Caregiver Burnout : July 2017

Monday, July 31, 2017

Birthplace in high stroke mortality state linked to increased dementia risk

Birthplace in high stroke mortality state linked to increased dementia risk:

Dementia Big
Is being born in states with high stroke mortality associated with dementia risk in a group of individuals who eventually all lived outside those states?

http://ift.tt/2vgLuv7

Specialist Training in Perioperative Practice

Specialist Training in Perioperative Practice:

Dementia Big
Perioperative practice is quite a specialised area focused on patients who are undergoing surgery. Patients come to theatre for a reason, usually to have an operation or procedure that will correct a condition or perhaps alleviate discomfort.

http://ift.tt/2tSHqxr

Machine learning can predict rate of memory change

Machine learning can predict rate of memory change:

Dementia Big
In new research published today, researchers have created a machine learning algorithm that is able to form two distinct groups of people who have early memory problems known as mild cognitive impairment. The algorithm was able to predict different rates of change in people’s memory and thinking skills, also showing how those in the rapid change group were at an increased risk of developing dementia.

http://ift.tt/2vgM3Fl

Birthplace in high stroke mortality state linked to increased dementia risk

Is being born in states with high stroke mortality associated with dementia risk in a group of individuals who eventually all lived outside those states?

from Dementia Big http://ift.tt/2vbG5G1 via alcoholic dementia

http://ift.tt/2vh94YJ

Specialist Training in Perioperative Practice

Perioperative practice is quite a specialised area focused on patients who are undergoing surgery. Patients come to theatre for a reason, usually to have an operation or procedure that will correct a condition or perhaps alleviate discomfort.

from Dementia Big http://ift.tt/2vb4mvL via alcoholic dementia

http://ift.tt/2tShkL1

Machine learning can predict rate of memory change

In new research published today, researchers have created a machine learning algorithm that is able to form two distinct groups of people who have early memory problems known as mild cognitive impairment. The algorithm was able to predict different rates of change in people’s memory and thinking skills, also showing how those in the rapid change group were at an increased risk of developing dementia.

from Dementia Big http://ift.tt/2f0oWc0 via alcoholic dementia

http://ift.tt/2tSGedB

Friday, July 28, 2017

New substance restores brain function in Alzheimer's animal model

New substance restores brain function in Alzheimer's animal model:

http://ift.tt/2hakqbp

Is it Alzheimer's or another dementia form? Why doctors need to distinguish

Is it Alzheimer's or another dementia form? Why doctors need to distinguish:

Dementia Big
Alzheimer’s disease now affects an estimated 5.5 million Americans, and after decades of feverish work, researchers have so far failed to find a treatment that halts or reverses the inexorable loss of memory, function and thinking ability that characterize this feared illness.

http://ift.tt/2eUPSK8

Newly discovered biomarkers may lead to promising diagnostic tool for Alzheimer's

Newly discovered biomarkers may lead to promising diagnostic tool for Alzheimer's:

Dementia Big
Diagnosing Alzheimer’s disease and determining a patient’s prognosis is an inexact business, and that stands in the way of better personalized care and advances in treatment.

http://ift.tt/2ha4NRg

BACE-Inhibitor successfully tested in Alzheimer's animal model

BACE-Inhibitor successfully tested in Alzheimer's animal model:

Dementia Big
The protein amyloid beta is believed to be the major cause of Alzheimer’s disease. Substances that reduce the production of amyloid beta, such as BACE inhibitors, are therefore promising candidates for new drug treatments. A team at the Technical University of Munich (TUM) has recently demonstrated that one such BACE inhibitor reduces the amount of amyloid beta in the brain. By doing so, it can restore the normal function of nerve cells and significantly improve memory performance.

http://ift.tt/2eVBi4Q

Scientists use novel algorithm to group similar Alzheimer’s patients for precise drug trials

Scientists use novel algorithm to group similar Alzheimer’s patients for precise drug trials:

Dementia Big
The push to develop treatments for Alzheimer’s disease has been a promising and disappointing endeavor over the past two decades, yielding a greater understanding of the disease yet still failing to generate successful new drugs.

http://ift.tt/2ha4KF4

Scientists use new data mining strategy to spot those at high Alzheimer's risk

Scientists use new data mining strategy to spot those at high Alzheimer's risk:

http://ift.tt/2eVkPhg

Juvenescence AI to develop first compounds generated by Insilico's deep-learned drug discovery engines

Juvenescence AI to develop first compounds generated by Insilico's deep-learned drug discovery engines:

Dementia Big
Insilico Medicine, a Baltimore-based leader in artificial intelligence for drug discovery and biomarker development, is pleased to announce a multi-year drug development agreement with the biotechnology company Juvenescence AI Limited.

http://ift.tt/2haEw5v

Research finds increased risk of dementia in patients who experience delirium after surgery

Research finds increased risk of dementia in patients who experience delirium after surgery:

Dementia Big
Delirium is common in elderly hospitalized patients, affecting an estimated 14 - 56% of patients. It frequently manifests as a sudden change in behavior, with patients suffering acute confusion, inattention, disorganized thinking and fluctuating mental status.

http://ift.tt/2eVkN98

Patients with postoperative delirium more likely to suffer dementia

Patients with postoperative delirium more likely to suffer dementia:

http://ift.tt/2haLbMM

Is it Alzheimer's or another dementia form? Why doctors need to distinguish

Alzheimer’s disease now affects an estimated 5.5 million Americans, and after decades of feverish work, researchers have so far failed to find a treatment that halts or reverses the inexorable loss of memory, function and thinking ability that characterize this feared illness.

