Friday, July 1, 2016

Sheffield researchers identify novel function of C9orf72 protein linked to ALS and FTD

Sheffield researchers identify novel function of C9orf72 protein linked to ALS and FTD:

Dementia Big
Scientists from the University of Sheffield have discovered a novel function of the C9orf72 protein which is linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) - giving a new insight into the most common genetic cause of the degenerative diseases.


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Thursday, June 30, 2016

An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo

An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo:

Dementia Big
The pathological hallmarks of Alzheimer’s disease (AD), viz defective Aβ and tau proteins, have been the center of AD-directed therapeutic studies. Although this approach still remains valid, it has not yet produced clinically meaningful results.


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An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo

The pathological hallmarks of Alzheimer’s disease (AD), viz defective Aβ and tau proteins, have been the center of AD-directed therapeutic studies. Although this approach still remains valid, it has not yet produced clinically meaningful results.

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Wednesday, June 29, 2016

Study links dopamine D2 receptor to long-term episodic memory

A European study led by Umea University Professor Lars Nyberg, has shown that the dopamine D2 receptor is linked to the long-term episodic memory, which function often reduces with age and due to dementia.

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New study demonstrates no risk of contracting dementia through blood transfusion

Previous studies have shown that neurological diseases such as Alzheimer’s and Parkinson’s can be induced in healthy laboratory animals, causing concern that dementia diseases can be transmitted between individuals, possibly via blood transfusions.

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Basketball legend Pat Summitt's death points to ravages of early Alzheimer's

(HealthDay)—Legendary coach Pat Summitt stared down myriad challenges as she thrust women’s college basketball onto the world stage. But her greatest foe wasn’t on the court—it was Alzheimer’s disease.

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DADM: The first 2 years of the Alzheimer Association's open access journal to support the research and development of novel biomarkers and diagnostic approaches

In March 2015, after several years of planning by the Alzheimer's Association, its main scientific journal Alzheimer’s & Dementia, and the journal’s publisher, the association launched its first online open access journal, Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring [1] (http://ift.tt/292dqp3). Going by the acronym “DADM,” this journal was conceived of as an important new vehicle to advance the discovery, development, and validation of much-needed biomarkers to refine the ability to diagnose the disease in its earliest stages, or to sensitively track disease progression [2].

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