Hyperphosphorylation determines both the spread and the morphology of tau pathology

Hyperphosphorylation determines both the spread and the morphology of tau pathology:

Dementia Big
Neurofibrillary pathology of abnormally hyperphosphorylated tau (P-tau) is a hallmark of Alzheimer’s disease (AD) and other tauopathies. Tau pathology can be experimentally induced and propagated. However, what induces the prion-like transmission character to tau and produces morphologically distinct tau lesions remains elusive.

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