from Dementia Big http://ift.tt/2v4YTGR via alcoholic dementia

http://ift.tt/2eVkKtY

New substance restores brain function in Alzheimer's animal model

http://ift.tt/2ha4E0a

Newly discovered biomarkers may lead to promising diagnostic tool for Alzheimer's

Diagnosing Alzheimer’s disease and determining a patient’s prognosis is an inexact business, and that stands in the way of better personalized care and advances in treatment.

from Dementia Big http://ift.tt/2veSfhA via alcoholic dementia

http://ift.tt/2ha4Axs

BACE-Inhibitor successfully tested in Alzheimer's animal model

The protein amyloid beta is believed to be the major cause of Alzheimer’s disease. Substances that reduce the production of amyloid beta, such as BACE inhibitors, are therefore promising candidates for new drug treatments. A team at the Technical University of Munich (TUM) has recently demonstrated that one such BACE inhibitor reduces the amount of amyloid beta in the brain. By doing so, it can restore the normal function of nerve cells and significantly improve memory performance.

from Dementia Big http://ift.tt/2v65oJ5 via alcoholic dementia

http://ift.tt/2eUXgoT

Scientists use novel algorithm to group similar Alzheimer’s patients for precise drug trials

The push to develop treatments for Alzheimer’s disease has been a promising and disappointing endeavor over the past two decades, yielding a greater understanding of the disease yet still failing to generate successful new drugs.

from Dementia Big http://ift.tt/2v3APUX via alcoholic dementia

http://ift.tt/2eVEgq3

Scientists use new data mining strategy to spot those at high Alzheimer's risk

http://ift.tt/2ha4yFQ

Juvenescence AI to develop first compounds generated by Insilico's deep-learned drug discovery engines

Insilico Medicine, a Baltimore-based leader in artificial intelligence for drug discovery and biomarker development, is pleased to announce a multi-year drug development agreement with the biotechnology company Juvenescence AI Limited.

from Dementia Big http://ift.tt/2v5fh9M via alcoholic dementia

http://ift.tt/2eUJuma

Research finds increased risk of dementia in patients who experience delirium after surgery

Delirium is common in elderly hospitalized patients, affecting an estimated 14 - 56% of patients. It frequently manifests as a sudden change in behavior, with patients suffering acute confusion, inattention, disorganized thinking and fluctuating mental status.

from Dementia Big http://ift.tt/2vdeFQj via alcoholic dementia

http://ift.tt/2ha4oye

Patients with postoperative delirium more likely to suffer dementia

http://ift.tt/2eV3uVR

Thursday, July 27, 2017

Novel perspectives on anti-amyloid treatment for the prevention of Alzheimer's disease

Novel perspectives on anti-amyloid treatment for the prevention of Alzheimer's disease:

Dementia Big
For decades researches have been investigating the underlying foundations of Alzheimer’s disease to provide clues for the design of a successful therapy. This week, VIB/KU Leuven scientists have published breakthrough insights in the prestigious journal Cell. A collaboration between Prof. Lucía Chávez-Gutiérrez and Prof. Bart De Strooper (both VIB-KU Leuven) revealed the molecular basis of the hereditary form of Alzheimer’s disease that strikes early in life. These new findings provide powerful insights for the design of novel therapeutic strategies to tackle the disease.The hereditary form of Alzheimer’s disease is caused by mutations in the Gamma Secretase enzyme and the APP protein. Gamma Secretase cuts APP several times in a progressive manner, with each cleavage generating a shorter fragment, called amyloid beta, which gets released into the brain.

http://ift.tt/2v2MIKO

New method may help distinguish frontotemporal dementia from Alzheimer's disease

New method may help distinguish frontotemporal dementia from Alzheimer's disease:

Dementia Big
A new method may help determine whether a person has Alzheimer’s disease or frontotemporal dementia, two different types of dementia that often have similar symptoms, according to a preliminary study published in the July 26, 2017, online issue of Neurology, the medical journal of the American Academy of Neurology.

http://ift.tt/2uH7ME2

Novel perspectives on anti-amyloid treatment for the prevention of Alzheimer's disease

For decades researches have been investigating the underlying foundations of Alzheimer’s disease to provide clues for the design of a successful therapy. This week, VIB/KU Leuven scientists have published breakthrough insights in the prestigious journal Cell. A collaboration between Prof. Lucía Chávez-Gutiérrez and Prof. Bart De Strooper (both VIB-KU Leuven) revealed the molecular basis of the hereditary form of Alzheimer’s disease that strikes early in life. These new findings provide powerful insights for the design of novel therapeutic strategies to tackle the disease.The hereditary form of Alzheimer’s disease is caused by mutations in the Gamma Secretase enzyme and the APP protein. Gamma Secretase cuts APP several times in a progressive manner, with each cleavage generating a shorter fragment, called amyloid beta, which gets released into the brain.

from Dementia Big http://ift.tt/2eQXsWf via alcoholic dementia

http://ift.tt/2v2psMT

New method may help distinguish frontotemporal dementia from Alzheimer's disease

A new method may help determine whether a person has Alzheimer’s disease or frontotemporal dementia, two different types of dementia that often have similar symptoms, according to a preliminary study published in the July 26, 2017, online issue of Neurology, the medical journal of the American Academy of Neurology.

from Dementia Big http://ift.tt/2ePlQYb via alcoholic dementia

http://ift.tt/2uHIS6Y

Wednesday, July 26, 2017

Is it Alzheimer's disease or another dementia?

http://ift.tt/2uZt2HH

Chronic Traumatic Encephalopathy (CTE) among former American football players: Study

A new study involved 202 deceased players of American football players’ brains. It was found that Chronic Traumatic Encephalopathy (CTE) could be neuropathologically diagnosed in 177 players. Of the sample of players who developed CTE, 110 of 111 former National Football League players were found to have CTE in their brains. Researchers connected the presence of CTE in the brains of the dead players to the participation in football.

from Dementia Big http://ift.tt/2uXKR9q via alcoholic dementia

http://ift.tt/2uDCNZk

Understanding Alzheimer's disease and Down syndrome

People who have Down syndrome may develop Alzheimer’s disease at a younger age than people without Down syndrome. Recently, however, research showed that some people with Down syndrome might not develop dementia at all. Doctors and researchers are still trying to learn why some people with Down syndrome develop dementia, either earlier or later, while others don’t.

from Dementia Big http://ift.tt/2h1KqWv via alcoholic dementia

http://ift.tt/2uZbMSI

Is it Alzheimer's disease or another dementia?

