eFdvnZ

Ionizing radiation may be confounding factor in Alzheimer's disease, study suggests

More humans than ever are exposed to higher levels of ionizing radiation from medical equipment, airplanes, etc. A new study suggests that this kind of radiation may be a confounding factor in the neurodegenerative disease Alzheimer´s.

from Dementia Big http://ift.tt/2dNsI76 via alcoholic dementia

http://ift.tt/2eWTsj2

The Colombian Alzheimer's Prevention Initiative (API) Registry

The Colombian Alzheimer’s Prevention Initiative (API) Registry is a collaborative project among the Neurosciences Group of Antioquia, the Banner Alzheimer’s Institute, and Genentech. The main goal is to provide a source of interested research participants and data to support the API-Colombia Autosomal Dominant Alzheimer’s Disease Trial and help find treatments to delay or prevent the clinical onset of Alzheimer’s disease.

from Dementia Big http://ift.tt/2dVbzUa via alcoholic dementia

http://ift.tt/2eFbfgg

Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study

Small vessel disease (SVD) is a common contributor to dementia. Subtle blood-brain barrier (BBB) leakage may be important in SVD-induced brain damage.

from Dementia Big http://ift.tt/2e2Uo6p via alcoholic dementia

http://ift.tt/2eWUQ5j

Structure of toxic tau aggregates determines type of dementia, rate of progression

Structure of toxic tau aggregates determines type of dementia, rate of progression:

Dementia Big
The distinct structures of toxic protein aggregates that form in degenerating brains determine which type of dementia will occur, which regions of brain will be affected, and how quickly the disease will spread, according to a study from the Peter O'Donnell Jr. Brain Institute.

http://ift.tt/2eZ0uU2

Ionizing radiation may be confounding factor in Alzheimer's disease, study suggests

Ionizing radiation may be confounding factor in Alzheimer's disease, study suggests:

Dementia Big
More humans than ever are exposed to higher levels of ionizing radiation from medical equipment, airplanes, etc. A new study suggests that this kind of radiation may be a confounding factor in the neurodegenerative disease Alzheimer´s.

http://ift.tt/2ffXQNO

The Colombian Alzheimer's Prevention Initiative (API) Registry

The Colombian Alzheimer's Prevention Initiative (API) Registry:

Dementia Big
The Colombian Alzheimer’s Prevention Initiative (API) Registry is a collaborative project among the Neurosciences Group of Antioquia, the Banner Alzheimer’s Institute, and Genentech. The main goal is to provide a source of interested research participants and data to support the API-Colombia Autosomal Dominant Alzheimer’s Disease Trial and help find treatments to delay or prevent the clinical onset of Alzheimer’s disease.

http://ift.tt/2eYXHdN

Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study

Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study:

Dementia Big
Small vessel disease (SVD) is a common contributor to dementia. Subtle blood-brain barrier (BBB) leakage may be important in SVD-induced brain damage.

http://ift.tt/2fg1XJE

Care assistant experiences of dementia care in long-term nursing and residential care environments

Care assistant experiences of dementia care in long-term nursing and residential care environments: Dementia Big

Care assistants have a unique insight into the lives of service users and those factors which may impede or enhance the delivery of high quality dementia oriented care. To address the paucity of research in this area, the present study examined care assistant experiences of dementia care in British long-term residential and nursing environments. Semi-structured interviews were conducted with eight care assistants and transcripts were analysed using interpretive phenomenological analysis. Super-ordinate themes emerging from the data were psychological wellbeing of the care assistant, barriers to effective dementia care, the dementia reality and organisational issues within the care environment. The study revealed important deficiencies in understanding and varying levels of dementia training. Whilst person centred strategies were being implemented, task orientated care remained dominant. Furthermore, care assistants reported taking the perspectives of those with dementia into account, and actively using these to develop relationship centred care.

http://ift.tt/2eDJJjs

Shame, hope, intimacy and growth: Dementia distress and growth in families from the perspective of senior aged care professionals

Shame, hope, intimacy and growth: Dementia distress and growth in families from the perspective of senior aged care professionals: Dementia Big

Minimal research explores the impact of dementia and a dementia diagnosis on families from the unique vantage of senior health professionals. The participants of this study, eight senior aged care professionals, provided unique interpretative insights into family dynamics and sense-making on the journey with dementia, and their own role in that journey. Both positive and negative perspectives were sought. Data from semi-structured interviews were analysed using Interpretative Phenomenological Analysis (IPA). One superordinate theme, Dementia naiveté; redefined intimacy, overarched Embarrassed shame; Maintaining hope; Redefining a model of intimacy; and Redefined relational intimacy and growth. Within these themes, the participants shed light on hurtful embarrassment and shame experienced by families associated with the diagnostic label given to a loved one. This label was perceived to either trigger separation, hurt and immobility through ignorance, or precipitate a frenzy of naive yet hopeful energy for seeking that elusive cure. The participants saw their role as one of enacting a new way of connecting what was with what could be. Thus, they modelled advocacy, integral care and relational intimacy. Validation came in witnessing a redefining of intimacy in many families who were able to embrace that holistic and empathic approach to the shifting presentation of dementia. Psychological well-being was observed to occur when families embraced growthful domains, e.g. acceptance, hope, relational closeness and altruistic concern for other families. Implications for future care models are discussed.

http://ift.tt/2eV83vH

Making sense of dementia: Exploring the use of the Markers of Assimilation of Problematic Experiences in Dementia scale to understand how couples process a diagnosis of dementia

Making sense of dementia: Exploring the use of the Markers of Assimilation of Problematic Experiences in Dementia scale to understand how couples process a diagnosis of dementia: Dementia Big

This qualitative study aimed to see whether the Markers of Assimilation of Problematic Experiences in Dementia (MAPED) scale could be applied to couples. It aimed to explore the interactions between couples and how this affected the levels of assimilation. Semi-structured interviews were conducted with four heterosexual couples. The results suggested that MAPED can be usefully applied to couples. It highlighted the oscillating process which couples undergo as they process a dementia diagnosis. This supports the notion that making sense of a dementia diagnosis is not static, but a fluctuating and ever changing process. The strategies couples employed either facilitated or prevented the expression and integration of the Problematic Voice. The study highlights the importance of supporting couples together during a dementia diagnosis.

http://ift.tt/2eDDc8a

Personal message cards: An evaluation of an alternative method of delivering simulated presence therapy

Personal message cards: An evaluation of an alternative method of delivering simulated presence therapy: Dementia Big

Simulated presence therapy is a technique which utilises a familiar recorded voice to calm and reassure people with dementia who are agitated or anxious. Although simulated presence therapy has shown potential benefits in small-scale studies, practical limitations in making and playing the recordings have restricted its use. An alternative method of delivering a message from an attachment figure is through a personal message card. This was one of seven products used within the Bath Memory Technology Library which was made available free of charge to people affected by dementia and their carers. This paper provides an evaluation of the personal message cards. Although feedback was received on only 10 of the 24 cards that were distributed, for nine people there was evidence that the cards met the goals that had been set either fully or in part, and that people affected by even quite severe levels of dementia could benefit from them.

http://ift.tt/2eVdY3H

Dementia, women and sexuality: How the intersection of ageing, gender and sexuality magnify dementia concerns among lesbian and bisexual women

Dementia, women and sexuality: How the intersection of ageing, gender and sexuality magnify dementia concerns among lesbian and bisexual women: Dementia Big

There is a growing appreciation of the significance of socio-cultural context for the experiences of an individual living with dementia. There is, too, an emergent awareness that dementia is a gendered issue, disproportionately affecting women compared with men. However, little attention has been given as yet to the experiences of lesbian and bisexual women living with dementia. This article addresses this gap in knowledge, exploring the significance of the intersection of ageing, gender and sexuality for lesbian and bisexual women with dementia. It suggests that stigma and social marginalisation associated with dementia and with ageing, gender and sexuality intersect to compound the social exclusion of lesbians and bisexual women. This has implications for early diagnosis and treatment. Moreover, community care policy, which is predicated on heterosexist norms fails to take into account older lesbians and bisexual women’s support networks and so is less likely to be attuned to their needs. Residential care provision is perceived by older lesbians and bisexual women as being heteronormative at best and homophobic at worst. Services which do not recognise, validate and support their identities will compound their anxiety, confusion and distress. This may be contrary to Equality and Human Rights legislation and UK social policies. This paper draws upon, and analyses, extracts from a range of authorship, synthesising the material to present novel insights into the significance of gender and sexuality for the experience of dementia and dementia care.

http://ift.tt/2eDLw80

Primary care-led dementia diagnosis services in South Gloucestershire: Themes from people and families living with dementia and health care professionals

Primary care-led dementia diagnosis services in South Gloucestershire: Themes from people and families living with dementia and health care professionals: Dementia Big
Background

Primary care-led dementia services are an increasingly common form of service delivery; however, little is known about how these services are understood by their main stakeholders: the patients, family members and health care professionals. A primary care-led dementia service was piloted in the South Gloucestershire area during 2012, in which general practitioners (GPs) led the process of assessment and establishing a diagnosis. Of the 26 surgeries in the area, 11 initially agreed to participate in the pilot, with 12 more joining the project by the end of December 2012.

Aim

The aim of this study was to provide a qualitative analysis of the experiences of health care professionals, patients and their families, of the new process of assessment, diagnosis and treatment of dementia within a primary care service.

Methods

Four patients, three care-givers and eight health care professionals were interviewed by peer researchers – all of whom were current care-givers. Interviews were transcribed and analysed using thematic analysis following Braun and Clarke’s model. Data were also gathered about the number of referrals and what happened to these referrals.

Results

Themes gathered into four main areas: ‘the journey’, ‘what next?’, ‘the benefits and limits of primary care’ and ‘are GPs getting it right’?