Is it Alzheimer's disease or another dementia?:

http://ift.tt/2uEba2q

Understanding Alzheimer's disease and Down syndrome

Understanding Alzheimer's disease and Down syndrome:

Dementia Big
People who have Down syndrome may develop Alzheimer’s disease at a younger age than people without Down syndrome. Recently, however, research showed that some people with Down syndrome might not develop dementia at all. Doctors and researchers are still trying to learn why some people with Down syndrome develop dementia, either earlier or later, while others don’t.

http://ift.tt/2uZmCs1

Chronic Traumatic Encephalopathy (CTE) among former American football players: Study

Chronic Traumatic Encephalopathy (CTE) among former American football players: Study:

Dementia Big
A new study involved 202 deceased players of American football players’ brains. It was found that Chronic Traumatic Encephalopathy (CTE) could be neuropathologically diagnosed in 177 players. Of the sample of players who developed CTE, 110 of 111 former National Football League players were found to have CTE in their brains. Researchers connected the presence of CTE in the brains of the dead players to the participation in football.

http://ift.tt/2uDU8Bm

Tuesday, July 25, 2017

Black seniors test power of reminisce to protect aging brain

Sharon Steen dons her tennis shoes and, with two fellow seniors, walks streets that in her youth were a vibrant center of Portland, Oregon’s African-American community. Wasn’t this the corner where an NAACP march began in 1963? Look, the record store is now a fancy high-rise.

from Dementia Big http://ift.tt/2uw0VNq via alcoholic dementia

http://ift.tt/2eMeg0w

Black seniors test power of reminisce to protect aging brain

Black seniors test power of reminisce to protect aging brain:

Dementia Big
Sharon Steen dons her tennis shoes and, with two fellow seniors, walks streets that in her youth were a vibrant center of Portland, Oregon’s African-American community. Wasn’t this the corner where an NAACP march began in 1963? Look, the record store is now a fancy high-rise.

http://ift.tt/2h19FIA

Monday, July 24, 2017

New trial shows ketamine's effectiveness to treat geriatric depression

Australian researchers have completed the world’s first randomised control trial (RCT) assessing the efficacy and safety of ketamine as a treatment for depression in elderly patients.

from Dementia Big http://ift.tt/2gX7DZG via alcoholic dementia

http://ift.tt/2vUr0W2

GSA-developed toolkit helps providers achieve earlier detection of cognitive impairment

The Gerontological Society of America is now offering a free online toolkit to aid primary care providers in achieving greater awareness of cognition in their older adult patients, increasing cognitive detection of cognitive impairment, securing earlier diagnostic evaluation, and referring to community services.

from Dementia Big http://ift.tt/2v0u3iY via alcoholic dementia

http://ift.tt/2v1SvAt

Chances to treat childhood dementia

Although dementia is most often seen in adults, childhood or adolescent dementia does occur. A team of researchers from the University of Würzburg believes that established therapeutic drugs might be effective against childhood dementia.

from Dementia Big http://ift.tt/2gWK7MF via alcoholic dementia

http://ift.tt/2vUFKnE

Established therapeutic drugs may be effective against childhood dementia

http://ift.tt/2v1ufi1

GSA-developed toolkit helps providers achieve earlier detection of cognitive impairment

GSA-developed toolkit helps providers achieve earlier detection of cognitive impairment:

Dementia Big
The Gerontological Society of America is now offering a free online toolkit to aid primary care providers in achieving greater awareness of cognition in their older adult patients, increasing cognitive detection of cognitive impairment, securing earlier diagnostic evaluation, and referring to community services.

http://ift.tt/2uRF1Xv

New trial shows ketamine's effectiveness to treat geriatric depression

New trial shows ketamine's effectiveness to treat geriatric depression:

Dementia Big
Australian researchers have completed the world’s first randomised control trial (RCT) assessing the efficacy and safety of ketamine as a treatment for depression in elderly patients.

http://ift.tt/2uvlvgQ

Chances to treat childhood dementia

Chances to treat childhood dementia:

Dementia Big
Although dementia is most often seen in adults, childhood or adolescent dementia does occur. A team of researchers from the University of Würzburg believes that established therapeutic drugs might be effective against childhood dementia.

http://ift.tt/2uRWcbv

Established therapeutic drugs may be effective against childhood dementia

Established therapeutic drugs may be effective against childhood dementia:

http://ift.tt/2uuQFVI

Saturday, July 22, 2017

People with genetic susceptibility to Alzheimer's may have greater cognitive deficits with sleep-disordered breathing

People who carry a genetic susceptibility to Alzheimer’s disease appear to be at greater risk of diminished cognition from sleep-disordered breathing than those without the susceptibility, according to new research published online, ahead of print in the Annals of the American Thoracic Society.

from Dementia Big http://ift.tt/2vuuhMq via alcoholic dementia

http://ift.tt/2unWmoz

People with genetic susceptibility to Alzheimer's may have greater cognitive deficits with sleep-disordered breathing