Conclusions

The analysis provided a perspective on the experiences of patients, family members and health care professionals involved in the relocation of part of the memory service, from secondary care (memory clinics) to primary care, being piloted in South Gloucestershire. This identified both practical issues to be improved upon as well as possible barriers.

http://ift.tt/2eVahet

The Thoughts Questionnaire (TQ) for family caregivers of people with dementia

The Thoughts Questionnaire (TQ) for family caregivers of people with dementia: Dementia Big
Objectives

To develop a new measure of dysfunctional thoughts for family caregivers of people living with dementia. These thoughts can contribute to negative outcomes, but they may be modifiable.

Method

A stepwise process was used to develop the Thoughts Questionnaire, commencing with item generation, concept mapping, and pilot testing in a sample of professional and nonprofessional caregivers of people with dementia (n = 18). Next, an independent sample of 35 family caregivers of people with dementia (30 female; M_age = 64.30, standard deviation = 10.65) completed: (a) the Thoughts Questionnaire; (b) an existing measure of dysfunctional thoughts, the Dementia Thoughts Caregivers Questionnaire; and © separate validated measures of depressive symptoms, caregiver stress, and coping, respectively.

Results

The level of agreement with dysfunctional thought statements from the Dementia Thoughts Caregivers Questionnaire and Thoughts Questionnaire was low. However, a small number of Thoughts Questionnaire statements were strongly endorsed by over 85% of the sample. Both dysfunctional thought measures had adequate reliability, but total scores were not significantly intercorrelated (r = .287, p = .095). Only the Thoughts Questionnaire was significantly, positively correlated with most caregiver stress measures. Thoughts Questionnaire items required a much lower reading level than the Dementia Thoughts Caregivers Questionnaire items.

Discussion

This study provides preliminary data on a tool for assessing the negative role-related thoughts that family caregivers of people with dementia may experience. Given that these thoughts are implicated in depression but they may be modified, the capacity to identify dysfunctional thoughts may prove useful in caregiver support programs.

http://ift.tt/2eDHGvz

Citizenship as practice: Handling communication problems in encounters between persons with dementia and social workers

Citizenship as practice: Handling communication problems in encounters between persons with dementia and social workers: Dementia Big

The overall aim of the study was to investigate if and how persons with dementia were able to take part in negotiations for formal support, as cases of citizenship as practice. The transcripts used for analysis were from 11 assessment meetings conducted in Sweden, in which the formal applicant was a person with dementia. The findings suggest that the actual participation of persons with dementia in assessment meetings varies. Communication problems were found in the meetings to different degrees and were dealt with differently and with various consequences. For those persons with dementia contributing at the same levels as the other participants, there was an attempt at mutual understanding. For those making fewer contributions, the other interlocutors took over the initiative and thus affected the practice of citizenship by persons with dementia in a negative way. The practice of citizenship is situation based and varies depending on all participants. When the person with dementia is able to participate in the conversation, social workers can facilitate for them to overcome communication problems by giving them more time and signaling acceptance. If the person with dementia has great problems in participating, the other participants can find different strategies to at least involve her or him in the conversation.

http://ift.tt/2eV3Yrc

Living with a diagnosis of behavioural-variant frontotemporal dementia: The persons experience

Living with a diagnosis of behavioural-variant frontotemporal dementia: The persons experience: Dementia Big

Research investigating behavioural-variant frontotemporal dementia has concentrated on identifying and quantifying people’s difficulties; yet few studies have considered how people with behavioural-variant frontotemporal dementia make sense of their difficulties. Five participants were interviewed and interpretive phenomenological analysis used to analyse the data. Two superordinate themes emerged: ‘Bewilderment’ and ‘Relationships with others’. ‘Bewilderment’ reflected the feelings of the participants from the start of their dementia, and was divided into two main themes (1) ‘Awareness of change: What’s the problem? and (2) Threats to self: This is not me. The superordinate theme, ‘Relationships with others’, reflected difficulties with social relationships and comprised two main themes (1) ‘Family and friends: Things haven’t changed… but do I say anything wrong?’ and (2) Coping with threats to self: Blame others or just avoid them. The themes were discussed in relation to literature evaluating the difficulties associated with behavioural-variant frontotemporal dementia together with implications for clinical practice.

http://ift.tt/2eDJgOf

Subjective quality of life of those 65 years and older experiencing dementia

Subjective quality of life of those 65 years and older experiencing dementia: Dementia Big
Background/Objectives

To describe how people experiencing dementia define quality of life and how this may be supported.

Design

Qualitative descriptive component of mixed methods cross-sectional study.

Setting

Western Canadian community (4-h weekly care minimum), supportive housing (24-h support/supervision), personal care homes (24-h nursing).

Participants

One hundred and thirty-six persons aged 65+ experiencing dementia.

Measurements

Semi-structured interview questions. Rating of meeting life’s goals.

Results

Participants characterised quality of life as: freedom, independence, having basic needs met, physical health, engagement in meaningful activities and tranquility. A need for self-determination/choice was evidenced across all domains. Increased access to skilled nursing care, support for meaningful engagement with family and meeting life’s goals were endorsed as adding most to quality of life; 43% reported meeting all life’s major goals.

Conclusion

People experiencing dementia may have better quality of life when choice/self-determination is supported. Enhancements in care environment, independence, engagement and meeting of life’s goals merit urgent attention.

http://ift.tt/2eV8jdN

The positive aspects of caregiving in dementia: A critical review of the qualitative literature

The positive aspects of caregiving in dementia: A critical review of the qualitative literature: Dementia Big

Positive aspects of caregiving in dementia have been identified as important in understanding the experiences of carers, yet the research base lacks clear definitions of key concepts. Qualitative research explores carers’ experiences of positive aspects of caregiving in rich detail which lends itself to supporting theory development. The aim of the present review was to critically evaluate the empirical findings of qualitative studies that have explored positive aspects of caregiving in dementia. A systematic search of the literature revealed 14 studies that met this aim. Carers described multiple positive dimensions of caregiving and identified several factors that were important in supporting their positive caregiving experience. The present review evidences a solid base of understanding of the positive aspects of caregiving in dementia from which concepts and theories can be further developed. Clinical and research implications are discussed.

http://ift.tt/2eDGJU8

Negotiating access to a diagnosis of dementia: Implications for policies in health and social care

Negotiating access to a diagnosis of dementia: Implications for policies in health and social care: Dementia Big

The ‘Pathways to Diagnosis’ study captured the experience of the prediagnosis period of Alzheimer’s disease and related dementias through indepth interviews with 29 persons with dementia and 34 of their family caregivers across four sites: anglophones in Calgary, francophones in Ottawa, Chinese-Canadians in Greater Vancouver and Indo-Canadians in Toronto. In this cross-site analysis, we use the ‘Candidacy’ framework to comprehensively explore the challenges to securing a diagnosis of dementia in Canada and to develop relevant health and social policy. Candidacy views eligibility for appropriate medical care as a process of joint negotiation between individuals and health services, which can be understood relative to seven dimensions: identification of need, navigation, appearances at services, adjudication by providers, acceptance of/resistance to offers, permeability of services and local conditions. Interviewees experienced challenges relative to each of the seven dimensions and these varied in form and emphasis across the four ethno-linguistic groups.

http://ift.tt/2eV86HG

Burden of care, social support, and sense of coherence in elderly caregivers living with individuals with symptoms of dementia

Burden of care, social support, and sense of coherence in elderly caregivers living with individuals with symptoms of dementia: Dementia Big

Family members are often the care providers of individuals with dementia, and it is assumed that the need for this will increase. There has been little research into the association between the burden of care and the caregiver’s sense of coherence or receipt of social support. This study examined the relationship between the social support subdimensions and sense of coherence and the burden of care among older people giving care to a partner with dementia. The study was a cross-sectional observation study of 97 individuals, ≥65 years old and living with a partner who had symptoms of dementia. We used the Informant Questionnaire on Cognitive Decline in the Elderly, the Relative Stress Scale, the Social Provisions Scale, the Sense of Coherence Scale, and a questionnaire on sociodemographic variables. We used multiple regression analysis in a general linear model procedure. We defined statistical significance as p < 0.05. With adjustments for sociodemographic variables, the association with burden of care was statistically significant for the subdimension attachment (p < 0.01) and for sense of coherence (p < 0.001). The burden of care was associated with attachment and with sense of coherence. Community nurses and other health professionals should take necessary action to strengthen attachment and sense of coherence among the caregivers of people with dementia. Qualitative studies could provide deeper understanding of the variation informal caregivers experience when living together with their partner with dementia.

http://ift.tt/2eDGgRX

Healing words: A study of poetry interventions in dementia care

Healing words: A study of poetry interventions in dementia care: Dementia Big

The personhood movement in dementia research has established the theoretical foundation for implementing cultural arts interventions in care practices. The underlying assumption is that professionals from the visual and the performance arts are well equipped to see the person behind the condition and to focus on possibilities for meaningful relationships in the here and now. This article focuses on poetry interventions as one example of cultural arts interventions. The use of poetry might seem counterintuitive, given that people with dementia lose their language abilities and that poetry is regarded to be the most complex literary form. I will argue that expanding on existing research on poetry interventions from a health and science perspective with a humanities approach will help illuminate how poetry works to enhance the exchange with people with dementia. Drawing on participant observations of poetry interventions by Gary Glazner (Alzheimer’s Poetry Project, USA) at the New York Memory Center, I will frame poetry interventions as a specific form of oral poetry in which people with dementia are positioned as cocreators of embodied texts and directly benefit from the power of the spoken word.

http://ift.tt/2eVdjPA

Barriers to leisure participation for people with dementia and their carers: An exploratory analysis of carer and people with dementias experiences

Barriers to leisure participation for people with dementia and their carers: An exploratory analysis of carer and people with dementias experiences: Dementia Big

Leisure has emerged as a prominent research theme within the growing body of knowledge on dementia, with a focus on physical activity. Yet participation in any form of leisure presupposes an ability to freely choose to partake in activities and to negotiate one’s way around key barriers. In the case of dementia, the ability to undertake leisure activities is subject to a greater range of barriers, structured in a hierarchical manner that contributes to social exclusion if not addressed. This study based on focus groups with people with dementia and their family members conducted in Dorset, UK illustrates a range of barriers to leisure participation. How to create or maintain leisure opportunities for those living with dementia where households affected by dementia do not adopt avoidance behaviour, compounding a sense of isolation and exclusion is a challenge. Leisure can be an important strategy framed as a form of resistance to the social disabilities experienced by those living with dementia and it is potentially isolating impact.

http://ift.tt/2eDKRDD

How does a woman with Alzheimers disease make sense of becoming cared for?