People with genetic susceptibility to Alzheimer's may have greater cognitive deficits with sleep-disordered breathing:

Dementia Big
People who carry a genetic susceptibility to Alzheimer’s disease appear to be at greater risk of diminished cognition from sleep-disordered breathing than those without the susceptibility, according to new research published online, ahead of print in the Annals of the American Thoracic Society.

http://ift.tt/2eEXf8d

Friday, July 21, 2017

Nine things that can affect whether you get dementia – and what you can do about them

Nine things that can affect whether you get dementia – and what you can do about them:

Dementia Big
Dementia is by no means an inevitable result of ageing. In fact, one in three dementia cases can be prevented, according to new findings published in The Lancet.

http://ift.tt/2vulhH0

Alzheimer's drug may help treat traumatic brain injury

Alzheimer's drug may help treat traumatic brain injury:

Dementia Big
Traumatic brain injury (TBI) is a major cause of disability and death globally, but medications have generally failed to benefit patients. A new study found that memantine, a drug that is used to treat dementia associated with Alzheimer’s disease, may be a promising therapy.

http://ift.tt/2ukh5Lz

Alzheimer’s drug may be promising treatment for traumatic brain injury

Alzheimer’s drug may be promising treatment for traumatic brain injury:

http://ift.tt/2vur5jQ

Researchers explore how physical exercise affects brain metabolism

Researchers explore how physical exercise affects brain metabolism:

Dementia Big
Numerous studies have shown that physical exercise seems beneficial in the prevention of cognitive impairment and dementia in old age. Now researchers at Goethe University Frankfurt have explored in one of the first studies worldwide how exercise affects brain metabolism.

http://ift.tt/2ujKvJH

Nine things that can affect whether you get dementia – and what you can do about them

Dementia is by no means an inevitable result of ageing. In fact, one in three dementia cases can be prevented, according to new findings published in The Lancet.

from Dementia Big http://ift.tt/2vrhbj5 via alcoholic dementia

http://ift.tt/2gRMVdH

Alzheimer's drug may help treat traumatic brain injury

Traumatic brain injury (TBI) is a major cause of disability and death globally, but medications have generally failed to benefit patients. A new study found that memantine, a drug that is used to treat dementia associated with Alzheimer’s disease, may be a promising therapy.

from Dementia Big http://ift.tt/2uhX200 via alcoholic dementia

http://ift.tt/2eDekjb

Alzheimer’s drug may be promising treatment for traumatic brain injury

http://ift.tt/2gRMUGF

Researchers explore how physical exercise affects brain metabolism

Numerous studies have shown that physical exercise seems beneficial in the prevention of cognitive impairment and dementia in old age. Now researchers at Goethe University Frankfurt have explored in one of the first studies worldwide how exercise affects brain metabolism.

from Dementia Big http://ift.tt/2gPZSVv via alcoholic dementia

http://ift.tt/2eDabeS

Second OFSTED-style rating of CCG dementia care reveals mixed picture

Second OFSTED-style rating of CCG dementia care reveals mixed picture:

Dementia Big
Today (Friday 21 July 2017) NHS England have published the end of year results from the Clinical Commissioning Group Improvement and Assessment Framework (CCG IAF).

http://ift.tt/2uPLind

Second OFSTED-style rating of CCG dementia care reveals mixed picture

Today (Friday 21 July 2017) NHS England have published the end of year results from the Clinical Commissioning Group Improvement and Assessment Framework (CCG IAF).

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http://ift.tt/2vIdqF0

Thursday, July 20, 2017

AAIC: Turnover kinetics vary for different amyloid beta isoforms

(HealthDay)—Amyloid beta (Aβ)38 has faster turnover kinetics than Aβ40 and Aβ42, according to a study published online July 19 in Alzheimer’s & Dementia to coincide with presentation at the annual Alzheimer’s Association International Conference, held from July 16 to 20 in London.

from Dementia Big http://ift.tt/2uGJ6h3 via alcoholic dementia

http://ift.tt/2uF40NK

UAlberta researchers find strong clues to underlying cause of HIV-associated neurocognitive disorders

UAlberta researchers believe they now have a clearer picture of why people living with HIV so commonly suffer from dementia and other neurocognitive disorders.

from Dementia Big http://ift.tt/2tvdfjK via alcoholic dementia

http://ift.tt/2tLFXIx

Study finds no convincing evidence to support link between PPI use and dementia risk

http://ift.tt/2uFmTAd

Targeting risk factors throughout life stages could prevent 35% of dementia cases, study reveals

A study published in The Lancet, on July 20th 2017, reveals that 1 out of 3 dementia cases are preventable when risk factors are targeted beginning from childhood.

from Dementia Big http://ift.tt/2gNeEw7 via alcoholic dementia

http://ift.tt/2uFlwBL

New study says PPIs do not cause dementia

Several studies have reported associations between proton-pump inhibitor (PPI) use and dementia. New research published on July 18 in Gastroenterology, the official journal of the American Gastroenterological Association (AGA), puts these claims to rest. The study authors report that there is no convincing evidence to support the suggestion that PPI use increases dementia risk. These findings are based on an analysis of 13,864 participants from the Nurses’ Health Study II who completed testing on cognitive function, which is key predictor of the risk of dementia later in life.

from Dementia Big http://ift.tt/2ucDh8D via alcoholic dementia

http://ift.tt/2tLIbYu

What it's really like to live with dementia

More than 225,000 people develop dementia every year – that’s roughly one person every three minute. At the moment, 850,000 people in the UK are living with dementia. This figure is set to rise to two million by 2051.

from Dementia Big http://ift.tt/2uLUZ61 via alcoholic dementia

http://ift.tt/2uF6ITs

Study of coffee and dementia stirs worldwide interest

Combine a product widely loved with a disease widely dreaded and what do you get? Widespread attention, a UWM researcher found.