How does a woman with Alzheimers disease make sense of becoming cared for?: Dementia Big

This case study explores the meaning one woman with Alzheimer’s disease (AD) gives to receiving assistance with instrumental activities of daily living (IADLs) from her spouse. Improving the care of people living with AD is widely accepted as an important outcome in dementia services. Understanding how it feels for the person with AD to receive that care is essential to enhance their quality of life. Experiences identified using interpretative phenomenological analysis focus on a connection to past self and maintaining identity whilst also accepting change. The experience of ‘Sameness and Change’ identifies her feelings of discontinuity whilst ‘Goodness’ depicts her continued emotional expression of care presented in an attempt to remain someone of value within her family. These findings offer new insight and understanding to assist a woman’s transition from carer to becoming cared for.

http://ift.tt/2eV3rW6

Football and dementia: A qualitative investigation of a community based sports group for men with early onset dementia

Football and dementia: A qualitative investigation of a community based sports group for men with early onset dementia: Dementia Big

This study investigates the impact of a weekly group providing sport and physical activities for men with early onset dementia established by Notts County Football in the Community (NCFC). There were three aims: to investigate the effect of early onset dementia on individuals with the condition and their carers; to examine the perceptions of current levels of service provision for people with early onset dementia; and to analyse the impact of the group. Men with dementia (n = 5) attending the sessions, their carers (n = 5), NCFC coaching staff (n = 5) and people organizing/facilitating the sessions (n = 5) were interviewed. Semi-structured interviews explored the participants’ experiences of dementia, their opinions on current service provisions and on the sessions. Data were analysed using thematic analysis. Four main themes were found: loss related to the condition of dementia and its impact on relationships (‘Loss’); lack of age-appropriate services for people with early onset dementia (‘Lack of Resources’); enjoyment and positive anticipation related to the group for all involved (‘Enjoyment and Anticipation’); and ‘the Notts County Effect’ which attributed the success of the sessions to the strong brand of the football club, and to personalized service in a “dementia-free” environment. The NCFC sessions provided a safe low-cost intervention with positive effects upon quality of life for both people with early onset dementia, their carers and the staff involved. This suggests that the service may be valuable to a wider range of people living in different areas.

http://ift.tt/2eDKSaF

Stigma, the medical model and dementia care: Psychological growth in senior health professionals through moral and professional integrity

Stigma, the medical model and dementia care: Psychological growth in senior health professionals through moral and professional integrity: Dementia Big

Minimal research explores the impact of a career in dementia care on senior health professionals. This study sought positive and negative subjective interpretations from seven senior health professionals regarding their experiences in dementia care. Data from semi-structured interviews were analysed using interpretative phenomenological analysis (IPA). One superordinate theme, Honouring stigmatised self, overarched four sub-themes: Systemic stigma, Invalidated, Self-respect and Moral integrity and Growth. Stigma was interpreted as systemically entrenched minimisation of aged care and the aged-care workforce, including poor remuneration and training. Participants experienced peer invalidation particularly when attempting to resolve complex professional and moral challenges in dementia care. These often occurred in the context of efforts to individualise care, constrained within a medical model. Paradoxically, external invalidation motivated a search for redefining ‘self’ and moral integrity. By wisely acknowledging career experience, growthful domains of self-respect, optimism, humility and innovation defined professional practice and personal choices. Implications are discussed.

http://ift.tt/2eVacrb

Development and effectiveness of an integrated inpatient and community service for challenging behaviour in late life: From Confused and Disturbed Elderly to Transitional Behavioural Assessment and Intervention Service

Development and effectiveness of an integrated inpatient and community service for challenging behaviour in late life: From Confused and Disturbed Elderly to Transitional Behavioural Assessment and Intervention Service: Dementia Big

A common method of managing challenging behaviour associated with dementia is long-stay special care units, though models are very diverse. In New South Wales, Australia, the five remaining state-run long-stay special care units for this population were funded to adopt a shorter-term model which had been trialled by one of the units. Transitional Behavioural Assessment and Intervention Service Units, incorporating an integrated outreach team, were to provide multi-disciplinary assessments, develop individualised bio-psychosocial management plans for, and appropriately discharge people with significant levels of Behavioural and Psychological Symptoms in Dementia. The current study assessed both the effects of the change and the clinical effectiveness of the model.

Method

A repeated measures design, supplemented by multiple one-time measures. A range of standard instruments were administered, patient data from other types of inpatient units were obtained, interviews conducted, and medical records examined.

Results

Transitional Behaviour Assessment and Intervention Service units were admitting patients with dementia and a variety of significant challenging behaviours. Length of stay was shortened in all units, patients turnover greatly increased, and there was a low re-admission rate. The model was substantially cheaper than psychiatric care in two units where it was fully implemented; one unit cost the same as psychiatric care, and two units were not cost-effective because of low occupancy – related to not fully implementing the model. Referring facilities reported that in the absence of the units, their main strategy would have been to increase sedation. In the Transitional Behavioural Assessment and Intervention Service units, behavioural incidents were primarily managed through psychosocial means. It is not known whether behaviour is reduced over time, staff become better at managing the behaviour when it occurs, or both.

Conclusion

The evaluation showed that the model can be transferred to other units and is a cost-effective way of assessing, managing, and successfully discharging people with complex challenging behaviours, though only when fully implemented.

http://ift.tt/2eDJAw2

The "not yet" horizon: Understandings of the future amongst couples living with dementia

The "not yet" horizon: Understandings of the future amongst couples living with dementia: Dementia Big

The way in which persons with dementia and their spouses regard the future could influence how they experience the disease itself. This study aims to explore how the future is understood by couples living with dementia. The analysis reveals different ways in which couples understand the future. The findings show that persons with dementia describe the here and now in ways that take the gloomy future they dread as a point of reference, and as a result of this, they operate in what we term “the not yet horizon”. But while they take for granted that there is a horizon that they have not yet reached, their spouses always seem to focus on the horizons that they have already crossed. The article discusses the findings in relation to ideas such as critical periods, existential coordinates and possible selves, and problematizes the implicit assumptions about the future that dementia researchers tend to operate from.

http://ift.tt/2eV9DO4

Desuto introduces new tool to transform decision-making process for health and social care professionals

Desuto introduces new tool to transform decision-making process for health and social care professionals:

Dementia Big
Desuto, a leader in health and social care decision-support, has launched a unique new tool designed to transform the decision-making process for health and social care professionals across the UK.

http://ift.tt/2dQ86pV

Concern that radiation may contribute to development of Alzheimer's

Concern that radiation may contribute to development of Alzheimer's:

Dementia Big
More humans than ever are exposed to higher levels of ionizing radiation from medical equipment, airplanes, etc. A new study suggests that this kind of radiation may be a confounding factor in the neurodegenerative disease Alzheimer’s.

http://ift.tt/2fkdCGr

High blood pressure in middle age could be potential risk factor for Alzheimer's disease

High blood pressure in middle age could be potential risk factor for Alzheimer's disease:

Dementia Big
High blood pressure in middle age can lead to impaired cognition and is a potential risk factor for Alzheimer’s disease, according to a statement from the American Heart Association co-authored by Loyola Medicine neurologist José Biller, MD.

http://ift.tt/2dQ6Pzf

Comfortable living conditions, independence can help elderly Chinese immigrants feel at home in the U.S.

Comfortable living conditions, independence can help elderly Chinese immigrants feel at home in the U.S.:

Dementia Big
Having comfortable living conditions and independence from their adult children can help elderly Chinese immigrants find a sense of home and life satisfaction in the United States, but the inability to speak fluent English makes them feel unsettled, according to a research study.

http://ift.tt/2fkdDua

Desuto introduces new tool to transform decision-making process for health and social care professionals

Desuto, a leader in health and social care decision-support, has launched a unique new tool designed to transform the decision-making process for health and social care professionals across the UK.

from Dementia Big http://ift.tt/2eQetMe via alcoholic dementia

http://ift.tt/2dQ5mZw

High blood pressure in middle age could be potential risk factor for Alzheimer's disease

High blood pressure in middle age can lead to impaired cognition and is a potential risk factor for Alzheimer’s disease, according to a statement from the American Heart Association co-authored by Loyola Medicine neurologist José Biller, MD.

from Dementia Big http://ift.tt/2f8VT5F via alcoholic dementia

http://ift.tt/2fkbq1J

Concern that radiation may contribute to development of Alzheimer's

More humans than ever are exposed to higher levels of ionizing radiation from medical equipment, airplanes, etc. A new study suggests that this kind of radiation may be a confounding factor in the neurodegenerative disease Alzheimer’s.

from Dementia Big http://ift.tt/2ezhmmm via alcoholic dementia

http://ift.tt/2dQ660G

Comfortable living conditions, independence can help elderly Chinese immigrants feel at home in the U.S.