from Dementia Big http://ift.tt/2ubHVDW via alcoholic dementia

http://ift.tt/2tLChqj

These preventive measures might help delay dementia or cognitive decline

In a landmark report, scientists have endorsed three strategies for preventing dementia and cognitive decline associated with normal aging — being physically active, engaging in cognitive training and controlling high blood pressure.

from Dementia Big http://ift.tt/2vmeH5o via alcoholic dementia

http://ift.tt/2uFEzfb

Lifestyle changes to stave off Alzheimer's? Hints, no proof

There are no proven ways to stave off Alzheimer’s, but a new report raises the prospect that avoiding nine key risks starting in childhood just might delay or even prevent about a third of dementia cases around the world.

from Dementia Big http://ift.tt/2gMmohW via alcoholic dementia

http://ift.tt/2tLFXs1

New report highlights beneficial effects of nonmedical interventions for people with dementia

Managing lifestyle factors such as hearing loss, smoking, hypertension and depression could prevent one-third of the world’s dementia cases, according to a report by the first Lancet Commission on Dementia Prevention and Care.

from Dementia Big http://ift.tt/2tsS3uJ via alcoholic dementia

http://ift.tt/2uF2Em1

UAlberta researchers find strong clues to underlying cause of HIV-associated neurocognitive disorders

UAlberta researchers find strong clues to underlying cause of HIV-associated neurocognitive disorders:

Dementia Big
UAlberta researchers believe they now have a clearer picture of why people living with HIV so commonly suffer from dementia and other neurocognitive disorders.

http://ift.tt/2tllmeJ

AAIC: Turnover kinetics vary for different amyloid beta isoforms

AAIC: Turnover kinetics vary for different amyloid beta isoforms:

Dementia Big
(HealthDay)—Amyloid beta (Aβ)38 has faster turnover kinetics than Aβ40 and Aβ42, according to a study published online July 19 in Alzheimer’s & Dementia to coincide with presentation at the annual Alzheimer’s Association International Conference, held from July 16 to 20 in London.

http://ift.tt/2tvdEms

Study finds no convincing evidence to support link between PPI use and dementia risk

Study finds no convincing evidence to support link between PPI use and dementia risk:

http://ift.tt/2tl3Mrq

Targeting risk factors throughout life stages could prevent 35% of dementia cases, study reveals

Targeting risk factors throughout life stages could prevent 35% of dementia cases, study reveals:

Dementia Big
A study published in The Lancet, on July 20th 2017, reveals that 1 out of 3 dementia cases are preventable when risk factors are targeted beginning from childhood.

http://ift.tt/2tv3XEu

New study says PPIs do not cause dementia

New study says PPIs do not cause dementia:

Dementia Big
Several studies have reported associations between proton-pump inhibitor (PPI) use and dementia. New research published on July 18 in Gastroenterology, the official journal of the American Gastroenterological Association (AGA), puts these claims to rest. The study authors report that there is no convincing evidence to support the suggestion that PPI use increases dementia risk. These findings are based on an analysis of 13,864 participants from the Nurses’ Health Study II who completed testing on cognitive function, which is key predictor of the risk of dementia later in life.

http://ift.tt/2tlvTq4

What it's really like to live with dementia

What it's really like to live with dementia:

Dementia Big
More than 225,000 people develop dementia every year – that’s roughly one person every three minute. At the moment, 850,000 people in the UK are living with dementia. This figure is set to rise to two million by 2051.

http://ift.tt/2tv2cY6

Study of coffee and dementia stirs worldwide interest

Study of coffee and dementia stirs worldwide interest:

Dementia Big
Combine a product widely loved with a disease widely dreaded and what do you get? Widespread attention, a UWM researcher found.

http://ift.tt/2tl14C3

These preventive measures might help delay dementia or cognitive decline

These preventive measures might help delay dementia or cognitive decline:

Dementia Big
In a landmark report, scientists have endorsed three strategies for preventing dementia and cognitive decline associated with normal aging — being physically active, engaging in cognitive training and controlling high blood pressure.

http://ift.tt/2tvvfuu

Lifestyle changes to stave off Alzheimer's? Hints, no proof

Lifestyle changes to stave off Alzheimer's? Hints, no proof:

Dementia Big
There are no proven ways to stave off Alzheimer’s, but a new report raises the prospect that avoiding nine key risks starting in childhood just might delay or even prevent about a third of dementia cases around the world.

http://ift.tt/2tlko2c

New report highlights beneficial effects of nonmedical interventions for people with dementia

New report highlights beneficial effects of nonmedical interventions for people with dementia:

Dementia Big
Managing lifestyle factors such as hearing loss, smoking, hypertension and depression could prevent one-third of the world’s dementia cases, according to a report by the first Lancet Commission on Dementia Prevention and Care.

http://ift.tt/2tvwxpj

Vulnerable adults being let down by poor social work practice, new report finds

Vulnerable adults being let down by poor social work practice, new report finds:

Dementia Big
Vulnerable people are being forced into situations against their will because care providers are not following the proper processes, the Local Government and Social Care Ombudsman has found.

http://ift.tt/2uclzlN

AAIC: Lancet Commission reveals a third of cases of dementia may be preventable – Alzheimer’s Society comment

AAIC: Lancet Commission reveals a third of cases of dementia may be preventable – Alzheimer’s Society comment:

Dementia Big
The Lancet Commission on dementia prevention, intervention, and care is being presented at the Alzheimer’s Association International Conference 2017.

http://ift.tt/2uMBQ3P

Vulnerable adults being let down by poor social work practice, new report finds

Vulnerable people are being forced into situations against their will because care providers are not following the proper processes, the Local Government and Social Care Ombudsman has found.

from Dementia Big http://ift.tt/2uFAbMv via alcoholic dementia
http://ift.tt/2tKg6Ax

AAIC: Lancet Commission reveals a third of cases of dementia may be preventable – Alzheimer’s Society comment

The Lancet Commission on dementia prevention, intervention, and care is being presented at the Alzheimer’s Association International Conference 2017.

from Dementia Big http://ift.tt/2uFt9Y9 via alcoholic dementia
http://ift.tt/2uBD9SY

Wednesday, July 19, 2017

Brain scans may change care for some people with memory loss

Does it really take an expensive brain scan to diagnose Alzheimer’s? Not everybody needs one but new research suggests that for a surprising number of patients whose memory problems are hard to pin down, PET scans may lead to changes in treatment.

from Dementia Big http://ift.tt/2uCfxNr via alcoholic dementia

http://nrgeticform.tumblr.com/post/163201308915

Blood-based screening test can detect key Alzheimer's marker

Decades before people with Alzheimer’s disease develop memory loss and confusion, their brains become dotted with plaques made of a sticky protein - called amyloid beta - that is thought to contribute to the disease and its progression.

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http://nrgeticform.tumblr.com/post/163201308725

Blood test identifies key Alzheimer's marker

A new study led by researchers at Washington University School of Medicine in St. Louis suggests that measures of amyloid beta in the blood have the potential to help identify people with altered levels of amyloid in their brains or cerebrospinal fluid. Currently, the only way to detect amyloid beta in the brain is via PET scanning, which is expensive and not widely available, or a spinal tap, which is invasive and requires a specialized medical procedure.

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http://nrgeticform.tumblr.com/post/163201308440

Study validates equivalency of paper and digital SAGE test in detecting cognitive impairment

BrainTest Inc., a medical software company that provides scientifically validated cognitive screening instruments on a wide range of tablets and mobile devices, today announced that that the results of its Validity/Equivalency Study were presented at the Alzheimer’s Association International Conference 2017.

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http://nrgeticform.tumblr.com/post/163201308215

Steering an enzyme's 'scissors' shows potential for stopping Alzheimer's disease

The old real estate adage about “location, location, location” might also apply to the biochemical genesis of Alzheimer’s disease, according to new research from the University of British Columbia.

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http://nrgeticform.tumblr.com/post/163201307960

Brain scans may change care for some people with memory loss

Brain scans may change care for some people with memory loss:

Dementia Big
Does it really take an expensive brain scan to diagnose Alzheimer’s? Not everybody needs one but new research suggests that for a surprising number of patients whose memory problems are hard to pin down, PET scans may lead to changes in treatment.

http://nrgeticform.tumblr.com/post/163201281600

Blood-based screening test can detect key Alzheimer's marker

Blood-based screening test can detect key Alzheimer's marker:

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Decades before people with Alzheimer’s disease develop memory loss and confusion, their brains become dotted with plaques made of a sticky protein - called amyloid beta - that is thought to contribute to the disease and its progression.

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Blood test identifies key Alzheimer's marker

Blood test identifies key Alzheimer's marker:

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A new study led by researchers at Washington University School of Medicine in St. Louis suggests that measures of amyloid beta in the blood have the potential to help identify people with altered levels of amyloid in their brains or cerebrospinal fluid. Currently, the only way to detect amyloid beta in the brain is via PET scanning, which is expensive and not widely available, or a spinal tap, which is invasive and requires a specialized medical procedure.

http://nrgeticform.tumblr.com/post/163201280810

Study validates equivalency of paper and digital SAGE test in detecting cognitive impairment

Study validates equivalency of paper and digital SAGE test in detecting cognitive impairment:

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BrainTest Inc., a medical software company that provides scientifically validated cognitive screening instruments on a wide range of tablets and mobile devices, today announced that that the results of its Validity/Equivalency Study were presented at the Alzheimer’s Association International Conference 2017.

http://nrgeticform.tumblr.com/post/163201280395

Steering an enzyme's 'scissors' shows potential for stopping Alzheimer's disease

Steering an enzyme's 'scissors' shows potential for stopping Alzheimer's disease:

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The old real estate adage about “location, location, location” might also apply to the biochemical genesis of Alzheimer’s disease, according to new research from the University of British Columbia.

http://nrgeticform.tumblr.com/post/163201279725

AAIC: Blood test could offer clues about the risk of Alzheimer’s disease, study shows – Alzheimer’s Society comment

AAIC: Blood test could offer clues about the risk of Alzheimer’s disease, study shows – Alzheimer’s Society comment:

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New research reported today investigates whether simpler, more practical test for amyloid deposition could in future offer clues about the development and progression of Alzheimer’s disease.

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Life expectancy has levelled off – Alzheimer’s Society comment

Life expectancy has levelled off – Alzheimer’s Society comment:

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Improvements in life expectancy have almost ‘ground to a halt’, says Professor Sir Michael Marmot, who’s said he is 'deeply concerned’ that increases in life expectancy had levelled off since 2010.

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AAIC: Blood test could offer clues about the risk of Alzheimer’s disease, study shows – Alzheimer’s Society comment

New research reported today investigates whether simpler, more practical test for amyloid deposition could in future offer clues about the development and progression of Alzheimer’s disease.

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Life expectancy has levelled off – Alzheimer’s Society comment

Improvements in life expectancy have almost ‘ground to a halt’, says Professor Sir Michael Marmot, who’s said he is 'deeply concerned’ that increases in life expectancy had levelled off since 2010.

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Tuesday, July 18, 2017

Can poor sleep boost odds for Alzheimer's?