Having comfortable living conditions and independence from their adult children can help elderly Chinese immigrants find a sense of home and life satisfaction in the United States, but the inability to speak fluent English makes them feel unsettled, according to a research study.

from Dementia Big http://ift.tt/2fg943N via alcoholic dementia

http://ift.tt/2fkfEqb

Novel approach to analyzing brain structures may help predict progression of Alzheimer's disease

Use of a novel approach to analyzing brain structure that focuses on the shape rather than the size of particular features may allow identification of individuals in early presymptomatic stages of Alzheimer’s disease.

from Dementia Big http://ift.tt/2eKkUAP via alcoholic dementia

http://ift.tt/2eLDBE8

Researchers find two new genetic risk factors for AD among African Americans

Researchers have identified two new genetic risk factors for Alzheimer’s disease (AD) among African Americans.

from Dementia Big http://ift.tt/2eE5Qn5 via alcoholic dementia

http://ift.tt/2ffEFCS

New drug appears to decrease inflammation in the brain linked to Alzheimer's disease

An experimental drug shows promise in treating Alzheimer’s disease by preventing inflammation and removing abnormal protein clumps in the brain that are associated with the disease, suggests a study in mice presented at the ANESTHESIOLOGY 2016 annual meeting.

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http://ift.tt/2eLCmok

Experimental drug shows promise in treating Alzheimer's disease

An experimental drug shows promise in treating Alzheimer’s disease by preventing inflammation and removing abnormal protein clumps in the brain that are associated with the disease, suggests a study in mice presented at the Anesthesiology 2016 annual meeting.

from Dementia Big http://ift.tt/2eCmR4f via alcoholic dementia

http://ift.tt/2ffAhUi

Study tests whether exercise, lowering cholesterol helps prevent Alzheimer's

Carol White can’t help but worry when she misplaces keys or can’t recall a name ever since relatives have been diagnosed with early onset Alzheimer’s.

from Dementia Big http://ift.tt/2eCmeHA via alcoholic dementia

http://ift.tt/2eLzyrm

Advanced analysis of brain structure shape may track progression to Alzheimer's disease

Use of a novel approach to analyzing brain structure that focuses on the shape rather than the size of particular features may allow identification of individuals in early presymptomatic stages of Alzheimer’s disease. A team of Massachusetts General Hospital (MGH) investigators using advanced computational tools to analyze data from standard MRI scans report that individuals with Alzheimer’s disease, including those diagnosed partway through a multi-year study, had greater levels of asymmetry - differences in shape between the left and right sides of the brain - of key brain structures. Their study has been published online in the journal Brain.

from Dementia Big http://ift.tt/2dSR9OI via alcoholic dementia

http://ift.tt/2ffGRKA

New report puts forward recommendations aimed at speeding up access to innovative dementia medicines

A new report published by the government today (24 October), puts forward a number of recommendations aimed at speeding up the process by which the NHS implements newly developed drugs and medical procedures.

from Dementia Big http://ift.tt/2eHJYIB via alcoholic dementia

http://ift.tt/2eLDBUr

New worm strain to facilitate study of Alzheimer's disease

Researchers from Yale-NUS College have partnered with researchers from the National University of Singapore (NUS) and SingHealth Group to develop a novel Caenorhabditis elegans (C. elegans) worm strain which expresses an amyloid beta protein fragment involved in the development of human Alzheimer’s Disease (AD). This strain will serve as a tool for the testing of interventions against AD and to help researchers understand the disease better.

from Dementia Big http://ift.tt/2dSpfme via alcoholic dementia

http://ift.tt/2ffDLWQ

Better general practice strategies may help reduce risk of hospital admissions

Hospital admission rates are 55 per cent higher in some areas than in others because of a greater prevalence of conditions such as diabetes, alcoholism, dementia and socioeconomic deprivation.

from Dementia Big http://ift.tt/2faXTtr via alcoholic dementia

http://ift.tt/2eLBz6V

Nuclear but not mitochondrial-encoded OXPHOS genes are altered in aging, mild cognitive impairment, and Alzheimer's disease

We have comprehensively described the expression profiles of mitochondrial DNA and nuclear DNA genes that encode subunits of the respiratory oxidative phosphorylation (OXPHOS) complexes (I–V) in the hippocampus from young controls, age matched, mild cognitively impaired (MCI), and AD subjects.

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http://ift.tt/2ffDSC0

Glucose level decline precedes dementia in elderly African Americans with diabetes

High blood glucose levels may be responsible for the increased risk for dementia in diabetic patients.

from Dementia Big http://ift.tt/2ePJnUP via alcoholic dementia

http://ift.tt/2eLzvfa

Novel telemedicine speech therapy could improve dementia patient’s ability to recall words

A novel telemedicine speech therapy program for people with language problems due to dementia significantly improved their ability to recall words they had “lost,” reports a new Northwestern Medicine study

from Dementia Big http://ift.tt/2eEdAqR via alcoholic dementia

http://ift.tt/2ffCKhM

Novel approach to analyzing brain structures may help predict progression of Alzheimer's disease

Novel approach to analyzing brain structures may help predict progression of Alzheimer's disease:

Dementia Big
Use of a novel approach to analyzing brain structure that focuses on the shape rather than the size of particular features may allow identification of individuals in early presymptomatic stages of Alzheimer’s disease.

http://ift.tt/2eG8RDI

Researchers find two new genetic risk factors for AD among African Americans

Researchers find two new genetic risk factors for AD among African Americans:

Dementia Big
Researchers have identified two new genetic risk factors for Alzheimer’s disease (AD) among African Americans.

http://ift.tt/2ev97ru

New drug appears to decrease inflammation in the brain linked to Alzheimer's disease

New drug appears to decrease inflammation in the brain linked to Alzheimer's disease:

Dementia Big
An experimental drug shows promise in treating Alzheimer’s disease by preventing inflammation and removing abnormal protein clumps in the brain that are associated with the disease, suggests a study in mice presented at the ANESTHESIOLOGY 2016 annual meeting.

http://ift.tt/2eG9XiE

Experimental drug shows promise in treating Alzheimer's disease

Experimental drug shows promise in treating Alzheimer's disease:

Dementia Big
An experimental drug shows promise in treating Alzheimer’s disease by preventing inflammation and removing abnormal protein clumps in the brain that are associated with the disease, suggests a study in mice presented at the Anesthesiology 2016 annual meeting.

http://ift.tt/2evbMkU

Study tests whether exercise, lowering cholesterol helps prevent Alzheimer's

Study tests whether exercise, lowering cholesterol helps prevent Alzheimer's:

Dementia Big
Carol White can’t help but worry when she misplaces keys or can’t recall a name ever since relatives have been diagnosed with early onset Alzheimer’s.

http://ift.tt/2eG8U2a

Advanced analysis of brain structure shape may track progression to Alzheimer's disease

Advanced analysis of brain structure shape may track progression to Alzheimer's disease:

Dementia Big
Use of a novel approach to analyzing brain structure that focuses on the shape rather than the size of particular features may allow identification of individuals in early presymptomatic stages of Alzheimer’s disease. A team of Massachusetts General Hospital (MGH) investigators using advanced computational tools to analyze data from standard MRI scans report that individuals with Alzheimer’s disease, including those diagnosed partway through a multi-year study, had greater levels of asymmetry - differences in shape between the left and right sides of the brain - of key brain structures. Their study has been published online in the journal Brain.

http://ift.tt/2ev99zp

New report puts forward recommendations aimed at speeding up access to innovative dementia medicines

New report puts forward recommendations aimed at speeding up access to innovative dementia medicines:

Dementia Big
A new report published by the government today (24 October), puts forward a number of recommendations aimed at speeding up the process by which the NHS implements newly developed drugs and medical procedures.

http://ift.tt/2eG4SXP

New worm strain to facilitate study of Alzheimer's disease

New worm strain to facilitate study of Alzheimer's disease:

Dementia Big
Researchers from Yale-NUS College have partnered with researchers from the National University of Singapore (NUS) and SingHealth Group to develop a novel Caenorhabditis elegans (C. elegans) worm strain which expresses an amyloid beta protein fragment involved in the development of human Alzheimer’s Disease (AD). This strain will serve as a tool for the testing of interventions against AD and to help researchers understand the disease better.

http://ift.tt/2ev7c6k

Helping dementia patients recall grandchildren's names

Helping dementia patients recall grandchildren's names:

Dementia Big
A novel telemedicine speech therapy program for people with language problems due to dementia significantly improved their ability to recall words they had “lost,” reports a new Northwestern Medicine study.

http://ift.tt/2dExvrg

Helping dementia patients recall grandchildren's names

A novel telemedicine speech therapy program for people with language problems due to dementia significantly improved their ability to recall words they had “lost,” reports a new Northwestern Medicine study.

from Dementia Big http://ift.tt/2f9cEN7 via alcoholic dementia

http://ift.tt/2dEMI75

Higher levels of tau protein found in children with early onset psychosis

Higher levels of tau protein found in children with early onset psychosis:

Dementia Big
New research presented at this year’s International Early Psychosis Association (IEPA) meeting in Milan, Italy (20-22 October) shows that levels of a certain type of the Alzheimer’s disease-related tau protein are higher in patients aged 18 years and under suffering early onset psychosis (EOP). The study is by Dr Mathias Lundberg and Dr Neil Cleland, Karolinska Institutet, Stockholm, Sweden and colleagues.

http://ift.tt/2ehiFX4

Scientists suggest potential approach of lowering tau levels to thwart Alzheimer's disease

Scientists suggest potential approach of lowering tau levels to thwart Alzheimer's disease:

Dementia Big
Taking a pill that prevents the accumulation of toxic molecules in the brain might someday help prevent or delay Alzheimer’s disease, according to scientists at Baylor College of Medicine, Texas Children’s Hospital and Johns Hopkins University School of Medicine.