(HealthDay)— Breathing problems during sleep may signal an increased risk for Alzheimer’s disease, a trio of studies suggests.

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AAIC: Alzheimer biomarkers up with sleep disordered breathing

(HealthDay)—Biological changes in the brain may underlie a relationship between sleep disordered breathing (SDB) and Alzheimer’s disease, according to new research. A trio of studies on the matter were scheduled for presentation at the annual Alzheimer’s Association International Conference, held from July 16 to 20 in London.

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Two new genes linked to Alzheimer's risk

A team of researchers led by Cardiff University has identified two genes that influence a person’s risk of developing Alzheimer’s disease.

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A heart-healthy diet may lower risk of cognitive impairment in old age, studies suggest

A diet designed to improve cardiovascular health is associated with improved cognitive maintenance in old age, say researchers. The finding comes from four large-scale, population-based studies that were reported on at the 2017 Alzheimer’s Association International Conference (AAIC) in London.

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Slowing life expectancy improvements linked to increase in deaths from dementia

A new report has highlighted increasing pressures on England’s health services as deaths from dementia rise, coupled with a slowing in life expectancy increases.

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27 Phase III and 8 Phase II Alzheimer's drugs on track to launch in next five years

Twenty-seven Alzheimer’s drugs in Phase III clinical trials and eight drugs in Phase II clinical trials may launch in the next five years, according to a revised Alzheimer’s pipeline analysis presented today at the Alzheimer’s Association International Conference (AAIC) by ResearchersAgainstAlzheimer’s (RA2), an UsAgainstAlzheimer’s network.

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People with dementia benefit from goal-oriented therapy

Personalised cognitive rehabilitation therapy can help people with early stage dementia significantly improve their ability to engage in important everyday activities and tasks.

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AAIC: Alzheimer biomarkers up with sleep disordered breathing

AAIC: Alzheimer biomarkers up with sleep disordered breathing:

Dementia Big
(HealthDay)—Biological changes in the brain may underlie a relationship between sleep disordered breathing (SDB) and Alzheimer’s disease, according to new research. A trio of studies on the matter were scheduled for presentation at the annual Alzheimer’s Association International Conference, held from July 16 to 20 in London.

http://ift.tt/2uHbLTW

Can poor sleep boost odds for Alzheimer's?

Can poor sleep boost odds for Alzheimer's?:

Dementia Big
(HealthDay)— Breathing problems during sleep may signal an increased risk for Alzheimer’s disease, a trio of studies suggests.

http://ift.tt/2vgRgKK

Two new genes linked to Alzheimer's risk

Two new genes linked to Alzheimer's risk:

Dementia Big
A team of researchers led by Cardiff University has identified two genes that influence a person’s risk of developing Alzheimer’s disease.

http://ift.tt/2uH8YKt

Slowing life expectancy improvements linked to increase in deaths from dementia

Slowing life expectancy improvements linked to increase in deaths from dementia:

Dementia Big
A new report has highlighted increasing pressures on England’s health services as deaths from dementia rise, coupled with a slowing in life expectancy increases.

http://ift.tt/2vgA4Fb

A heart-healthy diet may lower risk of cognitive impairment in old age, studies suggest

A heart-healthy diet may lower risk of cognitive impairment in old age, studies suggest:

Dementia Big
A diet designed to improve cardiovascular health is associated with improved cognitive maintenance in old age, say researchers. The finding comes from four large-scale, population-based studies that were reported on at the 2017 Alzheimer’s Association International Conference (AAIC) in London.

http://ift.tt/2uH58kh

27 Phase III and 8 Phase II Alzheimer's drugs on track to launch in next five years

27 Phase III and 8 Phase II Alzheimer's drugs on track to launch in next five years:

Dementia Big
Twenty-seven Alzheimer’s drugs in Phase III clinical trials and eight drugs in Phase II clinical trials may launch in the next five years, according to a revised Alzheimer’s pipeline analysis presented today at the Alzheimer’s Association International Conference (AAIC) by ResearchersAgainstAlzheimer’s (RA2), an UsAgainstAlzheimer’s network.

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People with dementia benefit from goal-oriented therapy

People with dementia benefit from goal-oriented therapy:

Dementia Big
Personalised cognitive rehabilitation therapy can help people with early stage dementia significantly improve their ability to engage in important everyday activities and tasks.

http://ift.tt/2uH59ol

Davina McCall and family unite with Alzheimer’s Society to kick off Memory Walk

Davina McCall and family unite with Alzheimer’s Society to kick off Memory Walk:

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Davina McCall and family are joining forces with Alzheimer’s Society to tackle dementia after being inspired by her dad who is living with Alzheimer’s disease.

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AAIC: Obstructive sleep apnoea may accelerate Alzheimer’s disease biomarkers – Alzheimer’s Society comments

AAIC: Obstructive sleep apnoea may accelerate Alzheimer’s disease biomarkers – Alzheimer’s Society comments:

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Several new research analyses found significant associations between disordered breathing during sleep and the accumulation of biomarkers for Alzheimer’s disease.

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Davina McCall and family unite with Alzheimer’s Society to kick off Memory Walk

Davina McCall and family are joining forces with Alzheimer’s Society to tackle dementia after being inspired by her dad who is living with Alzheimer’s disease.

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AAIC: Obstructive sleep apnoea may accelerate Alzheimer’s disease biomarkers – Alzheimer’s Society comments

Several new research analyses found significant associations between disordered breathing during sleep and the accumulation of biomarkers for Alzheimer’s disease.

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Researchers spot two genes that influence person's risk of Alzheimer's disease

A team of researchers led by Cardiff University has identified two genes that influence a person’s risk of developing Alzheimer’s disease.