http://ift.tt/2eEJGSj

Researchers discover how toxic proteins linked to neurological diseases impair membrane-less organelles

Researchers discover how toxic proteins linked to neurological diseases impair membrane-less organelles:

Dementia Big
Researchers at St. Jude Children’s Research Hospital have discovered the way toxic proteins linked to the most common forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) incapacitate membrane-less organelles inside cells.

http://ift.tt/2ehgGC4

Treatment approach used in cancer holds promise for Alzheimer's disease

Treatment approach used in cancer holds promise for Alzheimer's disease:

Dementia Big
Researchers have developed a novel treatment that could block the development of Alzheimer’s disease using microscopic droplets of fat to carry drugs into the brain. This treatment approach, which is used to target drugs to cancer cells, has been successfully applied to Alzheimer’s disease for the first time, restoring memory loss in mice.

http://ift.tt/2eEJcvz

Higher levels of tau protein found in children with early onset psychosis

New research presented at this year’s International Early Psychosis Association (IEPA) meeting in Milan, Italy (20-22 October) shows that levels of a certain type of the Alzheimer’s disease-related tau protein are higher in patients aged 18 years and under suffering early onset psychosis (EOP). The study is by Dr Mathias Lundberg and Dr Neil Cleland, Karolinska Institutet, Stockholm, Sweden and colleagues.

from Dementia Big http://ift.tt/2evwpMi via alcoholic dementia

http://ift.tt/2ehh2Z7

Researchers discover how toxic proteins linked to neurological diseases impair membrane-less organelles

Researchers at St. Jude Children’s Research Hospital have discovered the way toxic proteins linked to the most common forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) incapacitate membrane-less organelles inside cells.

from Dementia Big http://ift.tt/2e76jPG via alcoholic dementia

http://ift.tt/2eEKYwz

Treatment approach used in cancer holds promise for Alzheimer's disease

Researchers have developed a novel treatment that could block the development of Alzheimer’s disease using microscopic droplets of fat to carry drugs into the brain. This treatment approach, which is used to target drugs to cancer cells, has been successfully applied to Alzheimer’s disease for the first time, restoring memory loss in mice.

from Dementia Big http://ift.tt/2epLeAD via alcoholic dementia

http://ift.tt/2eheryq

Scientists suggest potential approach of lowering tau levels to thwart Alzheimer's disease

Taking a pill that prevents the accumulation of toxic molecules in the brain might someday help prevent or delay Alzheimer’s disease, according to scientists at Baylor College of Medicine, Texas Children’s Hospital and Johns Hopkins University School of Medicine.

from Dementia Big http://ift.tt/2euUCSE via alcoholic dementia

http://ift.tt/2eEHQAX

Newly identified rare Alzheimer's disease gene mutation more common in Icelandic people

People with Icelandic heritage are more likely to carry a novel rare mutation in the TM2D3 gene, which leads to greater risk for Alzheimer’s disease, based on a new study published October 14th, 2016 in PLOS Genetics by Johanna Jakobsdottir of the Icelandic Heart Association, Sven van der Lee of Erasmus University in Rotterdam, and colleagues.

from Dementia Big http://ift.tt/2enesQP via alcoholic dementia

http://ift.tt/2epOZEq

Novel Alzheimer's treatment uses microscopic droplets of fat to carry drugs into the brain

Researchers have developed a novel treatment that could block the development of Alzheimer’s disease using microscopic droplets of fat to carry drugs into the brain.

from Dementia Big http://ift.tt/2epJCG9 via alcoholic dementia

http://ift.tt/2edLoOG

Portsmouth academic’s dementia project shortlisted for RIBA President’s Awards for Research 2016

A Portsmouth academic’s research project has been shortlisted for an award by the Royal Institute of British Architects (RIBA).

from Dementia Big http://ift.tt/2dD46wc via alcoholic dementia

http://ift.tt/2epNhmJ

Penn physician argues for 'meaningful' update to national Alzheimer's act

A key strategy missing from the ambitious Alzheimer’s disease plan signed into law by President Obama six years ago could send investigational drugs down a precarious pipeline, argue two physicians from the Perelman School of Medicine at the University of Pennsylvania and the University of Michigan in JAMA Internal Medicine. The National Alzheimer Project Act (NAPA) calls for new treatments to slow or prevent the disease by 2025, but as it stands now, there’s no strategy in place to determine whether the interventions being studied today have a so-called “meaningful” clinical benefit for patients. Without that strategy, private interests could shape how a drug’s clinical benefit is established after approval and therefore costs, similar to what’s happening in the oncology world.

from Dementia Big http://ift.tt/2ebpiMP via alcoholic dementia

http://ift.tt/2edM9aw

Portsmouth academic’s dementia project shortlisted for RIBA President’s Awards for Research 2016

Portsmouth academic’s dementia project shortlisted for RIBA President’s Awards for Research 2016:

Dementia Big
A Portsmouth academic’s research project has been shortlisted for an award by the Royal Institute of British Architects (RIBA).

http://ift.tt/2epP1w2

Newly identified rare Alzheimer's disease gene mutation more common in Icelandic people

Newly identified rare Alzheimer's disease gene mutation more common in Icelandic people:

Dementia Big
People with Icelandic heritage are more likely to carry a novel rare mutation in the TM2D3 gene, which leads to greater risk for Alzheimer’s disease, based on a new study published October 14th, 2016 in PLOS Genetics by Johanna Jakobsdottir of the Icelandic Heart Association, Sven van der Lee of Erasmus University in Rotterdam, and colleagues.

http://ift.tt/2edNKgH

Novel Alzheimer's treatment uses microscopic droplets of fat to carry drugs into the brain

Novel Alzheimer's treatment uses microscopic droplets of fat to carry drugs into the brain:

Dementia Big
Researchers have developed a novel treatment that could block the development of Alzheimer’s disease using microscopic droplets of fat to carry drugs into the brain.

http://ift.tt/2epMPoG

Penn physician argues for 'meaningful' update to national Alzheimer's act

Penn physician argues for 'meaningful' update to national Alzheimer's act:

Dementia Big
A key strategy missing from the ambitious Alzheimer’s disease plan signed into law by President Obama six years ago could send investigational drugs down a precarious pipeline, argue two physicians from the Perelman School of Medicine at the University of Pennsylvania and the University of Michigan in JAMA Internal Medicine. The National Alzheimer Project Act (NAPA) calls for new treatments to slow or prevent the disease by 2025, but as it stands now, there’s no strategy in place to determine whether the interventions being studied today have a so-called “meaningful” clinical benefit for patients. Without that strategy, private interests could shape how a drug’s clinical benefit is established after approval and therefore costs, similar to what’s happening in the oncology world.

http://ift.tt/2ez4V6T

Exercise may benefit elderly people with memory and thinking problems

Exercise may be associated with a small benefit for elderly people who already have memory and thinking problems, according to new research published in the October 19, 2016, online issue of Neurology, a medical journal of the American Academy of Neurology.

from Dementia Big http://ift.tt/2drocpH via alcoholic dementia

http://ift.tt/2eiKyhP

Protein linked to Alzheimer's may also play a role in schizophrenia

A specific protein implicated in the cognitive decline of Alzheimer’s disease also appears to play a role in genetic predisposition to schizophrenia, meaning that a drug that targets that protein could treat a variety of neuropsychiatric disorders, according to a new study published October 18 in the journal Molecular Psychiatry.

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http://ift.tt/2dPNb72

Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans

African Americans’ (AAs) late-onset Alzheimer’s disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power.

from Dementia Big http://ift.tt/2eTf42r via alcoholic dementia

http://ift.tt/2eiLt1w

Hemodynamic and serum cardiac markers and risk of cognitive impairment and dementia

Cardiac function is a key player in maintaining energy homeostasis in the brain. Heart failure is closely related to higher risk of neurocognitive disorders. Recent evidence shows that this relationship might not be limited to patients with advanced heart failure, and even suboptimal cardiac functioning is associated with accelerated brain aging. Hence, hemodynamic and serum cardiac markers may provide valuable information about the risk of dementia.

from Dementia Big http://ift.tt/2eTesdh via alcoholic dementia

http://ift.tt/2dPNDSL

BUSM researcher receives nearly $20 million grant to support dementia and AD research

Sudha Seshadri, MD, professor of neurology at Boston University School of Medicine, has been awarded three grants this year totaling nearly $20 million from the National Institute on Aging and the National Institute of Neurological Disorders and Stroke.

from Dementia Big http://ift.tt/2dZDbdf via alcoholic dementia

http://ift.tt/2eiN9YP

Exercise may benefit elderly people with memory and thinking problems

Exercise may benefit elderly people with memory and thinking problems:

Dementia Big
Exercise may be associated with a small benefit for elderly people who already have memory and thinking problems, according to new research published in the October 19, 2016, online issue of Neurology, a medical journal of the American Academy of Neurology.

http://ift.tt/2dPLIO5

Protein linked to Alzheimer's may also play a role in schizophrenia

Protein linked to Alzheimer's may also play a role in schizophrenia:

Dementia Big
A specific protein implicated in the cognitive decline of Alzheimer’s disease also appears to play a role in genetic predisposition to schizophrenia, meaning that a drug that targets that protein could treat a variety of neuropsychiatric disorders, according to a new study published October 18 in the journal Molecular Psychiatry.

http://ift.tt/2eiKvTb

Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans

Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans:

Dementia Big
African Americans’ (AAs) late-onset Alzheimer’s disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power.

http://ift.tt/2dPMgDR

Hemodynamic and serum cardiac markers and risk of cognitive impairment and dementia

Hemodynamic and serum cardiac markers and risk of cognitive impairment and dementia:

Dementia Big
Cardiac function is a key player in maintaining energy homeostasis in the brain. Heart failure is closely related to higher risk of neurocognitive disorders. Recent evidence shows that this relationship might not be limited to patients with advanced heart failure, and even suboptimal cardiac functioning is associated with accelerated brain aging. Hence, hemodynamic and serum cardiac markers may provide valuable information about the risk of dementia.

http://ift.tt/2eiNI4X

BUSM researcher receives nearly $20 million grant to support dementia and AD research

BUSM researcher receives nearly $20 million grant to support dementia and AD research:

Dementia Big
Sudha Seshadri, MD, professor of neurology at Boston University School of Medicine, has been awarded three grants this year totaling nearly $20 million from the National Institute on Aging and the National Institute of Neurological Disorders and Stroke.

http://ift.tt/2dPLIxz

IED detection technique could be potential diagnostic tool for dementia

Researchers from the University of Adelaide in South Australia developed the Improvised Explosive Device (IED) detection method in 2014, which used light intensity to determine the presence of explosive residue.

from Dementia Big http://ift.tt/2dVTdVB via alcoholic dementia

http://ift.tt/2eiiqJE

Bomb detecting technology can be used for early dementia diagnosis

A technique for detecting Improvised Explosive Devices (IEDs) is being used to identify vitamins in the bloodstream linked to dementia.

from Dementia Big http://ift.tt/2ec56Gw via alcoholic dementia

http://ift.tt/2eObSVQ

IED detection technique could be potential diagnostic tool for dementia

IED detection technique could be potential diagnostic tool for dementia:

Dementia Big
Researchers from the University of Adelaide in South Australia developed the Improvised Explosive Device (IED) detection method in 2014, which used light intensity to determine the presence of explosive residue.

http://ift.tt/2eijlcY

Bomb detecting technology can be used for early dementia diagnosis

Bomb detecting technology can be used for early dementia diagnosis:

Dementia Big
A technique for detecting Improvised Explosive Devices (IEDs) is being used to identify vitamins in the bloodstream linked to dementia.

http://ift.tt/2eOdVsN

Icelandic people more likely to carry novel rare genetic variant linked to risk of Alzheimer's disease

Icelandic people more likely to carry novel rare genetic variant linked to risk of Alzheimer's disease:

Dementia Big
People with Icelandic heritage are more likely to carry a novel rare mutation in the TM2D3 gene, which leads to greater risk for Alzheimer’s disease, based on a new study published October 14th, 2016 in PLOS Genetics by Johanna Jakobsdottir of the Icelandic Heart Association, Sven van der Lee of Erasmus University in Rotterdam, and colleagues.

http://ift.tt/2emJuqx

Icelandic people more likely to carry novel rare genetic variant linked to risk of Alzheimer's disease

People with Icelandic heritage are more likely to carry a novel rare mutation in the TM2D3 gene, which leads to greater risk for Alzheimer’s disease, based on a new study published October 14th, 2016 in PLOS Genetics by Johanna Jakobsdottir of the Icelandic Heart Association, Sven van der Lee of Erasmus University in Rotterdam, and colleagues.

from Dementia Big http://ift.tt/2dZS433 via alcoholic dementia

http://ift.tt/2dY3iT6

Common hormone therapy to treat prostate cancer may increase dementia risk in men

Common hormone therapy to treat prostate cancer may increase dementia risk in men:

Dementia Big
A common hormone therapy to treat prostate cancer may double a man’s risk of dementia, regardless of his age, Penn Medicine researchers reported in a study published online today in JAMA Oncology.

http://ift.tt/2ebbOvD

Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome

Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome:

Dementia Big
Individuals with Down syndrome (DS) exhibit Alzheimer’s disease (AD) neuropathology and dementia early in life. Blood biomarkers of AD neuropathology would be valuable, as non-AD intellectual disabilities of DS and AD dementia overlap clinically. We hypothesized that elevations of amyloid-β (Aβ) peptides and phosphorylated-tau in neuronal exosomes may document preclinical AD.

http://ift.tt/2dX9zRp

Mild sedative could reduce risk of post-operative delirium

Mild sedative could reduce risk of post-operative delirium:

Dementia Big
A mild sedative could greatly reduce the risk of people experiencing delirium after an operation, according to new research.

http://ift.tt/2ebbMUx

Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition

Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition:

Dementia Big
The inhibition of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is a main therapeutic approach for the treatment of Alzheimer’s disease (AD). We previously reported an age-related increase of tau protein in the cerebrospinal fluid (CSF) of Aβ precursor protein (APP) transgenic mice.

http://ift.tt/2dXdTA4

Mild sedative could reduce risk of post-operative delirium

A mild sedative could greatly reduce the risk of people experiencing delirium after an operation, according to new research.

from Dementia Big http://ift.tt/2e4W12m via alcoholic dementia

http://ift.tt/2eb9K75

Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome

Individuals with Down syndrome (DS) exhibit Alzheimer’s disease (AD) neuropathology and dementia early in life. Blood biomarkers of AD neuropathology would be valuable, as non-AD intellectual disabilities of DS and AD dementia overlap clinically. We hypothesized that elevations of amyloid-β (Aβ) peptides and phosphorylated-tau in neuronal exosomes may document preclinical AD.

from Dementia Big http://ift.tt/2eaJ3zi via alcoholic dementia

http://ift.tt/2dXcEB7

Common hormone therapy to treat prostate cancer may increase dementia risk in men

A common hormone therapy to treat prostate cancer may double a man’s risk of dementia, regardless of his age, Penn Medicine researchers reported in a study published online today in JAMA Oncology.

from Dementia Big http://ift.tt/2dihSRn via alcoholic dementia

http://ift.tt/2eba19W

Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition

The inhibition of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is a main therapeutic approach for the treatment of Alzheimer’s disease (AD). We previously reported an age-related increase of tau protein in the cerebrospinal fluid (CSF) of Aβ precursor protein (APP) transgenic mice.

from Dementia Big http://ift.tt/2e0MjyI via alcoholic dementia

http://ift.tt/2dXcdGT

Study looks at how relationship to dementia patient can affect caregiver’s depression

Too often overlooked is the risk of depression in caregivers of patients with dementia, and a new study focuses on how depressive symptoms may differ depending on the familial relationship between caregiver and patient.

from Dementia Big http://ift.tt/2ebxabw via alcoholic dementia

http://ift.tt/2epVZoW

New study unravels cause of cognitive loss in tauopathy disorders

Tauopathies are a group of neurodegenerative disorders, including Alzheimer’s disease that are characterized by the deposition of aggregates of the tau protein inside brain cells.

from Dementia Big http://ift.tt/2ebmJ7H via alcoholic dementia

http://ift.tt/2e0FGwo

Study looks at how relationship to dementia patient can affect caregiver’s depression

Study looks at how relationship to dementia patient can affect caregiver’s depression:

Dementia Big
Too often overlooked is the risk of depression in caregivers of patients with dementia, and a new study focuses on how depressive symptoms may differ depending on the familial relationship between caregiver and patient.

http://ift.tt/2eBUGm9

New study unravels cause of cognitive loss in tauopathy disorders

New study unravels cause of cognitive loss in tauopathy disorders:

Dementia Big
Tauopathies are a group of neurodegenerative disorders, including Alzheimer’s disease that are characterized by the deposition of aggregates of the tau protein inside brain cells.

http://ift.tt/2eBV30b

Characterizing familial corticobasal syndrome due to Alzheimer's pathology and PSEN1 mutations

Characterizing familial corticobasal syndrome due to Alzheimer's pathology and PSEN1 mutations:

Dementia Big
Corticobasal syndrome (CBS) resulting from genetic Alzheimer’s disease (AD) has been described only once. Whether familial CBS-AD is a distinct clinical entity with its own imaging signature remains unknown.

http://ift.tt/2ewrWv0

Dysfunction in neuronal transport mechanism linked to Alzheimer's disease

Dysfunction in neuronal transport mechanism linked to Alzheimer's disease:

Dementia Big
Researchers at University of California San Diego School of Medicine have confirmed that mutation-caused dysfunction in a process cells use to transport molecules within the cell plays a previously suspected but underappreciated role in promoting the heritable form of Alzheimer’s disease (AD), but also one that might be remedied with existing therapeutic enzyme inhibitors.

http://ift.tt/2e09dFr

In the fight against Alzheimer's, online gamers can now get in on the action

In the fight against Alzheimer's, online gamers can now get in on the action:

Dementia Big
The researchers behind a new online game are inviting members of the public to look under a virtual microscope and contribute directly to Alzheimer’s disease research at Cornell University.

http://ift.tt/2ews9P7

How protein fragments associated with Alzheimer's could trigger Parkinson's

How protein fragments associated with Alzheimer's could trigger Parkinson's:

Dementia Big
Alzheimer’s and Parkinson’s diseases are different neurodegenerative conditions that can sometimes affect the same person, which has led scientists to investigate possible links between the two. Now one team, reporting in the journal ACS Chemical Neuroscience, has identified how amyloid beta, the protein fragment strongly associated with Alzheimer’s disease, can induce cellular changes that might lead to Parkinson’s.

http://ift.tt/2e06ADP

Characterizing familial corticobasal syndrome due to Alzheimer's pathology and PSEN1 mutations

Corticobasal syndrome (CBS) resulting from genetic Alzheimer’s disease (AD) has been described only once. Whether familial CBS-AD is a distinct clinical entity with its own imaging signature remains unknown.

from Dementia Big http://ift.tt/2d9aSem via alcoholic dementia

http://ift.tt/2ewsUaX

Dysfunction in neuronal transport mechanism linked to Alzheimer's disease

Researchers at University of California San Diego School of Medicine have confirmed that mutation-caused dysfunction in a process cells use to transport molecules within the cell plays a previously suspected but underappreciated role in promoting the heritable form of Alzheimer’s disease (AD), but also one that might be remedied with existing therapeutic enzyme inhibitors.