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NIH researchers show how investigational drug works against rare, fatal genetic disease

Scientists have demonstrated how an investigational drug works against a rare, fatal genetic disease, Niemann-Pick type C1 (NPC1).

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Urgent hospitalizations linked to increased rate of cognitive decline in older adults

Emergency and urgent hospitalizations are associated with an increased rate of cognitive decline in older adults, report researchers at Rush University Medical Center.

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Hospitalizations and cognitive decline in older adults

Emergency and urgent hospitalizations are associated with an increased rate of cognitive decline in older adults, report researchers at Rush University Medical Center. The results of their study suggest that hospitalization may be a more of a major risk factor for long-term cognitive decline in older adults than previously recognized.

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Bacteria found in Alzheimer's brains

Researchers in the UK have used DNA sequencing to examine bacteria in post-mortem brains from patients with Alzheimer’s disease. Their findings suggest increased bacterial populations and different proportions of specific bacteria in Alzheimer’s, compared with healthy brains. The findings may support evidence that bacterial infection and inflammation in the brain could contribute to Alzheimer’s disease.

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Racial disparity in dementia risk, experts report

A series of studies presented at the 2017 Alzheimer’s Association International Conference (AAIC 2017) has highlighted racial inequities in the risk of dementia. The studies showed that the number of people with Alzheimer’s and other dementias differed between races and also suggested that stress in early life and neighborhood disadvantage contribute to increased dementia risk.

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Stressful experiences equivalent to 'more than 4 years cognitive ageing'

Researchers at the Alzheimer’s Association International Conference 2017 in London have highlighted the impact stressful life events can have on brain function.

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Hearing loss linked to early memory and thinking problems

Researchers at the Alzheimer’s Association International Conference 2017 have suggested that people with a family history of Alzheimer’s disease who experience hearing loss, are more likely to also experience a decline in their brain function.

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The role of diet in healthy brain ageing and dementia risk

Four studies being presented at the Alzheimer’s Association International Conference 2017 are highlighting the potential benefits of certain diets and how they can support healthy brain ageing and help to reduce dementia risk.

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Being unmarried or widowed linked to increased dementia risk

Researchers from University College London have found that people who are single or widowed are at a greater risk of dementia than people who are married. The research, which is a review of 14 existing studies, is being presented today (17 July) at the Alzheimer’s Association International Conference (AAIC17) in London.

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Emergency but not elective hospital admissions linked to faster memory and thinking decline

Researchers in Chicago have investigated the link between hospital admissions and memory and thinking problems. Existing research indicates that older people are at an increased risk of both short- and long-term memory and thinking problems after being admitted to hospital. In this study researchers at the Rush Alzheimer’s Disease Centre at Rush University compared the risk associated with urgent or emergency admissions and elective stays that might be more common for routine procedures. The researchers found that non-elective hospitalisations were associated with a faster rate of cognitive decline from before hospitalisation, while elective hospitalisations were not.

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Less fluent speech could be a sign of early memory problems

Researchers in the US have found that people with very mild memory and thinking problems also show changes in their everyday speech.

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Brain amyloid PET scans enhance the diagnosis of Alzheimer's

The build-up of amyloid protein in the brain is a hallmark feature of Alzheimer’s disease, and its detection often relies on the testing of brain and spinal fluid samples. More recently, PET brain scans have been able to highlight the presence of amyloid in the brain and are extensively used in research studies into Alzheimer’s, such as clinical trials for new treatments. However, whether amyloid PET scans provide additional and more accurate information to aid dementia diagnosis is not clear cut, and the high costs associated with the scans (between £1,000-3,000 per scan) have so far limited their wider clinical use. Three studies presented today at the Alzheimer’s Association International Conference 2016 are challenging this view.

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Regular word puzzle use linked to better brain function in later life

The more regularly people report doing word puzzles such as crosswords, the better their brain function in later life, a large-scale and robust online trial has found.

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NIH researchers show how investigational drug works against rare, fatal genetic disease

NIH researchers show how investigational drug works against rare, fatal genetic disease:

Dementia Big
Scientists have demonstrated how an investigational drug works against a rare, fatal genetic disease, Niemann-Pick type C1 (NPC1).

http://ift.tt/2vwKlMN

Researchers spot two genes that influence person's risk of Alzheimer's disease

Researchers spot two genes that influence person's risk of Alzheimer's disease:

Dementia Big
A team of researchers led by Cardiff University has identified two genes that influence a person’s risk of developing Alzheimer’s disease.

http://ift.tt/2uxMvhT

Urgent hospitalizations linked to increased rate of cognitive decline in older adults

Urgent hospitalizations linked to increased rate of cognitive decline in older adults:

Dementia Big
Emergency and urgent hospitalizations are associated with an increased rate of cognitive decline in older adults, report researchers at Rush University Medical Center.

http://ift.tt/2uxTUxA

Hospitalizations and cognitive decline in older adults

Hospitalizations and cognitive decline in older adults:

Dementia Big
Emergency and urgent hospitalizations are associated with an increased rate of cognitive decline in older adults, report researchers at Rush University Medical Center. The results of their study suggest that hospitalization may be a more of a major risk factor for long-term cognitive decline in older adults than previously recognized.

http://ift.tt/2vwS79A

Bacteria found in Alzheimer's brains

Bacteria found in Alzheimer's brains:

Dementia Big
Researchers in the UK have used DNA sequencing to examine bacteria in post-mortem brains from patients with Alzheimer’s disease. Their findings suggest increased bacterial populations and different proportions of specific bacteria in Alzheimer’s, compared with healthy brains. The findings may support evidence that bacterial infection and inflammation in the brain could contribute to Alzheimer’s disease.

http://ift.tt/2uxJuxZ