from Dementia Big http://ift.tt/2e7Fg52 via alcoholic dementia

http://ift.tt/2e08ww7

In the fight against Alzheimer's, online gamers can now get in on the action

The researchers behind a new online game are inviting members of the public to look under a virtual microscope and contribute directly to Alzheimer’s disease research at Cornell University.

from Dementia Big http://ift.tt/2dckYWZ via alcoholic dementia

http://ift.tt/2ewsOzW

How protein fragments associated with Alzheimer's could trigger Parkinson's

Alzheimer’s and Parkinson’s diseases are different neurodegenerative conditions that can sometimes affect the same person, which has led scientists to investigate possible links between the two. Now one team, reporting in the journal ACS Chemical Neuroscience, has identified how amyloid beta, the protein fragment strongly associated with Alzheimer’s disease, can induce cellular changes that might lead to Parkinson’s.

from Dementia Big http://ift.tt/2e5BJcs via alcoholic dementia

http://ift.tt/2e06snS

Research finds that ultrasound slows brain ageing

Research finds that ultrasound slows brain ageing:

Dementia Big
Treatment with scanning ultrasound has already been proven to reverse Alzheimer’s disease in mice, and now it appears it could also slow down ageing in healthy brains, according to University of Queensland research.

http://ift.tt/2e7anO2

Symptoms linked to Alzheimer's disease manifest differently in Hispanics, study finds

Symptoms linked to Alzheimer's disease manifest differently in Hispanics, study finds:

Dementia Big
Certain symptoms associated with the development of Alzheimer’s disease, including agitation and depression, affect Hispanics more frequently and severely than other ethnicities.

http://ift.tt/2dkoVMF

Dementia study lists everyday factors that may influence risk

Dementia study lists everyday factors that may influence risk:

Dementia Big
Experts have created a shortlist of environmental factors that may contribute to our risk of developing dementia.

http://ift.tt/2e7ajxQ

Study finds Alzheimer's manifests differently in Hispanics

Study finds Alzheimer's manifests differently in Hispanics:

Dementia Big
Certain symptoms associated with the development of Alzheimer’s disease, including agitation and depression, affect Hispanics more frequently and severely than other ethnicities. The findings, published in the Journal of Neuropsychiatry and Clinical Neuroscience (JNCN), suggest that Alzheimer’s disease manifests itself differently in Hispanic populations.

http://ift.tt/2dkpsON

Sudden blood pressure drops associated with long-term dementia risk

Sudden blood pressure drops associated with long-term dementia risk:

Dementia Big
Orthostatic hypotension—low blood pressure when suddenly standing up—is associated with a 15 percent increase in a person’s long-term risk of dementia, including Alzheimer’s disease, according to a twenty-four year study of more than 6,000 people published this week in PLOS Medicine by Arfan Ikram and Frank Wolters from Erasmus Medical Center, the Netherlands, and colleagues.

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Symptoms linked to Alzheimer's disease manifest differently in Hispanics, study finds

Certain symptoms associated with the development of Alzheimer’s disease, including agitation and depression, affect Hispanics more frequently and severely than other ethnicities.

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Research finds that ultrasound slows brain ageing

Treatment with scanning ultrasound has already been proven to reverse Alzheimer’s disease in mice, and now it appears it could also slow down ageing in healthy brains, according to University of Queensland research.

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Sudden blood pressure drops associated with long-term dementia risk

Orthostatic hypotension—low blood pressure when suddenly standing up—is associated with a 15 percent increase in a person’s long-term risk of dementia, including Alzheimer’s disease, according to a twenty-four year study of more than 6,000 people published this week in PLOS Medicine by Arfan Ikram and Frank Wolters from Erasmus Medical Center, the Netherlands, and colleagues.

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Study finds Alzheimer's manifests differently in Hispanics

Certain symptoms associated with the development of Alzheimer’s disease, including agitation and depression, affect Hispanics more frequently and severely than other ethnicities. The findings, published in the Journal of Neuropsychiatry and Clinical Neuroscience (JNCN), suggest that Alzheimer’s disease manifests itself differently in Hispanic populations.

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Dementia study lists everyday factors that may influence risk

Experts have created a shortlist of environmental factors that may contribute to our risk of developing dementia.

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Alzheimer's disease could be treated with gene therapy, animal study suggests

Researchers have prevented the development of Alzheimer’s disease in mice by using a virus to deliver a specific gene into the brain.

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ICU ventilators overused with advanced-dementia patients

Mechanical ventilation may be lifesaving, but in certain patient cases it may prolong suffering without a clear benefit.

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Alzheimer's disease could be treated with gene therapy, animal study suggests

Alzheimer's disease could be treated with gene therapy, animal study suggests:

Dementia Big
Researchers have prevented the development of Alzheimer’s disease in mice by using a virus to deliver a specific gene into the brain.

http://ift.tt/2dRuUaO

ICU ventilators overused with advanced-dementia patients

ICU ventilators overused with advanced-dementia patients:

Dementia Big
Mechanical ventilation may be lifesaving, but in certain patient cases it may prolong suffering without a clear benefit.

http://ift.tt/2emUUNU

Study to examine efficacy of orally administered medication in treating stuttering

Stuttering, an interruption in the flow of speech, affects about three million Americans. It begins most often in childhood, affecting four men for every woman. A precise cause of this complex communicative disorder is not known.

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Study to examine efficacy of orally administered medication in treating stuttering

Study to examine efficacy of orally administered medication in treating stuttering:

Dementia Big
Stuttering, an interruption in the flow of speech, affects about three million Americans. It begins most often in childhood, affecting four men for every woman. A precise cause of this complex communicative disorder is not known.

http://ift.tt/2eeAlTT

Different brain atrophy patterns may explain variability in Alzheimers disease symptoms

Mathematical modeling of the brain scans of patients with Alzheimer’s disease and others at risk for the devastating neurodegenerative disorder has identified specific patterns of brain atrophy that appear to be related to the loss of particular cognitive abilities. In their report that has been published online in the Proceedings of the National Academy of Sciences, a team of researchers at Massachusetts General Hospital (MGH) and the National University of Singapore describe how different atrophy patterns may explain the different ways that Alzheimer’s disease can be manifested in individual patients.

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Study reveals potential new strategy to prevent Alzheimer's disease

Taking a pill that prevents the accumulation of toxic molecules in the brain might someday help prevent or delay Alzheimer’s disease, according to scientists at Baylor College of Medicine, Texas Children’s Hospital and Johns Hopkins University School of Medicine.

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New study of Phase II Alzheimer's drug pipeline reveals more ways to combat disease

A new analysis of the Phase II Alzheimer’s drug pipeline, conducted by ResearchersAgainstAlzheimer’s, revealed 57 new Alzheimer’s drugs. According to the analysis, nearly twice as many mechanisms of action are being tested in Phase II than in Phase III clinical trials.

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New online game invites public to help fight Alzheimer's

A new online science game allows the general public to directly contribute to Alzheimer’s disease research and help scientists search for a cure.

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http://ift.tt/2cXzC9a

Different brain atrophy patterns may explain variability in Alzheimers disease symptoms

Different brain atrophy patterns may explain variability in Alzheimers disease symptoms:

Dementia Big
Mathematical modeling of the brain scans of patients with Alzheimer’s disease and others at risk for the devastating neurodegenerative disorder has identified specific patterns of brain atrophy that appear to be related to the loss of particular cognitive abilities. In their report that has been published online in the Proceedings of the National Academy of Sciences, a team of researchers at Massachusetts General Hospital (MGH) and the National University of Singapore describe how different atrophy patterns may explain the different ways that Alzheimer’s disease can be manifested in individual patients.

http://ift.tt/2dFKDcU

Study reveals potential new strategy to prevent Alzheimer's disease

Study reveals potential new strategy to prevent Alzheimer's disease:

Dementia Big
Taking a pill that prevents the accumulation of toxic molecules in the brain might someday help prevent or delay Alzheimer’s disease, according to scientists at Baylor College of Medicine, Texas Children’s Hospital and Johns Hopkins University School of Medicine.

http://ift.tt/2eamFsW

New study of Phase II Alzheimer's drug pipeline reveals more ways to combat disease

New study of Phase II Alzheimer's drug pipeline reveals more ways to combat disease:

Dementia Big
A new analysis of the Phase II Alzheimer’s drug pipeline, conducted by ResearchersAgainstAlzheimer’s, revealed 57 new Alzheimer’s drugs. According to the analysis, nearly twice as many mechanisms of action are being tested in Phase II than in Phase III clinical trials.

http://ift.tt/2dFJd29

New online game invites public to help fight Alzheimer's

New online game invites public to help fight Alzheimer's:

Dementia Big
A new online science game allows the general public to directly contribute to Alzheimer’s disease research and help scientists search for a cure.

http://ift.tt/2eaolCY

New awards to explore role of glymphatic system in small vessel disease and trauma

More than $4.5 million in new grants to the lab of University of Rochester Medical Center scientist Maiken Nedergaard, M.D., D.M.Sc., underscore the important role the brain’s waste disposal system may play in a range of neurological disorders.

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Study examines existing tests that may be helpful in assessing safety of drivers with dementia

How do you know when it’s time for an older adult with mild dementia to stop driving? Dementia is a general term for a decline in mental ability severe enough to interfere with daily life.

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New study by Alzheimer’s Research UK highlights lack of dementia prevention research

A new study by Alzheimer’s Research UK has highlighted the lack of research into dementia prevention and called for changes to the way risk reduction studies are funded and carried out, in a bid to boost evidence on dementia risk factors.

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http://ift.tt/2dAUO2o

New awards to explore role of glymphatic system in small vessel disease and trauma

New awards to explore role of glymphatic system in small vessel disease and trauma:

Dementia Big
More than $4.5 million in new grants to the lab of University of Rochester Medical Center scientist Maiken Nedergaard, M.D., D.M.Sc., underscore the important role the brain’s waste disposal system may play in a range of neurological disorders.

http://ift.tt/2e5gXIL

Study examines existing tests that may be helpful in assessing safety of drivers with dementia

Study examines existing tests that may be helpful in assessing safety of drivers with dementia:

Dementia Big
How do you know when it’s time for an older adult with mild dementia to stop driving? Dementia is a general term for a decline in mental ability severe enough to interfere with daily life.

http://ift.tt/2dAO4Sn

New study by Alzheimer’s Research UK highlights lack of dementia prevention research

New study by Alzheimer’s Research UK highlights lack of dementia prevention research:

Dementia Big
A new study by Alzheimer’s Research UK has highlighted the lack of research into dementia prevention and called for changes to the way risk reduction studies are funded and carried out, in a bid to boost evidence on dementia risk factors.

http://ift.tt/2e5g5UN

When pretend play is real for Alzheimer's patients

Sitting beside a neatly made crib, 88-year-old Vivian Guzofsky held up a baby doll dressed in puppy dog pajamas.

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http://ift.tt/2cWaTgH

Can older adults with dementia continue to drive? More study is needed

How do you know when it’s time for an older adult with mild dementia to stop driving? Dementia is a general term for a decline in mental ability severe enough to interfere with daily life. It can impact a person’s ability to drive safely. Although all people with dementia will have to stop driving eventually, each case can be unique based on the individual. According to a new study published in the Journal of the American Geriatrics Society, we still need to explore mental or physical tests that can best predict when people with dementia should stop driving.

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Study highlights measures to boost dementia prevention research

A new study by Alzheimer’s Research UK has highlighted the lack of research into dementia prevention and called for changes to the way risk reduction studies are funded and carried out, in a bid to boost evidence on dementia risk factors. The discussion paper, which compiles recommendations from a workshop attended by leading UK academics, clinicians, funders and policymakers, is published in the Journal of Public Health.

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Enzyme treatment of gene may reverse effects of Alzheimer's

For the last 20 years, researchers have focused on amyloid beta peptides and the “plaque” they sprout in diseased brains as the main target of Alzheimer’s research. But the pace of progress in treating—not to mention curing—the debilitating, neurodegenerative disease has been painfully slow.

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When pretend play is real for Alzheimer's patients

When pretend play is real for Alzheimer's patients:

Dementia Big
Sitting beside a neatly made crib, 88-year-old Vivian Guzofsky held up a baby doll dressed in puppy dog pajamas.

http://ift.tt/2dAJzH8

Can older adults with dementia continue to drive? More study is needed

Can older adults with dementia continue to drive? More study is needed:

Dementia Big
How do you know when it’s time for an older adult with mild dementia to stop driving? Dementia is a general term for a decline in mental ability severe enough to interfere with daily life. It can impact a person’s ability to drive safely. Although all people with dementia will have to stop driving eventually, each case can be unique based on the individual. According to a new study published in the Journal of the American Geriatrics Society, we still need to explore mental or physical tests that can best predict when people with dementia should stop driving.

http://ift.tt/2e5fxhk

Enzyme treatment of gene may reverse effects of Alzheimer's

Enzyme treatment of gene may reverse effects of Alzheimer's:

Dementia Big
For the last 20 years, researchers have focused on amyloid beta peptides and the “plaque” they sprout in diseased brains as the main target of Alzheimer’s research. But the pace of progress in treating—not to mention curing—the debilitating, neurodegenerative disease has been painfully slow.

http://ift.tt/2dALag8

Study highlights measures to boost dementia prevention research

Study highlights measures to boost dementia prevention research:

Dementia Big
A new study by Alzheimer’s Research UK has highlighted the lack of research into dementia prevention and called for changes to the way risk reduction studies are funded and carried out, in a bid to boost evidence on dementia risk factors. The discussion paper, which compiles recommendations from a workshop attended by leading UK academics, clinicians, funders and policymakers, is published in the Journal of Public Health.

http://ift.tt/2e5dnym

Protein linked to high risk of Alzheimer's can be removed from brain without hindering learning

Protein linked to high risk of Alzheimer's can be removed from brain without hindering learning:

Dementia Big
A protein linked to higher risk of Alzheimer’s can be removed from the brains of mice without hindering memory and learning, according to a study that addresses whether potential therapeutics targeting this protein would have detrimental side effects.

http://ift.tt/2dIATgv

Caffeine consumption linked to reduction in risk of incident dementia in older women

Caffeine consumption linked to reduction in risk of incident dementia in older women:

Dementia Big
Among a group of older women, self-reported caffeine consumption of more than 261 mg per day was associated with a 36 percent reduction in the risk of incident dementia over 10 years of follow-up.

http://ift.tt/2d2nVfP

Caffeine consumption linked to reduction in risk of incident dementia in older women

Among a group of older women, self-reported caffeine consumption of more than 261 mg per day was associated with a 36 percent reduction in the risk of incident dementia over 10 years of follow-up.

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Protein linked to high risk of Alzheimer's can be removed from brain without hindering learning

A protein linked to higher risk of Alzheimer’s can be removed from the brains of mice without hindering memory and learning, according to a study that addresses whether potential therapeutics targeting this protein would have detrimental side effects.

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Computer simulations explore how Alzheimer's disease starts

A new Rice University study uses computer simulations to explore the initial steps of the molecular process that leads to Alzheimer’s disease.

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http://ift.tt/2dr1yjW

More than half of persons with Alzheimer's disease aged 90 years or more use psychotropic drugs

Psychotropic drug use is rather common among persons aged 90 years or more diagnosed with Alzheimer’s disease, compared with those who were diagnosed at younger age, concludes a study conducted at the University of Eastern Finland. Persons aged 90 years or more used antipsychotics five times more often and antidepressants 2.5 times more often than those without the disease in the same age group. The results were published in Age and Ageing.

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Research hints at underlying cause for Alzheimer's drug trial failures

Because Alzheimer’s disease (AD) is the leading cause of dementia, many people use the two terms interchangeably. But inadequate blood flow to the brain due to microinfarcts, mini-strokes, or strokes is a hallmark of a disease called Vascular Cognitive Impairment and Dementia (VCID). VCID is the second most common cause of dementia, and the two are not mutually exclusive – researchers estimate that 40-60% of Alzheimer’s disease patients also have VCID.

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Computer simulations explore how Alzheimer's disease starts

Computer simulations explore how Alzheimer's disease starts:

Dementia Big
A new Rice University study uses computer simulations to explore the initial steps of the molecular process that leads to Alzheimer’s disease.

http://ift.tt/2cOj6Zk

More than half of persons with Alzheimer's disease aged 90 years or more use psychotropic drugs

More than half of persons with Alzheimer's disease aged 90 years or more use psychotropic drugs:

Dementia Big
Psychotropic drug use is rather common among persons aged 90 years or more diagnosed with Alzheimer’s disease, compared with those who were diagnosed at younger age, concludes a study conducted at the University of Eastern Finland. Persons aged 90 years or more used antipsychotics five times more often and antidepressants 2.5 times more often than those without the disease in the same age group. The results were published in Age and Ageing.

http://ift.tt/2dr1JeV

Research hints at underlying cause for Alzheimer's drug trial failures

Research hints at underlying cause for Alzheimer's drug trial failures:

Dementia Big
Because Alzheimer’s disease (AD) is the leading cause of dementia, many people use the two terms interchangeably. But inadequate blood flow to the brain due to microinfarcts, mini-strokes, or strokes is a hallmark of a disease called Vascular Cognitive Impairment and Dementia (VCID). VCID is the second most common cause of dementia, and the two are not mutually exclusive – researchers estimate that 40-60% of Alzheimer’s disease patients also have VCID.

http://ift.tt/2cOhHSv

Detecting cognitive changes in preclinical Alzheimer's disease: A review of its feasibility

Significant progress has been made in characterizing the biological changes occurring in preclinical Alzheimer’s disease (AD). Cognitive dysfunction has been viewed, however, as a late-stage phenomenon, despite increasing evidence that changes may be detected in the decades preceding dementia. In the absence of comprehensive evidence-based guidelines for preclinical cognitive assessment, longitudinal cohort and neuroimaging studies have been reviewed to determine the temporal order and brain biomarker correlates of specific cognitive functions.

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Recommended cognitive outcomes in preclinical Alzheimer's disease: Consensus statement from the European Prevention of Alzheimer's Dementia project

The Horizon 2020/IMI European Prevention of Alzheimer’s Dementia (EPAD) project will undertake large-scale proof-of-concept trials in predementia AD. Within EPAD, the monitoring of cognitive trajectories in the preclinical period will constitute a central outcome measure; however, there are currently no clear guidelines as to how this should be achieved as most measures have been developed for the period around dementia diagnosis. The EPAD Scientific Advisory Group for Clinical and Cognitive Outcomes identified appropriate cognitive measures based on a literature search covering both cognitive correlates of preclinical brain changes from imaging studies and cognitive changes observed over time in nondementia population cohorts developing incident dementia.

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Detecting cognitive changes in preclinical Alzheimer's disease: A review of its feasibility

Detecting cognitive changes in preclinical Alzheimer's disease: A review of its feasibility:

Dementia Big
Significant progress has been made in characterizing the biological changes occurring in preclinical Alzheimer’s disease (AD). Cognitive dysfunction has been viewed, however, as a late-stage phenomenon, despite increasing evidence that changes may be detected in the decades preceding dementia. In the absence of comprehensive evidence-based guidelines for preclinical cognitive assessment, longitudinal cohort and neuroimaging studies have been reviewed to determine the temporal order and brain biomarker correlates of specific cognitive functions.

http://ift.tt/2dnSID8